LOCUS       NM_006763               2729 bp    mRNA    linear   PRI 24-JUN-2024
DEFINITION  Homo sapiens BTG anti-proliferation factor 2 (BTG2), mRNA.
ACCESSION   NM_006763
VERSION     NM_006763.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2729)
  AUTHORS   He,Y., Wang,Y., Luo,Z., Zhang,X., Bai,H. and Wang,J.
  TITLE     SMC2 knockdown inhibits malignant progression of lung
            adenocarcinoma by upregulating BTG2 expression
  JOURNAL   Cell Signal 120, 111216 (2024)
   PUBMED   38729325
  REMARK    GeneRIF: SMC2 knockdown inhibits malignant progression of lung
            adenocarcinoma by upregulating BTG2 expression.
REFERENCE   2  (bases 1 to 2729)
  AUTHORS   Pan,B., Teng,Y., Wang,R., Chen,D. and Chen,H.
  TITLE     Deciphering the molecular nexus of BTG2 in periodontitis and
            diabetic kidney disease
  JOURNAL   BMC Med Genomics 17 (1), 152 (2024)
   PUBMED   38831322
  REMARK    GeneRIF: Deciphering the molecular nexus of BTG2 in periodontitis
            and diabetic kidney disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2729)
  AUTHORS   Bestepe,F., Ghanem,G.F., Fritsche,C.M., Weston,J., Sahay,S.,
            Mauro,A.K., Sahu,P., Tas,S.M., Ruemmele,B., Persing,S., Good,M.E.,
            Chatterjee,A., Huggins,G.S., Salehi,P. and Icli,B.
  TITLE     MicroRNA-409-3p/BTG2 signaling axis improves impaired angiogenesis
            and wound healing in obese mice
  JOURNAL   FASEB J 38 (3), e23459 (2024)
   PUBMED   38329343
  REMARK    GeneRIF: MicroRNA-409-3p/BTG2 signaling axis improves impaired
            angiogenesis and wound healing in obese mice.
REFERENCE   4  (bases 1 to 2729)
  AUTHORS   He,Y., Yang,P., Yuan,T., Zhang,L., Yang,G., Jin,J. and Yu,T.
  TITLE     miR-103-3p Regulates the Proliferation and Differentiation of C2C12
            Myoblasts by Targeting BTG2
  JOURNAL   Int J Mol Sci 24 (20), 15318 (2023)
   PUBMED   37894995
  REMARK    GeneRIF: miR-103-3p Regulates the Proliferation and Differentiation
            of C2C12 Myoblasts by Targeting BTG2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2729)
  AUTHORS   Peng,B., Chen,Y., Wang,Y., Fu,Y., Zeng,X., Zhou,H., Abulaiti,Z.,
            Wang,S. and Zhang,H.
  TITLE     BTG2 acts as an inducer of muscle stem cell senescence
  JOURNAL   Biochem Biophys Res Commun 669, 113-119 (2023)
   PUBMED   37269593
  REMARK    GeneRIF: BTG2 acts as an inducer of muscle stem cell senescence.
REFERENCE   6  (bases 1 to 2729)
  AUTHORS   Rouault,J.P., Prevot,D., Berthet,C., Birot,A.M., Billaud,M.,
            Magaud,J.P. and Corbo,L.
  TITLE     Interaction of BTG1 and p53-regulated BTG2 gene products with
            mCaf1, the murine homolog of a component of the yeast CCR4
            transcriptional regulatory complex
  JOURNAL   J Biol Chem 273 (35), 22563-22569 (1998)
   PUBMED   9712883
REFERENCE   7  (bases 1 to 2729)
  AUTHORS   Rouault,J.P., Falette,N., Guehenneux,F., Guillot,C., Rimokh,R.,
            Wang,Q., Berthet,C., Moyret-Lalle,C., Savatier,P., Pain,B.,
            Shaw,P., Berger,R., Samarut,J., Magaud,J.P., Ozturk,M., Samarut,C.
            and Puisieux,A.
  TITLE     Identification of BTG2, an antiproliferative p53-dependent
            component of the DNA damage cellular response pathway
  JOURNAL   Nat Genet 14 (4), 482-486 (1996)
   PUBMED   8944033
  REMARK    GeneRIF: First evidence that BTG2 is a target of p53 and is
            activated p53-dependently by DNA damage.
REFERENCE   8  (bases 1 to 2729)
  AUTHORS   Montagnoli,A., Guardavaccaro,D., Starace,G. and Tirone,F.
  TITLE     Overexpression of the nerve growth factor-inducible PC3 immediate
            early gene is associated with growth inhibition
  JOURNAL   Cell Growth Differ 7 (10), 1327-1336 (1996)
   PUBMED   8891336
  REMARK    GeneRIF: PC3 / BTG2 inhibits the proliferation of different types
            of cells, including neural cells.
REFERENCE   9  (bases 1 to 2729)
  AUTHORS   Lin,W.J., Gary,J.D., Yang,M.C., Clarke,S. and Herschman,H.R.
  TITLE     The mammalian immediate-early TIS21 protein and the
            leukemia-associated BTG1 protein interact with a protein-arginine
            N-methyltransferase
  JOURNAL   J Biol Chem 271 (25), 15034-15044 (1996)
   PUBMED   8663146
REFERENCE   10 (bases 1 to 2729)
  AUTHORS   Fletcher,B.S., Lim,R.W., Varnum,B.C., Kujubu,D.A., Koski,R.A. and
            Herschman,H.R.
  TITLE     Structure and expression of TIS21, a primary response gene induced
            by growth factors and tumor promoters
  JOURNAL   J Biol Chem 266 (22), 14511-14518 (1991)
   PUBMED   1713584
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL513326.19.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 26, 2018 this sequence version replaced NM_006763.2.
            
            Summary: The protein encoded by this gene is a member of the
            BTG/Tob family. This family has structurally related proteins that
            appear to have antiproliferative properties. This encoded protein
            is involved in the regulation of the G1/S transition of the cell
            cycle. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.11497.1,
                                           SRR1660805.237860.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000290551.5/ ENSP00000290551.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-230               AL513326.19        19234-19463
            231-2729            AL513326.19        20819-23317
FEATURES             Location/Qualifiers
     source          1..2729
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..2729
                     /gene="BTG2"
                     /gene_synonym="APRO1; PC3; TIS21"
                     /note="BTG anti-proliferation factor 2"
                     /db_xref="GeneID:7832"
                     /db_xref="HGNC:HGNC:1131"
                     /db_xref="MIM:601597"
     exon            1..230
                     /gene="BTG2"
                     /gene_synonym="APRO1; PC3; TIS21"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..565
                     /gene="BTG2"
                     /gene_synonym="APRO1; PC3; TIS21"
                     /note="pheochromacytoma cell-3; NGF-inducible
                     anti-proliferative protein PC3; nerve growth
                     factor-inducible anti-proliferative; B-cell translocation
                     gene 2; BTG family member 2"
                     /codon_start=1
                     /product="protein BTG2"
                     /protein_id="NP_006754.1"
                     /db_xref="CCDS:CCDS1437.1"
                     /db_xref="GeneID:7832"
                     /db_xref="HGNC:HGNC:1131"
                     /db_xref="MIM:601597"
                     /translation="MSHGKGTDMLPEIAAAVGFLSSLLRTRGCVSEQRLKVFSGALQE
                     ALTEHYKHHWFPEKPSKGSGYRCIRINHKMDPIISRVASQIGLSQPQLHQLLPSELTL
                     WVDPYEVSYRIGEDGSICVLYEEAPLAASCGLLTCKNQVLLGRSSPSKNYVMAVSS"
     exon            231..2729
                     /gene="BTG2"
                     /gene_synonym="APRO1; PC3; TIS21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2708..2713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BTG2"
                     /gene_synonym="APRO1; PC3; TIS21"
                     /note="hexamer: AATAAA"
     polyA_site      2729
                     /gene="BTG2"
                     /gene_synonym="APRO1; PC3; TIS21"
                     /note="major polyA site"
ORIGIN      
        1 agagcccgag cagcggccag ggtaacgctg tcttgtggac ccgcacttcc cacccgagac
       61 ctctcactga gcccgagccg cgcgcgacat gagccacggg aagggaaccg acatgctccc
      121 ggagatcgcc gccgccgtgg gcttcctctc cagcctcctg aggacccggg gctgcgtgag
      181 cgagcagagg cttaaggtct tcagcggggc gctccaggag gcactcacag agcactacaa
      241 acaccactgg tttcccgaaa agccgtccaa gggctccggc taccgctgca ttcgcatcaa
      301 ccacaagatg gaccccatca tcagcagggt ggccagccag atcggactca gccagcccca
      361 gctgcaccag ctgctgccca gcgagctgac cctgtgggtg gacccctatg aggtgtccta
      421 ccgcattggg gaggacggct ccatctgcgt cttgtacgag gaggccccac tggccgcctc
      481 ctgtgggctc ctcacctgca agaaccaagt gctgctgggc cggagcagcc cctccaagaa
      541 ctacgtgatg gcagtctcca gctaggccct tccgcccccg ccctgggcgc cgccgtgctc
      601 atgctgccgt gacaacaggc caccacatac ctcaacctgg ggaactgtat ttttaaatga
      661 agagctattt atatatatta ttttttttta agaaaggagg aaaagaaacc aaaagttttt
      721 tttaagaaaa aaaatccttc aagggagctg cttggaagtg gcctccccag gtgcctttgg
      781 agagaactgt tgcgtgcttg agtctgtgag ccagtgtctg cctataggag ggggagctgt
      841 tagggggtag acctagccaa ggagaagtgg gagacgtttg gctagcaccc caggaagatg
      901 tgagagggag caagcaaggt tagcaactgt gaacagagag gtcgggattt gccctggggg
      961 aggaagagag gccaagttca gagctctctg tctcccccag ccagacacct gcatccctgg
     1021 ctcctctatt actcaggggc attcatgcct ggacttaaac aatactatgt tatcttttct
     1081 tttatttttc taatgaggtc ctgggcagag agtgaaaagg cctctcctga ttcctactgt
     1141 cctaagctgc ttttcttgaa atcatgactt gtttctaatt ctaccctcag gggcctgtag
     1201 atgttgcttt ccagccagga atctaaagct ttgggttttc tgaggggggg gaggagggaa
     1261 ctggaggtta ttggggttag gatggaaggg aactctgcac aaaacctttg ctttgctagt
     1321 gctgctttgt gtgtatgtgt ggcaaataat ttgggggtga tttgcaatga aattttggga
     1381 cccaaagagt atccactggg gatgtttttt ggccaaaact cttccttttg gaaccacatg
     1441 aaagtcttga tgctgctgcc atgatccctt tgagaggtgg ctcaaaagct acagggaact
     1501 ccaggtcctt tattactgcc ttcttttcaa aagcacaact ctcctctaac cctcccctcc
     1561 cccttccctt ctggtcgggt catagagcta ccgtattttc taggacaaga gttctcagtc
     1621 actgtgcaat atgccccctg ggtcccagga gggtctggag gaaaactggc tatcagaacc
     1681 tcctgatgcc ctggtgggct tagggaacca tctctcctgc tctccttggg atgatggctg
     1741 gctagtcagc cttgcatgta ttccttggct gaatgggaga gtgccccatg ttctgcaaga
     1801 ctacttggta ttcttgtagg gccgacacta aataaaagcc aaaccttggg cactgttttt
     1861 tctccctggt gctcagagca cctgtgggaa aggttgctgt ctgtctcagt acaatccaaa
     1921 tttgtcgtag acttgtgcaa tatatactgt tgtgggttgg agaaaagtgg aaagctacac
     1981 tgggaagaaa ctcccttcct tcaatttctc agtgacattg atgaggggtc ctcaaaagac
     2041 ctcgagtttc ccaaaccgaa tcaccttaag aaggacaggg ctagggcatt tggccaggat
     2101 ggccaccctc ctgctgttgc cccttagtga ggaatcttca ccccacttcc tctaccccca
     2161 ggttctcctc cccacagcca gtcccctttc ctggatttct aaactgctca attttgactc
     2221 aaaggtgcta tttaccaaac actctcccta cccattcctg ccagctctgc ctccttttca
     2281 actctccaca ttttgtattg ccttcccaga cctgcttcca gtctttattg ctttaaagtt
     2341 cactttgggc ccacagaccc aagagctaat tttctggttt gtgggttgaa acaaagctgt
     2401 gaatcactgc aggctgtgtt cttgcatctt gtctgcaaac aggtccctgc ctttttagaa
     2461 gcagcctcat ggtctcatgc ttaatcttgt ctctcttctc ttctttatga tgttcacttt
     2521 aaaaacaaca aaacccctga gctggactgt tgagcaggcc tgtctctcct attaagtaaa
     2581 aataaatagt agtagtatgt ttgtaagcta ttctgacaga aaagacaaag gttactaatt
     2641 gtatgatagt gtttttatat ggaagaatgt acagcttatg gacaaatgta cacctttttg
     2701 ttactttaat aaaaatgtag taggataaa
//
