LOCUS       NM_001731               4629 bp    mRNA    linear   PRI 11-AUG-2024
DEFINITION  Homo sapiens BTG anti-proliferation factor 1 (BTG1), mRNA.
ACCESSION   NM_001731
VERSION     NM_001731.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4629)
  AUTHORS   Delage,L., Lambert,M., Bardel,E., Kundlacz,C., Chartoire,D.,
            Conchon,A., Peugnet,A.L., Gorka,L., Auberger,P., Jacquel,A.,
            Soussain,C., Destaing,O., Delecluse,H.J., Delecluse,S., Merabet,S.,
            Traverse-Glehen,A., Salles,G., Bachy,E., Billaud,M.,
            Ghesquieres,H., Genestier,L., Rouault,J.P. and Sujobert,P.
  TITLE     BTG1 inactivation drives lymphomagenesis and promotes lymphoma
            dissemination through activation of BCAR1
  JOURNAL   Blood 141 (10), 1209-1220 (2023)
   PUBMED   36375119
  REMARK    GeneRIF: BTG1 inactivation drives lymphomagenesis and promotes
            lymphoma dissemination through activation of BCAR1.
REFERENCE   2  (bases 1 to 4629)
  AUTHORS   Mlynarczyk,C., Teater,M., Pae,J., Chin,C.R., Wang,L., Arulraj,T.,
            Barisic,D., Papin,A., Hoehn,K.B., Kots,E., Ersching,J.,
            Bandyopadhyay,A., Barin,E., Poh,H.X., Evans,C.M., Chadburn,A.,
            Chen,Z., Shen,H., Isles,H.M., Pelzer,B., Tsialta,I., Doane,A.S.,
            Geng,H., Rehman,M.H., Melnick,J., Morgan,W., Nguyen,D.T.T.,
            Elemento,O., Kharas,M.G., Jaffrey,S.R., Scott,D.W., Khelashvili,G.,
            Meyer-Hermann,M., Victora,G.D. and Melnick,A.
  TITLE     BTG1 mutation yields supercompetitive B cells primed for malignant
            transformation
  JOURNAL   Science 379 (6629), eabj7412 (2023)
   PUBMED   36656933
  REMARK    GeneRIF: BTG1 mutation yields supercompetitive B cells primed for
            malignant transformation.
REFERENCE   3  (bases 1 to 4629)
  AUTHORS   Kim,S.H., Jung,I.R. and Hwang,S.S.
  TITLE     Emerging role of anti-proliferative protein BTG1 and BTG2
  JOURNAL   BMB Rep 55 (8), 380-388 (2022)
   PUBMED   35880434
  REMARK    GeneRIF: Emerging role of anti-proliferative protein BTG1 and BTG2.
            Review article
REFERENCE   4  (bases 1 to 4629)
  AUTHORS   Cheng,Q., Li,Q., Xu,L. and Jiang,H.
  TITLE     Exosomal microRNA-301a-3p promotes the proliferation and invasion
            of nasopharyngeal carcinoma cells by targeting BTG1 mRNA
  JOURNAL   Mol Med Rep 23 (5) (2021)
   PUBMED   33760119
  REMARK    GeneRIF: Exosomal microRNA-301a-3p promotes the proliferation and
            invasion of nasopharyngeal carcinoma cells by targeting BTG1 mRNA.
REFERENCE   5  (bases 1 to 4629)
  AUTHORS   Almasmoum,H.A., Airhihen,B., Seedhouse,C. and Winkler,G.S.
  TITLE     Frequent loss of BTG1 activity and impaired interactions with the
            Caf1 subunit of the Ccr4-Not deadenylase in non-Hodgkin lymphoma
  JOURNAL   Leuk Lymphoma 62 (2), 281-290 (2021)
   PUBMED   33021411
  REMARK    GeneRIF: Frequent loss of BTG1 activity and impaired interactions
            with the Caf1 subunit of the Ccr4-Not deadenylase in non-Hodgkin
            lymphoma.
REFERENCE   6  (bases 1 to 4629)
  AUTHORS   Rouault,J.P., Prevot,D., Berthet,C., Birot,A.M., Billaud,M.,
            Magaud,J.P. and Corbo,L.
  TITLE     Interaction of BTG1 and p53-regulated BTG2 gene products with
            mCaf1, the murine homolog of a component of the yeast CCR4
            transcriptional regulatory complex
  JOURNAL   J Biol Chem 273 (35), 22563-22569 (1998)
   PUBMED   9712883
REFERENCE   7  (bases 1 to 4629)
  AUTHORS   Corjay,M.H., Kearney,M.A., Munzer,D.A., Diamond,S.M. and
            Stoltenborg,J.K.
  TITLE     Antiproliferative gene BTG1 is highly expressed in apoptotic cells
            in macrophage-rich areas of advanced lesions in Watanabe heritable
            hyperlipidemic rabbit and human
  JOURNAL   Lab Invest 78 (7), 847-858 (1998)
   PUBMED   9690562
REFERENCE   8  (bases 1 to 4629)
  AUTHORS   Lin,W.J., Gary,J.D., Yang,M.C., Clarke,S. and Herschman,H.R.
  TITLE     The mammalian immediate-early TIS21 protein and the
            leukemia-associated BTG1 protein interact with a protein-arginine
            N-methyltransferase
  JOURNAL   J Biol Chem 271 (25), 15034-15044 (1996)
   PUBMED   8663146
REFERENCE   9  (bases 1 to 4629)
  AUTHORS   Rouault,J.P., Rimokh,R., Tessa,C., Paranhos,G., Ffrench,M.,
            Duret,L., Garoccio,M., Germain,D., Samarut,J. and Magaud,J.P.
  TITLE     BTG1, a member of a new family of antiproliferative genes
  JOURNAL   EMBO J 11 (4), 1663-1670 (1992)
   PUBMED   1373383
REFERENCE   10 (bases 1 to 4629)
  AUTHORS   Rimokh,R., Rouault,J.P., Wahbi,K., Gadoux,M., Lafage,M.,
            Archimbaud,E., Charrin,C., Gentilhomme,O., Germain,D., Samarut,J.
            et al.
  TITLE     A chromosome 12 coding region is juxtaposed to the MYC
            protooncogene locus in a t(8;12)(q24;q22) translocation in a case
            of B-cell chronic lymphocytic leukemia
  JOURNAL   Genes Chromosomes Cancer 3 (1), 24-36 (1991)
   PUBMED   2069907
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK313309.1, BC064953.1,
            X61123.1, BC009050.1 and AC025164.37.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001731.2.
            
            Summary: This gene is a member of an anti-proliferative gene family
            that regulates cell growth and differentiation. Expression of this
            gene is highest in the G0/G1 phases of the cell cycle and
            downregulated when cells progressed through G1. The encoded protein
            interacts with several nuclear receptors, and functions as a
            coactivator of cell differentiation. This locus has been shown to
            be involved in a t(8;12)(q24;q22) chromosomal translocation in a
            case of B-cell chronic lymphocytic leukemia. [provided by RefSeq,
            Oct 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA700239.1, SRR1803614.241137.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256015.5/ ENSP00000256015.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               AK313309.1         3-281
            280-976             BC064953.1         274-970
            977-1780            X61123.1           975-1778
            1781-1856           BC009050.1         81-156
            1857-1857           AC025164.37        128625-128625       c
            1858-4629           BC009050.1         158-2929
FEATURES             Location/Qualifiers
     source          1..4629
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.33"
     gene            1..4629
                     /gene="BTG1"
                     /gene_synonym="APRO2"
                     /note="BTG anti-proliferation factor 1"
                     /db_xref="GeneID:694"
                     /db_xref="HGNC:HGNC:1130"
                     /db_xref="MIM:109580"
     exon            1..459
                     /gene="BTG1"
                     /gene_synonym="APRO2"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..827
                     /gene="BTG1"
                     /gene_synonym="APRO2"
                     /note="B-cell translocation gene 1 protein; B-cell
                     translocation gene 1, anti-proliferative"
                     /codon_start=1
                     /product="protein BTG1"
                     /protein_id="NP_001722.1"
                     /db_xref="CCDS:CCDS9043.1"
                     /db_xref="GeneID:694"
                     /db_xref="HGNC:HGNC:1130"
                     /db_xref="MIM:109580"
                     /translation="MHPFYTRAATMIGEIAAAVSFISKFLRTKGLTSERQLQTFSQSL
                     QELLAEHYKHHWFPEKPCKGSGYRCIRINHKMDPLIGQAAQRIGLSSQELFRLLPSEL
                     TLWVDPYEVSYRIGEDGSICVLYEASPAGGSTQNSTNVQMVDSRISCKEELLLGRTSP
                     SKNYNMMTVSG"
     exon            460..4629
                     /gene="BTG1"
                     /gene_synonym="APRO2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1753..1758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BTG1"
                     /gene_synonym="APRO2"
                     /note="hexamer: AATAAA"
     polyA_site      1782
                     /gene="BTG1"
                     /gene_synonym="APRO2"
                     /note="major polyA site"
     regulatory      4610..4615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BTG1"
                     /gene_synonym="APRO2"
                     /note="hexamer: AATAAA"
     polyA_site      4629
                     /gene="BTG1"
                     /gene_synonym="APRO2"
ORIGIN      
        1 cgcctctcgg agctggaaat gcagctattg agatcttcga atgctgcgga gctggaggcg
       61 gaggcagctg gggaggtccg agcgatgtga ccaggccgcc atcgctcgtc tcttcctctc
      121 tcctgccgcc tcctgtctcg aaaataactt ttttagtcta aagaaagaaa gacaaaagta
      181 gtcgtccgcc cctcacgccc tctcttcctc tcagccttcc gcccggtgag gaagcccggg
      241 gtggctgctc cgccgtcggg gccgcgccgc cgagccccag ccgccccggg ccgcccccgc
      301 acgccgcccc catgcatccc ttctacaccc gggccgccac catgataggc gagatcgccg
      361 ccgccgtgtc cttcatctcc aagtttctcc gcaccaaggg gctcacgagc gagcgacagc
      421 tgcagacctt cagccagagc ctgcaggagc tgctggcaga acattataaa catcactggt
      481 tcccagaaaa gccatgcaag ggatcgggtt accgttgtat tcgcatcaac cataaaatgg
      541 atcctctgat tggacaggca gcacagcgga ttggactgag cagtcaggag ctgttcaggc
      601 ttctcccaag tgaactcaca ctctgggttg acccctatga agtgtcctac agaattggag
      661 aggatggctc catctgtgtg ctgtatgaag cctcaccagc aggaggtagc actcaaaaca
      721 gcaccaacgt gcaaatggta gacagccgaa tcagctgtaa ggaggaactt ctcttgggca
      781 gaacgagccc ttccaaaaac tacaatatga tgactgtatc aggttaagat atagtctgtg
      841 gatggatcat ctgatgatga tggataaatt tgatttttgc tttgggtggg ctcctcttgg
      901 ggatggatta tggaatttaa accatgtcac agctgtgaag atctggcaca agatagaatg
      961 gtaaaaaaaa aaaaaatttt aagtgacagt gccatagttt ggacagtacc tttcaatgat
     1021 taattttaat agcctgtgag tccaagtaaa tgatcacttt atttgctagg gagggaagtc
     1081 ctagggtggt ttcagtttct cccagacata cctaaatttt tacatcaatc cttttaaaga
     1141 aaatctgtat ttcaaagaat ctttctctgc agtaaatctc gcaggggaat ttgcactatt
     1201 acacttgaaa gttgttattg ttaacctttt cggcagcttt taataggaaa gttaaacgtt
     1261 ttaaacatgg tagtactgga aattttacaa gacttttacc tagcacttaa atatgtataa
     1321 atgtacataa agacaaacta gtaagcatga cctggggaaa tggtcagacc ttgtattgtg
     1381 tttttggcct tgaaagtagc aagtgaccag aatctgccat ggcaacaggc tttaaaaaag
     1441 acccttaaaa agacactgtc tcaactgtgg tgttagcacc agccagctct ctgtacattt
     1501 gctagcttgt agttttctaa gactgagtaa acttcttatt tttagaaagt ggaggtctgg
     1561 tttgtaactt tccttgtact taattgggta aaagtctttt ccacaaacca ccatctattt
     1621 tgtgaacttt gttagtcatc ttttatttgg taaattatga actggtgtaa atttgtacag
     1681 ttcatgtata ttgattgtgg caaagttgta cagatttcta tattttggat gagaaatttt
     1741 tcttctctct ataataaatc gtttcttatc ttggcatttt aatcaatctc ttgtcatgat
     1801 tatagaggtt tagctaaaag tattttttct tagaagacag gttctataaa ctgaatctct
     1861 gttgcacact ggtcatgctg gaaaaacatt tgatgaggaa tgaagatgct ctgtatatac
     1921 atgtttaggt tttacaggaa acacaggagt agcatgtttt aaaaatttct aaagtcaaaa
     1981 catggacaca ttcacaggct aatgatctca tgaaataagg ataagagacc acggtagcat
     2041 ctaccaaaaa tgtgatactc aaaggattac atttcattgc ttccctgttg aagtgaagat
     2101 ataaatgttc cattctgacc cacctttgaa aaacaattac tttgccccat ggattctttg
     2161 ttcaattaga aatttccccg gggcaggtga cccatagtct taaagaacag gctaaacacc
     2221 acagagagat tggttgcttt ttgcttttca tcacctgcaa gatgtacata aaaatcacat
     2281 aagctggaat tcaacaaaag gtatgtttat gaacttttat tctcaaaagt tgaaatgctg
     2341 actttctcga ttcctcattt tcagactttt atttcagata aatactaaaa acctaagtga
     2401 accttgataa tgctgtagtg tagattactt cactacccca tataatagaa ggacttgctg
     2461 tttagttgta gaggataaca gcgtttttca gtggaaattg aaagtggaaa aattgaattt
     2521 tgctctacac agttaacata tagtggcctt tttttggtat atatgtaaac atgttgacac
     2581 tggaaatacg cagtctgaaa taaaattagt aattacttga aattagtaat ctcaaataac
     2641 ttttaagaag ttatttctac acccaggaat aaattattct gattttgtag acaacacagg
     2701 aataggccac tgaatatgca ggtatttaga gtacaaatgt ctgtggatat tattggcaca
     2761 ccattctcga gagttagaat tcgtagaccc gcaacacatg gactaccctt gccaattgtt
     2821 atggttttat ttttaaacct attctgtgaa aaagctcctc ggtatttcaa acttgaatta
     2881 caataaaaac accaggtagg gttgttttta aatgggtctc accccagtgc tgactactgt
     2941 tgtttaccaa ctacatttca tctggtaact ccattgaaac taagtacctc aaccattttt
     3001 tttttttatc ataaagcctt ttttcaaatg gaaagttgtt tttgaagatc ttgacatcag
     3061 actttttcaa tctttgaaaa tgatggaaac agttaataaa aatgtttatt ttagaattca
     3121 ggtgatgtct ggcttgtgag gagctgttta taagtttgtc tttgaaaaag gcttgcacac
     3181 atcactctga gaccagctgt ttcctgtgac tttaacctta ccttccccag acaattgagc
     3241 tgaacctgta tctgcggtac agtagctgtt tgtgatgtat ttcttgttca ctgtttctgg
     3301 ggaatgtttt gaaatatttt attataaatc cttttaagat aggatgacta ctttcaaaat
     3361 tattgttgcc tttggcacca ggaattcata gttgtgattg gcagtaagtt tgaggagtgt
     3421 tactttctaa gttttaacag gtagttttga aattatttcc ttttttccaa atttaagtag
     3481 tgcctccctc tgtaatgttg aaacaaggct tcaagtggat tgtatagcaa gagttaccct
     3541 ggttcatgca ggataatgcg gctgttatct ttgtcatctg gaatgggaat ctcatgtctt
     3601 tatccttatg tgcaatattt ctataataat agactggaaa ggccaccaga aagtggcttt
     3661 caggtacatt gcacaaatag tttccttaag tcattataac tcacacattg caagtaatta
     3721 attttgtttt gtataggtgt tgcagtttat gaaattggcc ttcaagttaa aaggaaggaa
     3781 gccgtattcc cgatggctag tgtttaatga ctacaggttt ccaggctccc tttaatcttg
     3841 ggagcaaata aatctactat tggacttctc cctgcgtgac ttttaacatt tctgatactc
     3901 tctcttcttc ctctttacag aagagaggta tgataactga agttgtactt tgcatattga
     3961 agtttaaaga tacttcctct ccccttttca cccctatttc aaatgatgtg ataaaatcct
     4021 cttgataggc tatatggaga acatttgtca atagttttat ctatgcatgg aagtcttcaa
     4081 aaagtatatc ttggattgtc taaaactgaa tagatttctt atttatctga aggtatacag
     4141 actgccaaca ttttagactt atctctcagt ctctgccact gaacttttat atatggctgc
     4201 tatcaaaata taaccggttt attttcatat ttggaactaa tataacagta tcacaaaatc
     4261 ttttacagta agatagtttg taataccagc cgacccagct gcttaactga gtccttaaat
     4321 catttaatat atgggactgt aaatagagaa atctgtacat tatgagatct gatttctggt
     4381 tatgcctata gatctttatt ttctttatcc ctatagatca ttttcttctg atgttaagtg
     4441 ttatattttt gaaatgctcc taaacaagta agccttagat tgtattaatc ctgaggattg
     4501 ataccatttc ctcaacactt tgtggagtat gattgacacc agtttttttt tgactgcagg
     4561 tttaacttgg cttatcactt ttcgtattgc tcagtatgtc caagatagga ataaaaaaat
     4621 gtagttcaa
//
