LOCUS       NM_152265               4533 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens basic transcription factor 3 like 4 (BTF3L4),
            transcript variant 1, mRNA.
ACCESSION   NM_152265 XM_371577 XM_496364
VERSION     NM_152265.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4533)
  AUTHORS   Lu,B., Lu,T., Shi,J., Sun,P., Zhang,X., Yang,L., Wang,Z. and
            Huang,J.
  TITLE     Basic Transcription Factor 3 Like 4 Enhances Malignant Phenotypes
            through Modulating Tumor Cell Function and Immune Microenvironment
            in Glioma
  JOURNAL   Am J Pathol 194 (5), 772-784 (2024)
   PUBMED   38320629
  REMARK    GeneRIF: Basic Transcription Factor 3 Like 4 Enhances Malignant
            Phenotypes through Modulating Tumor Cell Function and Immune
            Microenvironment in Glioma.
REFERENCE   2  (bases 1 to 4533)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4533)
  AUTHORS   Ji,Y.H., Ji,J.L., Sun,F.Y., Zeng,Y.Y., He,X.H., Zhao,J.X., Yu,Y.,
            Yu,S.H. and Wu,W.
  TITLE     Quantitative proteomics analysis of chondrogenic differentiation of
            C3H10T1/2 mesenchymal stem cells by iTRAQ labeling coupled with
            on-line two-dimensional LC/MS/MS
  JOURNAL   Mol Cell Proteomics 9 (3), 550-564 (2010)
   PUBMED   20008835
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC070378.1 and AL139156.11.
            
            On Nov 22, 2018 this sequence version replaced NM_152265.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.26945.1,
                                           SRR1803611.61306.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313334.13/ ENSP00000360664.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-795               BC070378.1         1-795
            796-4533            AL139156.11        6218-9955
FEATURES             Location/Qualifiers
     source          1..4533
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..4533
                     /gene="BTF3L4"
                     /note="basic transcription factor 3 like 4"
                     /db_xref="GeneID:91408"
                     /db_xref="HGNC:HGNC:30547"
     exon            1..85
                     /gene="BTF3L4"
                     /inference="alignment:Splign:2.1.0"
     exon            86..152
                     /gene="BTF3L4"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..575
                     /gene="BTF3L4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor BTF3 homolog 4"
                     /codon_start=1
                     /product="transcription factor BTF3 homolog 4 isoform 1"
                     /protein_id="NP_689478.1"
                     /db_xref="CCDS:CCDS30713.1"
                     /db_xref="GeneID:91408"
                     /db_xref="HGNC:HGNC:30547"
                     /translation="MNQEKLAKLQAQVRIGGKGTARRKKKVVHRTATADDKKLQSSLK
                     KLAVNNIAGIEEVNMIKDDGTVIHFNNPKVQASLSANTFAITGHAEAKPITEMLPGIL
                     SQLGADSLTSLRKLAEQFPRQVLDSKAPKPEDIDEEDDDVPDLVENFDEASKNEAN"
     exon            153..266
                     /gene="BTF3L4"
                     /inference="alignment:Splign:2.1.0"
     exon            267..468
                     /gene="BTF3L4"
                     /inference="alignment:Splign:2.1.0"
     exon            469..528
                     /gene="BTF3L4"
                     /inference="alignment:Splign:2.1.0"
     exon            529..4533
                     /gene="BTF3L4"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      802
                     /gene="BTF3L4"
                     /note="major polyA site"
     regulatory      2185..2190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BTF3L4"
                     /note="hexamer: AATAAA"
     polyA_site      2209
                     /gene="BTF3L4"
                     /note="major polyA site"
     regulatory      3321..3326
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BTF3L4"
                     /note="hexamer: ATTAAA"
     polyA_site      3344
                     /gene="BTF3L4"
     regulatory      3570..3575
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BTF3L4"
                     /note="hexamer: AGTAAA"
     polyA_site      3589
                     /gene="BTF3L4"
     regulatory      3686..3691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BTF3L4"
                     /note="hexamer: ATTAAA"
     regulatory      3700..3705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BTF3L4"
                     /note="hexamer: AATAAG"
     polyA_site      3709
                     /gene="BTF3L4"
     polyA_site      3731
                     /gene="BTF3L4"
     regulatory      4512..4517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BTF3L4"
                     /note="hexamer: AATACA"
     polyA_site      4533
                     /gene="BTF3L4"
ORIGIN      
        1 gccgccgtcg tctttctctg tctcggctga ggcagccatc tttctcttgc cgcgtgctgg
       61 tgttggagga ccctccctgc ttcagattta ccaacagcat gaatcaagaa aagttagcca
      121 aacttcaggc tcaggtccgg atagggggca agggtacagc tcgcagaaag aagaaggtgg
      181 tacatagaac agccacagct gatgacaaaa agcttcagag ttctctaaaa aaactggctg
      241 tgaataatat agctggtatt gaagaggtga acatgattaa agatgatggg acagttattc
      301 atttcaacaa tcccaaagtc caagcttccc tttctgctaa tacctttgca attactggtc
      361 atgcagaagc caaaccaatc acagaaatgc ttcctggaat attaagtcag cttggtgctg
      421 acagtttaac aagccttagg aagttagctg aacagttccc acggcaagtc ttggacagta
      481 aagcaccaaa accagaagac attgatgagg aagatgatga tgttccagat cttgtagaaa
      541 attttgatga ggcatcaaag aatgaagcta actaaaagtt tggtttttgg aagctggcat
      601 ggactagatt taacaaatca gctatgtggt tccaaagttt tacagacatg gagaacatca
      661 cctgttacta gttcagtaat ataaatattt tgtatattaa taatgctgtt tgttcagcat
      721 ttttcggtca tttgattttg cattttgcac ttcctcccag gatatttttt tggtcaaaat
      781 atgaagtatt ggtgcagttt gagggtgttt tggtttttga ttcctggttt ttttgttttt
      841 tgtttggggt atttttggtg tatgtatgtt tatgtatgtg tgtgggtatg tgtgtataca
      901 gtggagagca aattggaaaa cagttctatt tatcctcctc cctccccagt agaaataaaa
      961 aaaatcttta catttgttac ttttcttttc cccccgtaag acacagaatt aatggaaagt
     1021 gagtatcttg gatttcaaat ctgaagagat ttttaccatt agtggtttga ttttaatttg
     1081 cttggttaac tatcatattt ttcatacact tctctggatt taaaatatct tgaggtattt
     1141 tgccactggc ttcatgctgg agtaatgggt aacatatctt tggtatggtt gccttagatt
     1201 aacttaccta gtcagaccca gaagaacttc ttttactagc ttgcttccta aatgcctttt
     1261 ttcctctcct tttggtctcc aaatggcctg gtcagctttt ggtaatattc ttcctcatct
     1321 tccacctagc ttgagaagga tgttctccat atagagttta gcgagtgcct aatccctcct
     1381 tttgtaagat tttgttccct cagcttgagg aacaacttca tcttcaactt tttatttctc
     1441 cctgatgtta cagtttggta gatttcaaac tggaatagct agcatgtgct tgctaaataa
     1501 ttttatgcca gccttatcct gtatcctagc tgttcttaac agcaggtaca aaaatgcctg
     1561 tttttcagca aggttgaaat tgggaatgtc cttttgaatc agaagaaaat aggccataga
     1621 ctcatctccc agcacaaatg ggcattctat gaaatggtac tggccctagg aggatttcct
     1681 caaccactct cctactcttg gccttgaacc tacctctggg ttggatctta ctattgtagc
     1741 tgctcactat accctcctgc atgcttagaa taatgctttg aggggagcac tggtaaaaca
     1801 cagtatttat ttttttacct cctttaagag gacttggagg taagttgcat tcattcactc
     1861 aagtttccct cttgctgtct aatagaagct tactttttgc tatatcagca tttgttacag
     1921 ccaatattta aggacaaaat ttagaaaata tatcatttcc tggcccatca tcaaactaat
     1981 acagcttaac cttgcagcta ccaacttttg tgtcaagcta gatatcttta tttgatatct
     2041 aaggtgcaag accaacaata tattaagaga tctgtagaca tgaaggcaaa gctcttgtat
     2101 tttttttcat ccaaacacct caatttattt tataaattcg ttcatttttc ctgttatgtt
     2161 ttatataata tatggactaa acaaaataaa ataacagtgc aaaagaggag aatatttcct
     2221 cttgtgcttt tcttgatgtt gtgtacagaa tttcctttta tattattcct ctaccctcca
     2281 cctgtaaatg aatgttagtg cagtaattgt ttgaaataat gcctcatcca gtgttaggtc
     2341 agtagctcca cagtctacac agtccagaat tctttctcta attgtcccaa agggggacat
     2401 tgtggaggca gagttagggg gaaccacttc aagtggttag ggacagataa ataataggca
     2461 gtatagcaca tgaaagaaaa cacacacttg gaagccagga gacttgtgtc ctagtcaaaa
     2521 ctctggcatt atgtgacctt ggacaggtca tctaactact ctgaaattta tcatcagtca
     2581 aataagattt tattctgttt tgttttgttt gagatgggga tttgctcttg ttgtccaggc
     2641 cgaactgcaa tgttgtggtc tcggctgact gcaacctcca cctcccagat tcaagcgatt
     2701 ctcctgtctc agcctccaca gtagctggga tttttttttt ttttttttgt atttttagta
     2761 gagatggggt tttaccatgt tgcccaggcc ggtcttgaat tcctgtcctc aggtgattca
     2821 tttgcctcgg cctcccaaag tgctaggatt acaggcgtga gccactgcac ccagcccaaa
     2881 tgagatgttt ctaaatctaa agtttcttct gcttctgcat ttctgtgaat ctcatttgaa
     2941 atttttcagg gaagggattt tatcatttgt tcagagatgt ctttattttt attaataccc
     3001 ataaaacgtt tgtgtatttg cttcttcctc tttctccttt tgatcacatt ttagctactt
     3061 atctagagga tctctggcca agtattccct tttattgtat tgataacaat tcttaatggc
     3121 tggcctctct tgtgtacaat gagccaatat tcttttttgt tctatatttt tgtatcttcc
     3181 cctttcctga acaaagcata tttagagtct caaagaaatc ctctccacaa agacatgttc
     3241 ctccctctgg tgtgggtaga catagggtaa gagtttggat gaaacttttg taaattgtag
     3301 tgttcttggc ataaatatga attaaatctt tttttatatt taaataacta gttaaatatg
     3361 tgcttcttac taagattagg tattttttgc caagataaca atgataaaaa cattttgggg
     3421 gggaaattga ccttaaaatt ttgggataat tcaagaaatg tctgcagaaa attgatttat
     3481 gatcttaatt tttgtgttag tcctttgagg tttttttgtt tttgtttttg ttctttgtaa
     3541 agcgccttat ctgttttgga caagtccaaa gtaaatggtt gggctcttat atctgtttta
     3601 cccttatttt tcccattaag taatggttta agaatatatc aagcacctta atttgttgtt
     3661 aagtagctag tgcttacagg attccattaa attcacttta ataagcctat gaagttctta
     3721 tgaaaaaccc atatctgcga tatgtttgat ttgtttcttt gttttaattc agtgtttaac
     3781 cctaggtatg ctacataccc ataaataaga taccatggta agagatagta tgttatagtg
     3841 ggaaaagcac aagtttttag atagagatca attctgctat ctacccttac attgtaacct
     3901 ttctgacagg gctgctgcgg tgcacaactt cgggagccat cacttatttt tgttgtgttc
     3961 cagaaggtgt cattttcata gactgcagtg tgaatagtgt cctccattaa taatgcaatg
     4021 atggccttgc tctctgagcc tcagttttat ctataaaatg gtacctagaa gagtcatgat
     4081 ttcttagaat cccctaaatt attaaggtga aggtagaaga tgattaaagc gtgttatctc
     4141 ctaagctatg gcttagattt tccgaagctc atggttctag gcacagaaag tctccattct
     4201 acactgcatt tcaacctgtg ttgaacaaca ctccagttca gcctgtattg ctatgccaca
     4261 tagagtttgc ctgaattatt atagctttct taatagtttt gtttatgatc cactctctcc
     4321 agcccattac acaggagcca gctacctaaa tttcctatct gagcatgtcc ttacatttac
     4381 ttccagcata ctattcattt gccatagtag agtattaaga ttatttgatt ttctttttac
     4441 tttctcgtag tgcccaatgt gtagtttact caacatcata atatgtaatg tttttcaact
     4501 acttactgtt gaatacaaag ttatctcatt taa
//
