LOCUS       NM_001393652            1219 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens basic transcription factor 3 (BTF3), transcript
            variant 3, mRNA.
ACCESSION   NM_001393652
VERSION     NM_001393652.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1219)
  AUTHORS   Cui,Y., Pu,M., Gong,Y., Li,R., Wang,X., Ye,J., Huang,H., Liao,D.,
            Yang,Y., Yin,A., Li,J., Deng,Y., Tian,Z. and Pu,R.
  TITLE     METTL3-driven m6A modification of lncRNA FAM230B suppresses
            ferroptosis by modulating miR-27a-5p/BTF3 axis in gastric cancer
  JOURNAL   Biochim Biophys Acta Gen Subj 1868 (11), 130714 (2024)
   PUBMED   39278369
  REMARK    GeneRIF: METTL3-driven m6A modification of lncRNA FAM230B
            suppresses ferroptosis by modulating miR-27a-5p/BTF3 axis in
            gastric cancer.
REFERENCE   2  (bases 1 to 1219)
  AUTHORS   Hu,M., Dai,C., Sun,X., Chen,Y., Xu,N., Lin,Z., Xu,S., Cheng,C.,
            Tan,Z., Bian,S. and Zheng,W.
  TITLE     Ubiquitination-specific protease 7 enhances stemness of
            hepatocellular carcinoma by stabilizing basic transcription factor
            3
  JOURNAL   Funct Integr Genomics 24 (1), 28 (2024)
   PUBMED   38340226
  REMARK    GeneRIF: Ubiquitination-specific protease 7 enhances stemness of
            hepatocellular carcinoma by stabilizing basic transcription factor
            3.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1219)
  AUTHORS   Wang,P., Sun,J., Sun,C., Zhao,H., Zhang,Y. and Chen,J.
  TITLE     BTF3 promotes proliferation and glycolysis in hepatocellular
            carcinoma by regulating GLUT1
  JOURNAL   Cancer Biol Ther 24 (1), 2225884 (2023)
   PUBMED   37382415
  REMARK    GeneRIF: BTF3 promotes proliferation and glycolysis in
            hepatocellular carcinoma by regulating GLUT1.
REFERENCE   4  (bases 1 to 1219)
  AUTHORS   Zhou,W., Yun,Z., Wang,T., Li,C. and Zhang,J.
  TITLE     BTF3-mediated regulation of BMI1 promotes colorectal cancer through
            influencing epithelial-mesenchymal transition and stem cell-like
            traits
  JOURNAL   Int J Biol Macromol 187, 800-810 (2021)
   PUBMED   34293363
  REMARK    GeneRIF: BTF3-mediated regulation of BMI1 promotes colorectal
            cancer through influencing epithelial-mesenchymal transition and
            stem cell-like traits.
REFERENCE   5  (bases 1 to 1219)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1219)
  AUTHORS   Beatrix,B., Sakai,H. and Wiedmann,M.
  TITLE     The alpha and beta subunit of the nascent polypeptide-associated
            complex have distinct functions
  JOURNAL   J Biol Chem 275 (48), 37838-37845 (2000)
   PUBMED   10982809
REFERENCE   7  (bases 1 to 1219)
  AUTHORS   Grein,S. and Pyerin,W.
  TITLE     BTF3 is a potential new substrate of protein kinase CK2
  JOURNAL   Mol Cell Biochem 191 (1-2), 121-128 (1999)
   PUBMED   10094400
REFERENCE   8  (bases 1 to 1219)
  AUTHORS   Wiedmann,B., Sakai,H., Davis,T.A. and Wiedmann,M.
  TITLE     A protein complex required for signal-sequence-specific sorting and
            translocation
  JOURNAL   Nature 370 (6489), 434-440 (1994)
   PUBMED   8047162
REFERENCE   9  (bases 1 to 1219)
  AUTHORS   Kanno,M., Chalut,C. and Egly,J.M.
  TITLE     Genomic structure of the putative BTF3 transcription factor
  JOURNAL   Gene 117 (2), 219-228 (1992)
   PUBMED   1386332
REFERENCE   10 (bases 1 to 1219)
  AUTHORS   Zheng,X.M., Black,D., Chambon,P. and Egly,J.M.
  TITLE     Sequencing and expression of complementary DNA for the general
            transcription factor BTF3
  JOURNAL   Nature 344 (6266), 556-559 (1990)
   PUBMED   2320128
  REMARK    GeneRIF: In addition to RNA polymerase II (otherwise RNA pol II,
            RNA polymerase B), four general transcription factors are required
            for initiation of transcription: BTF1 (also referred to as TFIID)
            which has recently been cloned from yeast, BTF2, BTF3 and STF.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC099522.3.
            
            Summary: This gene encodes the basic transcription factor 3. This
            protein forms a stable complex with RNA polymerase IIB and is
            required for transcriptional initiation. Alternative splicing
            results in multiple transcript variants encoding different
            isoforms. This gene has multiple pseudogenes. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2142853
                              [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-358               AC099522.3         21380-21737         c
            359-427             AC099522.3         20977-21045         c
            428-541             AC099522.3         17578-17691         c
            542-743             AC099522.3         17062-17263         c
            744-1219            AC099522.3         14512-14987         c
FEATURES             Location/Qualifiers
     source          1..1219
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.2"
     gene            1..1219
                     /gene="BTF3"
                     /gene_synonym="BETA-NAC; BTF3a; BTF3b; NACB"
                     /note="basic transcription factor 3"
                     /db_xref="GeneID:689"
                     /db_xref="HGNC:HGNC:1125"
                     /db_xref="MIM:602542"
     exon            1..358
                     /gene="BTF3"
                     /gene_synonym="BETA-NAC; BTF3a; BTF3b; NACB"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..790
                     /gene="BTF3"
                     /gene_synonym="BETA-NAC; BTF3a; BTF3b; NACB"
                     /note="isoform C is encoded by transcript variant 3; RNA
                     polymerase B transcription factor 3; transcription factor
                     BTF3; nascent-polypeptide-associated complex beta
                     polypeptide; NAC-beta; nascent polypeptide-associated
                     complex subunit beta"
                     /codon_start=1
                     /product="transcription factor BTF3 isoform C"
                     /protein_id="NP_001380581.1"
                     /db_xref="GeneID:689"
                     /db_xref="HGNC:HGNC:1125"
                     /db_xref="MIM:602542"
                     /translation="MRRTGAPAQADSRGRGRARGGCPGGEATLSQPPPRGGTRGQEPQ
                     MKETIMNQEKLAKLQAQVRIGGKGTARRKKKVVHRTATADDKKLQFSLKKLGVNNISG
                     IEEVNMFTNQGTVIHFNNPKVQASLAANTFTITGHAETKQLTEMLPSILNQLGADSLT
                     SLRRLAEALPKQYLVENFDEASKNEAN"
     exon            359..427
                     /gene="BTF3"
                     /gene_synonym="BETA-NAC; BTF3a; BTF3b; NACB"
                     /inference="alignment:Splign:2.1.0"
     exon            428..541
                     /gene="BTF3"
                     /gene_synonym="BETA-NAC; BTF3a; BTF3b; NACB"
                     /inference="alignment:Splign:2.1.0"
     exon            542..743
                     /gene="BTF3"
                     /gene_synonym="BETA-NAC; BTF3a; BTF3b; NACB"
                     /inference="alignment:Splign:2.1.0"
     exon            744..1219
                     /gene="BTF3"
                     /gene_synonym="BETA-NAC; BTF3a; BTF3b; NACB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1027..1032
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BTF3"
                     /gene_synonym="BETA-NAC; BTF3a; BTF3b; NACB"
                     /note="hexamer: AATAAA"
     polyA_site      1047
                     /gene="BTF3"
                     /gene_synonym="BETA-NAC; BTF3a; BTF3b; NACB"
                     /note="major polyA site"
     regulatory      1157..1162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BTF3"
                     /gene_synonym="BETA-NAC; BTF3a; BTF3b; NACB"
                     /note="hexamer: ATTAAA"
     polyA_site      1174
                     /gene="BTF3"
                     /gene_synonym="BETA-NAC; BTF3a; BTF3b; NACB"
     regulatory      1197..1202
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BTF3"
                     /gene_synonym="BETA-NAC; BTF3a; BTF3b; NACB"
                     /note="hexamer: TATAAA"
     polyA_site      1219
                     /gene="BTF3"
                     /gene_synonym="BETA-NAC; BTF3a; BTF3b; NACB"
ORIGIN      
        1 ccctttagct gccatcttgc gtccccgcgt gtgtgcgcct aatctcaggt ggtccacccg
       61 agaccccttg agcaccaacc ctagtccccc gcgcggcccc ttattcgctc cgacaaggta
      121 caaaaaggct ctggacggcg gcgtggtagg aggacgggag cgggggcggg aagttccctg
      181 aaggagcgag acagggaggg acagggcaga ggaggagagg aaggcgatgc gacggacagg
      241 cgcacccgct caggctgact ctcgggggcg aggtcgagcc aggggcggct gccctggggg
      301 cgaggcgacg ctgtctcaac ctccacctcg cggcggaacc cgaggacagg agcctcagat
      361 gaaagaaaca atcatgaacc aggaaaaact cgccaaactg caggcacaag tgcgcattgg
      421 tgggaaagga actgctcgca gaaagaagaa ggtggttcat agaacagcca cagcagatga
      481 caaaaaactt cagttctcct taaagaagtt aggggtaaac aatatctctg gtattgaaga
      541 ggtgaatatg tttacaaacc aaggaacagt gatccacttt aacaacccta aagttcaggc
      601 atctctggca gcgaacactt tcaccattac aggccatgct gagacaaagc agctgacaga
      661 aatgctaccc agcatcttaa accagcttgg tgcggatagt ctgactagtt taaggagact
      721 ggccgaagct ctgcccaaac aatatcttgt ggagaatttt gatgaggctt ccaagaatga
      781 ggcaaactga attgagtcaa cttctgaaga taaaacctga agaagttact gggagctgct
      841 attttatatt atgactgctt tttaagaaat ttttgtttat ggatctgata aaatctagat
      901 ctctaatatt tttaagccca agccccttgg acactgcagc tcttttcagt ttttgcttat
      961 acacaattca ttctttgcag ctaattaagc cgaagaagcc tgggaatcaa gtttgaaaca
     1021 aagattaata aagttctttg cctagtatac agttttattt ttttatttca ttgacaccga
     1081 tctgtacaca gtaaaaaaaa ttgcttatag aaagctaatc atggcatgta atatggctga
     1141 taacctttgg aatttgatta aagatttaaa atcacggtgt agtgtaacaa aggtggtata
     1201 aagttctcag gtttgaaaa
//
