LOCUS       NM_001099272            8530 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens BTB domain containing 9 (BTBD9), transcript variant 2,
            mRNA.
ACCESSION   NM_001099272
VERSION     NM_001099272.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8530)
  AUTHORS   Fawzy,M.S., Fakhr-Eldeen,A., Abu AlSel,B.T. and Toraih,E.A.
  TITLE     Molecular analysis of homeostatic iron regulator, transmembrane
            protease serine-6, and BTB domain-containing protein-9 variants and
            iron parameters in blood donors
  JOURNAL   Biosci Rep 41 (1) (2021)
   PUBMED   33367529
  REMARK    GeneRIF: Molecular analysis of homeostatic iron regulator,
            transmembrane protease serine-6, and BTB domain-containing
            protein-9 variants and iron parameters in blood donors.
REFERENCE   2  (bases 1 to 8530)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 8530)
  AUTHORS   Li,L., Zhang,W., Liu,Y., Liu,X., Cai,L., Kang,J., Zhang,Y.,
            Chen,W., Dong,C., Zhang,Y., Wang,M., Wei,W. and Jia,L.
  TITLE     The CRL3BTBD9 E3 ubiquitin ligase complex targets TNFAIP1 for
            degradation to suppress cancer cell migration
  JOURNAL   Signal Transduct Target Ther 5 (1), 42 (2020)
   PUBMED   32327643
  REMARK    GeneRIF: The CRL3(BTBD9) E3 ubiquitin ligase complex targets
            TNFAIP1 for degradation to suppress cancer cell migration.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8530)
  AUTHORS   Li,G., Tang,H., Wang,C., Qi,X., Chen,J., Chen,S. and Ma,J.
  TITLE     Association of BTBD9 and MAP2K5/SKOR1 With Restless Legs Syndrome
            in Chinese Population
  JOURNAL   Sleep 40 (4) (2017)
   PUBMED   28329290
  REMARK    GeneRIF: results confirmed the association of BTBD9 and
            MAP2K5/SKOR1 with primary Restless Legs Syndrome in Chinese
            population
REFERENCE   5  (bases 1 to 8530)
  AUTHORS   Winkelman,J.W., Blackwell,T., Stone,K., Ancoli-Israel,S.,
            Tranah,G.J. and Redline,S.
  CONSRTM   Osteoporotic Fractures in Men (MrOS) Study Research Group
  TITLE     Genetic associations of periodic limb movements of sleep in the
            elderly for the MrOS sleep study
  JOURNAL   Sleep Med 16 (11), 1360-1365 (2015)
   PUBMED   26498236
  REMARK    GeneRIF: Our findings confirm an association between the BTBD9,
            MEIS1, and MAP2K5/SKOR1 SNPs and periodic limb movements of sleep
            in an elderly cohort.
REFERENCE   6  (bases 1 to 8530)
  AUTHORS   Schimmelmann,B.G., Friedel,S., Nguyen,T.T., Sauer,S., Ganz
            Vogel,C.I., Konrad,K., Wilhelm,C., Sinzig,J., Renner,T.J.,
            Romanos,M., Palmason,H., Dempfle,A., Walitza,S., Freitag,C.,
            Meyer,J., Linder,M., Schafer,H., Warnke,A., Lesch,K.P.,
            Herpertz-Dahlman,B., Hinney,A. and Hebebrand,J.
  TITLE     Exploring the genetic link between RLS and ADHD
  JOURNAL   J Psychiatr Res 43 (10), 941-945 (2009)
   PUBMED   19223043
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 8530)
  AUTHORS   Kemlink,D., Polo,O., Frauscher,B., Gschliesser,V., Hogl,B.,
            Poewe,W., Vodicka,P., Vavrova,J., Sonka,K., Nevsimalova,S.,
            Schormair,B., Lichtner,P., Silander,K., Peltonen,L., Gieger,C.,
            Wichmann,H.E., Zimprich,A., Roeske,D., Muller-Myhsok,B.,
            Meitinger,T. and Winkelmann,J.
  TITLE     Replication of restless legs syndrome loci in three European
            populations
  JOURNAL   J Med Genet 46 (5), 315-318 (2009)
   PUBMED   19279021
  REMARK    GeneRIF: Among the known loci, BTBD9 seems to be the most
            consistent in its effect on RLS across populations.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 8530)
  AUTHORS   Jones,L.C., Earley,C.J., Allen,R.P. and Jones,B.C.
  TITLE     Of mice and men, periodic limb movements and iron: how the human
            genome informs the mouse genome
  JOURNAL   Genes Brain Behav 7 (5), 513-514 (2008)
   PUBMED   18363860
  REMARK    GeneRIF: BTBD9, was recently linked to restless legs syndrome,
            periodic limb movements and iron status in humans
            Review article
REFERENCE   9  (bases 1 to 8530)
  AUTHORS   Stefansson,H., Rye,D.B., Hicks,A., Petursson,H., Ingason,A.,
            Thorgeirsson,T.E., Palsson,S., Sigmundsson,T., Sigurdsson,A.P.,
            Eiriksdottir,I., Soebech,E., Bliwise,D., Beck,J.M., Rosen,A.,
            Waddy,S., Trotti,L.M., Iranzo,A., Thambisetty,M., Hardarson,G.A.,
            Kristjansson,K., Gudmundsson,L.J., Thorsteinsdottir,U., Kong,A.,
            Gulcher,J.R., Gudbjartsson,D. and Stefansson,K.
  TITLE     A genetic risk factor for periodic limb movements in sleep
  JOURNAL   N Engl J Med 357 (7), 639-647 (2007)
   PUBMED   17634447
  REMARK    GeneRIF: We have discovered a variant associated with
            susceptibility to periodic limb movements in sleep.
            GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   10 (bases 1 to 8530)
  AUTHORS   Winkelmann,J., Schormair,B., Lichtner,P., Ripke,S., Xiong,L.,
            Jalilzadeh,S., Fulda,S., Putz,B., Eckstein,G., Hauk,S.,
            Trenkwalder,C., Zimprich,A., Stiasny-Kolster,K., Oertel,W.,
            Bachmann,C.G., Paulus,W., Peglau,I., Eisensehr,I., Montplaisir,J.,
            Turecki,G., Rouleau,G., Gieger,C., Illig,T., Wichmann,H.E.,
            Holsboer,F., Muller-Myhsok,B. and Meitinger,T.
  TITLE     Genome-wide association study of restless legs syndrome identifies
            common variants in three genomic regions
  JOURNAL   Nat Genet 39 (8), 1000-1006 (2007)
   PUBMED   17637780
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB095510.1, AL079341.19,
            BX537534.1, BC101355.1, AL033518.14 and AL157476.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001099272.1.
            
            Summary: This locus encodes a BTB/POZ domain-containing protein.
            This domain is known to be involved in protein-protein
            interactions. Polymorphisms at this locus have been reported to be
            associated with susceptibility to Restless Legs Syndrome and may
            also be associated with Tourette Syndrome. Alternatively spliced
            transcript variants have been described. [provided by RefSeq, Aug
            2011].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853567.25601.1,
                                           SRR1660803.132909.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000481247.6/ ENSP00000418751.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                DB095510.1         222-264
            44-48               AL079341.19        18711-18715
            49-343              BX537534.1         1-295
            344-2022            BC101355.1         221-1899
            2023-7497           AL033518.14        94467-99941
            7498-8530           AL157476.1         1112-2144
FEATURES             Location/Qualifiers
     source          1..8530
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.2"
     gene            1..8530
                     /gene="BTBD9"
                     /gene_synonym="dJ322I12.1"
                     /note="BTB domain containing 9"
                     /db_xref="GeneID:114781"
                     /db_xref="HGNC:HGNC:21228"
                     /db_xref="MIM:611237"
     exon            1..130
                     /gene="BTBD9"
                     /gene_synonym="dJ322I12.1"
                     /inference="alignment:Splign:2.1.0"
     exon            131..342
                     /gene="BTBD9"
                     /gene_synonym="dJ322I12.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1996
                     /gene="BTBD9"
                     /gene_synonym="dJ322I12.1"
                     /note="isoform a is encoded by transcript variant 2;
                     BTB/POZ domain-containing protein 9; BTB (POZ) domain
                     containing 9"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein 9 isoform a"
                     /protein_id="NP_001092742.1"
                     /db_xref="CCDS:CCDS47418.1"
                     /db_xref="GeneID:114781"
                     /db_xref="HGNC:HGNC:21228"
                     /db_xref="MIM:611237"
                     /translation="MSNSHPLRPFTAVGEIDHVHILSEHIGALLIGEEYGDVTFVVEK
                     KRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPLQDTTAEAFTMLLKYIYTGRATL
                     TDEKEEVLLDFLSLAHKYGFPELEDSTSEYLCTILNIQNVCMTFDVASLYSLPKLTCM
                     CCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAAPEKDIFLALLNWCKHNSKENH
                     AEIMQAVRLPLMSLTELLNVVRPSGLLSPDAILDAIKVRSESRDMDLNYRGMLIPEEN
                     IATMKYGAQVVKGELKSALLDGDTQNYDLDHGFSRHPIDDDCRSGIEIKLGQPSIINH
                     IRILLWDRDSRSYSYFIEVSMDELDWVRVIDHSQYLCRSWQKLYFPARVCRYIRIVGT
                     HNTVNKIFHIVAFECMFTNKTFTLEKGLIVPMENVATIADCASVIEGVSRSRNALLNG
                     DTKNYDWDSGYTCHQLGSGAIVVQLAQPYMIGSIRLLLWDCDDRSYSYYVEVSTNQQQ
                     WTMVADRTKVSCKSWQSVTFERQPASFIRIVGTHNTANEVFHCVHFECPEQQSSQKEE
                     NSEESGTGDTSLAGQQLDSHALRAPSGSSLPSSPGSNSRSPNRQHQ"
     exon            343..706
                     /gene="BTBD9"
                     /gene_synonym="dJ322I12.1"
                     /inference="alignment:Splign:2.1.0"
     exon            707..971
                     /gene="BTBD9"
                     /gene_synonym="dJ322I12.1"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1191
                     /gene="BTBD9"
                     /gene_synonym="dJ322I12.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1311
                     /gene="BTBD9"
                     /gene_synonym="dJ322I12.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1421
                     /gene="BTBD9"
                     /gene_synonym="dJ322I12.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1611
                     /gene="BTBD9"
                     /gene_synonym="dJ322I12.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1719
                     /gene="BTBD9"
                     /gene_synonym="dJ322I12.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1798
                     /gene="BTBD9"
                     /gene_synonym="dJ322I12.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..8530
                     /gene="BTBD9"
                     /gene_synonym="dJ322I12.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5553..5558
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BTBD9"
                     /gene_synonym="dJ322I12.1"
                     /note="hexamer: AATGAA"
     polyA_site      5576
                     /gene="BTBD9"
                     /gene_synonym="dJ322I12.1"
     regulatory      8507..8512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BTBD9"
                     /gene_synonym="dJ322I12.1"
                     /note="hexamer: AATAAA"
     polyA_site      8530
                     /gene="BTBD9"
                     /gene_synonym="dJ322I12.1"
                     /note="major polyA site"
ORIGIN      
        1 gcagcagccg gggcggcggc gaggacggcg gccacggaag cggccaaggg ggcggtggcg
       61 cagagagggg tgcggagcgg gcggaagagg cgtctgtgtc gcagcttggt ctcagaggag
      121 catcgctggg aacaacgact atcgtctatt ccacaagatg agtaacagcc accctcttcg
      181 cccctttact gcagtggggg aaattgatca tgtgcacatt ttgtctgaac atattggtgc
      241 cttgttgatt ggggaagaat atggcgacgt cacattcgtg gtggaaaaga aacgttttcc
      301 tgcccacagg gtaattttag cagccaggtg ccaatatttt cgagcattat tatatggtgg
      361 aatgcgagag tctcagcctg aagcagaaat tcctctccaa gacaccactg cagaagcatt
      421 cacaatgcta ctcaaatata tctacactgg gcgggcaacg ctgacagatg agaaggagga
      481 ggtgctgctg gactttttga gcctggctca taaatatgga tttccagagc tagaggattc
      541 tacctctgag tatctctgca ccatacttaa cattcagaat gtctgcatga cttttgatgt
      601 tgccagtctc tactcacttc ccaagttaac ttgtatgtgc tgcatgttta tggataggaa
      661 tgctcaggaa gtcctctcaa gtgaaggttt cctctccctt tctaagacag cacttttaaa
      721 catcgtgtta agagactcat ttgcagctcc cgaaaaagat attttcctag ccttattaaa
      781 ctggtgtaag cacaattcaa aggagaatca tgctgaaatc atgcaggctg tgcgtttacc
      841 tctcatgagc ctcacagagc ttctgaatgt tgtgaggcct tcaggactgc tgtctcctga
      901 tgccatcctg gatgccatta aagtgcgatc tgagagccgg gatatggacc tcaattatag
      961 aggcatgctc ataccagaag aaaacattgc aactatgaag tatggagccc aagttgtaaa
     1021 gggggagctg aaatcagcct tattagatgg tgatactcaa aattatgatt tggatcatgg
     1081 attttcaagg cacccaattg atgatgactg ccgttccggc atcgagatta agctaggtca
     1141 gccatccatt atcaatcaca tacggatact cttgtgggac cgagatagcc ggtcttactc
     1201 atacttcatt gaagtgtcaa tggatgaact tgattgggtc agagtgatag atcattcaca
     1261 atatctgtgt cgttcttggc agaaattata ttttccagcc cgtgtctgca ggtatattcg
     1321 aattgttggg actcacaaca cagtgaacaa gatttttcac attgtggctt ttgaatgtat
     1381 gtttacaaac aaaaccttca ctcttgagaa ggggctgata gttcccatgg agaatgttgc
     1441 aacaattgct gattgtgcca gtgtgattga aggagtcagt cggagccgaa atgccttgct
     1501 gaatggggac actaagaatt atgactggga ttctggctac acatgtcacc agctaggaag
     1561 tggtgcgatt gtggttcagt tggcacaacc gtacatgatt gggtcaatac ggttactact
     1621 ttgggattgt gatgatcgaa gctatagcta ctacgttgag gtttctacca accagcaaca
     1681 gtggaccatg gttgctgaca gaactaaagt ctcctgcaag tcctggcagt cagtaacttt
     1741 tgaaaggcag cctgcctcct tcatccgtat cgttgggaca cacaacacag caaatgaggt
     1801 gttccactgt gtccactttg agtgtccaga gcagcagagc agccagaagg aggaaaatag
     1861 tgaggaatcg gggacagggg acaccagcct ggccggtcag cagctcgact cccatgcgct
     1921 gcgggcgcct agtggcagct cactaccctc cagcccaggc tccaactcac gctcccccaa
     1981 ccggcagcac caataaagga ggcagcgggc ctggtgtgac ttggtgggct cgggcaacgg
     2041 caggaaacgg tctcctccct gagcaggggt ctctgttgac tgcccccacc tctgcccctt
     2101 tccagggagg agccgaccta gctgcaaaag cagacaccga acaggttttc tcccaaggac
     2161 agaaaggggc tgctttgttc ttctcaattt atccaaatca ggcaggtctc aagggggaga
     2221 aaatgggtct tcaatcttca tcaagtccac cattaacacc ctacctctct aatctagccc
     2281 aggcgcaggg aacaggagga agtcatagac aggcctgtgt tggaatacaa aaatggcacg
     2341 caaacactca ggcggaggag aaagccattg ggcctttgct acctggaggc accctttagg
     2401 aatgggcctc catagagtgt tcattctgct ggaatacatt gccctggcaa ctaaatgatt
     2461 ttttatttgt tttagttatt ctccactcag tgaatcatag gtgttccgga tctatttgaa
     2521 atgctcaaac agcaaatcac tagttttaat cccttttgat gctataattt tccttccttg
     2581 gttttgaacg gttcagcttg cggggacaga gacccatcgt gcatgtctcc taaatgagac
     2641 acggatgcag ctcatcctgg cacttgggcc acagaggaag tgccacaaat gcacacaagc
     2701 aaatcaacct gtggacactg gagttaatag tcactcgtgt ggctgagtta ctcacctgtc
     2761 attcctgaca tggatccagc ctttaagctt gggaggctga caaggaaata gttactatgc
     2821 ccgctgctaa ttcactgttc cgaagtccat gtagataaac atataccgag ttctggcgtg
     2881 gccaaacctg ccggggactg ccgtggctta gctgcccctc cagttgtgtt tatcgaagca
     2941 ttggagaggc agccacctgc ccatcagcgt caggaacgca gaactgggac tccgtgcttc
     3001 ccccacacca cagtactcaa ctggggactg aaaaatagca gttccaagaa gcttttctcc
     3061 taatcctcat caaaaggacc tcatttgacg atggtggctt gatgtggctc cgtctcctac
     3121 ttagtgattt ccattccagt gctgcctgcc ctgggtaact gcgcacaaca ttgcctgccc
     3181 ctccgctgtc cccagagctc cggcctctgt cgccatcagc atcagcctgg gagtctcccc
     3241 aggacggcat ggcacgtgag cagcactgca gtccttgggt cttcggcgcc aacctgcaac
     3301 cctgatcaaa ggagggtgag ggcgtgggag tttcctttca ggtgtgtcaa agacatatca
     3361 gctgcgctct agaaagagcc aacgggtcag ccgcttcctc ctagtttaac ttgattttga
     3421 gtgatttgtc catatggaaa tagtagggta gcatcaaact gcgtgattaa attggaagac
     3481 tgtctttccg tgtgaacaca ggatggcaga catcagaggg ctaccggggc agggtggaca
     3541 cgttcctgag gagaagccag ggtctgcagc tctccatcct ccccggtagc tccagctgca
     3601 gggctgagct gcttcctatc ccctcagctc tgatctctgc cacttccctg ttgtgtggga
     3661 gagtggaaca ctcctgggat gccaggcatt tcataatggg aggaggctcc tgtaaggaac
     3721 ggtgggcgcc cgctcacagt ggggggccct ccagcatggt tgctgactct gtcagccccc
     3781 agccccgggt tgccaattag ccagagagct cctgcacaca cagcacttcc ttccccagtg
     3841 tgttttctac ccagatgggg acaaaggagc cagacagtca tatcaagggc agagttcaaa
     3901 cattttgaaa tgagccattc acatgcttct ttttaaacat gggcatcacc tgcccagagg
     3961 cccttggcct gaagcagcat gctgctgacc ttgggaagag agggtgggct ggtgggggtg
     4021 ctggaggagc tgcccggccc tgcatctgca accctccagt cccctgccca cagagcacgc
     4081 agagccctcc tgtgctccgg gaacgagata gcagcttggc agctcggcct cgcatctgaa
     4141 aaggaatacg ctgcaaagcc tcggccctag acccacatct gcagctccct ggcctgtggc
     4201 ggttctttcc ttcggggcat gcccttccag atctctgtcc ctcctgtctt ctagcacttt
     4261 aaagatgccc cttatcatca gataaagaga agtatgggga cgatggggtg gcactaacag
     4321 tagatgtcat tggtgaggac tgatggcaaa gtctcattcc ctcacagccg cgctgccagc
     4381 tcgcctcccc ctcgctttgc tgggagcctg ccctggactc caaaaggaca cgggttcacc
     4441 tcctttccca ggctggaggg gtactgccct tccctgaggg gccttctgac tggggcagga
     4501 actcttttcg tgtgtccagc tgggcctgga ggccaagtca aggtgtgtca caccacacac
     4561 cagggcaagg acctcatctc cagggaacag ggacaagtga gtggctacca gaaagtcccc
     4621 gggcagcctg gagttcccca gagcctggct ggtcctacag agcacttctc ccctgggcca
     4681 ccaggaccaa agcgacctaa acacttgaag ctaaaagcaa gtgctgatga tgggatgggc
     4741 tggcacgtgg ctgggagggc tcctgggcac cacagagccc tcagcccagc agagagtgga
     4801 ggctcagtcc gtggggagcg ggggttgtga aggagacatg gccaagcccc tggtcgggga
     4861 gataagctcc cccatgccca ggccagcccc aggggcaaca agccaacatg gagagaggtg
     4921 gcaggtgagg ctgacaggtg ggtgcctgtg gcctgggccc atgagggcaa tggtcctcag
     4981 taaccaatgg aaaggacaca agggcgccat ggtcaccacc acccaggcaa agaaatggga
     5041 ggtggccagc acccccaccc ttcacttttc attattatta ttattattat tattattatt
     5101 tttttttttt tttttttttt tttttttttt ttttgagagt agaaaggcaa cttcattgga
     5161 gcttttgggg aaaaaagcct tcaaagtcac cttctggcag ctctggggag ggtcatttgg
     5221 ggtggactga gagtgtaggg caggtagggt gtgtgctggg cagcagctgt gtccatgcag
     5281 ccagcaccca gcagggcagt ctcacaggag ccgttgtgag cactttggac ttgaagcagc
     5341 tatgaaccac cccccgcccc caccgtctct ccctctcaca cacacacaca cacacacaca
     5401 cacacacaca cacacacaca cacacccgtt ttaccatttt ctcagtgctt tttctgcttt
     5461 cattcctttg attttagtta gaagcacaag ccatgatgga tgtgggactc ttctcaattg
     5521 ctctttaaat tgtcactttt taaatcctat taaatgaagt gtcgattcct gacaaataca
     5581 ttaaaagtgt tttattccta gaagagttgg gaaaagaaat tattttcagc aagagtagga
     5641 tgtttgttaa actgattcct tggcaaaaaa gagaaaaaaa gcttttgaat tgtgcaaaaa
     5701 attgcccagt attatgctgt cgccccagtt gtcaaactgc tgtgcagatg gctccagccc
     5761 agtcaacttc accttctttt taatttagaa gataacaaaa ttgtaatcac ttatcctttc
     5821 cagagccaag ggggaaaagg aaggtataat ctacaataaa aagcgagcgt tctgtgtact
     5881 gaggccactt ggtgataaag agatggagcg ctcccctcac agacttcaat taagaacctc
     5941 cctttggaca gggaagaaag gtgtcaaaga ggaaaagaaa attaaatttg cttccttcca
     6001 ggagtttttc ctcattagtg cttgcttgtc ggtgttatta ttttaatctt accttctatg
     6061 tggtgaccag ctcctccgag cgatgcccag gtcgggcacg gcccgggcag ggcaggtctg
     6121 cagcgatgcc gtggcagagg tgggcatact ccatttgttt tggcagctgc agccattgat
     6181 tctgcatatt tttcctgaca acagccccgg caggagttca gttaggaatt taaagtgcag
     6241 ttcatggttc tgtgccaccg tggcttttat tattataata ttaaattaga agttgtccta
     6301 gtgcctggtg tttgctcaga gtttccagaa gagagggaag ggcaaggttt aaatggcatg
     6361 caggacaact ggaatgcccc catctctctc gctgacacgg atccagtcat acctggggct
     6421 ggacgggatt tggaggccct ggtcatttgc agagtgaatg gtgaagggcg cggaaaaggt
     6481 ttgcttggag gaaagaccgg ttgcagaggc gaggcggagg gaggaggggc ggaggcagca
     6541 ggtctttgtt tgtggtaggt ctctggcttc catcagggag gaggaaagag gctgtgccct
     6601 tcctggctct tggctgcacc actgaggacg ctccgaggga cagcgtgctc acccatcctt
     6661 tgcacagtgc tggccccaag ccccacggcc ttccagctag gattttctgc tgggctcatg
     6721 cagaggcagg ggacaggtgc atggaagagc cgccccaccc gacacaccat tgtttgaaaa
     6781 tcactgttct ctttactcac ttaaaaaagt gtacagggaa cacctgttcc tggcataatg
     6841 ctccaacctc gcggaagggg ccaggtgccc ttcatctggc tctggctgct tccgacctgg
     6901 gcccacgtca tcgttcacgt cctctgtgac caccactggt cacggtgctc cctggcccag
     6961 cctccaaccc acccagcacc ctggcatctc ccaggccagt ctgctgcacc cagcgagctt
     7021 ccagtcagaa gccaggctga acggccctcc tgccccatca gcttcgtgtc ttcttttttt
     7081 taaagaactg aaatagtccc caagaggcct catggcctga agactcacaa tcatccacct
     7141 gtaatttatg ataaatgtct gggagcattt accatttgcg tccgtgagta tttatagccc
     7201 tgaatgggcg ggggggaggg ggggtggagg aggccctgca gccaggagct acacacctgt
     7261 ccccactagt gtcccctggt tgacagagcc ccctcagcct ccccaaggct gtcactgcgg
     7321 ctgtgacagc tgaggagtgc cgcctttgaa agccagtgga cagtcgctcc actaggggga
     7381 gaggccctgg ccctggcgca gaggaggcgt tgcgaggcgg gacgggggct ggaggggctg
     7441 agcagccttc agggcaggga ctgggccctg ggtcactgga gacgttgata ttagtccgtc
     7501 tgctgccaaa ttgctcccca ccacatgagc cccaggggtt tatgtcccag gaaggcgagg
     7561 gtgcccatct gagcggaatt gggaggggac ggcaccagct catctccctc agggcctttg
     7621 cctcctggtg ctgccctggt ggctgctcct gcaccacagc ccctgatggc tgctgctagt
     7681 cctgagttgc tgggtttacc cccagcccac acttcccacc tgggcctgag ggtgcggcca
     7741 gtgccctagt cctagccact acaggagtca ttctgagacc tgctggaggc catggggtct
     7801 tcccaggccc ctcaatcagc tgcttccagg gtcagcaggg cagggtgctg ccagtaaggt
     7861 cctcagggag cacagcccgg ccgcccaggc tgggggatac tggggcagag cttccaggtc
     7921 tgtggggcct gatctctccc caaggctctc caggccttgg tgcgccctcc acagtgacct
     7981 tcagagaggc tgcaccccct cagaagaaca gtgagaaatc tctccatcac acgctccctg
     8041 gtccttatgt ccctgaggcc acccttcccc accccccagt gcctggagaa gcgtgagact
     8101 ctggaggggc gccaggaggc caggggtcct cagggctagg cctggagctc ggcccaagag
     8161 ctgcttttgc gaagcctgtc ttgaatccgg attcaccaga gaacaagagc ctcccagcct
     8221 ttggcgtttc tgggcctgta aagatgtgtg tacctcccag gccactctga tgcaagggca
     8281 gggaccatgc caggcctggg ttgggaatgg ctctgtgact ccagaagctc cgtctaaaac
     8341 tccaaagatg cccaaaaggc tgtgctgcta tgtggaatgt gtattatttg tgagcacgat
     8401 gcggcttctt cctcattttg cagagcaacc taagcgggca gatgtacaaa ccgtgtgttc
     8461 gaaacccctg agtccatgtg tgtgaaaatg caggttttct cttagaaata aagtggtgac
     8521 ttgtgctgta
//
