LOCUS       NM_001387567            2217 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens BTB domain containing 6 (BTBD6), transcript variant 2,
            mRNA.
ACCESSION   NM_001387567 XM_005268188
VERSION     NM_001387567.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2217)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2217)
  AUTHORS   Sobieszczuk,D.F., Poliakov,A., Xu,Q. and Wilkinson,D.G.
  TITLE     A feedback loop mediated by degradation of an inhibitor is required
            to initiate neuronal differentiation
  JOURNAL   Genes Dev 24 (2), 206-218 (2010)
   PUBMED   20080956
  REMARK    GeneRIF: Btbd6a promotes the relocation of Plzf from nucleus to
            cytoplasm and targets Plzf for ubiquitination and degradation
REFERENCE   3  (bases 1 to 2217)
  AUTHORS   Bury,F.J., Moers,V., Yan,J., Souopgui,J., Quan,X.J., De Geest,N.,
            Kricha,S., Hassan,B.A. and Bellefroid,E.J.
  TITLE     Xenopus BTBD6 and its Drosophila homologue lute are required for
            neuronal development
  JOURNAL   Dev Dyn 237 (11), 3352-3360 (2008)
   PUBMED   18855900
REFERENCE   4  (bases 1 to 2217)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   5  (bases 1 to 2217)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Behal,A., Touchman,J.W.,
            Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human lens for the NEIBank
            Project: over 2000 non-redundant transcripts, novel genes and
            splice variants
  JOURNAL   Mol Vis 8, 171-184 (2002)
   PUBMED   12107413
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL512355.6.
            
            On Oct 6, 2020 this sequence version replaced XM_005268188.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF353674.1, SRR14038195.2513482.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392554.8/ ENSP00000376337.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-553               AL512355.6         107973-108525
            554-644             AL512355.6         108597-108687
            645-763             AL512355.6         108800-108918
            764-2217            AL512355.6         109080-110533
FEATURES             Location/Qualifiers
     source          1..2217
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.33"
     gene            1..2217
                     /gene="BTBD6"
                     /gene_synonym="BDPL"
                     /note="BTB domain containing 6"
                     /db_xref="GeneID:90135"
                     /db_xref="HGNC:HGNC:19897"
     exon            1..553
                     /gene="BTBD6"
                     /gene_synonym="BDPL"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1796
                     /gene="BTBD6"
                     /gene_synonym="BDPL"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; glucocorticoid receptor AF-1 coactivator-1; BTB
                     domain protein BDPL; BTB/POZ domain-containing protein 6;
                     lens BTB domain protein; BTB (POZ) domain containing 6;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein 6 isoform 2
                     precursor"
                     /protein_id="NP_001374496.1"
                     /db_xref="CCDS:CCDS91955.1"
                     /db_xref="GeneID:90135"
                     /db_xref="HGNC:HGNC:19897"
                     /translation="MLLPLACLHGRVAQCLTSLLLLAEPLPRPRRGARARGAASTGAE
                     AAPAAPPAKMAAELYAPASAAAADLANSNAGAAVGRKAGPRSPPSAPAPAPPPPAPAP
                     PTLGNNHQESPGWRCCRPTLRERNALMFNNELMADVHFVVGPPGATRTVPAHKYVLAV
                     GSSVFYAMFYGDLAEVKSEIHIPDVEPAAFLILLKYMYSDEIDLEADTVLATLYAAKK
                     YIVPALAKACVNFLETSLEAKNACVLLSQSRLFEEPELTQRCWEVIDAQAEMALRSEG
                     FCEIDRQTLEIIVTREALNTKEAVVFEAVLNWAEAECKRQGLPITPRNKRHVLGRALY
                     LVRIPTMTLEEFANGAAQSDILTLEETHSIFLWYTATNKPRLDFPLTKRKGLAPQRCH
                     RFQSSAYRSNQWRYRGRCDSIQFAVDRRVFIAGLGLYGSSSGKAEYSVKIELKRLGVV
                     LAQNLTKFMSDGSSNTFPVWFEHPVQVEQDTFYTASAVLDGSELSYFGQEGMTEVQCG
                     KVAFQFQCSSDSTNGTGVQGGQIPELIFYA"
     exon            554..644
                     /gene="BTBD6"
                     /gene_synonym="BDPL"
                     /inference="alignment:Splign:2.1.0"
     exon            645..763
                     /gene="BTBD6"
                     /gene_synonym="BDPL"
                     /inference="alignment:Splign:2.1.0"
     exon            764..2217
                     /gene="BTBD6"
                     /gene_synonym="BDPL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2195..2200
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BTBD6"
                     /gene_synonym="BDPL"
                     /note="hexamer: AATAAA"
     polyA_site      2217
                     /gene="BTBD6"
                     /gene_synonym="BDPL"
                     /note="major polyA site"
ORIGIN      
        1 gcagcgtgac gcaccggcgc cgcggcgggt acgggctcgg gcgggcgggc gggcgggacg
       61 gcgccccccg cggccgggcc tggccgggct gcgctaggct gggctcgggc agggtcgcag
      121 gggcgggggt ggcaggggag cgggtggcag ccccgcgggt cacagcgccg ccgccgccca
      181 tgctgctgcc cctagcctgc ctgcacggcc gcgtcgctca gtgcctgacc tccttgcttt
      241 tgcttgcaga gccgctcccg aggccccggc gcggcgcgag ggcgcggggc gcggcgtcca
      301 caggcgccga ggctgccccc gccgccccgc ccgcgaagat ggcggcggaa ctctacgctc
      361 ccgccagcgc cgcggccgcg gacctagcca acagcaacgc cggcgccgcc gtgggcagga
      421 aggccgggcc gcgcagcccg cccagcgccc ccgcgccagc gccgccgccg cccgcgcccg
      481 cgccgcccac actcggcaac aaccaccagg agagccccgg ctggcggtgc tgccgcccca
      541 cgctgcgcga gaggaacgcg ctcatgttca acaacgagct catggccgac gtgcacttcg
      601 tcgtggggcc cccgggggcg accaggacgg tgcccgccca caagtacgtc ttggctgtcg
      661 gcagctccgt cttctatgcc atgttctacg gagacctggc ggaagtcaaa tctgaaattc
      721 acattccaga cgtggagccc gcagcctttc tgatcctctt aaagtacatg tacagtgatg
      781 agatcgatct ggaagccgac acggtgctgg ccactctgta cgctgctaag aagtacatcg
      841 tcccagcatt ggcaaaagcc tgtgtcaact ttctggagac aagtttggaa gccaagaacg
      901 cctgcgtcct gctgtcccag agccggctgt ttgaggagcc cgagctgacg cagcgctgct
      961 gggaggtcat tgacgcacag gccgagatgg ccctacggtc cgaaggcttc tgtgagatag
     1021 accggcagac gctggagatc attgtcactc gggaggccct caacaccaaa gaggcggtgg
     1081 tcttcgaggc cgtcctgaac tgggccgagg cggagtgcaa gaggcagggg ctgccaatca
     1141 ccccacgaaa caagaggcat gttctggggc gagccctcta tctggtccga attccaacca
     1201 tgaccctaga ggagtttgcc aacggcgctg cccagtcaga catcctgact ctggaggaga
     1261 cccacagcat cttcctgtgg tacacggcca ccaacaagcc ccgcctggac tttcccctga
     1321 ccaagaggaa gggcctcgcc ccgcagaggt gccaccgatt ccagtcttct gcctaccgca
     1381 gcaaccagtg gcggtaccgc gggcgctgcg acagcatcca gtttgcagtg gacagaaggg
     1441 tatttattgc agggctgggc ctgtatggct ccagctctgg gaaggctgag tacagcgtga
     1501 agattgagct caagcggctc ggggtggttc tggctcagaa cttgaccaag ttcatgtcag
     1561 acggatccag taacaccttc ccggtctggt ttgaacaccc ggtccaggtt gaacaagaca
     1621 ccttctacac ggccagtgcc gtcctggacg gcagcgaact cagctacttt gggcaggagg
     1681 ggatgacgga agtgcagtgt ggaaaggtgg ccttccagtt ccagtgctcc tcggacagca
     1741 ccaacgggac tggggtccag ggtgggcaga tccctgagct cattttctat gcctgaggtg
     1801 cccggggagg ctgcagcagg tcagcgagtg agtggagggg aagtcaagat gctaactgct
     1861 tcttgacacc atgaaaggct gctcttaact ttgtctctct ttgacatgta gtcagctgaa
     1921 gcttgactgt gtagagacat tttccacaca gccagaaccc agggattgga gtcttaggca
     1981 tctctggtac agtggggtgc acgtctcagg tggaggaaga tttacggctc aagacaggcc
     2041 ccagatcccc tcccagtggc acccatgcca cctgctttga ggggttggat cttcctgcta
     2101 ccctcttgga ttctaagtgg ttccaagctt aacttgagac cttcccttca aatctaaaat
     2161 tggcaaaaag tcacttaaaa tagtggactt ctgtaataaa ggttgcctaa aataaca
//
