LOCUS       NM_017797               2629 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens BTB domain containing 2 (BTBD2), mRNA.
ACCESSION   NM_017797
VERSION     NM_017797.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2629)
  AUTHORS   Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
            Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
            O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
            Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
            Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein network map of head and neck cancer reveals PIK3CA mutant
            drug sensitivity
  JOURNAL   Science 374 (6563), eabf2911 (2021)
   PUBMED   34591642
REFERENCE   2  (bases 1 to 2629)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2629)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2629)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 2629)
  AUTHORS   Bennett,E.J., Rush,J., Gygi,S.P. and Harper,J.W.
  TITLE     Dynamics of cullin-RING ubiquitin ligase network revealed by
            systematic quantitative proteomics
  JOURNAL   Cell 143 (6), 951-965 (2010)
   PUBMED   21145461
REFERENCE   6  (bases 1 to 2629)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   7  (bases 1 to 2629)
  AUTHORS   Xu,L., Yang,L., Moitra,P.K., Hashimoto,K., Rallabhandi,P., Kaul,S.,
            Meroni,G., Jensen,J.P., Weissman,A.M. and D'Arpa,P.
  TITLE     BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the
            RBCC/tripartite motif protein, TRIM5delta
  JOURNAL   Exp Cell Res 288 (1), 84-93 (2003)
   PUBMED   12878161
  REMARK    GeneRIF: subcellular colocalization of BTBD1 and BTBD2 to
            cytoplasmic bodies; TRIM5delta colocalized with BTBD1/2 and
            appeared to serve as a scaffold for the assembly of endogenous
            BTBD1/2 proteins
REFERENCE   8  (bases 1 to 2629)
  AUTHORS   Yamada,A., Kawano,K., Koga,M., Takamori,S., Nakagawa,M. and Itoh,K.
  TITLE     Gene and peptide analyses of newly defined lung cancer antigens
            recognized by HLA-A2402-restricted tumor-specific cytotoxic T
            lymphocytes
  JOURNAL   Cancer Res 63 (11), 2829-2835 (2003)
   PUBMED   12782588
REFERENCE   9  (bases 1 to 2629)
  AUTHORS   Xu,L., Yang,L., Hashimoto,K., Anderson,M., Kohlhagen,G., Pommier,Y.
            and D'Arpa,P.
  TITLE     Characterization of BTBD1 and BTBD2, two similar
            BTB-domain-containing Kelch-like proteins that interact with
            Topoisomerase I
  JOURNAL   BMC Genomics 3, 1 (2002)
   PUBMED   11818025
REFERENCE   10 (bases 1 to 2629)
  AUTHORS   Carim-Todd,L., Sumoy,L., Andreu,N., Estivill,X. and Escarceller,M.
  TITLE     Identification and characterization of BTBD1, a novel BTB domain
            containing gene on human chromosome 15q24
  JOURNAL   Gene 262 (1-2), 275-281 (2001)
   PUBMED   11179693
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004678.1, AF355797.1,
            BU849231.1, BC000564.2 and BC008035.2.
            
            On May 17, 2019 this sequence version replaced NM_017797.3.
            
            Summary: The C-terminus of the protein encoded by this gene binds
            topoisomerase I. The N-terminus contains a proline-rich region and
            a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox
            virus and Zinc finger), both of which are typically involved in
            protein-protein interactions. Subcellularly, the protein localizes
            to cytoplasmic bodies. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF355797.1, BC094820.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000255608.9/ ENSP00000255608.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC004678.1         23852-23862         c
            12-517              AF355797.1         1-506
            518-519             BU849231.1         486-487
            520-1620            AF355797.1         509-1609
            1621-2025           BC000564.2         900-1304
            2026-2629           BC008035.2         1299-1902
FEATURES             Location/Qualifiers
     source          1..2629
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2629
                     /gene="BTBD2"
                     /note="BTB domain containing 2"
                     /db_xref="GeneID:55643"
                     /db_xref="HGNC:HGNC:15504"
                     /db_xref="MIM:608531"
     exon            1..418
                     /gene="BTBD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..1589
                     /gene="BTBD2"
                     /note="BTB (POZ) domain containing 2"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein 2"
                     /protein_id="NP_060267.2"
                     /db_xref="CCDS:CCDS12078.1"
                     /db_xref="GeneID:55643"
                     /db_xref="HGNC:HGNC:15504"
                     /db_xref="MIM:608531"
                     /translation="MAAGGSGGRASCPPGVGVGPGTGGSPGPSANAAATPAPGNAAAA
                     AAAAAAAAAAPGPTPPAPPGPGTDAQAAGAERAEEAAGPGAAALQREAAYNWQASKPT
                     VQERFAFLFNNEVLCDVHFLVGKGLSSQRIPAHRFVLAVGSAVFDAMFNGGMATTSTE
                     IELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEAHCVEFLKKNLR
                     ADNAFMLLTQARLFDEPQLASLCLENIDKNTADAITAEGFTDIDLDTLVAVLERDTLG
                     IREVRLFNAVVRWSEAECQRQQLQVTPENRRKVLGKALGLIRFPLMTIEEFAAGPAQS
                     GILVDREVVSLFLHFTVNPKPRVEFIDRPRCCLRGKECSINRFQQVESRWGYSGTSDR
                     IRFSVNKRIFVVGFGLYGSIHGPTDYQVNIQIIHTDSNTVLGQNDTGFSCDGSASTFR
                     VMFKEPVEVLPNVNYTACATLKGPDSHYGTKGLRKVTHESPTTGAKTCFTFCYAAGNN
                     NGTSVEDGQIPEVIFYT"
     exon            419..538
                     /gene="BTBD2"
                     /inference="alignment:Splign:2.1.0"
     exon            539..695
                     /gene="BTBD2"
                     /inference="alignment:Splign:2.1.0"
     exon            696..801
                     /gene="BTBD2"
                     /inference="alignment:Splign:2.1.0"
     exon            802..999
                     /gene="BTBD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1192
                     /gene="BTBD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1280
                     /gene="BTBD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1427
                     /gene="BTBD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..2629
                     /gene="BTBD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2607..2612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BTBD2"
                     /note="hexamer: AATAAA"
     polyA_site      2629
                     /gene="BTBD2"
                     /note="major polyA site"
ORIGIN      
        1 gcagccacaa aatggcggcg ggtgggagcg gcgggcgtgc gtcgtgcccg ccgggggtcg
       61 gggtcggccc gggcacgggg ggcagtcccg ggcccagcgc caacgccgcc gccaccccgg
      121 cccccggcaa cgcggccgcc gccgccgccg ccgccgccgc cgccgccgcc gcccctgggc
      181 cgacgccgcc cgccccgccg ggccccggga cagacgcgca ggccgcgggc gcggagcggg
      241 cggaggaggc ggcgggcccg ggggcggcgg cgctgcagcg cgaggccgcg tacaactggc
      301 aggccagcaa gcccaccgtg caggagcgct tcgccttcct cttcaacaac gaggtgctgt
      361 gcgacgtgca cttcctggtg ggcaaggggc tcagctcgca gcgcatcccc gcgcacaggt
      421 tcgtgctggc cgtgggcagc gccgtctttg atgccatgtt caacggggga atggccacaa
      481 catccacgga gattgagctg cccgacgtgg aacccgctgc cttcctcgca ctgctcaagt
      541 ttctctactc ggacgaggtg cagattggcc cggagacggt gatgaccacg ctatacaccg
      601 ccaagaagta cgcggtgcca gcgctcgagg cccattgcgt ggagttcctg aagaagaacc
      661 tgcgagccga caacgccttc atgctgctca cgcaggcgcg actcttcgat gaaccgcagc
      721 tggccagcct gtgcctggag aacatcgaca aaaacactgc agacgccatc accgcggagg
      781 gcttcaccga cattgacctg gacacgctgg tggctgtcct ggagcgcgac acactgggca
      841 tccgtgaggt gcggctgttc aatgccgttg tccgctggtc cgaggccgag tgtcagcggc
      901 agcagctgca ggtgacgcca gagaacaggc ggaaggttct gggcaaggcc ctgggcctca
      961 ttcgcttccc gctcatgacc atcgaggagt tcgctgcagg tcccgcacag tcgggcatcc
     1021 tggtggaccg cgaggtggtc agcctcttcc tgcacttcac cgtcaacccc aagccacgag
     1081 tggagttcat tgaccggccc cgctgctgcc tgcgtgggaa ggagtgcagc atcaaccgct
     1141 tccagcaggt ggagagtcgc tggggctaca gcgggaccag tgaccgcatc aggttctcag
     1201 tcaacaagcg catcttcgtg gtgggatttg ggctgtatgg atccatccac gggcccaccg
     1261 actaccaagt gaacatccag attattcaca ccgatagcaa caccgtcttg ggccagaacg
     1321 acacgggctt cagctgcgac ggctcagcca gcaccttccg cgtcatgttc aaggagccgg
     1381 tggaggtgct gcccaacgtc aactacacgg cctgtgccac gctcaagggc ccagactccc
     1441 actacggcac caaaggcctg cgcaaggtga cacacgagtc gcccaccacg ggcgccaaga
     1501 cctgcttcac cttttgctac gcggccggga acaacaatgg cacatccgtg gaggacggcc
     1561 agatccccga ggtcatcttc tacacctagg ctgcccgaca ccgacaccgc cctccctccg
     1621 tggggatagc cgcagcccca ggccatcatc tgctgctggg gcccccccac cacgcggtgc
     1681 caggcccagt gtcccccagg ccgtctgtcc actccatgcc acctttctca gcatcaggac
     1741 ggggttgccc tgtgttcacc acgagtgtgg ctgctggatc agggcagccg gggaggtggc
     1801 caggccagtg gccaggccct gtggagacaa tccctcagga ctagggacag ggctgtgccg
     1861 gcctgggcca gggcccacgg acccgcagct cagggcgcct gcccacgtcg tctgccggcg
     1921 gtgcgccgcg ggcgtccctc gcgtctcttc actgcacatt gcaatgcatt tgcgattccc
     1981 atttctctgc taggagccag cctgggtggc gctgctccca gagccgtggg tcccagacct
     2041 tgcgttcctt ttgttcctgt ccgtttatca ggacacgggc cccacctgtc acgtgcccga
     2101 ggccacccaa gcccagcctg cggggcgttc ccactgcctg gatgccggct tgagttctgc
     2161 gcacgcagga ttcagtgtgg ggacggcccc tgccggatag gcctagccct ggcccaggtg
     2221 gtgagcggtt tgcagtgtcc gttctcatcc acctgatggg cccagataaa ggcccccgct
     2281 gtccagcctc cctggacggc cctcgcggtc cctgcagccc aagatgggac tcagaccctg
     2341 tgccccagag ctcccctgcc gcagaatggg gccccagccg gccccgaccg ggtccaggag
     2401 cactgctcgc ctgtacatac tgttgcccta gcccacctgg tgccgtggga gccaccccca
     2461 ggtgctgggg gcacagcccc tccccactcc ggccacgccc ccacccaccc cgcgtgtttc
     2521 tgccctgtga ctcctggaac ctgcgtcctc cccaaagcca tgggaggggt gtcctcctca
     2581 gaccatgccc ccagatgatt tttttaaata aagaaacaaa tgcacctgc
//
