LOCUS       NM_001145101            3086 bp    mRNA    linear   PRI 17-MAR-2025
DEFINITION  Homo sapiens BTB domain containing 18 (BTBD18), mRNA.
ACCESSION   NM_001145101 XR_041749 XR_041750 XR_041751
VERSION     NM_001145101.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3086)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3086)
  AUTHORS   Zhou,L., Canagarajah,B., Zhao,Y., Baibakov,B., Tokuhiro,K.,
            Maric,D. and Dean,J.
  TITLE     BTBD18 Regulates a Subset of piRNA-Generating Loci through
            Transcription Elongation in Mice
  JOURNAL   Dev Cell 40 (5), 453-466 (2017)
   PUBMED   28292424
REFERENCE   3  (bases 1 to 3086)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   4  (bases 1 to 3086)
  AUTHORS   Alonso,C.N., Meyer,C., Gallego,M.S., Rossi,J.G., Mansini,A.P.,
            Rubio,P.L., Medina,A., Marschalek,R. and Felice,M.S.
  TITLE     BTBD18: A novel MLL partner gene in an infant with acute
            lymphoblastic leukemia and inv(11)(q13;q23)
  JOURNAL   Leuk Res 34 (11), e294-e296 (2010)
   PUBMED   20598370
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001931.5.
            
            On Apr 24, 2021 this sequence version replaced NM_001145101.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DC346943.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1968968,
                                           SAMEA2148093 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000422652.6/ ENSP00000394472.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-279               AP001931.5         31598-31876         c
            280-451             AP001931.5         31122-31293         c
            452-3086            AP001931.5         23571-26205         c
FEATURES             Location/Qualifiers
     source          1..3086
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..3086
                     /gene="BTBD18"
                     /note="BTB domain containing 18"
                     /db_xref="GeneID:643376"
                     /db_xref="HGNC:HGNC:37214"
     exon            1..279
                     /gene="BTBD18"
                     /inference="alignment:Splign:2.1.0"
     exon            280..451
                     /gene="BTBD18"
                     /inference="alignment:Splign:2.1.0"
     CDS             328..2466
                     /gene="BTBD18"
                     /note="hCG1730474; BTB (POZ) domain containing 18"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein 18"
                     /protein_id="NP_001138573.1"
                     /db_xref="CCDS:CCDS44603.1"
                     /db_xref="GeneID:643376"
                     /db_xref="HGNC:HGNC:37214"
                     /translation="MCSPASPKILYRNPRFLRLAFLQLHHQQQSDVFCDVLLQAEGEA
                     VPAHCCILSACSPFFTERLERERPAQGGKVVLELGGLKISTLRKLVDFLYTSEMEVSQ
                     EEAQDVLSAARQLRVSELESLQLEGGKLVKAPQGRRLNRECLQPTSAAPISARVVTPS
                     HHPHTPLPTNQTPCPLGAIRLKSLGKEEGPQENNRQNADNLSGTLLLKRKARACPTPQ
                     EKNSSPSSHSQEPRENKNDTALDPTVLSPPSLYPSVDKHLLPRKIRLSRSKPSPGICT
                     SKPSSILSGSSSVPATPGRRLWRQRSVNKETPEDKPKPGRASPLQSTPNPSGLGKTGG
                     SRKRSPEVRAPNSDSAEEGQVGRVKLRKIVNGTCWEVVQETPLKNTQDSPQIPDPGGD
                     FQEPSGTQPFSSNEQEMSPTRTELCQDSPMCTKLQDILVSASHSPDHPVVKSEFESSP
                     ELVEKEPMLAIDCREPYAFDTALLEQPCEAEEYRITSAAATSELEEILDFMLCGSDIE
                     PPIGSLESPGAEGCRTPTYHLTETGKNWIEGEEWCLPDMELWPRELTELEKEPAGENR
                     GPTELLSPLVMPSEVSEVLSVGGRWTPDLEITSSQPLDGQEDKLLHVSSLDTPQRSYG
                     DLSPPCSNWVETGLEVSLTTDELLYPSPKAGKEVSGHSELLGSLPASSEEEEIDVVDW
                     TAEGRLVPTTVPSVWPDPSSESETEVDILT"
     exon            452..3086
                     /gene="BTBD18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3060..3065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BTBD18"
                     /note="hexamer: AATAAA"
     polyA_site      3086
                     /gene="BTBD18"
                     /note="major polyA site"
ORIGIN      
        1 ggcgcatacg acttactaga gataatttta tacccagtaa tgtttcctta aaagtgttaa
       61 cttgaagatt atacctgtgg agctgggatg tggtgctcag gaagaatata agtagtcagc
      121 attgtagcag ttgagtctca gtggtaatgg aaatgaggaa ggttgaagga taataatagt
      181 taccatttgg ggcttggtag ttattttgtg ccaggcactc actgtgctaa gcaactttac
      241 cttcactgac tcatttaatc tttaaaacaa ccctacaagg agtctgatct gtgaaaacct
      301 agaaggtttg ttaagactct tgccaacatg tgctctcctg ccagtcccaa aatcctatac
      361 aggaaccccc ggttcctcag gttagctttt ctgcagcttc atcaccagca gcagagtgat
      421 gtgttctgtg atgtccttct gcaggcagaa ggtgaggcag ttccagctca ctgctgcatc
      481 ctgtcagctt gtagcccctt cttcacagag cgcctggagc gggagaggcc agctcagggt
      541 gggaaggtgg tgctagagct gggtggcctg aagatcagca cacttaggaa gctggtggac
      601 ttcttgtata cctcagaaat ggaagtatct caagaagaag cccaggatgt gctatctgct
      661 gcccgtcagc tccgtgtgtc tgagctggaa tcccttcagc ttgagggtgg aaagttggtg
      721 aaggccccac agggccgaag gctgaaccga gagtgcttac aaccaacaag tgctgcacca
      781 atctctgcca gagtggtgac acccagccac caccctcaca ccccactgcc cactaatcaa
      841 actccttgtc ctcttggggc aataagattg aagtccttgg ggaaggaaga ggggccccag
      901 gaaaacaacc gacagaatgc agacaatttg tctggcactc ttctgctcaa gaggaaggcc
      961 agagcctgcc caactccaca agaaaaaaac tcttcaccat caagccatag tcaagagcct
     1021 agagagaaca agaatgacac tgcccttgat cctacagtgc tctccccacc cagcttgtac
     1081 ccctctgtgg acaaacacct gttgcccaga aagatcaggc tcagtcgctc aaagccatct
     1141 cctggtatct gtacatcaaa gccttccagc attttaagtg gatctagctc agtgcctgca
     1201 acccctggcc ggcgtctttg gcggcagagg agtgtaaata aagaaacacc agaggacaag
     1261 ccaaaaccag gcagagctag tcctctgcag agcaccccaa acccatctgg tctgggaaag
     1321 acaggtggga gcaggaagcg gagccctgaa gtcagggcac ctaactcaga ctctgcagag
     1381 gaggggcagg ttgggagagt taaacttagg aagattgtca atgggacttg ctgggaagtg
     1441 gtacaagaga ctcctctcaa aaacactcaa gatagccccc agatcccaga tcccggagga
     1501 gacttccaag agccttcagg aactcagcca ttctccagta atgagcagga aatgtcacct
     1561 actagaacag aactgtgtca ggactccccc atgtgcacta agctacaaga cattctggtc
     1621 tctgctagcc actccccaga ccacccagtg gtgaagtcag agtttgagtc cagtccagaa
     1681 ctggtagaga aggaacctat gttggctatt gactgcagag aaccctatgc atttgacaca
     1741 gctctgctgg agcagccctg tgaggctgag gagtaccgaa tcacaagtgc tgctgccacc
     1801 agtgagctgg aggagatcct ggacttcatg ctctgtggct cagacattga accacctata
     1861 gggtctctgg agagtccagg ggctgagggc tgcagaacgc ctacctacca tctgacagaa
     1921 acaggaaaga actggattga aggggaagaa tggtgtctac cagacatgga actctggccc
     1981 agggagctca cagaattgga aaaggaacct gctggtgaga acagagggcc aactgagctc
     2041 cttagccccc ttgtcatgcc ctctgaggtg agtgaagtgc tttcagtagg aggccgttgg
     2101 acaccagacc ttgaaattac cagctcccag ccactggatg gtcaggaaga caaacttctc
     2161 catgtcagct cccttgatac tccccagagg tcttatgggg acctctcacc tccctgctca
     2221 aactgggtgg agactgggct ggaagtctcc ttgactacag atgagttatt atacccttct
     2281 cccaaggcag gcaaggaggt atctggtcac tctgaactac taggctcact tcctgccagc
     2341 tctgaagagg aagagattga tgtggtggac tggacagcag aggggaggct ggtacccact
     2401 actgttccct ccgtgtggcc tgacccttcc tcagagtcag aaacagaggt agatatacta
     2461 acatagtgga gaggggaggg caggttaggg gccttgggag ggtgggaaat gttagctagc
     2521 aaaaggctta ctggcagaga agctggcacg tgccctcagc acaagaggca ggtgtaccct
     2581 ggctctttgt aggtcccttc ctcccttccc taagcctcag aagccaggca gaagccaagg
     2641 gtaccataga tagaaaatta tgaacttgta ccatcttatt tgtaatctat tttccggtta
     2701 gtgacaactg aaacaaactg tgtgctcccc aattctggtg ggtcataggt aacagccaag
     2761 gccagatctc tcaggtcata aggcatccag tcactggtaa tttaggaaaa gctgagaaag
     2821 aacaccctcc tctgtggtgg ggtattgttt aagaaaatgt tccagaggaa ggtgtgaagc
     2881 agtgttgggt ggaatactaa gtgggtggga gtgatggatg ctgtccagca cccaacgtgg
     2941 ggcttattca ctgccagtat taggaagtct agctaaaacc tctgcagggg ccaagaagat
     3001 gtacttccat cattacttcc aaaaagtaag ttgaaaaaga tacagttgct tttttaaaaa
     3061 ataaattatt tactttgctc ccataa
//
