LOCUS       NP_001073935             478 aa            linear   PRI 28-APR-2025
DEFINITION  BTB/POZ domain-containing protein 17 precursor [Homo sapiens].
ACCESSION   NP_001073935 XP_371078
VERSION     NP_001073935.1
DBSOURCE    REFSEQ: accession NM_001080466.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 478)
  AUTHORS   Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
            Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
            Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
            Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
            Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
            Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
            Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
            Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
            LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
            Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
            Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
            Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
            Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
            Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
            Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC103809.2.
            
            On Jan 18, 2007 this sequence version replaced XP_371078.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DN831663.1, HY139693.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157437 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375366.4/ ENSP00000364515.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..478
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     Protein         1..478
                     /product="BTB/POZ domain-containing protein 17 precursor"
                     /note="BTB/POZ domain-containing protein 17; BTB/POZ and
                     BACK domain-containing protein LOC388419; transport and
                     golgi organization 10 homolog A; BTB (POZ) domain
                     containing 17"
                     /calculated_mol_wt=49382
     sig_peptide     1..28
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (A6NE02.1)"
                     /calculated_mol_wt=3107
     mat_peptide     29..478
                     /product="BTB/POZ domain-containing protein 17.
                     /id=PRO_0000340704"
                     /note="propagated from UniProtKB/Swiss-Prot (A6NE02.1)"
                     /calculated_mol_wt=49382
     Region          46..158
                     /region_name="BTB_POZ_BTBD17"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in BTB/POZ
                     domain-containing protein 17 (BTBD17); cd18292"
                     /db_xref="CDD:349601"
     Site            61
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (A6NE02.1)"
     Site            100
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (A6NE02.1)"
     Region          166..238
                     /region_name="BACK_BTBD17"
                     /note="BACK (BTB and C-terminal Kelch) domain found in
                     BTB/POZ domain-containing protein 17 (BTBD17); cd18493"
                     /db_xref="CDD:350568"
     Site            195
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (A6NE02.1)"
     CDS             1..478
                     /gene="BTBD17"
                     /gene_synonym="BTBD17A; LGALS3BPL; TANGO10A"
                     /coded_by="NM_001080466.2:50..1486"
                     /db_xref="CCDS:CCDS32719.1"
                     /db_xref="GeneID:388419"
                     /db_xref="HGNC:HGNC:33758"
ORIGIN      
        1 mprrgyskpg swgsfwamlt lvglvthaaq radvggeaag tsinhsqavl qrlqellrqg
       61 nasdvvlrvq aagtdevrvf hahrlllglh selflellsn qseavlqepq dcaavfdkfi
      121 rylycgeltv lltqaiplhr latkygvssl qrgvadymra hlaggagpav gwyhyavgtg
      181 dealresclq flawnlsava astewgavsp ellwqllqrs dlvlqdelel fhaleawlgr
      241 arpppavaer alrairypmi ppaqlfqlqa rsaalarhgp avadlllqay qfhaasplhy
      301 akffdvngsa flprnylapa wgapwvinnp arddrstsfq tqlgpsghda grrvtwnvlf
      361 sprwlpvslr pvyadaagta lpaarpedgr prlvvtpass ggdaagvsfq ktvlvgarqq
      421 grllvrhays fhqsseeagd flahadlqrr nseylvenal hlhlivkpvy htlirtpk
//
