LOCUS       NM_144587               1856 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens BTB domain containing 16 (BTBD16), transcript variant
            2, mRNA.
ACCESSION   NM_144587
VERSION     NM_144587.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1856)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1856)
  AUTHORS   Smith,E.N., Bloss,C.S., Badner,J.A., Barrett,T., Belmonte,P.L.,
            Berrettini,W., Byerley,W., Coryell,W., Craig,D., Edenberg,H.J.,
            Eskin,E., Foroud,T., Gershon,E., Greenwood,T.A., Hipolito,M.,
            Koller,D.L., Lawson,W.B., Liu,C., Lohoff,F., McInnis,M.G.,
            McMahon,F.J., Mirel,D.B., Murray,S.S., Nievergelt,C.,
            Nurnberger,J., Nwulia,E.A., Paschall,J., Potash,J.B., Rice,J.,
            Schulze,T.G., Scheftner,W., Panganiban,C., Zaitlen,N., Zandi,P.P.,
            Zollner,S., Schork,N.J. and Kelsoe,J.R.
  TITLE     Genome-wide association study of bipolar disorder in European
            American and African American individuals
  JOURNAL   Mol Psychiatry 14 (8), 755-763 (2009)
   PUBMED   19488044
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB052430.1 and AK058088.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 31, 2019 this sequence version replaced NM_144587.4.
            
            Summary: This gene encodes a protein that contains a BTB/POZ
            domain. This domain mediates protein-protein interactions. A
            mutation in this gene may be associated with bipolar disorder.
            [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1,
            resulting in an isoform (b) that is 1 aa shorter than isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK058088.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260723.6/ ENSP00000260723.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-551               DB052430.1         1-551
            552-1856            AK058088.1         542-1846
FEATURES             Location/Qualifiers
     source          1..1856
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.13"
     gene            1..1856
                     /gene="BTBD16"
                     /gene_synonym="C10orf87"
                     /note="BTB domain containing 16"
                     /db_xref="GeneID:118663"
                     /db_xref="HGNC:HGNC:26340"
     exon            1..219
                     /gene="BTBD16"
                     /gene_synonym="C10orf87"
                     /inference="alignment:Splign:2.1.0"
     exon            220..279
                     /gene="BTBD16"
                     /gene_synonym="C10orf87"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..1782
                     /gene="BTBD16"
                     /gene_synonym="C10orf87"
                     /note="isoform b is encoded by transcript variant 2;
                     BTB/POZ domain-containing protein 16"
                     /codon_start=1
                     /product="BTB/POZ domain-containing protein 16 isoform b"
                     /protein_id="NP_653188.2"
                     /db_xref="CCDS:CCDS31301.1"
                     /db_xref="GeneID:118663"
                     /db_xref="HGNC:HGNC:26340"
                     /translation="MIMSNTHKARLERRVTGSTNRWRLPKQPFSGDLLSLSQMCKALS
                     IDFEEALRNPDRLCISQIQKFFFENFKNKDIQSGEADVILECLGFKWELHQPQLFQSE
                     TLAKLYLKALAQGTTHPLRELEELLRAQSPKKTKEKSPAKRIIISLKINDPLVTKVAF
                     ATALKNLYMSEVEINLEDLLGVLASAHILQFSGLFQRCVDVMIARLKPSTIKKFYEAG
                     CKYKEEQLTTGCEKWLEMNLVPLGGTQIHLHKIPQDLLHKVLKSPRLFTFSEFHLLKT
                     MLLWVFLQLNYKIQAIPTYETVMTFFKSFPENCCFLDRDIGRSLRPLFLCLRLHGITK
                     GKDLEVLRHLNFFPESWLDQVTVNHYHALENGGDMVHLKDLNTQAVRFGLLFNQENTT
                     YSKTIALYGFFFKIKGLKHDTTSYSFYMQRIKHTDLESPSAVYEHNHVSLRAARLVKY
                     EIRAEALVDGKWQEFRTNQIKQKFGLTTSSCKSHTLKIQTVGIPIYVSFAFIFPAS"
     exon            280..428
                     /gene="BTBD16"
                     /gene_synonym="C10orf87"
                     /inference="alignment:Splign:2.1.0"
     exon            429..502
                     /gene="BTBD16"
                     /gene_synonym="C10orf87"
                     /inference="alignment:Splign:2.1.0"
     exon            503..646
                     /gene="BTBD16"
                     /gene_synonym="C10orf87"
                     /inference="alignment:Splign:2.1.0"
     exon            647..736
                     /gene="BTBD16"
                     /gene_synonym="C10orf87"
                     /inference="alignment:Splign:2.1.0"
     exon            737..851
                     /gene="BTBD16"
                     /gene_synonym="C10orf87"
                     /inference="alignment:Splign:2.1.0"
     exon            852..921
                     /gene="BTBD16"
                     /gene_synonym="C10orf87"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1052
                     /gene="BTBD16"
                     /gene_synonym="C10orf87"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1172
                     /gene="BTBD16"
                     /gene_synonym="C10orf87"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1264
                     /gene="BTBD16"
                     /gene_synonym="C10orf87"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1347
                     /gene="BTBD16"
                     /gene_synonym="C10orf87"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1425
                     /gene="BTBD16"
                     /gene_synonym="C10orf87"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1524
                     /gene="BTBD16"
                     /gene_synonym="C10orf87"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1713
                     /gene="BTBD16"
                     /gene_synonym="C10orf87"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1856
                     /gene="BTBD16"
                     /gene_synonym="C10orf87"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1836..1841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BTBD16"
                     /gene_synonym="C10orf87"
                     /note="hexamer: AATAAA"
     polyA_site      1856
                     /gene="BTBD16"
                     /gene_synonym="C10orf87"
                     /note="major polyA site"
ORIGIN      
        1 acaaccaccc aggaaaccaa ggcaagctcc ccctgtcaaa gcaccttggc ccataagaag
       61 aaaaggggga gccccagatg tgatgagcgc ttccaggctt caggctcaga aggcgccccc
      121 agctctcctg taactcagag gccagtgtga tgggagttcc tccactcagc acacttcccc
      181 tgtaaacacg cctgtggtgg gcaaaagggc tttggaacgg ttgcttgtct tttctctcct
      241 gcgtaatttc cactttcatt catgataatg tcgaacacgc acaaagctcg gctggaacgc
      301 cgggtcactg gctcaaccaa ccggtggcgt ttgcccaaac agcctttctc tggggacctg
      361 ctctcacttt cccagatgtg caaggctctg agcatagact ttgaggaagc tttgaggaac
      421 ccagacaggt tatgcatttc acaaatccag aagtttttct ttgagaattt caagaacaag
      481 gacatccaaa gtggggaagc agatgtgatt ctcgagtgcc tgggcttcaa atgggagctc
      541 catcagcccc agctttttca gtctgagacc ttggccaagc tctacctgaa agccctggcg
      601 cagggcacca cacaccccct gagggagctg gaggagcttc tgcgagctca atcacctaag
      661 aagaccaaag aaaaatcccc tgcaaagagg atcatcattt ccttgaagat caatgaccca
      721 ctggtcacta aagtcgcctt cgccacggcc ctgaagaacc tctacatgag tgaggtggag
      781 attaacttgg aagacctact gggagtgctg gcttccgccc acatcctcca gttcagtggc
      841 ctgtttcaaa ggtgcgtgga tgtgatgata gccagactca agccaagcac catcaagaaa
      901 ttctacgagg ccggctgcaa gtacaaggaa gagcagctca ccaccggctg cgagaagtgg
      961 ctggaaatga acttggttcc tctagggggg acgcagatcc acctccacaa aatcccacag
     1021 gacctgctcc acaaagtgct gaagtccccc aggttattta cctttagtga attccatctt
     1081 ctgaaaacaa tgcttttgtg ggtcttcttg caactgaact acaagattca ggcaattccg
     1141 acttatgaaa ccgtgatgac attttttaag agctttcctg agaactgttg ctttctggac
     1201 cgggacatag gacggagctt gaggccgctc ttcctctgct tgcgtctgca cggcatcacc
     1261 aaaggcaagg atctggaggt gctgcggcac cttaacttct tcccagagtc atggctcgac
     1321 caggttacag tcaaccatta ccacgcactg gagaatgggg gcgacatggt ccacctgaaa
     1381 gatcttaaca cccaggctgt gagatttggg ctgctcttta accaggagaa tacaacttat
     1441 tcgaaaacga ttgctctata tggattcttc tttaagataa agggactcaa acatgatact
     1501 acctcttata gtttttacat gcagagaata aagcacacag acctggaatc tccctctgcg
     1561 gtctacgagc acaaccacgt cagcctgcga gcggcacgcc tggtgaagta tgagatcaga
     1621 gcagaggccc tggttgacgg caagtggcag gagttcagga caaaccagat caagcagaag
     1681 tttgggttga ccacgtcatc ctgcaaaagc cataccttga aaatccaaac tgtgggcatc
     1741 ccaatctatg taagttttgc attcatcttc ccagcatctt gacagtttcc agaagaatct
     1801 atgggatttt ccccccactg gtctgcataa aagaaaataa aatgacataa aaggga
//
