LOCUS       NM_001098169             944 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens brain specific homeobox (BSX), mRNA.
ACCESSION   NM_001098169 XM_372433 XM_939530
VERSION     NM_001098169.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 944)
  AUTHORS   Carstensen,M.B., Medvetzky,A., Weinberger,A., Driever,W.,
            Gothilf,Y. and Rath,M.F.
  TITLE     Genetic ablation of the Bsx homeodomain transcription factor in
            zebrafish: Impact on mature pineal gland morphology and circadian
            behavior
  JOURNAL   J Pineal Res 72 (4), e12795 (2022)
   PUBMED   35249239
  REMARK    GeneRIF: Genetic ablation of the Bsx homeodomain transcription
            factor in zebrafish: Impact on mature pineal gland morphology and
            circadian behavior.
REFERENCE   2  (bases 1 to 944)
  AUTHORS   Schredelseker,T. and Driever,W.
  TITLE     Bsx controls pineal complex development
  JOURNAL   Development 145 (13) (2018)
   PUBMED   29945867
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 944)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   4  (bases 1 to 944)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
REFERENCE   5  (bases 1 to 944)
  AUTHORS   Elks,C.E., Perry,J.R., Sulem,P., Chasman,D.I., Franceschini,N.,
            He,C., Lunetta,K.L., Visser,J.A., Byrne,E.M., Cousminer,D.L.,
            Gudbjartsson,D.F., Esko,T., Feenstra,B., Hottenga,J.J.,
            Koller,D.L., Kutalik,Z., Lin,P., Mangino,M., Marongiu,M.,
            McArdle,P.F., Smith,A.V., Stolk,L., van Wingerden,S.H., Zhao,J.H.,
            Albrecht,E., Corre,T., Ingelsson,E., Hayward,C., Magnusson,P.K.,
            Smith,E.N., Ulivi,S., Warrington,N.M., Zgaga,L., Alavere,H.,
            Amin,N., Aspelund,T., Bandinelli,S., Barroso,I., Berenson,G.S.,
            Bergmann,S., Blackburn,H., Boerwinkle,E., Buring,J.E., Busonero,F.,
            Campbell,H., Chanock,S.J., Chen,W., Cornelis,M.C., Couper,D.,
            Coviello,A.D., d'Adamo,P., de Faire,U., de Geus,E.J., Deloukas,P.,
            Doring,A., Smith,G.D., Easton,D.F., Eiriksdottir,G., Emilsson,V.,
            Eriksson,J., Ferrucci,L., Folsom,A.R., Foroud,T., Garcia,M.,
            Gasparini,P., Geller,F., Gieger,C., Gudnason,V., Hall,P.,
            Hankinson,S.E., Ferreli,L., Heath,A.C., Hernandez,D.G., Hofman,A.,
            Hu,F.B., Illig,T., Jarvelin,M.R., Johnson,A.D., Karasik,D.,
            Khaw,K.T., Kiel,D.P., Kilpelainen,T.O., Kolcic,I., Kraft,P.,
            Launer,L.J., Laven,J.S., Li,S., Liu,J., Levy,D., Martin,N.G.,
            McArdle,W.L., Melbye,M., Mooser,V., Murray,J.C., Murray,S.S.,
            Nalls,M.A., Navarro,P., Nelis,M., Ness,A.R., Northstone,K.,
            Oostra,B.A., Peacock,M., Palmer,L.J., Palotie,A., Pare,G.,
            Parker,A.N., Pedersen,N.L., Peltonen,L., Pennell,C.E., Pharoah,P.,
            Polasek,O., Plump,A.S., Pouta,A., Porcu,E., Rafnar,T., Rice,J.P.,
            Ring,S.M., Rivadeneira,F., Rudan,I., Sala,C., Salomaa,V., Sanna,S.,
            Schlessinger,D., Schork,N.J., Scuteri,A., Segre,A.V.,
            Shuldiner,A.R., Soranzo,N., Sovio,U., Srinivasan,S.R.,
            Strachan,D.P., Tammesoo,M.L., Tikkanen,E., Toniolo,D., Tsui,K.,
            Tryggvadottir,L., Tyrer,J., Uda,M., van Dam,R.M., van Meurs,J.B.,
            Vollenweider,P., Waeber,G., Wareham,N.J., Waterworth,D.M.,
            Weedon,M.N., Wichmann,H.E., Willemsen,G., Wilson,J.F., Wright,A.F.,
            Young,L., Zhai,G., Zhuang,W.V., Bierut,L.J., Boomsma,D.I.,
            Boyd,H.A., Crisponi,L., Demerath,E.W., van Duijn,C.M., Econs,M.J.,
            Harris,T.B., Hunter,D.J., Loos,R.J., Metspalu,A., Montgomery,G.W.,
            Ridker,P.M., Spector,T.D., Streeten,E.A., Stefansson,K.,
            Thorsteinsdottir,U., Uitterlinden,A.G., Widen,E., Murabito,J.M.,
            Ong,K.K. and Murray,A.
  CONSRTM   GIANT Consortium
  TITLE     Thirty new loci for age at menarche identified by a meta-analysis
            of genome-wide association studies
  JOURNAL   Nat Genet 42 (12), 1077-1085 (2010)
   PUBMED   21102462
REFERENCE   6  (bases 1 to 944)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 944)
  AUTHORS   Coldren,C.D., Lai,Z., Shragg,P., Rossi,E., Glidewell,S.C.,
            Zuffardi,O., Mattina,T., Ivy,D.D., Curfs,L.M., Mattson,S.N.,
            Riley,E.P., Treier,M. and Grossfeld,P.D.
  TITLE     Chromosomal microarray mapping suggests a role for BSX and
            Neurogranin in neurocognitive and behavioral defects in the 11q
            terminal deletion disorder (Jacobsen syndrome)
  JOURNAL   Neurogenetics 10 (2), 89-95 (2009)
   PUBMED   18855024
  REMARK    GeneRIF: Data suggest that BSX is essential for global cognitive
            function and that haplo-insufficiency may cause severe mental
            retardation, and that deletion of Neurogranin
REFERENCE   8  (bases 1 to 944)
  AUTHORS   Chu,H.Y. and Ohtoshi,A.
  TITLE     Cloning and functional analysis of hypothalamic homeobox gene Bsx1a
            and its isoform, Bsx1b
  JOURNAL   Mol Cell Biol 27 (10), 3743-3749 (2007)
   PUBMED   17353277
REFERENCE   9  (bases 1 to 944)
  AUTHORS   Cremona,M., Colombo,E., Andreazzoli,M., Cossu,G. and Broccoli,V.
  TITLE     Bsx, an evolutionary conserved Brain Specific homeoboX gene
            expressed in the septum, epiphysis, mammillary bodies and arcuate
            nucleus
  JOURNAL   Gene Expr Patterns 4 (1), 47-51 (2004)
   PUBMED   14678827
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP003040.2.
            
            On May 17, 2019 this sequence version replaced NM_001098169.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343035.3/ ENSP00000344285.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-425               AP003040.2         36624-37048         c
            426-622             AP003040.2         34475-34671         c
            623-944             AP003040.2         32784-33105         c
FEATURES             Location/Qualifiers
     source          1..944
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.1"
     gene            1..944
                     /gene="BSX"
                     /gene_synonym="BSX1"
                     /note="brain specific homeobox"
                     /db_xref="GeneID:390259"
                     /db_xref="HGNC:HGNC:20450"
                     /db_xref="MIM:611074"
     exon            1..425
                     /gene="BSX"
                     /gene_synonym="BSX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..865
                     /gene="BSX"
                     /gene_synonym="BSX1"
                     /codon_start=1
                     /product="brain-specific homeobox protein homolog"
                     /protein_id="NP_001091639.1"
                     /db_xref="CCDS:CCDS41728.1"
                     /db_xref="GeneID:390259"
                     /db_xref="HGNC:HGNC:20450"
                     /db_xref="MIM:611074"
                     /translation="MNLNFTSPLHPASSQRPTSFFIEDILLHKPKPLREVAPDHFASS
                     LASRVPLLDYGYPLMPTPTLLAPHAHHPLHKGDHHHPYFLTTSGMPVPALFPHPQHAE
                     LPGKHCRRRKARTVFSDSQLSGLEKRFEIQRYLSTPERVELATALSLSETQVKTWFQN
                     RRMKHKKQLRKSQDEPKAPDGPESPEGSPRGSEAATAAEARLSLPAGPFVLTEPEDEV
                     DIGDEGELGSGPHVL"
     exon            426..622
                     /gene="BSX"
                     /gene_synonym="BSX1"
                     /inference="alignment:Splign:2.1.0"
     exon            623..944
                     /gene="BSX"
                     /gene_synonym="BSX1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcttcttgc ctctccagcg cccggggtag cccaggcccg ggagagagca gcggagattc
       61 gagcctcgga gggtggttgc cggctttcga gcaggcttgg agactctgcc tgcgtcctcc
      121 acttcgtccc ggcccttgtc ctgtggcagg tgctccgctc aagatgaatc tcaacttcac
      181 ctctcctcta cacccggcgt cttctcagag gcccacatcc ttcttcatcg aggacatcct
      241 gctgcacaag cccaagccgc tgagagaggt ggccccagac catttcgcca gctctctggc
      301 ctctcgggtg cctctgctag actatggcta ccccctcatg cccacaccca ccctcttggc
      361 tcctcacgcc catcaccctc tgcataaggg agaccaccat catccttatt tcctcaccac
      421 ctcggggatg ccagtcccag cgctgttccc gcacccgcag cacgcggagc tgccggggaa
      481 gcactgccgc cgccgcaaag cccgcacggt tttctctgac tcgcagctct cgggcttgga
      541 gaagaggttc gagatccagc gctacctgtc cacgccagaa cgagtggagc tggccacggc
      601 cctcagcctg tccgagacgc aggtgaaaac gtggttccag aaccggcgga tgaagcataa
      661 aaagcaactg cggaaaagcc aagacgaacc caaagcacca gacgggccag aaagccccga
      721 gggcagcccc cgcggttcag aggccgccac cgccgccgag gctcggctga gcctgcccgc
      781 cggtcccttc gtgctgaccg agccagagga cgaggtggac attggagacg agggggagct
      841 gggctcaggg ccgcacgtgc tctgagccgc caggctgggg agggtagtag gcaggggagg
      901 agactgcggg gccgagcgcg gttccctcct ggaccggaag actc
//
