LOCUS       NM_004335               1001 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens bone marrow stromal cell antigen 2 (BST2), mRNA.
ACCESSION   NM_004335
VERSION     NM_004335.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1001)
  AUTHORS   Li,Y., Chen,W., Zhu,X., Mei,H., Steinhoff,M., Buddenkotte,J.,
            Wang,J., Zhang,W., Li,Z., Dai,X., Shan,C., Wang,J. and Meng,J.
  TITLE     Neuronal BST2: A Pruritic Mediator alongside Protease-Activated
            Receptor 2 in the IL-27-Driven Itch Pathway
  JOURNAL   J Invest Dermatol 144 (8), 1829-1842 (2024)
   PUBMED   38360199
  REMARK    GeneRIF: Neuronal BST2: A Pruritic Mediator alongside
            Protease-Activated Receptor 2 in the IL-27-Driven Itch Pathway.
REFERENCE   2  (bases 1 to 1001)
  AUTHORS   Li,Q., Wen,W., Wang,Y., Gong,T., Wang,X., Tan,Q., Fan,B., Xie,H.,
            Li,Y., Li,S., Yang,C., Zhou,Z., Duan,X., Lin,W. and Chen,L.
  TITLE     Autophagy-related protein 5 (ATG5) interacts with bone marrow
            stromal cell antigen 2 (BST2) to stimulate HBV replication through
            antagonizing the antiviral activity of BST2
  JOURNAL   J Med Virol 96 (5), e29659 (2024)
   PUBMED   38747016
  REMARK    GeneRIF: Autophagy-related protein 5 (ATG5) interacts with bone
            marrow stromal cell antigen 2 (BST2) to stimulate HBV replication
            through antagonizing the antiviral activity of BST2.
REFERENCE   3  (bases 1 to 1001)
  AUTHORS   Li,J., Yang,P., Hong,L., Xiao,W., Zhang,L., Yu,Z., Zhang,J.,
            Pei,M., Peng,Y., Wei,X., Wu,X., Tang,W., Zhao,Y., Yang,J., Lin,Z.,
            Jiang,P., Xiang,L., Zhang,H., Lin,J. and Wang,J.
  TITLE     BST2 promotes gastric cancer metastasis under the regulation of
            HOXD9 and PABPC1
  JOURNAL   Mol Carcinog 63 (4), 663-676 (2024)
   PUBMED   38197534
  REMARK    GeneRIF: BST2 promotes gastric cancer metastasis under the
            regulation of HOXD9 and PABPC1.
REFERENCE   4  (bases 1 to 1001)
  AUTHORS   Hagelauer,E., Lotke,R., Kmiec,D., Hu,D., Hohner,M., Stopper,S.,
            Nchioua,R., Kirchhoff,F., Sauter,D. and Schindler,M.
  TITLE     Tetherin Restricts SARS-CoV-2 despite the Presence of Multiple
            Viral Antagonists
  JOURNAL   Viruses 15 (12), 2364 (2023)
   PUBMED   38140605
  REMARK    GeneRIF: Tetherin Restricts SARS-CoV-2 despite the Presence of
            Multiple Viral Antagonists.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1001)
  AUTHORS   Tanwattana,N., Wanasen,N., Jantraphakorn,Y., Srisutthisamphan,K.,
            Chailungkarn,T., Boonrungsiman,S., Lumlertdacha,B.,
            Lekchareonsuk,P. and Kaewborisuth,C.
  TITLE     Human BST2 inhibits rabies virus release independently of
            cysteine-linked dimerization and asparagine-linked glycosylation
  JOURNAL   PLoS One 18 (11), e0292833 (2023)
   PUBMED   37922253
  REMARK    GeneRIF: Human BST2 inhibits rabies virus release independently of
            cysteine-linked dimerization and asparagine-linked glycosylation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1001)
  AUTHORS   Vidal-Laliena,M., Romero,X., March,S., Requena,V., Petriz,J. and
            Engel,P.
  TITLE     Characterization of antibodies submitted to the B cell section of
            the 8th Human Leukocyte Differentiation Antigens Workshop by flow
            cytometry and immunohistochemistry
  JOURNAL   Cell Immunol 236 (1-2), 6-16 (2005)
   PUBMED   16157322
REFERENCE   7  (bases 1 to 1001)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   8  (bases 1 to 1001)
  AUTHORS   Ohtomo,T., Sugamata,Y., Ozaki,Y., Ono,K., Yoshimura,Y., Kawai,S.,
            Koishihara,Y., Ozaki,S., Kosaka,M., Hirano,T. and Tsuchiya,M.
  TITLE     Molecular cloning and characterization of a surface antigen
            preferentially overexpressed on multiple myeloma cells
  JOURNAL   Biochem Biophys Res Commun 258 (3), 583-591 (1999)
   PUBMED   10329429
REFERENCE   9  (bases 1 to 1001)
  AUTHORS   Furuya,Y., Takasawa,S., Yonekura,H., Tanaka,T., Takahara,J. and
            Okamoto,H.
  TITLE     Cloning of a cDNA encoding rat bone marrow stromal cell antigen 1
            (BST-1) from the islets of Langerhans
  JOURNAL   Gene 165 (2), 329-330 (1995)
   PUBMED   8522202
REFERENCE   10 (bases 1 to 1001)
  AUTHORS   Ishikawa,J., Kaisho,T., Tomizawa,H., Lee,B.O., Kobune,Y.,
            Inazawa,J., Oritani,K., Itoh,M., Ochi,T., Ishihara,K. et al.
  TITLE     Molecular cloning and chromosomal mapping of a bone marrow stromal
            cell surface gene, BST2, that may be involved in pre-B-cell growth
  JOURNAL   Genomics 26 (3), 527-534 (1995)
   PUBMED   7607676
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010319.10.
            
            On Nov 23, 2018 this sequence version replaced NM_004335.3.
            
            Summary: Bone marrow stromal cells are involved in the growth and
            development of B-cells. The specific function of the protein
            encoded by the bone marrow stromal cell antigen 2 is undetermined;
            however, this protein may play a role in pre-B-cell growth and in
            rheumatoid arthritis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.37787.1,
                                           SRR1163655.21422.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000252593.7/ ENSP00000252593.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-340               AC010319.10        85958-86297
            341-407             AC010319.10        87151-87217
            408-468             AC010319.10        87399-87459
            469-613             AC010319.10        87764-87908
            614-1001            AC010319.10        88262-88649
FEATURES             Location/Qualifiers
     source          1..1001
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..1001
                     /gene="BST2"
                     /gene_synonym="CD317; HM1.24; TETHERIN"
                     /note="bone marrow stromal cell antigen 2"
                     /db_xref="GeneID:684"
                     /db_xref="HGNC:HGNC:1119"
                     /db_xref="MIM:600534"
     exon            1..340
                     /gene="BST2"
                     /gene_synonym="CD317; HM1.24; TETHERIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..598
                     /gene="BST2"
                     /gene_synonym="CD317; HM1.24; TETHERIN"
                     /note="bone marrow stromal antigen 2; NPC-A-7; BST-2;
                     HM1.24 antigen; antiviral factor tetherin"
                     /codon_start=1
                     /product="bone marrow stromal antigen 2 precursor"
                     /protein_id="NP_004326.1"
                     /db_xref="CCDS:CCDS12358.1"
                     /db_xref="GeneID:684"
                     /db_xref="HGNC:HGNC:1119"
                     /db_xref="MIM:600534"
                     /translation="MASTSYDYCRVPMEDGDKRCKLLLGIGILVLLIIVILGVPLIIF
                     TIKANSEACRDGLRAVMECRNVTHLLQQELTEAQKGFQDVEAQAATCNHTVMALMASL
                     DAEKAQGQKKVEELEGEITTLNHKLQDASAEVERLRRENQVLSVRIADKKYYPSSQDS
                     SSAAAPQLLIVLLGLSALLQ"
     exon            341..407
                     /gene="BST2"
                     /gene_synonym="CD317; HM1.24; TETHERIN"
                     /inference="alignment:Splign:2.1.0"
     exon            408..468
                     /gene="BST2"
                     /gene_synonym="CD317; HM1.24; TETHERIN"
                     /inference="alignment:Splign:2.1.0"
     exon            469..613
                     /gene="BST2"
                     /gene_synonym="CD317; HM1.24; TETHERIN"
                     /inference="alignment:Splign:2.1.0"
     exon            614..1001
                     /gene="BST2"
                     /gene_synonym="CD317; HM1.24; TETHERIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      968..973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BST2"
                     /gene_synonym="CD317; HM1.24; TETHERIN"
                     /note="hexamer: AATAAA"
     polyA_site      1001
                     /gene="BST2"
                     /gene_synonym="CD317; HM1.24; TETHERIN"
                     /note="major polyA site"
ORIGIN      
        1 gaagattcca gcaccctccc ctaactccag gccagactct aaaggggaga tctggatggc
       61 atctacttcg tatgactatt gcagagtgcc catggaagac ggggataagc gctgtaagct
      121 tctgctgggg ataggaattc tggtgctcct gatcatcgtg attctggggg tgcccttgat
      181 tatcttcacc atcaaggcca acagcgaggc ctgccgggac ggccttcggg cagtgatgga
      241 gtgtcgcaat gtcacccatc tcctgcaaca agagctgacc gaggcccaga agggctttca
      301 ggatgtggag gcccaggccg ccacctgcaa ccacactgtg atggccctaa tggcttccct
      361 ggatgcagag aaggcccaag gacaaaagaa agtggaggag cttgagggag agatcactac
      421 attaaaccat aagcttcagg acgcgtctgc agaggtggag cgactgagaa gagaaaacca
      481 ggtcttaagc gtgagaatcg cggacaagaa gtactacccc agctcccagg actccagctc
      541 cgctgcggcg ccccagctgc tgattgtgct gctgggcctc agcgctctgc tgcagtgaga
      601 tcccaggaag ctggcacatc ttggaaggtc cgtcctgctc ggcttttcgc ttgaacattc
      661 ccttgatctc atcagttctg agcgggtcat ggggcaacac ggttagcggg gagagcacgg
      721 ggtagccgga gaagggcctc tggagcaggt ctggaggggc catggggaag tcctgggtgt
      781 ggggacacag tcgggttgac ccagggctgt ctccctccag agcctccctc cggacaatga
      841 gtcccccctc ttgtctccca ccctgagatt gggcatgggg tgcggtgtgg ggggcatgtg
      901 ctgcctgttg ttatgggttt tttttgcggg gggggttgct tttttctggg gtctttgagc
      961 tccaaaaaat aaacacttcc tttgagggag agcacacctg a
//
