LOCUS       NM_004334               1979 bp    mRNA    linear   PRI 03-SEP-2023
DEFINITION  Homo sapiens bone marrow stromal cell antigen 1 (BST1), mRNA.
ACCESSION   NM_004334
VERSION     NM_004334.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1979)
  AUTHORS   Yokoyama S.
  TITLE     Genetic polymorphisms of bone marrow stromal cell antigen-1
            (BST-1/CD157): implications for immune/inflammatory dysfunction in
            neuropsychiatric disorders
  JOURNAL   Front Immunol 14, 1197265 (2023)
   PUBMED   37313401
  REMARK    GeneRIF: Genetic polymorphisms of bone marrow stromal cell
            antigen-1 (BST-1/CD157): implications for immune/inflammatory
            dysfunction in neuropsychiatric disorders.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1979)
  AUTHORS   Huang Y, Wang P, Luo Q and Ma J.
  TITLE     Association of BST1 polymorphism with idiopathic restless legs
            syndrome in Chinese population
  JOURNAL   Sleep Breath 25 (4), 1987-1993 (2021)
   PUBMED   33625657
  REMARK    GeneRIF: Association of BST1 polymorphism with idiopathic restless
            legs syndrome in Chinese population.
REFERENCE   3  (bases 1 to 1979)
  AUTHORS   Yaku K, Palikhe S, Izumi H, Yoshida T, Hikosaka K, Hayat F, Karim
            M, Iqbal T, Nitta Y, Sato A, Migaud ME, Ishihara K, Mori H and
            Nakagawa T.
  TITLE     BST1 regulates nicotinamide riboside metabolism via its
            glycohydrolase and base-exchange activities
  JOURNAL   Nat Commun 12 (1), 6767 (2021)
   PUBMED   34799586
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1979)
  AUTHORS   Yakymiv Y, Augeri S, Bracci C, Marchisio S, Aydin S, D'Ardia S,
            Massaia M, Ferrero E, Ortolan E and Funaro A.
  TITLE     CD157 signaling promotes survival of acute myeloid leukemia cells
            and modulates sensitivity to cytarabine through regulation of
            anti-apoptotic Mcl-1
  JOURNAL   Sci Rep 11 (1), 21230 (2021)
   PUBMED   34707185
  REMARK    GeneRIF: CD157 signaling promotes survival of acute myeloid
            leukemia cells and modulates sensitivity to cytarabine through
            regulation of anti-apoptotic Mcl-1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1979)
  AUTHORS   Mufti K, Yu E, Rudakou U, Krohn L, Ruskey JA, Asayesh F, Laurent
            SB, Spiegelman D, Arnulf I, Hu MTM, Montplaisir JY, Gagnon JF,
            Desautels A, Dauvilliers Y, Gigli GL, Valente M, Janes F,
            Bernardini A, Hogl B, Stefani A, Holzknecht E, Sonka K, Kemlink D,
            Oertel W, Janzen A, Plazzi G, Antelmi E, Figorilli M, Puligheddu M,
            Mollenhauer B, Trenkwalder C, Sixel-Doring F, Cochen De Cock V,
            Monaca CC, Heidbreder A, Ferini-Strambi L, Dijkstra F, Viaene M,
            Abril B, Boeve BF, Trempe JF, Rouleau GA, Postuma RB and Gan-Or Z.
  TITLE     Novel Associations of BST1 and LAMP3 With REM Sleep Behavior
            Disorder
  JOURNAL   Neurology 96 (10), e1402-e1412 (2021)
   PUBMED   33397775
  REMARK    GeneRIF: Novel Associations of BST1 and LAMP3 With REM Sleep
            Behavior Disorder.
REFERENCE   6  (bases 1 to 1979)
  AUTHORS   Okuyama Y, Ishihara K, Kimura N, Hirata Y, Sato K, Itoh M, Ok LB
            and Hirano T.
  TITLE     Human BST-1 expressed on myeloid cells functions as a receptor
            molecule
  JOURNAL   Biochem Biophys Res Commun 228 (3), 838-845 (1996)
   PUBMED   8941363
REFERENCE   7  (bases 1 to 1979)
  AUTHORS   Lee BO, Ishihara K, Denno K, Kobune Y, Itoh M, Muraoka O, Kaisho T,
            Sasaki T, Ochi T and Hirano T.
  TITLE     Elevated levels of the soluble form of bone marrow stromal cell
            antigen 1 in the sera of patients with severe rheumatoid arthritis
  JOURNAL   Arthritis Rheum 39 (4), 629-637 (1996)
   PUBMED   8630113
REFERENCE   8  (bases 1 to 1979)
  AUTHORS   Kajimoto Y, Miyagawa J, Ishihara K, Okuyama Y, Fujitani Y, Itoh M,
            Yoshida H, Kaisho T, Matsuoka T, Watada H, Hanafusa T, Yamasaki Y,
            Kamada T, Matsuzawa Y and Hirano T.
  TITLE     Pancreatic islet cells express BST-1, a CD38-like surface molecule
            having ADP-ribosyl cyclase activity
  JOURNAL   Biochem Biophys Res Commun 219 (3), 941-946 (1996)
   PUBMED   8645283
REFERENCE   9  (bases 1 to 1979)
  AUTHORS   Hirata Y, Kimura N, Sato K, Ohsugi Y, Takasawa S, Okamoto H,
            Ishikawa J, Kaisho T, Ishihara K and Hirano T.
  TITLE     ADP ribosyl cyclase activity of a novel bone marrow stromal cell
            surface molecule, BST-1
  JOURNAL   FEBS Lett 356 (2-3), 244-248 (1994)
   PUBMED   7805847
REFERENCE   10 (bases 1 to 1979)
  AUTHORS   Kaisho T, Ishikawa J, Oritani K, Inazawa J, Tomizawa H, Muraoka O,
            Ochi T and Hirano T.
  TITLE     BST-1, a surface molecule of bone marrow stromal cell lines that
            facilitates pre-B-cell growth
  JOURNAL   Proc Natl Acad Sci U S A 91 (12), 5325-5329 (1994)
   PUBMED   8202488
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA382561.1, D21878.1, BU732655.1 and AC114744.7.
            
            On Nov 23, 2018 this sequence version replaced NM_004334.2.
            
            Summary: Bone marrow stromal cell antigen-1 is a stromal cell
            line-derived glycosylphosphatidylinositol-anchored molecule that
            facilitates pre-B-cell growth. The deduced amino acid sequence
            exhibits 33% similarity with CD38. BST1 expression is enhanced in
            bone marrow stromal cell lines derived from patients with
            rheumatoid arthritis. The polyclonal B-cell abnormalities in
            rheumatoid arthritis may be, at least in part, attributed to BST1
            overexpression in the stromal cell population. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.203463.1, D21878.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265016.9/ ENSP00000265016.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-509               DA382561.1         117-625
            510-1022            D21878.1           557-1069
            1023-1365           BU732655.1         18-360              c
            1366-1979           AC114744.7         110958-111571
FEATURES             Location/Qualifiers
     source          1..1979
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p15.32"
     gene            1..1979
                     /gene="BST1"
                     /gene_synonym="cADPR2; CD157"
                     /note="bone marrow stromal cell antigen 1"
                     /db_xref="GeneID:683"
                     /db_xref="HGNC:HGNC:1118"
                     /db_xref="MIM:600387"
     exon            1..268
                     /gene="BST1"
                     /gene_synonym="cADPR2; CD157"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1037
                     /gene="BST1"
                     /gene_synonym="cADPR2; CD157"
                     /EC_number="3.2.2.6"
                     /note="NAD(+) nucleosidase; ADP-ribosyl cyclase 2; cADPr
                     hydrolase 2; bone marrow stromal antigen 1; cyclic
                     ADP-ribose hydrolase 2; ADP-ribosyl cyclase/cyclic
                     ADP-ribose hydrolase 2"
                     /codon_start=1
                     /product="ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
                     2 precursor"
                     /protein_id="NP_004325.2"
                     /db_xref="CCDS:CCDS3416.1"
                     /db_xref="GeneID:683"
                     /db_xref="HGNC:HGNC:1118"
                     /db_xref="MIM:600387"
                     /translation="MAAQGCAASRLLQLLLQLLLLLLLLAAGGARARWRGEGTSAHLR
                     DIFLGRCAEYRALLSPEQRNKNCTAIWEAFKVALDKDPCSVLPSDYDLFINLSRHSIP
                     RDKSLFWENSHLLVNSFADNTRRFMPLSDVLYGRVADFLSWCRQKNDSGLDYQSCPTS
                     EDCENNPVDSFWKRASIQYSKDSSGVIHVMLNGSEPTGAYPIKGFFADYEIPNLQKEK
                     ITRIEIWVMHEIGGPNVESCGEGSMKVLEKRLKDMGFQYSCINDYRPVKLLQCVDHST
                     HPDCALKSAAAATQRKAPSLYTEQRAGLIIPLFLVLASRTQL"
     exon            269..395
                     /gene="BST1"
                     /gene_synonym="cADPR2; CD157"
                     /inference="alignment:Splign:2.1.0"
     exon            396..531
                     /gene="BST1"
                     /gene_synonym="cADPR2; CD157"
                     /inference="alignment:Splign:2.1.0"
     exon            532..614
                     /gene="BST1"
                     /gene_synonym="cADPR2; CD157"
                     /inference="alignment:Splign:2.1.0"
     exon            615..691
                     /gene="BST1"
                     /gene_synonym="cADPR2; CD157"
                     /inference="alignment:Splign:2.1.0"
     exon            692..784
                     /gene="BST1"
                     /gene_synonym="cADPR2; CD157"
                     /inference="alignment:Splign:2.1.0"
     exon            785..871
                     /gene="BST1"
                     /gene_synonym="cADPR2; CD157"
                     /inference="alignment:Splign:2.1.0"
     exon            872..931
                     /gene="BST1"
                     /gene_synonym="cADPR2; CD157"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1979
                     /gene="BST1"
                     /gene_synonym="cADPR2; CD157"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1344..1349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BST1"
                     /gene_synonym="cADPR2; CD157"
                     /note="hexamer: AATAAA"
     polyA_site      1365
                     /gene="BST1"
                     /gene_synonym="cADPR2; CD157"
                     /note="major polyA site"
     regulatory      1952..1957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BST1"
                     /gene_synonym="cADPR2; CD157"
                     /note="hexamer: AATAAA"
     polyA_site      1979
                     /gene="BST1"
                     /gene_synonym="cADPR2; CD157"
ORIGIN      
        1 atcagtttgc ggaaccgcct tggtagaagg agagaagggg agtggaggaa gcacgggact
       61 ggagggacca aagttccccg atggcggccc aggggtgcgc ggcatcgcgg ctgctccagc
      121 tgctgctgca gcttctgctt ctactgttgc tgctggcggc gggcggggcg cgcgcgcggt
      181 ggcgcgggga gggcaccagc gcacacttgc gggacatctt cctgggccgc tgcgccgagt
      241 accgcgcact gctgagtccc gagcagcgga acaagaactg cacagccatc tgggaagcct
      301 ttaaagtggc gctggacaag gatccctgct ccgtgctgcc ctcagactat gaccttttta
      361 ttaacttgtc caggcactct attcccagag ataagtccct gttctgggaa aatagccacc
      421 tccttgttaa cagctttgca gacaacaccc gtcgttttat gcccctgagc gatgttctgt
      481 atggcagggt tgcagatttc ttgagctggt gtcgacagaa aaatgactct ggactcgatt
      541 accaatcctg ccctacatca gaagactgtg aaaataatcc tgtggattcc ttttggaaaa
      601 gggcatccat ccagtattcc aaggatagtt ctggggtgat ccacgtcatg ctgaatggtt
      661 cagagccaac aggagcctat cccatcaaag gtttttttgc agattatgaa attccaaacc
      721 tccagaagga aaaaattaca cgaatcgaga tctgggttat gcatgaaatt gggggaccca
      781 atgtggaatc ctgcggggaa ggcagcatga aagtcctgga aaagaggctg aaggacatgg
      841 ggttccagta cagctgtatt aatgattacc gaccagtgaa gctcttacag tgcgtggacc
      901 acagcaccca tcctgactgt gccttaaagt cggcagcagc cgctactcaa agaaaagccc
      961 caagtcttta tacagaacaa agggcgggtc ttatcattcc cctctttctg gtgctggctt
     1021 ccaggactca actgtaactg gaaactgtgt tgctctaacc ctcctccagc cctgcagcct
     1081 ccccttgcag tcatcattcg tgttctgtgt ataccaaatg attctgttat ctaaagaagc
     1141 tttttgctgg gaaaacgatg tcctgaaaat ggtatttcaa tgaggcatat gttcaggatt
     1201 tcagaaacaa gaagttagtt ctatttagca ggttaaaaaa tgctgcatta gaattaaagc
     1261 aagttatttt cttatttgta taatgacaca aagcattggg agtcagactg cttgtatatt
     1321 atcaaacatt ttaagagaat tctaataaag ctgtatttta catcatctat attttcctat
     1381 atctccagca gcacggacac tgcatgcttg ttgattgctt aagacatatg tatactatat
     1441 aaatgtatgc atatatggtc tgcaaagttt tcatttttca tttatttggt ataaagatgt
     1501 tcagttaatg gttccttttt gttttgagag acagagtttc gctcctttgc ccaggctgga
     1561 gtgaggtggg gagatctcag ctcactgcaa cctctgcttc caggattcaa gcgattctcc
     1621 tgcctcagcc tcccaagtag ctgggattgc aggtgcctgc caccatgtcc agctaatttt
     1681 tgtattttta gtagagatgg ggtttcacca tgttggccag gctagtctcg aattcctgac
     1741 ctcaggtgat ccacccacct cagcctccca aagtgctagg attacaggcg tgagccacca
     1801 catccagcca taatagttac ttataatgag ggaaaaaccc aaaatatcca gtaatattta
     1861 catatttact gaaactgttt ggaacttgta ttagtttgtt cttgcattgc tataaagaac
     1921 tgcccgagac tgggtaattt acaaaaataa aaataaaaaa gaggtttaat tgactcaca
//
