LOCUS       NM_001128326             654 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens binder of sperm protein homolog 1 (BSPH1), mRNA.
ACCESSION   NM_001128326 XM_001723676 XM_001723736 XM_001725617
VERSION     NM_001128326.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 654)
  AUTHORS   Plante,G., Therien,I., Lachance,C., Leclerc,P., Fan,J. and
            Manjunath,P.
  TITLE     Implication of the human Binder of SPerm Homolog 1 (BSPH1) protein
            in capacitation
  JOURNAL   Mol Hum Reprod 20 (5), 409-421 (2014)
   PUBMED   24435510
  REMARK    GeneRIF: Results show that the human epididymal BSPH1 shares many
            biochemical and functional characteristics with BSP proteins
            secreted by seminal vesicles of ungulates, and behaves similarly to
            its murine epididymal orthologue BSPH1.
REFERENCE   2  (bases 1 to 654)
  AUTHORS   Manjunath,P., Lefebvre,J., Jois,P.S., Fan,J. and Wright,M.W.
  TITLE     New nomenclature for mammalian BSP genes
  JOURNAL   Biol Reprod 80 (3), 394-397 (2009)
   PUBMED   18923155
  REMARK    Review article
REFERENCE   3  (bases 1 to 654)
  AUTHORS   Lefebvre,J., Boileau,G. and Manjunath,P.
  TITLE     Recombinant expression and affinity purification of a novel
            epididymal human sperm-binding protein, BSPH1
  JOURNAL   Mol Hum Reprod 15 (2), 105-114 (2009)
   PUBMED   19091820
  REMARK    GeneRIF: BSPH1 accumulates in inclusion bodies when expressed with
            an N-terminal hexahistidine tag in BL21 (DE3) Escherichia coli
            cells, and recombinant protein bound phosphatidylcholine liposomes,
            low-density lipoproteins and human sperm.
REFERENCE   4  (bases 1 to 654)
  AUTHORS   Lefebvre,J., Fan,J., Chevalier,S., Sullivan,R., Carmona,E. and
            Manjunath,P.
  TITLE     Genomic structure and tissue-specific expression of human and mouse
            genes encoding homologues of the major bovine seminal plasma
            proteins
  JOURNAL   Mol Hum Reprod 13 (1), 45-53 (2007)
   PUBMED   17085770
REFERENCE   5  (bases 1 to 654)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ227497.1 and AC010330.7.
            
            On Jul 11, 2008 this sequence version replaced NM_001128326.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ227497.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1968968,
                                           SAMEA2147596 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344839.3/ ENSP00000341762.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DQ227497.1         1-9
            10-534              DQ227497.1         11-535
            535-535             AC010330.7         71495-71495
            536-654             DQ227497.1         537-655
FEATURES             Location/Qualifiers
     source          1..654
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..654
                     /gene="BSPH1"
                     /gene_synonym="BSP1; ELSPBP2"
                     /note="binder of sperm protein homolog 1"
                     /db_xref="GeneID:100131137"
                     /db_xref="HGNC:HGNC:33906"
                     /db_xref="MIM:612213"
     exon            1..162
                     /gene="BSPH1"
                     /gene_synonym="BSP1; ELSPBP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..488
                     /gene="BSPH1"
                     /gene_synonym="BSP1; ELSPBP2"
                     /note="epididymal sperm binding protein 2; bovine seminal
                     plasma protein homolog 1; binder of sperm 1; bovine
                     seminal plasma protein-like 1"
                     /codon_start=1
                     /product="binder of sperm protein homolog 1 precursor"
                     /protein_id="NP_001121798.1"
                     /db_xref="CCDS:CCDS46135.1"
                     /db_xref="GeneID:100131137"
                     /db_xref="HGNC:HGNC:33906"
                     /db_xref="MIM:612213"
                     /translation="MGSLMLLFVETTRNSSACIFPVILNELSSTVETITHFPEVTDGE
                     CVFPFHYKNGTYYDCIKSKARHKWCSLNKTYEGYWKFCSAEDFANCVFPFWYRRLIYW
                     ECTDDGEAFGKKWCSLTKNFNKDRIWKYCE"
     exon            163..183
                     /gene="BSPH1"
                     /gene_synonym="BSP1; ELSPBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            184..213
                     /gene="BSPH1"
                     /gene_synonym="BSP1; ELSPBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            214..345
                     /gene="BSPH1"
                     /gene_synonym="BSP1; ELSPBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            346..490
                     /gene="BSPH1"
                     /gene_synonym="BSP1; ELSPBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            491..654
                     /gene="BSPH1"
                     /gene_synonym="BSP1; ELSPBP2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagcctccct gggcctctcc aggggattct tgagccctgg ctgacaaaga ccaggaagat
       61 ctgagatacc gggaagcctg tgactgccca tgggctccct gatgcttctc ttcgtggaaa
      121 cgacgcgaaa ttcctcagct tgcatcttcc ctgttatttt aaatgaatta tcatcaactg
      181 tggaaactat aactcatttt ccagaagtta cagatgggga gtgtgtcttt ccattccact
      241 ataaaaatgg aacatattat gactgcatca agtccaaggc aagacacaag tggtgctcgt
      301 taaacaagac ctacgaagga tactggaagt tttgcagtgc agaagatttt gcaaactgtg
      361 tatttccctt ctggtacaga cgcttgatct actgggagtg tactgatgat ggggaagcat
      421 ttgggaaaaa atggtgttca ctgaccaaga attttaacaa ggaccgaatt tggaaatact
      481 gtgaatgatg gtttgcttgc atctgctggc tatcagatac agacaaaaca tgatcgatgc
      541 atccagcagt aataatcttc ttcctgaaag ccatggattc ttcagcaggt cagaatggtc
      601 tgatatacag taacccccaa ttttcttaat aaaataaaac tctttttctc cagc
//
