LOCUS       NM_003458              15971 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens bassoon presynaptic cytomatrix protein (BSN), mRNA.
ACCESSION   NM_003458
VERSION     NM_003458.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 15971)
  AUTHORS   Zhao,Y., Chukanova,M., Kentistou,K.A., Fairhurst-Hunter,Z.,
            Siegert,A.M., Jia,R.Y., Dowsett,G.K.C., Gardner,E.J., Lawler,K.,
            Day,F.R., Kaisinger,L.R., Tung,Y.L., Lam,B.Y.H., Chen,H.C.,
            Wang,Q., Berumen-Campos,J., Kuri-Morales,P., Tapia-Conyer,R.,
            Alegre-Diaz,J., Barroso,I., Emberson,J., Torres,J.M., Collins,R.,
            Saleheen,D., Smith,K.R., Paul,D.S., Merkle,F., Farooqi,I.S.,
            Wareham,N.J., Petrovski,S., O'Rahilly,S., Ong,K.K., Yeo,G.S.H. and
            Perry,J.R.B.
  TITLE     Protein-truncating variants in BSN are associated with severe
            adult-onset obesity, type 2 diabetes and fatty liver disease
  JOURNAL   Nat Genet 56 (4), 579-584 (2024)
   PUBMED   38575728
  REMARK    GeneRIF: Protein-truncating variants in BSN are associated with
            severe adult-onset obesity, type 2 diabetes and fatty liver
            disease.
REFERENCE   2  (bases 1 to 15971)
  AUTHORS   Ye,T., Zhang,J., Wang,J., Lan,S., Zeng,T., Wang,H., He,X., Li,B.M.,
            Deng,W., Liao,W.P. and Liu,X.R.
  TITLE     Variants in BSN gene associated with epilepsy with favourable
            outcome
  JOURNAL   J Med Genet 60 (8), 776-783 (2023)
   PUBMED   36600631
  REMARK    GeneRIF: Variants in BSN gene associated with epilepsy with
            favourable outcome.
REFERENCE   3  (bases 1 to 15971)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   4  (bases 1 to 15971)
  AUTHORS   Martins-de-Souza,D., Gattaz,W.F., Schmitt,A., Rewerts,C.,
            Maccarrone,G., Dias-Neto,E. and Turck,C.W.
  TITLE     Prefrontal cortex shotgun proteome analysis reveals altered calcium
            homeostasis and immune system imbalance in schizophrenia
  JOURNAL   Eur Arch Psychiatry Clin Neurosci 259 (3), 151-163 (2009)
   PUBMED   19165527
  REMARK    GeneRIF: Using shotgun mass spectrometry, we found this protein
            differentially expressed in the dorsolateral prefrontal cortex from
            patients with schizophrenia.
REFERENCE   5  (bases 1 to 15971)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   6  (bases 1 to 15971)
  AUTHORS   Sudhof,T.C.
  TITLE     The synaptic vesicle cycle
  JOURNAL   Annu Rev Neurosci 27, 509-547 (2004)
   PUBMED   15217342
  REMARK    Review article
REFERENCE   7  (bases 1 to 15971)
  AUTHORS   Altrock,W.D., tom Dieck,S., Sokolov,M., Meyer,A.C., Sigler,A.,
            Brakebusch,C., Fassler,R., Richter,K., Boeckers,T.M., Potschka,H.,
            Brandt,C., Loscher,W., Grimberg,D., Dresbach,T., Hempelmann,A.,
            Hassan,H., Balschun,D., Frey,J.U., Brandstatter,J.H., Garner,C.C.,
            Rosenmund,C. and Gundelfinger,E.D.
  TITLE     Functional inactivation of a fraction of excitatory synapses in
            mice deficient for the active zone protein bassoon
  JOURNAL   Neuron 37 (5), 787-800 (2003)
   PUBMED   12628169
  REMARK    GeneRIF: Loss of Bassoon in Bsn mutant mice causes a reduction in
            normal synaptic transmission, which can be attributed to the
            inactivation of a significant fraction of glutamatergic synapses.
REFERENCE   8  (bases 1 to 15971)
  AUTHORS   Winter,C., tom Dieck,S., Boeckers,T.M., Bockmann,J., Kampf,U.,
            Sanmarti-Vila,L., Langnaese,K., Altrock,W., Stumm,M., Soyke,A.,
            Wieacker,P., Garner,C.C. and Gundelfinger,E.D.
  TITLE     The presynaptic cytomatrix protein Bassoon: sequence and
            chromosomal localization of the human BSN gene
  JOURNAL   Genomics 57 (3), 389-397 (1999)
   PUBMED   10329005
REFERENCE   9  (bases 1 to 15971)
  AUTHORS   Hashida,H., Goto,J., Zhao,N., Takahashi,N., Hirai,M., Kanazawa,I.
            and Sakaki,Y.
  TITLE     Cloning and mapping of ZNF231, a novel brain-specific gene encoding
            neuronal double zinc finger protein whose expression is enhanced in
            a neurodegenerative disorder, multiple system atrophy (MSA)
  JOURNAL   Genomics 54 (1), 50-58 (1998)
   PUBMED   9806829
REFERENCE   10 (bases 1 to 15971)
  AUTHORS   tom Dieck,S., Sanmarti-Vila,L., Langnaese,K., Richter,K.,
            Kindler,S., Soyke,A., Wex,H., Smalla,K.H., Kampf,U., Franzer,J.T.,
            Stumm,M., Garner,C.C. and Gundelfinger,E.D.
  TITLE     Bassoon, a novel zinc-finger CAG/glutamine-repeat protein
            selectively localized at the active zone of presynaptic nerve
            terminals
  JOURNAL   J Cell Biol 142 (2), 499-509 (1998)
   PUBMED   9679147
  REMARK    GeneRIF: This paper describes the structure of the mouse and rat
            Bsn genes, and characterizes the subcellular distribution of the
            Bassoon protein.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104452.2, AF052224.1,
            AC099668.2, AB007894.1 and AW131629.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003458.3.
            
            Summary: Neurotransmitters are released from a specific site in the
            axon terminal called the active zone, which is composed of synaptic
            vesicles and a meshwork of cytoskeleton underlying the plasma
            membrane. The protein encoded by this gene is thought to be a
            scaffolding protein involved in organizing the presynaptic
            cytoskeleton. The gene is expressed primarily in neurons in the
            brain. A similar gene product in rodents is concentrated in the
            active zone of axon terminals and tightly associated with
            cytoskeletal structures, and is essential for regulating
            neurotransmitter release from a subset of synapses. [provided by
            RefSeq, Jul 2008].
            
            CCDS Note: This CCDS ID represents the protein described in PMIDs:
            10329005 and 9679147. This transcript is supported by AF052224.1.
            It should be noted this transcript is predicted to undergo
            nonsense-mediated mRNA decay (NMD). However, the protein is
            represented because it was detected endogenously in PMIDs: 9679147
            and 19165527. It is likely that the majority of transcripts
            representing this variant will undergo NMD, while some low level of
            NMD escape may allow for the expression of this protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF052224.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296452.5/ ENSP00000296452.4
            NMD candidate          :: PMID: 10329005
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC104452.2         12970-12981         c
            13-3335             AF052224.1         2-3324
            3336-3336           AC099668.2         83507-83507         c
            3337-11634          AF052224.1         3326-11623
            11635-11734         AC099668.2         72387-72486         c
            11735-12840         AB007894.1         4545-5650
            12841-15580         AC099668.2         65115-67854         c
            15581-15971         AW131629.1         6-396               c
FEATURES             Location/Qualifiers
     source          1..15971
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..15971
                     /gene="BSN"
                     /gene_synonym="ZNF231"
                     /note="bassoon presynaptic cytomatrix protein"
                     /db_xref="GeneID:8927"
                     /db_xref="HGNC:HGNC:1117"
                     /db_xref="MIM:604020"
     exon            1..350
                     /gene="BSN"
                     /gene_synonym="ZNF231"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..11907
                     /gene="BSN"
                     /gene_synonym="ZNF231"
                     /note="zinc finger protein 231; neuronal double zinc
                     finger protein"
                     /codon_start=1
                     /product="protein bassoon"
                     /protein_id="NP_003449.2"
                     /db_xref="CCDS:CCDS2800.1"
                     /db_xref="GeneID:8927"
                     /db_xref="HGNC:HGNC:1117"
                     /db_xref="MIM:604020"
                     /translation="MGNEVSLEGGAGDGPLPPGGAGPGPGPGPGPGAGKPPSAPAGGG
                     QLPAAGAARSTAVPPVPGPGPGPGPGPGPGSTSRRLDPKEPLGNQRAASPTPKQASAT
                     TPGHESPRETRAQGPAGQEADGPRRTLQVDSRTQRSGRSPSVSPDRGSTPTSPYSVPQ
                     IAPLPSSTLCPICKTSDLTSTPSQPNFNTCTQCHNKVCNQCGFNPNPHLTQVKEWLCL
                     NCQMQRALGMDMTTAPRSKSQQQLHSPALSPAHSPAKQPLGKPDQERSRGPGGPQPGS
                     RQAETARATSVPGPAQAAAPPEVGRVSPQPPQPTKPSTAEPRPPAGEAPAKSATAVPA
                     GLGATEQTQEGLTGKLFGLGASLLTQASTLMSVQPEADTQGQPAPSKGTPKIVFNDAS
                     KEAGPKPLGSGPGPGPAPGAKTEPGARMGPGSGPGALPKTGGTTSPKHGRAEHQAASK
                     AAAKPKTMPKERAICPLCQAELNVGSKSPANYNTCTTCRLQVCNLCGFNPTPHLVEKT
                     EWLCLNCQTKRLLEGSLGEPTPLPPPTSQQPPVGAPHRASGTSPLKQKGPQGLGQPSG
                     PLPAKASPLSTKASPLPSKASPQAKPLRASEPSKTPSSVQEKKTRVPTKAEPMPKPPP
                     ETTPTPATPKVKSGVRRAEPATPVVKAVPEAPKGGEAEDLVGKPYSQDASRSPQSLSD
                     TGYSSDGISSSQSEITGVVQQEVEQLDSAGVTGPHPPSPSEIHKVGSSMRPLLQAQGL
                     APSERSKPLSSGTGEEQKQRPHSLSITPEAFDSDEELEDILEEDEDSAEWRRRREQQD
                     TAESSDDFGSQLRHDYVEDSSEGGLSPLPPQPPARAAELTDEDFMRRQILEMSAEEDN
                     LEEDDTATSGRGLAKHGTQKGGPRPRPEPSQEPAALPKRRLPHNATTGYEELLPEGGS
                     AEATDGSGTLQGGLRRFKTIELNSTGSYGHELDLGQGPDPSLDREPELEMESLTGSPE
                     DRSRGEHSSTLPASTPSYTSGTSPTSLSSLEEDSDSSPSRRQRLEEAKQQRKARHRSH
                     GPLLPTIEDSSEEEELREEEELLREQEKMREVEQQRIRSTARKTRRDKEELRAQRRRE
                     RSKTPPSNLSPIEDASPTEELRQAAEMEELHRSSCSEYSPSPSLDSEAEALDGGPSRL
                     YKSGSEYNLPTFMSLYSPTETPSGSSTTPSSGRPLKSAEEAYEEMMRKAELLQRQQGQ
                     AAGARGPHGGPSQPTGPRGLGSFEYQDTTDREYGQAAQPAAEGTPASLGAAVYEEILQ
                     TSQSIVRMRQASSRDLAFAEDKKKEKQFLNAESAYMDPMKQNGGPLTPGTSPTQLAAP
                     VSFSTPTSSDSSGGRVIPDVRVTQHFAKETQDPLKLHSSPASPSSASKEIGMPFSQGP
                     GTPATTAVAPCPAGLPRGYMTPASPAGSERSPSPSSTAHSYGHSPTTANYGSQTEDLP
                     QAPSGLAAAGRAAREKPLSASDGEGGTPQPSRAYSYFASSSPPLSPSSPSESPTFSPG
                     KMGPRATAEFSTQTPSPAPASDMPRSPGAPTPSPMVAQGTQTPHRPSTPRLVWQESSQ
                     EAPFMVITLASDASSQTRMVHASASTSPLCSPTETQPTTHGYSQTTPPSVSQLPPEPP
                     GPPGFPRVPSAGADGPLALYGWGALPAENISLCRISSVPGTSRVEPGPRTPGTAVVDL
                     RTAVKPTPIILTDQGMDLTSLAVEARKYGLALDPIPGRQSTAVQPLVINLNAQEHTFL
                     ATATTVSITMASSVFMAQQKQPVVYGDPYQSRLDFGQGGGSPVCLAQVKQVEQAVQTA
                     PYRSGPRGRPREAKFARYNLPNQVAPLARRDVLITQMGTAQSIGLKPGPVPEPGAEPH
                     RATPAELRSHALPGARKPHTVVVQMGEGTAGTVTTLLPEEPAGALDLTGMRPESQLAC
                     CDMVYKLPFGSSCTGTFHPAPSVPEKSMADAAPPGQSSSPFYGPRDPEPPEPPTYRAQ
                     GVVGPGPHEEQRPYPQGLPGRLYSSMSDTNLAEAGLNYHAQRIGQLFQGPGRDSAMDL
                     SSLKHSYSLGFADGRYLGQGLQYGSVTDLRHPTDLLAHPLPMRRYSSVSNIYSDHRYG
                     PRGDAVGFQEASLAQYSATTAREISRMCAALNSMDQYGGRHGSGGGGPDLVQYQPQHG
                     PGLSAPQSLVPLRPGLLGNPTFPEGHPSPGNLAQYGPAAGQGTAVRQLLPSTATVRAA
                     DGMIYSTINTPIAATLPITTQPASVLRPMVRGGMYRPYASGGITAVPLTSLTRVPMIA
                     PRVPLGPTGLYRYPAPSRFPIASSVPPAEGPVYLGKPAAAKAPGAGGPSRPEMPVGAA
                     REEPLPTTTPAAIKEAAGAPAPAPLAGQKPPADAAPGGGSGALSRPGFEKEEASQEER
                     QRKQQEQLLQLERERVELEKLRQLRLQEELERERVELQRHREEEQLLVQRELQELQTI
                     KHHVLQQQQEERQAQFALQREQLAQQRLQLEQIQQLQQQLQQQLEEQKQRQKAPFPAA
                     CEAPGRGPPLAAAELAQNGQYWPPLTHAAFIAMAGPEGLGQPREPVLHRGLPSSASDM
                     SLQTEEQWEASRSGIKKRHSMPRLRDACELESGTEPCVVRRIADSSVQTDDEDGESRY
                     LLSRRRRARRSADCSVQTDDEDSAEWEQPVRRRRSRLPRHSDSGSDSKHDATASSSSA
                     AATVRAMSSVGIQTISDCSVQTEPDQLPRVSPAIHITAATDPKVEIVRYISAPEKTGR
                     GESLACQTEPDGQAQGVAGPQLVGPTAISPYLPGIQIVTPGPLGRFEKKKPDPLEIGY
                     QAHLPPESLSQLVSRQPPKSPQVLYSPVSPLSPHRLLDTSFASSERLNKAHVSPQKHF
                     TADSALRQQTLPRPMKTLQRSLSDPKPLSPTAEESAKERFSLYQHQGGLGSQVSALPP
                     NSLVRKVKRTLPSPPPEEAHLPLAGQASPQLYAASLLQRGLTGPTTVPATKASLLREL
                     DRDLRLVEHESTKLRKKQAELDEEEKEIDAKLKYLELGITQRKESLAKDRGGRDYPPL
                     RGLGEHRDYLSDSELNQLRLQGCTTPAGQFVDFPATAAAPATPSGPTAFQQPRFQPPA
                     PQYSAGSGGPTQNGFPAHQAPTYPGPSTYPAPAFPPGASYPAEPGLPNQQAFRPTGHY
                     AGQTPMPTTQSTLFPVPADSRAPLQKPRQTSLADLEQKVPTNYEVIASPVVPMSSAPS
                     ETSYSGPAVSSGYEQGKVPEVPRAGDRGSVSQSPAPTYPSDSHYTSLEQNVPRNYVMI
                     DDISELTKDSTSTAPDSQRLEPLGPGSSGRPGKEPGEPGVLDGPTLPCCYARGEEESE
                     EDSYDPRGKGGHLRSMESNGRPASTHYYGDSDYRHGARVEKYGPGPMGPKHPSKSLAP
                     AAISSKRSKHRKQGMEQKISKFSPIEEAKDVESDLASYPPPAVSSSLVSRGRKFQDEI
                     TYGLKKNVYEQQKYYGMSSRDAVEDDRIYGGSSRSRAPSAYSGEKLSSHDFSGWGKGY
                     EREREAVERLQKAGPKPSSLSMAHSRVRPPMRSQASEEESPVSPLGRPRPAGGPLPPG
                     GDTCPQFCSSHSMPDVQEHVKDGPRAHAYKREEGYILDDSHCVVSDSEAYHLGQEETD
                     WFDKPRDARSDRFRHHGGHAVSSSSQKRGPARHSYHDYDEPPEEGLWPHDEGGPGRHA
                     SAKEHRHGDHGRHSGRHTGEEPGRRAAKPHARDLGRHEARPHSQPSSAPAMPKKGQPG
                     YPSSAEYSQPSRASSAYHHASDSKKGSRQAHSGPAALQSKAEPQAQPQLQGRQAAPGP
                     QQSQSPSSRQIPSGAASRQPQTQQQQQGLGLQPPQQALTQARLQQQSQPTTRGSAPAA
                     SQPAGKPQPGPSTATGPQPAGPPRAEQTNGSKGTAKAPQQGRAPQAQPAPGPGPAGVK
                     AGARPGGTPGAPAGQPGADGESVFSKILPGGAAEQAGKLTEAVSAFGKKFSSFW"
     exon            351..759
                     /gene="BSN"
                     /gene_synonym="ZNF231"
                     /inference="alignment:Splign:2.1.0"
     exon            760..1644
                     /gene="BSN"
                     /gene_synonym="ZNF231"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..2112
                     /gene="BSN"
                     /gene_synonym="ZNF231"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..8766
                     /gene="BSN"
                     /gene_synonym="ZNF231"
                     /inference="alignment:Splign:2.1.0"
     exon            8767..10843
                     /gene="BSN"
                     /gene_synonym="ZNF231"
                     /inference="alignment:Splign:2.1.0"
     exon            10844..11634
                     /gene="BSN"
                     /gene_synonym="ZNF231"
                     /inference="alignment:Splign:2.1.0"
     exon            11635..11734
                     /gene="BSN"
                     /gene_synonym="ZNF231"
                     /inference="alignment:Splign:2.1.0"
     exon            11735..11866
                     /gene="BSN"
                     /gene_synonym="ZNF231"
                     /inference="alignment:Splign:2.1.0"
     exon            11867..11921
                     /gene="BSN"
                     /gene_synonym="ZNF231"
                     /inference="alignment:Splign:2.1.0"
     exon            11922..12011
                     /gene="BSN"
                     /gene_synonym="ZNF231"
                     /inference="alignment:Splign:2.1.0"
     exon            12012..15971
                     /gene="BSN"
                     /gene_synonym="ZNF231"
                     /inference="alignment:Splign:2.1.0"
     regulatory      15944..15949
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BSN"
                     /gene_synonym="ZNF231"
                     /note="hexamer: AATAAA"
     polyA_site      15971
                     /gene="BSN"
                     /gene_synonym="ZNF231"
                     /note="major polyA site"
ORIGIN      
        1 aggcggcggc gcgagccgag ctgggagatg gcggcggcag cggcggcgcc gagagtgtga
       61 gcaccgcccg ggagccgccg gcccgggcgc agcgcgaccc cgaccccgcc cgcccgcctg
      121 cccgccatgg gcaacgaggt cagcctggag ggcggcgctg gcgacgggcc gctgccgccc
      181 ggcggcgccg gccccggccc gggccccggc cccggccccg gcgcaggaaa gccgccttca
      241 gcaccggccg gtggcggaca gctccccgcg gcgggagcag cgcggtcgac cgcggtacca
      301 ccggtccctg gccccggccc cggccccggt cccggccctg gcccgggcag cacttcccgg
      361 agactggacc ccaaggaacc cctgggtaac cagagagcag cttccccaac tccgaagcag
      421 gcttctgcta ccactcctgg ccatgagagc ccccgagaga caagggcaca gggaccagca
      481 ggccaggagg ctgatggtcc ccgcaggacg ctgcaggtag acagcaggac acagagatca
      541 gggcggtccc cctcagtgtc accggacaga ggcagcaccc ccacatcacc ctactccgtc
      601 cctcagatcg ccccccttcc cagcagcacg ctgtgtccca tatgcaagac ttcggacctc
      661 acgtcgaccc ccagccagcc aaacttcaac acctgcaccc agtgtcacaa caaggtctgc
      721 aaccagtgtg ggttcaaccc caaccctcat ctcacccagg tgaaggagtg gctctgtctg
      781 aactgtcaga tgcagagggc tctgggaatg gacatgacca ctgcacctcg ctccaagagc
      841 cagcagcagc tgcactcccc agccctgtct cctgcccact ccccggccaa acagcccctg
      901 gggaagccag accaagagag atctcggggc ccaggaggac cacagcctgg gtcccgccag
      961 gctgagacag ccagggccac ctcagtgccg gggcctgccc aagcagctgc ccctccagag
     1021 gtggggaggg tgtctcctca gccccctcaa cccaccaagc cttccacagc tgagcccagg
     1081 ccacctgcag gagaggcccc ggccaaaagt gccaccgcag tgcccgctgg gcttggtgcc
     1141 actgagcaga cccaggaggg cctcactggt aagctcttcg gccttggcgc gtcactgcta
     1201 acccaggcga gcaccctcat gtctgtgcag cccgaggctg acacccaggg ccagcctgcc
     1261 cccagcaagg ggacacctaa gatcgtcttc aatgatgcca gcaaggaggc tggcccaaaa
     1321 cccttgggct cagggcccgg gcctgggcca gcacctggag ccaaaactga gcctggggct
     1381 agaatgggtc ctggatctgg acctggagcc ctgccgaaaa ctgggggaac aaccagtcca
     1441 aagcatggca gagcagaaca tcaggcagca tcgaaggctg ctgccaagcc aaagaccatg
     1501 ccgaaggaaa gggccatctg cccactgtgc caagccgagc tcaacgtggg cagcaagagc
     1561 ccagccaact ataacacatg caccacctgc aggctccagg tgtgcaacct gtgtggcttc
     1621 aacccaacac cccacctggt ggagaaaaca gagtggctct gtctgaactg ccaaaccaag
     1681 cggctactgg agggcagcct aggagagccg acccccctgc cgccgcccac ctcacagcag
     1741 ccccctgtag gggcccctca ccgtgcatct ggaacatccc ctctgaagca gaaagggcca
     1801 caggggctgg gccagccttc aggccccctg cctgccaagg ccagccctct atccaccaag
     1861 gccagccctc tgcccagcaa ggccagcccc caggccaagc ccctcagggc ttctgaaccc
     1921 agcaagaccc caagcagtgt ccaggaaaag aagacccgag tccccactaa agctgagccc
     1981 atgccgaagc cacctccaga gactacccca acccctgcga ctcctaaagt aaagagtggg
     2041 gtgaggaggg ctgaacctgc cacccctgtc gtcaaggctg ttccagaagc ccccaagggt
     2101 ggggaggcgg aggacctggt gggcaagcct tactctcagg atgcgtctcg gagcccacag
     2161 agcctcagtg acacaggcta ttcctctgac ggcatctcta gctcccagag tgagatcaca
     2221 ggagtcgtgc agcaggaggt ggaacagctg gacagtgcag gggtgacagg gccacatcca
     2281 cccagcccct ccgagatcca caaggtgggg agcagcatgc ggcctttgct gcaggcccag
     2341 ggcctggccc caagtgagcg gagcaagcca ctctccagcg gtactggcga ggagcagaag
     2401 cagcggcccc actccttgtc catcacgcct gaggcctttg actctgatga ggagctggag
     2461 gatatcctgg aggaagacga agactctgct gagtggaggc gccggagaga gcagcaggac
     2521 actgccgagt cctcagacga ctttggcagc caattgaggc acgactatgt ggaggacagc
     2581 agtgagggtg gcctgtcccc tcttccaccc cagcccccag cccgggcagc agaactgact
     2641 gatgaggatt tcatgcgacg gcagattctc gagatgagcg ccgaggaaga caacctggag
     2701 gaggatgaca ctgccacctc cgggcgtggc ctggccaaac atggcaccca gaaaggtggc
     2761 cccagaccca ggcctgagcc tagccaagaa ccagcagcac tgcccaagag gcgcctgccc
     2821 cacaatgcca ccacgggcta tgaggagctg ctccctgagg gaggctcagc agaggctacc
     2881 gatggcagtg ggaccctgca gggtgggctc cgtcgcttca agaccattga gctcaacagc
     2941 acgggaagtt atggtcatga gttggacctg ggccaaggcc cagaccccag tctggaccgg
     3001 gagcctgagc tggagatgga gagcctaacg ggctcccctg aggaccgctc ccgtggtgag
     3061 cactcctcta cattgcctgc ctccacaccc agctacacct cgggcacctc tcccacctct
     3121 ctgtcctccc tagaggagga cagtgacagc agccccagcc gcaggcagcg tctagaagaa
     3181 gcaaagcagc agcgcaaggc ccggcaccgc tcccacgggc ccctgctacc caccatcgag
     3241 gactcctcag aggaggagga gctgcgggag gaagaggagc tgcttcgtga gcaagagaag
     3301 atgcgggagg tggagcagca gcgcatccgc agcacggccc gcaagacccg gcgggacaag
     3361 gaagaactgc gggcccagcg gaggcgagag cgctccaaga caccacccag taacttgtca
     3421 cccatcgagg atgcctcccc gacggaggag ctgaggcagg cggccgagat ggaggagcta
     3481 caccgctcct cctgctctga gtactcaccc tcaccctccc ttgactctga ggctgaggcc
     3541 ttggatggtg gccctagccg gctttacaag tcaggcagtg agtacaacct gcccaccttc
     3601 atgtccctct actcaccaac cgagacaccc tccggcagct ccaccactcc cagttccgga
     3661 cggccgctca agagcgctga ggaggcttat gaggagatga tgcgcaaagc tgagctgctc
     3721 cagaggcagc aaggccaggc agcaggggcc cggggacccc atggcggccc ctctcagccc
     3781 acaggccccc ggggcctggg ctccttcgaa tatcaagaca ctacagaccg tgagtatggc
     3841 caggctgctc agcctgccgc agagggcacg ccagccagcc tgggagcagc cgtgtacgaa
     3901 gaaatccttc agacatcaca gagcatagtc cgcatgcggc aggcctcctc acgagacctg
     3961 gcttttgctg aggacaaaaa gaaggagaag cagtttctaa atgctgagag tgcatacatg
     4021 gacccaatga agcaaaatgg tggccccctt acccctggta ccagtcccac ccagctcgct
     4081 gcccctgtgt ccttctctac ccccacctcc tcagacagca gcgggggccg agttattccc
     4141 gatgtccgtg tcactcagca ttttgcaaag gagactcagg accccctcaa gctgcacagc
     4201 tctcctgcct cccccagctc agcctccaag gagataggca tgcccttttc ccagggccct
     4261 gggaccccag ccaccacagc tgtggctcct tgtccagctg ggctgccacg aggatatatg
     4321 actccagcct ccccagcagg ctccgagcgt agtccttcac catcttccac agcccacagc
     4381 tatggacaca gcccaaccac tgcaaactat gggtcccaaa ctgaggatct accccaggcc
     4441 cccagtggcc ttgctgcagc tggacgagct gctagagaga agcccttgag tgcgagtgac
     4501 ggtgagggtg gcactcctca gccttcccgg gcatattcct actttgcaag ctccagccca
     4561 cctctctccc cgtcttcccc ctcagagagt cccacattct cccctggcaa gatgggccca
     4621 agggccacag cagagttctc tacacagacg ccaagtccag cccctgcctc agacatgcca
     4681 cggagccctg gtgcccccac tccatcacct atggtagccc agggtacaca aacaccacat
     4741 cgacccagca cgcctcgcct ggtgtggcag gagtcctctc aagaggctcc ctttatggtc
     4801 atcacgctgg catctgacgc ctccagccag accaggatgg tacatgccag tgcctccacc
     4861 tccccgctct gctcacctac tgaaacccag cccaccaccc atggctacag ccagacaaca
     4921 cctccgagtg tgtctcagct gcccccagag ccacctgggc cacctggctt tccacgggtg
     4981 cccagtgctg gtgcagatgg gcccctggca ctatatggct ggggtgccct ccctgctgag
     5041 aacatctccc tgtgccggat ctcctctgtc cctgggacgt ctagggttga gccaggcccc
     5101 aggacccctg gcactgcagt ggtagacctc cgtacagctg tcaagcccac tcccatcatc
     5161 ctcactgacc agggcatgga cctcacctct cttgctgtgg aagcgaggaa gtatggtctt
     5221 gccctggatc caatcccagg acggcagtcg accgccgtgc agcccttggt tatcaacctc
     5281 aatgcccagg agcatacctt ccttgctact gccaccaccg tgagcatcac catggcctcg
     5341 tctgtgttca tggctcaaca aaagcagcct gtggtctatg gagaccccta ccagagccgc
     5401 cttgactttg gccagggtgg gggtagccct gtgtgcctgg cccaggtcaa acaagtagag
     5461 caggctgtcc agacagcccc ataccgaagt gggccccggg gaagacccag ggaggccaag
     5521 tttgccagat ataacctacc caaccaagta gctcctctgg ccagaagaga cgttttgatc
     5581 actcagatgg gcaccgccca gagcattggc ctcaagccag gcccagtgcc agagccaggt
     5641 gccgagcccc accgggccac ccctgcagag ctgcggtcac atgctctgcc aggtgccagg
     5701 aagccacaca cagtggtggt gcagatggga gagggcacag caggcactgt gaccacactg
     5761 ctcccagagg agcctgcggg tgccctggac cttaccggga tgaggcctga gagccagctg
     5821 gcatgctgtg acatggtcta caagctcccc tttggcagca gctgcactgg caccttccac
     5881 ccggccccca gtgtgcctga gaagagcatg gcagatgctg ccccacctgg ccaaagcagc
     5941 agccccttct atggtccccg ggaccctgag cctcctgagc ccccaaccta ccgggcacag
     6001 ggggtggtgg ggcctgggcc ccatgaggag cagaggccct acccacaagg cctgcctggt
     6061 aggctgtact cctccatgtc tgacaccaat ttggctgagg ctggcctcaa ctaccatgcc
     6121 cagaggatcg ggcagctctt ccagggtcct ggacgagact cggctatgga cctcagctca
     6181 ctgaagcact cctacagcct gggctttgcg gatggacgct acctagggca gggcttgcag
     6241 tatggctcag tcacggacct gcgtcatcct acagaccttt tggctcaccc gcttcccatg
     6301 cggcgctata gctcagtgtc gaacatctac tcagaccaca ggtacggccc acggggagat
     6361 gcagttggct tccaggaggc cagcctggcc cagtacagtg ccaccacagc ccgtgaaatc
     6421 agtcgcatgt gcgctgccct caactccatg gaccagtatg gtgggcggca tggcagtggt
     6481 ggtggtggcc ctgaccttgt gcagtaccag ccccagcacg ggcccgggct cagtgctcca
     6541 cagagtctgg ttcccctcag acctggactc cttggtaacc ccacctttcc agagggccac
     6601 ccaagtcctg ggaacttggc ccagtatggg cctgcagcag gccaaggaac agcagtcaga
     6661 cagctgctgc cgtccacagc cactgtacgt gcagctgatg gcatgatcta ctcgactatc
     6721 aataccccaa ttgctgcaac actgcccatc accacccagc ctgcctcagt cctgcggccc
     6781 atggtgcgtg gtggcatgta caggccttac gcatctggtg gaatcacagc cgtgccactc
     6841 accagtctga cacgtgtgcc catgattgcc ccccgggtac ctcttggacc cacagggctg
     6901 taccgctatc ctgcaccaag tagatttccc attgcttcca gtgttccacc tgcagaaggg
     6961 cctgtctatc tggggaaacc tgctgctgcc aaggcccctg gggctggggg cccttcaagg
     7021 ccagagatgc cagtaggggc tgcacgggaa gagcctcttc ccacaaccac ccctgctgcc
     7081 atcaaggagg ctgcaggagc cccagctcct gccccactag ctggccagaa gccaccagca
     7141 gatgctgctc ctgggggtgg cagtggggcc ctcagccggc cagggttcga gaaagaggaa
     7201 gcatcacagg aggagaggca gcggaagcaa caggagcagc tgctccagct agagcgggag
     7261 cgggtggagt tggagaagct gcgacaactt cggctgcaag aggagctaga gcgggaacgt
     7321 gtggagctgc agaggcaccg tgaggaggag cagctgctgg tgcagcggga gttgcaggag
     7381 ctgcagacca tcaagcacca tgtgctgcag cagcagcaag aggaacgcca ggctcaattt
     7441 gcactgcagc gggaacagct agcgcagcag cgtctgcagc tggagcagat ccagcagctg
     7501 cagcagcagc tgcagcagca gctagaggag cagaagcagc ggcagaaggc tccctttcct
     7561 gcagcctgtg aggcacctgg ccgagggcct cccctagcgg ctgctgagtt ggcccagaat
     7621 ggccagtatt ggccccccct tacacatgca gccttcattg ccatggcagg gcctgaagga
     7681 cttgggcagc ctcgtgagcc tgtgctgcac cggggtctcc ccagctctgc ctcagacatg
     7741 tcactgcaaa cggaggagca gtgggaggcc agccgtagtg gcatcaagaa gcggcactcc
     7801 atgccacgcc tgcgggatgc ctgtgagcta gagtctggga ctgagccctg tgtggtcagg
     7861 aggattgccg acagcagcgt gcagacagac gatgaggatg gggagagccg ctacctcttg
     7921 agtcggcgac gccgggcacg gcggagtgct gactgcagtg tgcagacgga cgacgaagac
     7981 agtgctgagt gggagcagcc agtgcgccgc cgcaggtctc gtcttccccg ccactcagac
     8041 tcaggctctg acagcaagca cgatgccact gcctcatcat ccagtgctgc tgccactgtg
     8101 agggccatga gcagcgtggg catccagacc atcagtgact gctccgtgca gacggagcct
     8161 gaccagctgc ccagggtctc tccagccatc cacatcacag ctgccaccga tcccaaggtg
     8221 gagatcgtca ggtacatatc ggcgccagag aagactgggc gtggggagag cctggcctgc
     8281 cagacggagc cagatgggca ggcccagggt gtagccgggc cgcagcttgt agggccaact
     8341 gccatcagcc cctacctgcc tggcatccag atcgtcaccc cagggcctct gggcagattt
     8401 gaaaaaaaga agccagatcc cctggagatt gggtaccagg cccacctgcc tccggagtct
     8461 ctctcacagc ttgtgagccg ccagcctccc aagtcccctc aggtcctcta ctcaccagtc
     8521 tcacccctgt cccctcaccg gctcctggac acctcctttg cttccagtga gaggctgaac
     8581 aaagctcacg tgagtcccca gaagcacttc acggctgaca gcgctctccg ccagcagacg
     8641 ctgcctcgcc ccatgaagac cctgcagcgg tccctgtctg accctaagcc cctcagcccc
     8701 accgccgaag agtctgccaa agagagattc tccctctacc agcaccaggg gggactgggt
     8761 agccaggtgt cggcgttgcc acccaacagc ctggtccgca aggtgaagcg gacactgccc
     8821 agcccccctc cagaggaggc tcaccttccc ctggctggcc aggcctcccc acagctgtat
     8881 gcagccagcc tgctgcagcg agggctgacg gggcccacca ctgtccctgc taccaaggcc
     8941 agcctgctcc gggagctgga ccgggacctg cggctggtgg agcatgagtc caccaaactg
     9001 cgcaagaagc aggcagagct ggatgaggag gagaaggaga ttgacgccaa gctcaagtac
     9061 ctggagttgg gtatcacaca acgcaaagag tctttggcca aagaccgggg tggccgtgac
     9121 tacccaccct tgcgtggtct tggcgagcat cgtgactacc tatcggacag tgagctcaac
     9181 cagctgcggc tccagggctg caccactccc gctggccagt ttgtggactt ccctgccact
     9241 gccgctgctc ctgccacccc ctctggtccc actgccttcc agcagccccg cttccagcct
     9301 ccagccccac agtattctgc aggcagtggt gggccaactc agaacggatt cccagcccac
     9361 caggccccca cctaccctgg ccccagcacg tacccagctc ctgcctttcc tcctggtgcc
     9421 agttacccag ctgagcctgg cctgccaaac cagcaggctt tccgccccac aggccactat
     9481 gcaggccaaa cacccatgcc aaccacacag agcacccttt ttccagtccc cgctgatagc
     9541 cgtgccccac tgcagaagcc acgccagaca tcgctagccg acttggagca gaaggtgccc
     9601 accaactatg aggtgatcgc cagccccgtt gtgcccatgt cttcagcccc atctgaaacc
     9661 agctacagtg gcccagcagt gagcagcggc tatgagcagg gcaaggtccc tgaggtgccc
     9721 cgggctggtg accgtggcag tgtgagccag agcccagccc ccacctaccc ctctgactca
     9781 cactatacca gtctggagca gaacgttcct cgaaactacg taatgattga tgacatcagt
     9841 gaactgacca aggacagcac ctctactgct cctgatagcc aacggctgga gcccctgggg
     9901 ccaggcagca gtgggcgtcc agggaaggag cctggagaac caggtgtcct tgacgggccc
     9961 acactgccct gctgctatgc cagaggagaa gaggaatctg aggaggactc atacgatccc
    10021 cgcgggaagg gtggccacct ccggagcatg gagagcaatg gtcgaccagc cagtacccac
    10081 tactatggtg acagtgacta caggcatggg gctcgagtag agaagtatgg tccagggccc
    10141 atggggccca agcatccctc caagagcctg gctccagctg ccatctcctc aaagcgcagc
    10201 aagcaccgga agcagggcat ggagcaaaag atatccaagt tctcgcctat tgaagaggcc
    10261 aaagacgtag agtcagacct ggcgtcctac cccccacctg cagtcagcag cagcctggtc
    10321 tctcggggca ggaagttcca ggatgaaatc acctatgggc tcaagaagaa cgtgtatgag
    10381 cagcaaaaat actatgggat gtccagccgg gacgcagtgg aggacgaccg catttatggc
    10441 gggagcagcc ggtcccgggc accttctgca tacagtgggg agaagctgtc cagccacgac
    10501 ttcagtggct ggggcaaggg gtacgaaagg gaacgggagg ctgtggagcg acttcaaaaa
    10561 gcgggcccca agccctcatc cctaagtatg gcccacagcc gggtacgacc ccccatgcgg
    10621 agccaggcct ctgaagagga gagccccgtc agtcctttgg ggaggccccg ccctgccgga
    10681 gggcccctcc ctcccggcgg ggatacctgc ccacagttct gctccagcca ctccatgcct
    10741 gatgtccagg aacatgtcaa ggacggacct cgggcccacg catataagcg tgaggagggc
    10801 tacatcctgg atgattccca ttgcgtggtt tccgacagcg aagcgtatca cctgggccag
    10861 gaggagacgg actggtttga taagccccgg gatgcccgct ctgaccggtt caggcaccac
    10921 gggggccatg cagtttcctc ctcctcccag aagcgaggcc ctgccaggca cagctaccat
    10981 gactacgatg aaccccctga ggagggcctg tggcctcatg atgagggtgg cccaggccgc
    11041 catgcctcag ccaaggaaca ccggcacggt gaccacgggc ggcactcagg ccgccacact
    11101 ggtgaggagc cgggacggcg tgctgccaaa ccacacgctc gggacctggg tcgccatgag
    11161 gcccggcccc actctcagcc cagctctgct ccagctatgc cgaagaaggg tcagcctggg
    11221 tatcccagct ctgctgagta ctcacagcca tcccgtgctt catccgcata ccatcatgcc
    11281 tctgacagca agaagggctc ccggcaagcc cactccgggc ccgctgcact gcagtcaaag
    11341 gcagaacccc aggcgcagcc gcagctgcaa ggtcggcagg cagctccagg accacagcag
    11401 tcacagtcac catcatccag gcaaataccc tctggggcag catcacgcca gccacagaca
    11461 cagcagcagc agcaaggtct tgggctgcag cccccacagc aggctctgac acaggctcgg
    11521 ctgcagcaac agagccagcc aaccacccgg ggctcagccc ctgctgccag ccagcctgca
    11581 gggaagcctc agccaggccc cagcacagcc acaggtcctc aaccagcagg accgccacgg
    11641 gcagaacaga caaatggctc taaagggaca gccaaagcac cgcaacaggg gagggctcct
    11701 caggcccagc cagcaccagg acctggacct gcaggtgtga aggctggagc caggcctgga
    11761 ggaaccccag gggctcccgc cggccagcca ggtgccgatg gggagagcgt gttctccaag
    11821 atcctccctg gcggggcagc cgagcaagct ggcaaactga cggaagctgt ctctgctttt
    11881 ggcaaaaaat tttcctcatt ctggtgacca tgcccagcat ggctcttgaa gaaatgaaga
    11941 gaggtatcat tgctgtggaa aaatctctgg agtcagaggc ctgggcgcag ctctggactc
    12001 tgcgtataac acatctacaa tctggcaaac ccttggccca aagactcacc aggtgggacg
    12061 tggcaggcag gcctcagttg aggacgtgat gttttctcac agcagctgcc tgggtgaagc
    12121 atctgctgga caagtcggac cactggccag gggacctttg attgtctttc cagagatgct
    12181 gctctctgca gggcaccacc ttcaaggcac agcccttgtt gggagggaga accctctcca
    12241 gaaaccctgc caccatggtg tcttgccgta cttcccacag ccgccttttt gcggcctggc
    12301 cggccaggct tcccgtgcgt tatacacaga gtttgggcac acactgccct ccctccgaga
    12361 tgccagaagt ttttccacag ccttggagag gggctttgac tgagggctgg gggccctggg
    12421 ctccgtttcc ttcacattcc agctggcccg gatccctctg tggcacaggg ccctgcccgt
    12481 cacatgccct ctgggtgaca tcggagcaga cctccatgtg gccaggggtt gggagaactt
    12541 tacaaacatt aggacctaac actgtctcat cgctgaaata agaggccata gcaccgaaaa
    12601 gcagcgtggg cgccggctga ggcttctccc agcccgtggg tggcagcgtg ctagcacact
    12661 gccaccatct caaagccatc cccctagcca tcgtgagcat cccagcggca ccgccattgt
    12721 ctcaaccagc cggctcctcg tctgtacacc tggggatttc ttttgatttc aagaacagcc
    12781 ttaatcattc cagtttgatt tacgtgtata cctcataaac atttttcttt tgtttctctc
    12841 tccccctttc tctcttctct tggctcactc ccttgcctct ccccctccac caccaccttg
    12901 tgactgatgg tttggtttcc tctctgctct gcccctgctc agcacaggga gaatgttgac
    12961 ttagaagcaa tagggggcag caggccacca agagcacaac cccagggcga ggtctgggga
    13021 ggcctcccag cccgcctctg tttactgtgc aattccagtc gttcttaagc catcaccagt
    13081 gggtgtactc agagcagagg ggccaggact tctgccagcc aagggaaagg cccagagccc
    13141 tgtgcggggg aatgtggcac tgtctatcca tccggtggac tgggcagcat tcctccccag
    13201 ggctcttccc ttgggggcct cctttcatct ggggcacagc cacaagtctc atctctaacg
    13261 ttctatgcaa tgaaatataa accctcaatg acaactgtta atatttaata aattccatgt
    13321 tatgtataag gagttaattg caaacatgca attgagaaac tggatagata cactcataaa
    13381 acccccaccc ctccccaccc cacccctgct cccattgtgt gtgtgaaatt ctcagtctgt
    13441 ggcatgtttg acctgtggca ggactcgctg ctgccaggtg agtcaccgcc tgtcctgcag
    13501 tggagcatgc acagctcgca gcctctttgc acgatttcat ccattttaaa tgcttgaccc
    13561 tcttgcttgg agttcttttt gcctcagaac ctctccttca ggagcacttc tagctgactt
    13621 ctgcacaagc tagtgaggac ctgccagaat tgttgcctga gcgtgccagg ctgcagggca
    13681 ggcagtaaaa ggcccccaca taccctgcag ttttctctgt ccaggacagc aggtaaaaag
    13741 gaatccccag agcagacgca atggtaggag cctgcacagg atgtgtgtgt atggacattc
    13801 tgaaggtttg ctgtaggata tctgtctgtc tgtcattttc ccttcctacc ccaaccctga
    13861 gccagaggca tctgacagcc ctttcccaga gggcaccacg caagggcaga gctgggcggc
    13921 atccacagcc agagaggcag aggcaagagc agagccaggc tgtgcccgag ggaccccagc
    13981 tcttgactgc acctgtttca tgcctctcct ctgtggctag gaggctcaaa ggactgtgag
    14041 ccaggagatc tgggctggag ctagggggtc aatggatgct caggaagagc tgggcctttg
    14101 gcacttgtgg tgagaacagt tgacagtggt catctggaac tgttcatata aacagtggct
    14161 tcaagctaag tttcttgtga agtttctcaa tagcaaatct tacagaaggt cctgtgtgac
    14221 cctctctgca tctgtcccca ggacctatgc tccctgctca cccccttctc caaagcccaa
    14281 gcgtcccgct gctcatcagc ttttttacca ttgagccagg agtgcggcag gcagtacctg
    14341 cctgaccctt caaggcctga ccttcgtcca gagtgctctg gtttgcacca tgcatttctc
    14401 aggggtccgc atttctcatg cttttctata agatctacac accccttcag agagggctcc
    14461 tcgctcacct ctggtagcta tggatgggac aggaagctgc caacctttgt gttggactta
    14521 acacccttgc ctttctggga cttggcctca ccccacccat ggaatacctg cctcatccca
    14581 aagatcaggt atgggctgaa tgcagccatc tgagcaaggg ctgagggaag ccatcaccta
    14641 acacctctgg ccacccagga ccaggtctgt gtggggatgt gccttggaga ccaaggcaat
    14701 agtcctttcc actacaggcc aggggatggg acaagaagta gggaacaggc agggaaatgt
    14761 taggaggtca gcctccagca ggcctagtct caggctctaa agtactgact tttcagcaaa
    14821 tttcctttct ggccaagccc tctgagtttg aaattctgac atctgccact cctcatcccc
    14881 cactgtaccc acaggataca tcatcgcccc tctgtgaagg tggctggagc aggcctctgg
    14941 tccatggact gtccttcctg gcccttgcat ggatgcagtt gtgactctgg ggacaatgca
    15001 gccagaagct gagggaccag cacttggtgc cttggaaagt agagagcaac agacacatct
    15061 ccaaatgggc aaggagtctc tagcatgcag cccaggcctt ctccataccc ctctccccag
    15121 catcatgagc aagggcattg cctcctctct ctgctcactt cagggcccag tgcactcact
    15181 tcacagtgac agccctcccc tacaatcctt gggcagagca tgtggtctga gggcccacag
    15241 tgaaagaaca gcagtggtgg caactatgcc ttgccttctg gagcctgtag ggagttttcc
    15301 aggcaggtcc tttgccagga cagcatggtc ctgccctgtt gtcccgtctg ctctcctctt
    15361 acccaccccc atgctgtaaa tacttgtcat catggactcc aacagggtta gagggacagg
    15421 cctaatcaac tgaaactcct cggagatgcc atctctgtct ccctgggtgc cagcagccct
    15481 gctgccatgt gcactggggt ggcactggag agccatggca gtcgtgagat attgtatgtg
    15541 tatgcacatg atcatgtgtg tatgtgcgtg cgtgcgtgcg tgtgtgtgtg tgtgtgtgtt
    15601 tctgcctcat tcagtttctg gggtcaaatc agctccttct ctccaagtgc actaccctgg
    15661 agagtggtgg ccactcaata ccttttcctc tagctttcat gtcttgtttt tgctttcccc
    15721 ttcctcctcc ctctctccct ttctttcctt ctctccttct ttatttgagg ggggaagagt
    15781 gctgtacaaa gtcaaacaaa caagtttaca gttgtaagtg caatgacccg agtcctccac
    15841 atgaccttgt gaattgtgtg ctgtccttct gtgctctgtg agaactcgtg gtacttcagt
    15901 gtccctcccc ctgtattgtg acaaggtaat tctgtggtat cagaataaaa ggacttgata
    15961 taaacaacct a
//
