LOCUS       NM_001728               1946 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens basigin (Ok blood group) (BSG), transcript variant 1,
            mRNA.
ACCESSION   NM_001728
VERSION     NM_001728.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1946)
  AUTHORS   Dai,P., Ma,C., Jiang,T., Shi,J., Liu,S., Zheng,M., Zhou,Y., Li,X.,
            Liu,Y. and Chen,H.
  TITLE     CD147 mediates S protein pseudovirus of SARS-CoV-2 infection and
            its induction of spermatogonia apoptosis
  JOURNAL   Endocrine 85 (3), 1435-1445 (2024)
   PUBMED   38824220
  REMARK    GeneRIF: CD147 mediates S protein pseudovirus of SARS-CoV-2
            infection and its induction of spermatogonia apoptosis.
REFERENCE   2  (bases 1 to 1946)
  AUTHORS   Mygind,K.J., Nikodemus,D., Gnosa,S., Kweder,R., Albrechtsen,N.J.W.,
            Kveiborg,M., Erler,J.T. and Albrechtsen,R.
  TITLE     ADAM12-Generated Basigin Ectodomain Binds beta1 Integrin and
            Enhances the Expression of Cancer-Related Extracellular Matrix
            Proteins
  JOURNAL   Int J Mol Sci 25 (11), 5871 (2024)
   PUBMED   38892056
  REMARK    GeneRIF: ADAM12-Generated Basigin Ectodomain Binds beta1 Integrin
            and Enhances the Expression of Cancer-Related Extracellular Matrix
            Proteins.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1946)
  AUTHORS   Meng,S., Sorensen,E.E., Ponniah,M., Thorlacius-Ussing,J.,
            Crouigneau,R., Larsen,T., Borre,M.T., Willumsen,N., Flinck,M. and
            Pedersen,S.F.
  TITLE     MCT4 and CD147 colocalize with MMP14 in invadopodia and support
            matrix degradation and invasion by breast cancer cells
  JOURNAL   J Cell Sci 137 (8) (2024)
   PUBMED   38661040
  REMARK    GeneRIF: MCT4 and CD147 colocalize with MMP14 in invadopodia and
            support matrix degradation and invasion by breast cancer cells.
REFERENCE   4  (bases 1 to 1946)
  AUTHORS   Liu,P., Xie,L., Wu,Q., Huang,L., Liu,X., Li,W., Cai,J., Wang,Z.,
            Yang,P. and Cai,L.
  TITLE     TIE1 promotes cervical cancer progression via Basigin-matrix
            metalloproteinase axis
  JOURNAL   Int J Biol Sci 20 (6), 2297-2309 (2024)
   PUBMED   38617545
  REMARK    GeneRIF: TIE1 promotes cervical cancer progression via
            Basigin-matrix metalloproteinase axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1946)
  AUTHORS   Huang,Y., Zhou,H., Wang,Y., Xiao,L., Qin,W. and Li,L.
  TITLE     A comprehensive investigation on the receptor BSG expression
            reveals the potential risk of healthy individuals and cancer
            patients to 2019-nCoV infection
  JOURNAL   Aging (Albany NY) 16 (6), 5412-5434 (2024)
   PUBMED   38484369
  REMARK    GeneRIF: A comprehensive investigation on the receptor BSG
            expression reveals the potential risk of healthy individuals and
            cancer patients to 2019-nCoV infection.
REFERENCE   6  (bases 1 to 1946)
  AUTHORS   Spring,F.A., Holmes,C.H., Simpson,K.L., Mawby,W.J., Mattes,M.J.,
            Okubo,Y. and Parsons,S.F.
  TITLE     The Oka blood group antigen is a marker for the M6 leukocyte
            activation antigen, the human homolog of OX-47 antigen, basigin and
            neurothelin, an immunoglobulin superfamily molecule that is widely
            expressed in human cells and tissues
  JOURNAL   Eur J Immunol 27 (4), 891-897 (1997)
   PUBMED   9130641
REFERENCE   7  (bases 1 to 1946)
  AUTHORS   Kasinrerk,W., Fiebiger,E., Stefanova,I., Baumruker,T., Knapp,W. and
            Stockinger,H.
  TITLE     Human leukocyte activation antigen M6, a member of the Ig
            superfamily, is the species homologue of rat OX-47, mouse basigin,
            and chicken HT7 molecule
  JOURNAL   J Immunol 149 (3), 847-854 (1992)
   PUBMED   1634773
REFERENCE   8  (bases 1 to 1946)
  AUTHORS   Miyauchi,T., Masuzawa,Y. and Muramatsu,T.
  TITLE     The basigin group of the immunoglobulin superfamily: complete
            conservation of a segment in and around transmembrane domains of
            human and mouse basigin and chicken HT7 antigen
  JOURNAL   J Biochem 110 (5), 770-774 (1991)
   PUBMED   1783610
REFERENCE   9  (bases 1 to 1946)
  AUTHORS   Nabeshima,K., Lane,W.S. and Biswas,C.
  TITLE     Partial sequencing and characterization of the tumor cell-derived
            collagenase stimulatory factor
  JOURNAL   Arch Biochem Biophys 285 (1), 90-96 (1991)
   PUBMED   1846736
REFERENCE   10 (bases 1 to 1946)
  AUTHORS   Kanekura,T., Miyauchi,T., Tashiro,M. and Muramatsu,T.
  TITLE     Basigin, a new member of the immunoglobulin superfamily: genes in
            different mammalian species, glycosylation changes in the molecule
            from adult organs and possible variation in the N-terminal
            sequences
  JOURNAL   Cell Struct Funct 16 (1), 23-30 (1991)
   PUBMED   2032306
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY358113.1 and GU557064.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001728.3.
            
            Summary: The protein encoded by this gene, basigin, is a plasma
            membrane protein that is important in spermatogenesis, embryo
            implantation, neural network formation, and tumor progression.
            Basigin is also a member of the immunoglobulin superfamily,
            ubiquitously expressed in various tissues. Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, May 2020].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK297880.1, AY358113.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333511.9/ ENSP00000333769.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1943              AY358113.1         14-1956
            1944-1946           GU557064.1         1760-1762
FEATURES             Location/Qualifiers
     source          1..1946
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1946
                     /gene="BSG"
                     /gene_synonym="5F7; CD147; EMMPRIN; EMPRIN; HAb18G; OK;
                     TCSF"
                     /note="basigin (Ok blood group)"
                     /db_xref="GeneID:682"
                     /db_xref="HGNC:HGNC:1116"
                     /db_xref="MIM:109480"
     exon            1..106
                     /gene="BSG"
                     /gene_synonym="5F7; CD147; EMMPRIN; EMPRIN; HAb18G; OK;
                     TCSF"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1197
                     /gene="BSG"
                     /gene_synonym="5F7; CD147; EMMPRIN; EMPRIN; HAb18G; OK;
                     TCSF"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; collagenase stimulatory factor; extracellular
                     matrix metalloproteinase inducer; OK blood group antigen;
                     leukocyte activation antigen M6; tumor cell-derived
                     collagenase stimulatory factor; hepatoma-associated
                     antigen"
                     /codon_start=1
                     /product="basigin isoform 1 precursor"
                     /protein_id="NP_001719.2"
                     /db_xref="CCDS:CCDS12033.1"
                     /db_xref="GeneID:682"
                     /db_xref="HGNC:HGNC:1116"
                     /db_xref="MIM:109480"
                     /translation="MAAALFVLLGFALLGTHGASGAAGFVQAPLSQQRWVGGSVELHC
                     EAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLVEED
                     TGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSLN
                     DSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTANIQLH
                     GPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFV
                     SSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSHLAALWPFLGIVAE
                     VLVLVTIIFIYEKRRKPEDVLDDDDAGSAPLKSSGQHQNDKGKNVRQRNSS"
     exon            107..454
                     /gene="BSG"
                     /gene_synonym="5F7; CD147; EMMPRIN; EMPRIN; HAb18G; OK;
                     TCSF"
                     /inference="alignment:Splign:2.1.0"
     exon            455..611
                     /gene="BSG"
                     /gene_synonym="5F7; CD147; EMMPRIN; EMPRIN; HAb18G; OK;
                     TCSF"
                     /inference="alignment:Splign:2.1.0"
     exon            612..694
                     /gene="BSG"
                     /gene_synonym="5F7; CD147; EMMPRIN; EMPRIN; HAb18G; OK;
                     TCSF"
                     /inference="alignment:Splign:2.1.0"
     exon            695..831
                     /gene="BSG"
                     /gene_synonym="5F7; CD147; EMMPRIN; EMPRIN; HAb18G; OK;
                     TCSF"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1108
                     /gene="BSG"
                     /gene_synonym="5F7; CD147; EMMPRIN; EMPRIN; HAb18G; OK;
                     TCSF"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1133
                     /gene="BSG"
                     /gene_synonym="5F7; CD147; EMMPRIN; EMPRIN; HAb18G; OK;
                     TCSF"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1202
                     /gene="BSG"
                     /gene_synonym="5F7; CD147; EMMPRIN; EMPRIN; HAb18G; OK;
                     TCSF"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1946
                     /gene="BSG"
                     /gene_synonym="5F7; CD147; EMMPRIN; EMPRIN; HAb18G; OK;
                     TCSF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1918..1923
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BSG"
                     /gene_synonym="5F7; CD147; EMMPRIN; EMPRIN; HAb18G; OK;
                     TCSF"
                     /note="hexamer: AATAAA"
     polyA_site      1946
                     /gene="BSG"
                     /gene_synonym="5F7; CD147; EMMPRIN; EMPRIN; HAb18G; OK;
                     TCSF"
                     /note="major polyA site"
ORIGIN      
        1 agcggttgga ggttgtagga ccggcgagga ataggaatca tggcggctgc gctgttcgtg
       61 ctgctgggat tcgcgctgct gggcacccac ggagcctccg gggctgccgg cttcgtccag
      121 gcgccgctgt cccagcagag gtgggtgggg ggcagtgtgg agctgcactg cgaggccgtg
      181 ggcagcccgg tgcccgagat ccagtggtgg tttgaagggc agggtcccaa cgacacctgc
      241 tcccagctct gggacggcgc ccggctggac cgcgtccaca tccacgccac ctaccaccag
      301 cacgcggcca gcaccatctc catcgacacg ctcgtggagg aggacacggg cacttacgag
      361 tgccgggcca gcaacgaccc ggatcgcaac cacctgaccc gggcgcccag ggtcaagtgg
      421 gtccgcgccc aggcagtcgt gctagtcctg gaacccggca cagtcttcac taccgtagaa
      481 gaccttggct ccaagatact cctcacctgc tccttgaatg acagcgccac agaggtcaca
      541 gggcaccgct ggctgaaggg gggcgtggtg ctgaaggagg acgcgctgcc cggccagaaa
      601 acggagttca aggtggactc cgacgaccag tggggagagt actcctgcgt cttcctcccc
      661 gagcccatgg gcacggccaa catccagctc cacgggcctc ccagagtgaa ggctgtgaag
      721 tcgtcagaac acatcaacga gggggagacg gccatgctgg tctgcaagtc agagtccgtg
      781 ccacctgtca ctgactgggc ctggtacaag atcactgact ctgaggacaa ggccctcatg
      841 aacggctccg agagcaggtt cttcgtgagt tcctcgcagg gccggtcaga gctacacatt
      901 gagaacctga acatggaggc cgaccccggc cagtaccggt gcaacggcac cagctccaag
      961 ggctccgacc aggccatcat cacgctccgc gtgcgcagcc acctggccgc cctctggccc
     1021 ttcctgggca tcgtggctga ggtgctggtg ctggtcacca tcatcttcat ctacgagaag
     1081 cgccggaagc ccgaggacgt cctggatgat gacgacgccg gctctgcacc cctgaagagc
     1141 agcgggcagc accagaatga caaaggcaag aacgtccgcc agaggaactc ttcctgaggc
     1201 aggtggcccg aggacgctcc ctgctccacg tctgcgccgc cgccggagtc cactcccagt
     1261 gcttgcaaga ttccaagttc tcacctctta aagaaaaccc accccgtaga ttcccatcat
     1321 acacttcctt cttttttaaa aaagttgggt tttctccatt caggattctg ttccttaggt
     1381 ttttttcctt ctgaagtgtt tcacgagagc ccgggagctg ctgccctgcg gccccgtctg
     1441 tggctttcag cctctgggtc tgagtcatgg ccgggtgggc ggcacagcct tctccactgg
     1501 ccggagtcag tgccaggtcc ttgccctttg tggaaagtca caggtcacac gaggggcccc
     1561 gtgtcctgcc tgtctgaagc caatgctgtc tggttgcgcc atttttgtgc ttttatgttt
     1621 aattttatga gggccacggg tctgtgttcg actcagcctc agggacgact ctgacctctt
     1681 ggccacagag gactcacttg cccacaccga gggcgacccc gtcacagcct caagtcactc
     1741 ccaagccccc tccttgtctg tgcatccggg ggcagctctg gagggggttt gctggggaac
     1801 tggcgccatc gccgggactc cagaaccgca gaagcctccc cagctcaccc ctggaggacg
     1861 gccggctctc tatagcacca gggctcacgt gggaaccccc ctcccaccca ccgccacaat
     1921 aaagatcgcc cccacctcca ccctca
//
