LOCUS       NM_018045               3309 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens BSD domain containing 1 (BSDC1), transcript variant 2,
            mRNA.
ACCESSION   NM_018045
VERSION     NM_018045.8
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3309)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3309)
  AUTHORS   Christians,A., Poisel,E., Hartmann,C., von Deimling,A. and Pusch,S.
  TITLE     Characterization of the epithelial membrane protein 3 interaction
            network reveals a potential functional link to mitogenic signal
            transduction regulation
  JOURNAL   Int J Cancer 145 (2), 461-473 (2019)
   PUBMED   30614533
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP363955.1, BC028381.2, CD628901.1, BQ222609.1, DB159029.1 and
            DB213122.1.
            
            On Jun 2, 2019 this sequence version replaced NM_018045.7.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site, compared to variant 1. The encoded isoform (b) is
            shorter than isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.120027.1,
                                           SRR1803611.123256.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000455895.7/ ENSP00000412173.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 BP363955.1         21-28
            9-1959              BC028381.2         1-1951
            1960-2341           CD628901.1         104-485
            2342-2766           BQ222609.1         220-644
            2767-3215           DB159029.1         109-557
            3216-3309           DB213122.1         464-557
FEATURES             Location/Qualifiers
     source          1..3309
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.1"
     gene            1..3309
                     /gene="BSDC1"
                     /note="BSD domain containing 1"
                     /db_xref="GeneID:55108"
                     /db_xref="HGNC:HGNC:25501"
                     /db_xref="MIM:617518"
     exon            1..38
                     /gene="BSDC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1320
                     /gene="BSDC1"
                     /note="isoform b is encoded by transcript variant 2; BSD
                     domain-containing protein 1"
                     /codon_start=1
                     /product="BSD domain-containing protein 1 isoform b"
                     /protein_id="NP_060515.3"
                     /db_xref="CCDS:CCDS363.2"
                     /db_xref="GeneID:55108"
                     /db_xref="HGNC:HGNC:25501"
                     /db_xref="MIM:617518"
                     /translation="MAEGEDVGWWRSWLQQSYQAVKEKSSEALEFMKRDLTEFTQVVQ
                     HDTACTIAATASVVKEKLATEGSSGATEKMKKGLSDFLGVISDTFAPSPDKTIDCDVI
                     TLMGTPSGTAEPYDGTKARLYSLQSDPATYCNEPDGPPELFDAWLSQFCLEEKKGEIS
                     ELLVGSPSIRALYTKMVPAAVSHSEFWHRYFYKVHQLEQEQARRDALKQRAEQSISEE
                     PGWEEEEEELMGISPISPKEAKVPVAKISTFPEGEPGPQSPCEENLVTSVEPPAEVTP
                     SESSESISLVTQIANPATAPEARVLPKDLSQKLLEASLEEQGLAVDVGETGPSPPIHS
                     KPLTPAGHTGGPEPRPPARVETLREEAPTDLRVFELNSDSGKSTPSNNGKKGSSTDIS
                     EDWEKDFDLDMTEEEVQMALSKVDASGELEDVEWEDWE"
     exon            39..99
                     /gene="BSDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            100..216
                     /gene="BSDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            217..384
                     /gene="BSDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            385..439
                     /gene="BSDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            440..555
                     /gene="BSDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            556..624
                     /gene="BSDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            625..703
                     /gene="BSDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            704..1183
                     /gene="BSDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1287
                     /gene="BSDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..3309
                     /gene="BSDC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2752..2757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BSDC1"
                     /note="hexamer: ATTAAA"
     polyA_site      2771
                     /gene="BSDC1"
     regulatory      2813..2818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BSDC1"
                     /note="hexamer: ATTAAA"
     polyA_site      2839
                     /gene="BSDC1"
                     /note="major polyA site"
ORIGIN      
        1 aaatagtggt gatgtcatgc aggcaagatg gcggaagggg aggacgtggg atggtggcgg
       61 agctggctgc agcagagcta ccaagcagtc aaagagaagt cctctgaagc cttggagttt
      121 atgaagcggg acctgacgga gtttacccag gtggtgcagc atgacacggc ctgtaccatc
      181 gcagccacgg ccagcgtggt caaggagaag ctggctacgg aaggctcctc aggagcaaca
      241 gagaagatga agaaagggtt atctgacttc ctaggggtga tctcagacac ctttgcccct
      301 tcgccagaca aaaccatcga ctgcgatgtc atcaccctga tgggcacacc gtctggcaca
      361 gctgagccct atgatggcac caaggctcgc ctctatagcc tgcagtcgga cccagcaacc
      421 tactgtaatg aaccagatgg gcccccggaa ttgtttgacg cctggctttc ccagttctgc
      481 ttggaggaga agaaggggga gatctcagag ctccttgtag gcagcccctc catccgggcc
      541 ctctacacca agatggttcc agcagctgtt tcccattcag aattctggca tcggtatttc
      601 tataaagtcc atcagttaga gcaggagcag gcccggaggg acgccctgaa gcagcgggcg
      661 gaacagagca tctctgaaga gcccggctgg gaggaggagg aagaggagct catgggcatt
      721 tcacccatat ctccaaaaga ggcaaaggtt cctgtggcca aaatttctac attccctgaa
      781 ggagaacctg gcccccagag cccctgtgaa gagaatctgg tgacttcagt tgagccccca
      841 gcagaggtga ctccatcaga gagcagtgag agcatctccc tcgtgacaca gatcgccaac
      901 ccggccactg cacctgaggc acgagtgcta cccaaggacc tgtcccaaaa gctgctagag
      961 gcatccttgg aggaacaggg cctggctgtg gatgtgggtg agactggacc ctcaccccct
     1021 attcactcca agcccctaac gcctgctggc cacaccggcg gcccagagcc caggcctcca
     1081 gccagagtag agactctgag ggaggaggcg cccacagact tacgggtgtt tgagctgaac
     1141 tcggatagtg ggaagtctac accctccaac aatggaaaga aaggctcaag cacggacatc
     1201 agtgaggact gggagaaaga ctttgacttg gacatgactg aagaggaggt gcagatggca
     1261 ctttccaaag tggatgcctc cggggagctg gaagatgtag agtgggagga ctgggagtga
     1321 gggagccaga gggagcagct cccccaccca tggcatctct cgcctccctc gctcgtctca
     1381 gcccagccct ggaagactga gaatgttccc ccaaatctcc tctgccaacc agagctctgg
     1441 gcacagattc tggtggctcc ctgctggccc tcttgggcct ctgctcacac ctgggaaggg
     1501 gctctctaaa tcccggccag aaactctgac ttgtgccaac aataggatga cccaagggag
     1561 aggaaaccta tcctcctcac cagaagagcc tgtgtttttc tgctgaacac ccactgttcc
     1621 tgaggactcc tgctgggaag tcccaaggga tagttctagc ccttctgcct gtgtagacag
     1681 aagctaaacc accagtctct ctcggaggaa gctgagacaa catactctgt ccatacataa
     1741 gcaggcaggg agggccatgc cacctaccct tggctaaaca gggacagtga acacattttg
     1801 gttcctatcc cagtgggtaa gaggcactta tctctgggaa atttgcctct cttgggactc
     1861 tccccctccc aggcattttc cattcctgga aaggctcctt tggggttcag aatccagaga
     1921 ccaaaccctg acccacctcc ttcctttcct ccagcccacg ctggtctgtc cccatgcctt
     1981 cccagggctt cttcatgtcg gatgcaccca agtccttagc ccagctgtgc cacctgcagg
     2041 agttcgctct tgcgtttctt cccctcccca agaagggagg gggctacttc aggcccttct
     2101 gtgtgttgcc tggcaggata ccttgtccaa ccagctaccc acctcaactc ccctgtagtt
     2161 taggacacaa aacagctacc agcggtacag agcggtgatc aaagccgagt acttacaact
     2221 ctggtaagcc tagcttctcc gcctcagccc ttctgcttct ggaagggcta tcctgggggt
     2281 gaacttgaaa ctctcatcag gcttctgcaa aagctcttct tcctgaagac agacccagcc
     2341 tttgtgctct caccctccac tctggtaaag ctgcacctct gggggaatga ggggctgcag
     2401 gaatctctgg agagcctggt gcttcacgat gctgctctgg tgattcttgt acctaatctg
     2461 gtgtgctcac caatgagtga aagggatcgt gggtcaggga caccgagaga gtgaggtcac
     2521 ttccacttca aaccttcagt gagggggtgg gatggagaga atgctgaatc ttttttttga
     2581 cgggatgggg tttttctctt tgtaattatt tctttagttt aattaacctt ttggttgttt
     2641 gtgcaatatt atatatttta aattataatg catctcccca gagtattttg tagctgggaa
     2701 aagaaaaaag gaaaaaaaga aaaaaagatt ctaacagctg ttagttttat aattaaaaaa
     2761 gaaagaaaaa agaactttgt cctgaacctt ttacagactt gccgttaaca gcattaaagt
     2821 gattcacccg aagctgaaag gtgtctgggg gtctgttttt gtccccttgg cagctgcact
     2881 gggccagggc aggactggct tcccacttgg agccagagac agggtagggg gatagcctag
     2941 gtccagagga cgtaccttgt cctcatccca gattcagctt tgcctttggg atgagaaagg
     3001 gtcagggctc gcaacaggcc tctcactggg acaaggagtc gggaggccat ctctgcactc
     3061 ccagtgcctc tgctttcctt tggaaaggaa gttgcaacaa gaatggcttc agttgctctt
     3121 ggtcattttt atcctctctt ccccctgttt gtatatgatt cttgggtcta ttttaattaa
     3181 ctttagtatg aaaatcactt gtcatgccag gcgcagtggc tcatgcctgt aatcccaaca
     3241 ttttgggagg ccaaggtggg tggatcacta aggtcaggag ttccagacca gcctggccaa
     3301 catggtgaa
//
