LOCUS       NM_153252              12921 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens bromodomain and WD repeat domain containing 3 (BRWD3),
            mRNA.
ACCESSION   NM_153252
VERSION     NM_153252.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12921)
  AUTHORS   Tian,M.Q., Liu,X.R., Lin,S.M., Wang,J., Luo,S., Gao,L.D.,
            Chen,X.B., Liang,X.Y., Liu,Z.G., He,N., Yi,Y.H. and Liao,W.P.
  CONSRTM   China Epilepsy Gene 1.0 Project
  TITLE     Variants in BRWD3 associated with X-linked partial epilepsy without
            intellectual disability
  JOURNAL   CNS Neurosci Ther 29 (2), 727-735 (2023)
   PUBMED   36514184
  REMARK    GeneRIF: Variants in BRWD3 associated with X-linked partial
            epilepsy without intellectual disability.
REFERENCE   2  (bases 1 to 12921)
  AUTHORS   Delanne,J., Lecat,M., Blackburn,P.R., Klee,E.W., Stumpel,C.T.R.M.,
            Stegmann,S., Stevens,S.J.C., Nava,C., Heron,D., Keren,B.,
            Mahida,S., Naidu,S., Babovic-Vuksanovic,D., Herkert,J.C.,
            Torring,P.M., Kibaek,M., De Bie,I., Pfundt,R., Hendriks,Y.M.C.,
            Ousager,L.B., Bend,R., Warren,H., Skinner,S.A., Lyons,M.J., Poe,C.,
            Chevarin,M., Jouan,T., Garde,A., Thomas,Q., Kuentz,P.,
            Tisserant,E., Duffourd,Y., Philippe,C., Faivre,L. and
            Thauvin-Robinet,C.
  TITLE     Further clinical and molecular characterization of an XLID syndrome
            associated with BRWD3 variants, a gene implicated in the
            leukemia-related JAK-STAT pathway
  JOURNAL   Eur J Med Genet 66 (1), 104670 (2023)
   PUBMED   36414205
  REMARK    GeneRIF: Further clinical and molecular characterization of an XLID
            syndrome associated with BRWD3 variants, a gene implicated in the
            leukemia-related JAK-STAT pathway.
            Review article
REFERENCE   3  (bases 1 to 12921)
  AUTHORS   Manojlovic,Z., Christofferson,A., Liang,W.S., Aldrich,J.,
            Washington,M., Wong,S., Rohrer,D., Jewell,S., Kittles,R.A.,
            Derome,M., Auclair,D., Craig,D.W., Keats,J. and Carpten,J.D.
  TITLE     Comprehensive molecular profiling of 718 Multiple Myelomas reveals
            significant differences in mutation frequencies between African and
            European descent cases
  JOURNAL   PLoS Genet 13 (11), e1007087 (2017)
   PUBMED   29166413
  REMARK    GeneRIF: BCL7A, BRWD3, and AUTS2 demonstrate significantly higher
            mutation frequencies among AA cases. These genes are all involved
            in translocations in B-cell malignancies. Moreover, we detected a
            significant difference in mutation frequency of TP53 and IRF4 with
            frequencies higher among CA cases. Our study provides rationale for
            interrogating diverse tumor cohorts to best understand tumor
            genomics across populations.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 12921)
  AUTHORS   Grotto,S., Drouin-Garraud,V., Ounap,K., Puusepp-Benazzouz,H.,
            Schuurs-Hoeijmakers,J., Le Meur,N., Chambon,P., Fehrenbach,S., van
            Bokhoven,H., Frebourg,T., de Brouwer,A.P. and Saugier-Veber,P.
  TITLE     Clinical assessment of five patients with BRWD3 mutation at Xq21.1
            gives further evidence for mild to moderate intellectual disability
            and macrocephaly
  JOURNAL   Eur J Med Genet 57 (5), 200-206 (2014)
   PUBMED   24462886
  REMARK    GeneRIF: A nonsense mutation in BRWD3 in a family with X-linked
            intellectual disability associated with macrocephaly.
REFERENCE   5  (bases 1 to 12921)
  AUTHORS   Suh,E.J., Kabir,M.H., Kang,U.B., Lee,J.W., Yu,J., Noh,D.Y. and
            Lee,C.
  TITLE     Comparative profiling of plasma proteome from breast cancer
            patients reveals thrombospondin-1 and BRWD3 as serological
            biomarkers
  JOURNAL   Exp Mol Med 44 (1), 36-44 (2012)
   PUBMED   22024541
  REMARK    GeneRIF: potential serological biomarker of breast cancer
REFERENCE   6  (bases 1 to 12921)
  AUTHORS   Bai,S.W., Herrera-Abreu,M.T., Rohn,J.L., Racine,V., Tajadura,V.,
            Suryavanshi,N., Bechtel,S., Wiemann,S., Baum,B. and Ridley,A.J.
  TITLE     Identification and characterization of a set of conserved and new
            regulators of cytoskeletal organization, cell morphology and
            migration
  JOURNAL   BMC Biol 9, 54 (2011)
   PUBMED   21834987
  REMARK    Erratum:[BMC Biol. 2024 Oct 10;22(1):228. doi:
            10.1186/s12915-024-02036-3.. PMID: 39390519]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 12921)
  AUTHORS   Tarpey,P.S., Smith,R., Pleasance,E., Whibley,A., Edkins,S.,
            Hardy,C., O'Meara,S., Latimer,C., Dicks,E., Menzies,A.,
            Stephens,P., Blow,M., Greenman,C., Xue,Y., Tyler-Smith,C.,
            Thompson,D., Gray,K., Andrews,J., Barthorpe,S., Buck,G., Cole,J.,
            Dunmore,R., Jones,D., Maddison,M., Mironenko,T., Turner,R.,
            Turrell,K., Varian,J., West,S., Widaa,S., Wray,P., Teague,J.,
            Butler,A., Jenkinson,A., Jia,M., Richardson,D., Shepherd,R.,
            Wooster,R., Tejada,M.I., Martinez,F., Carvill,G., Goliath,R., de
            Brouwer,A.P., van Bokhoven,H., Van Esch,H., Chelly,J., Raynaud,M.,
            Ropers,H.H., Abidi,F.E., Srivastava,A.K., Cox,J., Luo,Y.,
            Mallya,U., Moon,J., Parnau,J., Mohammed,S., Tolmie,J.L.,
            Shoubridge,C., Corbett,M., Gardner,A., Haan,E., Rujirabanjerd,S.,
            Shaw,M., Vandeleur,L., Fullston,T., Easton,D.F., Boyle,J.,
            Partington,M., Hackett,A., Field,M., Skinner,C., Stevenson,R.E.,
            Bobrow,M., Turner,G., Schwartz,C.E., Gecz,J., Raymond,F.L.,
            Futreal,P.A. and Stratton,M.R.
  TITLE     A systematic, large-scale resequencing screen of X-chromosome
            coding exons in mental retardation
  JOURNAL   Nat Genet 41 (5), 535-543 (2009)
   PUBMED   19377476
  REMARK    GeneRIF: Includes the identification of truncating mutations in
            this gene that segregated with mental retardation in the families
            tested.
REFERENCE   8  (bases 1 to 12921)
  AUTHORS   Field,M., Tarpey,P.S., Smith,R., Edkins,S., O'Meara,S., Stevens,C.,
            Tofts,C., Teague,J., Butler,A., Dicks,E., Barthorpe,S., Buck,G.,
            Cole,J., Gray,K., Halliday,K., Hills,K., Jenkinson,A., Jones,D.,
            Menzies,A., Mironenko,T., Perry,J., Raine,K., Richardson,D.,
            Shepherd,R., Small,A., Varian,J., West,S., Widaa,S., Mallya,U.,
            Wooster,R., Moon,J., Luo,Y., Hughes,H., Shaw,M., Friend,K.L.,
            Corbett,M., Turner,G., Partington,M., Mulley,J., Bobrow,M.,
            Schwartz,C., Stevenson,R., Gecz,J., Stratton,M.R., Futreal,P.A. and
            Raymond,F.L.
  TITLE     Mutations in the BRWD3 gene cause X-linked mental retardation
            associated with macrocephaly
  JOURNAL   Am J Hum Genet 81 (2), 367-374 (2007)
   PUBMED   17668385
  REMARK    GeneRIF: BRWD3 is therefore a new gene implicated in the etiology
            of XLMR associated with macrocephaly and may cause disease by
            altering intracellular signaling pathways affecting cellular
            proliferation.
REFERENCE   9  (bases 1 to 12921)
  AUTHORS   Muller,P., Kuttenkeuler,D., Gesellchen,V., Zeidler,M.P. and
            Boutros,M.
  TITLE     Identification of JAK/STAT signalling components by genome-wide RNA
            interference
  JOURNAL   Nature 436 (7052), 871-875 (2005)
   PUBMED   16094372
REFERENCE   10 (bases 1 to 12921)
  AUTHORS   Kalla,C., Nentwich,H., Schlotter,M., Mertens,D., Wildenberger,K.,
            Dohner,H., Stilgenbauer,S. and Lichter,P.
  TITLE     Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic
            leukemia disrupts two novel genes
  JOURNAL   Genes Chromosomes Cancer 42 (2), 128-143 (2005)
   PUBMED   15543602
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590031.6, AL669934.6 and
            AL512504.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_153252.4.
            
            Summary: The protein encoded by this gene contains a bromodomain
            and several WD repeats. It is thought to have a chromatin-modifying
            function, and may thus play a role in transcription. Mutations in
            this gene are associated with a spectrum of cognitive disabilities
            and X-linked macrocephaly. This gene is also associated with
            translocations in patients with B-cell chronic lymphocytic
            leukemia. [provided by RefSeq, Jul 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY497046.1, SRR7346977.2671199.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373275.5/ ENSP00000362372.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-437               AL590031.6         60951-61387         c
            438-496             AL590031.6         60756-60814         c
            497-526             AL590031.6         60523-60552         c
            527-586             AL590031.6         60049-60108         c
            587-737             AL590031.6         45132-45282         c
            738-836             AL590031.6         43364-43462         c
            837-997             AL669934.6         25333-25493         c
            998-1219            AL669934.6         23796-24017         c
            1220-1320           AL669934.6         15752-15852         c
            1321-1391           AL669934.6         14891-14961         c
            1392-1492           AL669934.6         13882-13982         c
            1493-1533           AL669934.6         13220-13260         c
            1534-1638           AL669934.6         9680-9784           c
            1639-1792           AL669934.6         8516-8669           c
            1793-1927           AL669934.6         4697-4831           c
            1928-2056           AL669934.6         3512-3640           c
            2057-2282           AL669934.6         2326-2551           c
            2283-2450           AL512504.9         220331-220498       c
            2451-2637           AL512504.9         218415-218601       c
            2638-2731           AL512504.9         216999-217092       c
            2732-2881           AL512504.9         210270-210419       c
            2882-2958           AL512504.9         208269-208345       c
            2959-3127           AL512504.9         205520-205688       c
            3128-3241           AL512504.9         204322-204435       c
            3242-3349           AL512504.9         200799-200906       c
            3350-3474           AL512504.9         197581-197705       c
            3475-3557           AL512504.9         196750-196832       c
            3558-3669           AL512504.9         193782-193893       c
            3670-3731           AL512504.9         192931-192992       c
            3732-3887           AL512504.9         192665-192820       c
            3888-4008           AL512504.9         191895-192015       c
            4009-4134           AL512504.9         190809-190934       c
            4135-4213           AL512504.9         190610-190688       c
            4214-4270           AL512504.9         188911-188967       c
            4271-4411           AL512504.9         187705-187845       c
            4412-4486           AL512504.9         186304-186378       c
            4487-4639           AL512504.9         184852-185004       c
            4640-4803           AL512504.9         183307-183470       c
            4804-4901           AL512504.9         182839-182936       c
            4902-5060           AL512504.9         182183-182341       c
            5061-12921          AL512504.9         170345-178205       c
FEATURES             Location/Qualifiers
     source          1..12921
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq21.1"
     gene            1..12921
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /note="bromodomain and WD repeat domain containing 3"
                     /db_xref="GeneID:254065"
                     /db_xref="HGNC:HGNC:17342"
                     /db_xref="MIM:300553"
     exon            1..437
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     CDS             407..5815
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /note="novel WD repeat domain protein; bromo
                     domain-containing protein disrupted in leukemia"
                     /codon_start=1
                     /product="bromodomain and WD repeat-containing protein 3"
                     /protein_id="NP_694984.5"
                     /db_xref="CCDS:CCDS14447.1"
                     /db_xref="GeneID:254065"
                     /db_xref="HGNC:HGNC:17342"
                     /db_xref="MIM:300553"
                     /translation="MAAAPTQIEAELYYLIARFLQSGPCNKSAQVLVQELEEHQLIPR
                     RLDWEGKEHRRSFEDLVAANAHIPPDYLLKICERIGPLLDKEIPQSVPGVQTLLGVGR
                     QSLLRDAKDCKSTLWNGSAFAALHRGRPPELPVNYVKPPNVVNITSARQLTGCSRFGH
                     IFPSSAYQHIKMHKRILGHLSSVYCVAFDRSGRRIFTGSDDCLVKIWATDDGRLLATL
                     RGHSAEISDMAVNYENTLIAAGSCDKVVRVWCLRTCAPVAVLQGHSASITSIQFCPST
                     KGTNRYLTSTGADGTICFWQWHVKTMKFRDRPVKFTERSRPGVQISCSSFSSGGMFIT
                     TGSTDHVIRIYYLGSEVPEKIAELESHTDKVVAVQFCNNGDSLRFVSGSRDGTARIWQ
                     YQQQEWKSIVLDMATKMTGNNLPSGEDKITKLKVTMVAWDRYDTTVITAVNNFLLKVW
                     NSITGQLLHTLSGHDDEVFVLEAHPFDQRIILSAGHDGNIFIWDLDRGTKIRNYFNMI
                     EGQGHGAVFDCKFSPDGNHFACTDSHGHLLLFGFGCSKYYEKIPDQMFFHTDYRPLIR
                     DANNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKFQRLVPGRENCKDEQLIPQLGYVA
                     NGDGEVVEQVIGQQTNDQDESILDGIIRELQREQDLRLINEGDVPHLPVNRAYSVNGA
                     LRSPNMDISSSPNIRLRRHSSQIEGVRQMHNNAPRSQMATERDLMAWSRRVVVNELNN
                     GVSRVQEECRTAKGDIEISLYTVEKKKKPSYTTQRNDYEPSCGRSLRRTQRKRQHTYQ
                     TRSNIEHNSQASCQNSGVQEDSDSSSEEDETVGTSDASVEDPVVEWQSESSSSDSSSE
                     YSDWTADAGINLQPPKRQTRQTTRKICSSSDEENLKSLEERQKKPKQTRKKKGGLVSI
                     AGEPNEEWFAPQWILDTIPRRSPFVPQMGDELIYFRQGHEAYVRAVRKSKIYSVNLQK
                     QPWNKMDLREQEFVKIVGIKYEVGPPTLCCLKLAFLDPISGKMTGESFSIKYHDMPDV
                     IDFLVLHQFYNEAKERNWQIGDRFRSIIDDAWWFGTVESQQPFQPEYPDSSFQCYSVH
                     WDNNEREKMSPWDMEPIPEGTAFPDEVGAGVPVSQEELTALLYKPQEGEWGAHSRDEE
                     CERVIQGINHLLSLDFASPFAVPVDLSAYPLYCTVVAYPTDLNTIRRRLENRFYRRIS
                     ALMWEVRYIEHNARTFNEPDSPIVKAAKIVTDVLLRFIGDQSCTDILDTYNKIKAEER
                     NSTDAEEDTEIVDLDSDGPGTSSGRKVKCRGRRQSLKCNPDAWKKQCKELLSLIYERE
                     DSEPFRQPADLLSYPGHQEQEGESSESVVPERQQDSSLSEDYQDVIDTPVDFSTVKET
                     LEAGNYGSPLEFYKDVRQIFNNSKAYTSNKKSRIYSMMLRLSALFESHIKNIISEYKS
                     AIQSQKRRRPRYRKRLRSSSSSLSSSGAPSPKGKQKQMKLQPKNDQNTSVSHARTSSP
                     FSSPVSDAAEGLSLYLLDDEPDGPFSSSSFGGYSRSGNSHDPGKAKSFRNRVLPVKQD
                     HSLDGPLTNGDGREPRTGIKRKLLSASEEDENMGGEDKEKKETKEKSHLSTSESGELG
                     SSLSSESTCGSDSDSESTSRTDQDYVDGDHDYSKFIQTRPKRKLRKQHGNGKRNWKTR
                     GTGGRGRWGRWGRWSRGGRGRGGRGRGSRGRGGGGTRGRGRGRGGRGASRGATRAKRA
                     RIADDEFDTMFSGRFSRLPRIKTRNQGRRTVLYNDDSDNDNFVSTEDPLNLGTSRSGR
                     VRKMTEKARVSHLMGWNY"
     exon            438..496
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            497..526
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            527..586
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            587..737
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            738..836
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            837..997
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1219
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1320
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1391
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1492
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1533
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1638
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1792
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1927
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2056
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2282
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2450
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            2451..2637
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2731
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2881
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            2882..2958
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            2959..3127
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            3128..3241
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            3242..3349
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            3350..3474
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..3557
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            3558..3669
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            3670..3731
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            3732..3887
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            3888..4008
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            4009..4134
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            4135..4213
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            4214..4270
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            4271..4411
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            4412..4486
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            4487..4639
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            4640..4803
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            4804..4901
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            4902..5060
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     exon            5061..12921
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      6607
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /note="major polyA site"
     regulatory      10852..10857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /note="hexamer: AATAAA"
     polyA_site      10884
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /note="major polyA site"
     regulatory      11139..11144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /note="hexamer: AATAAA"
     polyA_site      11164
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /note="major polyA site"
     regulatory      11544..11549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /note="hexamer: AATAAA"
     polyA_site      11570
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
     regulatory      12854..12859
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
                     /note="hexamer: AATAGA"
     polyA_site      12873
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
     polyA_site      12921
                     /gene="BRWD3"
                     /gene_synonym="BRODL; DCAF20; MRX93; XLID93"
ORIGIN      
        1 acttcggctc ctccctcttc tcgctccgtc tatctctctc tctctctctc tctccgcccc
       61 cccacccccc gcgtctctct ctctctctct ctctctctct ctctctctct ctctctcttt
      121 ttcctctctc tctctctctc ttctctctct ctctctcact cactcactct ctctctccct
      181 ctccctctcc tctccttcct cctccgcctc ctcagctctt gggctagaat atctatgggt
      241 cgaaacgtga tgcgatgaat tcgagagaga gcgaaactag gacgaggagt gcggcggaag
      301 cggcgggact cccgggcatg ggggcttcac cacaatagag gcagcgcccc cacccgcccc
      361 cgccagcccc tccggagcga agcccccaaa ccccctcggg aaaaggatgg cggcagcacc
      421 tacccagatc gaagccgagc tgtattacct gatcgctagg ttcttgcagt ctggaccctg
      481 caacaaatcc gctcaggtgc tagtgcagga gctcgaggag catcagctga ttccgcgccg
      541 cttagattgg gaggggaaag agcaccgaag aagcttcgag gatctggtgg cagcaaatgc
      601 acacattcct ccagactacc tccttaaaat ttgtgagaga attggtcctt tactagataa
      661 agagatccct cagagtgttc ctggggtaca gacattatta ggtgttggtc ggcagtctct
      721 gctacgggat gccaaagact gtaagagtac actatggaat gggtctgctt ttgcggctct
      781 gcatagaggc agacctccag aactacctgt aaattatgtg aaacctccaa atgtggtgaa
      841 tatcacctct gccaggcaat taaccggctg tagtcgcttt ggtcatattt tcccttcatc
      901 tgcttaccag cacattaaga tgcataagag aattctgggg cacttgtcat ctgtctactg
      961 tgtagcattt gaccgaagcg ggagaagaat ttttacaggt tcagatgact gtttagtaaa
     1021 aatttgggct acagatgatg gacgccttct tgctacactt cgtggacact ctgctgaaat
     1081 ttctgacatg gctgttaact atgaaaacac tcttattgct gcaggcagct gtgataaggt
     1141 agtaagagta tggtgtcttc gaacttgtgc acccgttgca gtccttcagg gccattcagc
     1201 ttctattact tccatacagt tttgtccatc aactaaaggc acaaacagat acctcacttc
     1261 tactggtgct gatggaacaa tctgtttctg gcaatggcat gtaaaaacaa tgaagtttag
     1321 agatcgcccg gtgaaattta ctgagagatc cagacctgga gtccagatat cttgttcatc
     1381 tttcagttct ggtggtatgt tcattacaac tggtagtact gaccatgtga ttagaatata
     1441 ttatttgggt tctgaggttc ctgagaaaat tgctgaatta gagtcacata cggataaagt
     1501 tgttgctgtt cagttctgta acaatggaga cagtttaaga tttgttagtg gaagtcgaga
     1561 tggaacggca agaatttggc agtatcagca acaagaatgg aagagtatag tgctagacat
     1621 ggctactaaa atgactggca ataatttgcc atctggagaa gacaagatca ctaaacttaa
     1681 ggtgactatg gtggcctggg atcgctatga taccacagtt attactgcag tgaacaattt
     1741 tcttttgaaa gtgtggaatt ctatcacagg acagcttctt catacattat ctggacatga
     1801 tgatgaagta ttcgttctag aagcccatcc atttgatcaa aggatcatac tttcagcagg
     1861 tcatgatggg aacattttta tttgggacct tgaccggggg accaaaattc ggaattactt
     1921 taacatgatt gaaggccaag gccatggtgc ggtgtttgat tgtaaatttt caccagatgg
     1981 aaaccatttt gcctgcacag attctcatgg acatttgctg ctttttggtt ttggatgcag
     2041 taaatactac gaaaagattc cagatcagat gttcttccac acggattatc gtcctcttat
     2101 tcgtgatgcc aataactatg tattggatga acaaacccaa caagctcctc acctcatgcc
     2161 tcctccattt ttggtggatg ttgatggaaa tcctcatccc acaaaattcc aacggttggt
     2221 accaggacgg gaaaattgta aagatgaaca gcttatacca cagctgggat atgtggctaa
     2281 tggtgatggt gaggtagtag aacaggtaat tgggcagcaa accaatgacc aagatgagag
     2341 cattcttgat ggaataatca gggagctgca gagagaacaa gacctgagac taattaatga
     2401 aggagatgtt ccacatttac cagttaatag agcatactct gttaatggtg ctctgagaag
     2461 tccaaacatg gacatatctt cttccccaaa catcaggctt cgaagacata gtagtcaaat
     2521 tgaaggtgtt agacaaatgc ataacaatgc tcctcggagc cagatggcca ctgaaagaga
     2581 tctcatggcg tggagcagaa gagtggtggt caatgaacta aataatgggg ttagtagggt
     2641 acaggaagaa tgtcgaactg caaaaggtga catagaaatc agtctttata cagttgaaaa
     2701 gaagaaaaag ccatcttaca ctactcaaag gaatgattat gagcctagct gtgggcgttc
     2761 tttacgcagg acacagcgca aacgtcagca tacttaccaa acacggtcca acatagagca
     2821 taattcacag gcatcatgtc aaaattcagg tgtacaggaa gactcagaca gttcttcaga
     2881 ggaagatgaa actgttggca caagtgacgc ttcggtagag gatcctgttg ttgaatggca
     2941 aagtgaaagt tcttccagtg actcatcaag tgaatattct gattggacag cagatgctgg
     3001 aataaattta caacccccaa aaagacaaac cagacagaca acacgtaaaa tatgcagcag
     3061 ctctgatgag gaaaatttga agtccctaga agaaaggcag aagaaaccta agcagactag
     3121 aaagaagaaa ggaggactgg tttctatagc aggtgagcct aatgaagaat ggtttgcccc
     3181 tcagtggatc ttggatacta taccccgacg ttccccattt gtcccacaaa tgggagatga
     3241 gcttatctat tttaggcaag gacatgaagc ttatgttcgg gctgtaagga aatcgaaaat
     3301 atacagtgtt aatttacaaa aacagccatg gaacaaaatg gatctcaggg agcaagagtt
     3361 tgttaagatt gtaggaatca aatatgaggt tggcccaccc acactgtgct gcttgaagct
     3421 tgcatttctg gacccaattt caggcaaaat gactggagaa tctttttcca ttaagtatca
     3481 tgacatgccg gatgtcattg acttccttgt gctacatcag ttttataatg aagccaaaga
     3541 aaggaactgg cagattggtg atagattccg cagtataata gatgacgcct ggtggtttgg
     3601 gactgtggag agtcagcagc cttttcaacc agagtatcct gatagttctt tccagtgtta
     3661 cagtgttcac tgggacaata atgagagaga aaagatgagc ccatgggata tggagccaat
     3721 tccagaagga actgcctttc cagatgaagt tggtgctggt gttcctgtct cccaggaaga
     3781 attgactgct ttgctataca aaccccagga aggagagtgg ggggctcatt ccagagacga
     3841 agaatgtgaa cgggttattc agggcatcaa ccaccttctt tccctggatt ttgccagccc
     3901 ttttgctgtt ccagtggatc tcagtgccta ccccttgtat tgtactgtag ttgcttatcc
     3961 aactgacctc aataccatca ggcggagact tgaaaatcgc ttttacagga gaatatcagc
     4021 attaatgtgg gaggtacgct atattgaaca taatgccagg actttcaatg agccagacag
     4081 tcctatagtt aaagcagcta aaattgtaac tgatgtctta cttcgattta ttggggatca
     4141 gagctgtact gatatactgg atacttataa taaaattaaa gcagaagaac gaaacagtac
     4201 tgatgcagag gaggatacag aaattgttga tttagattca gacggtcctg gtacttcatc
     4261 tggaagaaag gtcaaatgcc gaggcagaag acagtcttta aagtgtaatc ctgatgcttg
     4321 gaaaaaacaa tgcaaggaac tattgagcct catttatgaa cgtgaagact cggagccatt
     4381 tcgacagcca gctgatcttc tttcttaccc aggtcatcag gagcaagagg gagaatcctc
     4441 agagtctgtt gttccagaaa gacaacaaga ttcatctctt tctgaggatt atcaagatgt
     4501 tatagatact cctgtggact tcagcactgt gaaagaaact ttggaagcag gaaactatgg
     4561 tagtcctctg gaattttata aggatgttcg ccaaatattc aacaactcca aagcttatac
     4621 ctctaataaa aagtcaagga tctatagcat gatgctgcga ttatctgcct tatttgaaag
     4681 tcatatcaaa aatatcatct ctgaatataa gtcagcaatc cagagtcaga agaggagaag
     4741 gccacggtac agaaaacgtc taagaagcag cagcagttca ttatctagta gtggagcacc
     4801 tagtccaaaa gggaagcaga aacaaatgaa gttgcagcct aaaaatgacc agaatacctc
     4861 agtatctcat gccaggacta gctctccttt ctcatctcct gtttcagatg ctgctgaagg
     4921 gctttcacta tatctacttg atgatgagcc agatgggcca ttttcttcat cgagcttcgg
     4981 tggatatagc cgaagtggaa atagccatga cccagggaaa gccaaatcat ttcggaatag
     5041 agttttgcca gttaaacaag atcactccct tgatggaccc cttacaaatg gtgatggcag
     5101 agagccccgg acaggaatca agagaaaact acttagtgca tcagaagaag atgaaaacat
     5161 gggaggagaa gataaagaga aaaaagaaac aaaagagaaa tctcatttat ccacctcaga
     5221 gagtggagag ttaggatcca gtttaagttc tgaaagtacc tgtggttctg actctgactc
     5281 tgaatcaact tccagaacag atcaagatta cgtagatgga gaccatgatt atagcaaatt
     5341 catacaaacc agacctaaaa gaaaactcag aaagcaacat ggcaatggaa aaagaaattg
     5401 gaagaccaga ggcacaggag gaagaggcag atggggaaga tggggtagat ggagtagagg
     5461 aggcagagga agaggaggca ggggacgagg gagtcgagga agaggtggag gtggcactag
     5521 ggggagggga agagggagag gaggaagagg tgcttctaga ggagctacca gagccaaacg
     5581 agcacgtatt gcagatgatg aatttgatac catgttttca ggacgtttca gtagactgcc
     5641 tcgaattaaa acaagaaacc aaggcaggag gactgtttta tataatgatg attctgataa
     5701 tgacaatttt gtgtccactg aggatcctct gaatcttggt acatccagat caggcagagt
     5761 gcgtaaaatg acagaaaaag ccagggttag ccatctcatg ggatggaatt attaacagtt
     5821 aataaattta gaataactta aaaaattcaa tggccttcta ctgcagggaa tttaccagga
     5881 aatctacaaa gcaagttgtg tggggacttc tgcttccttt cacattggtg cttttccatt
     5941 tatgccagta tacatttgtt tcaagacttt tgatctccac acttcatttg ttcaaataag
     6001 ccttactcat taggccttaa attaaaagaa attctgccca cacacacaca aacacataca
     6061 cacacataca cacacacaga cacacacaca cgaaacacaa cacagacact acagatttac
     6121 tacattaaag gagcattcag cttcttaaga gtagcatgac atttttatct caatagaata
     6181 gccctctttt gcttttgtat cacagaagta tagcaccttc ttacagagtt ttatatagtt
     6241 tgtttttgcc attttgattc ctatacccag taataataac ttttgcacaa tacaccaatc
     6301 ctaaaggcag ctattaaatg tttacagttt ctatattgta agagcgatct ggattatttt
     6361 actcttccca ggccaaactt tcatgacttg tactgaactg aagtatatat ttatactaca
     6421 gttttttggg gggtgggggg atcttgatat gcttttcatt gatttgcata attcacgtta
     6481 aaggtgagaa agggttggtg ccttgtaaat atgtagcaga tcttcgtggt gtgttctgat
     6541 gtgtgcatta actttattaa aaaagaatac ttgaggtatc aatctagaca aggtgccaaa
     6601 tgcaaaagtt tcccgcatca atttttttcc tatcacattt tattgcatta atagaatttg
     6661 tgtagcttaa ataacttaaa catttgaaaa atcctcatcc acaaagaaca acttctttga
     6721 acagtagctc agctacctct taactacaac tactggaaac attaaggaaa atagatgctg
     6781 ttattcctta ctgactaagg agaaatagaa caagcttagt aggaatgaat accccataag
     6841 ttataagctg agaggttgtt aataattgta ttggctctca aattaataat tgtaattaac
     6901 aaagtttcat aaatatagta tgctctacca ccttaggctt tcttagaaca tatttgtgta
     6961 agtagacttg ggctactgct tatatatttc tgctccactt accatttaac agctgtgagt
     7021 tgctggtttt catttgaatc ttaaaattta acaaagcacc tggtttgatt tggaatgttt
     7081 tggctagcta gtattatgaa tcaacttata gattctgctc atatcattcc aaagggttct
     7141 tctgttctag tctttcagga aagaacctta ttgcactgca cactcatgtt gtgaatcatt
     7201 attttataga taaaaaacat ctttaaaaac ccttattgtc ttgtttacag cagtagagtg
     7261 cacatggttc cataagtgag cttgagttcc aaggtcagtt ttactcccca aatttaatat
     7321 tacagatttg ttcatttgtt agatacttac atttctgagg taagagggat aatagcaatt
     7381 tctgtttctg taacagcaaa tttgttgcac ttagatcagg ctcatgggat aaaacagact
     7441 tcttagtata tacctagcta tcccaggata tttcttaagc taatgtgttt gtctcatgct
     7501 ttcaatcatt tcatgcatct gaaaaccctt aagtgcagag gaaggcgtac acacataaaa
     7561 ctttgctttt ttggtagggt cggcagtagg gttattcttg gactaacatc tttaagcagt
     7621 tttcacttgc agtggaaatg atgttcaggc tttaagagaa agtattgtga attgttaatg
     7681 gcactaactt ctgttactag acagcagacc aagctatttt tttgttgtag tctttttttc
     7741 actaaaccaa aactacttct ggttgtaact cagctgccac tttaaaccat agtagagatt
     7801 caaaacgttc ctatttgaaa ctacatttga tttttgctaa aatgtgctgt ttcggttatt
     7861 tatctcttgg gcatttagac taaattgtgc ctgtattcct gaaatcaata atactttggc
     7921 ttatcctgat ctaagtaaca tagttactta aattcctgga tatacccaaa tatggatcac
     7981 atgtatcatt ttagtttgaa attttttgtt gacattcttc tatgaagagc tgacctcttg
     8041 aaatgtagaa gaattgacat ttgtgtgatt ttggctatct ggagctttat ttataattta
     8101 ttttgaaaaa taaaaatgcc acatttattt cccaaatgtc aagattttct agaattagat
     8161 aattagaata ataaggctga agacatttta aagcatattt tatatgtagt gaaatactgt
     8221 gaaaatatta gtgaacagca ttttgctgta atgtttattt cagttattaa gatttaaaga
     8281 gttagtcatc agggtatgtt agataaacat agttatcatt tattaaacaa acagataatt
     8341 ttctgtttgc atgcaaatta ttttaataag tgtgaaaata aaagtttgga agatagtatt
     8401 tttactttta tatctggact tttttttccc ccaatttaca ctttgctttc ttgtaatacc
     8461 acctcctgtg aatgtgttgt aattagtatc acattgatta ctttatcatt ttaatttctt
     8521 tgaggccctt taaacctacg taaaatctgg gtccagccat agcaaagcaa gtacaaaatg
     8581 aacaaagaat tttgaagaaa agcctaaatc ttaaattgct aagaaaaaac actgttatat
     8641 ttaggcccgt gagagcatat acatgtataa acctaatcct atgctagata tgaatagtca
     8701 gtgagctgta atatttctca taaatgctaa taatgtttaa attcccagct ttaagatctt
     8761 agtgtgtgta tatatttata aaatctgaat tgtgtgtttc ttctatggct tactgtgtgt
     8821 ttctctttca gcaataggat gctctctaaa acattcacta gcctactagc ctacttacta
     8881 aatttttgta tatgtgtgtt tgtgcacttg tatgtgtgta aagttttttc cccaacttga
     8941 cacaccttat ctcagacatt caaaaaaaga gaacattttg tatggaggac agtctgccaa
     9001 ctttttgcct ctctacagct cttagcctgt atatttactg cttgatcatt cattatgcct
     9061 tctagataac cagtccaggt tttgtcatat acctgtgtcc ctctattctt tttatttccc
     9121 tttttaattt tttttctttt ttttccctcc ccagaaatca ggcttgtgtt ggaattcttc
     9181 tctataatac tttgtttccc gcagatgcaa agtaacaaag taactgagta aaattagaaa
     9241 tctcattctg cacaactgtg cgctcagata tttaactcag ccttctaata cttttaagta
     9301 cgtttctgtt atttatcttt ttgttgtttt tgttttaatc ccatagattg tcatcagaca
     9361 ataatagagt gattgagaga gaaagatata aatgccactt ctaacttttt gataaaactt
     9421 ttttgagcat ttttcaaaaa tttgtatgtt tgtggtaatg gggaattaaa caccttttac
     9481 agctgatgta tgttggaaat cattttatgt acatttacca actggtactt atcttcaagt
     9541 tggaattttc acatccataa aagggagact tgcatcatat ataattttca gtatactttg
     9601 ctgtccagcc ttttaaacaa ttacagtaac attttgagtt ctgtgatgaa tagttctagg
     9661 ggaagggatg gaactttcga catgtaaagt ccattgtttt aaatgctaac cccatcccca
     9721 atatttttgt ggaacgtgag gctttatgaa aggtttatca gaaatagaat attctaaagt
     9781 cacttttatg gcttatttca aaaactagtg tgaaagtatt ttcatgcttt tttgtttctc
     9841 atcttttagc aaagcttctt taccaagttt tgattaaatt gcaatataaa attaagtttt
     9901 ttcacggtgc tatattttgt ggaatatggg tagcactcag gtttctttct tttttctttt
     9961 ctccttcctt cttccttcat tccttcattc ctccctcccc cctccctccc tccctctctt
    10021 ccttccctcc ttccttcctt cctcacctcg gcctcccaaa gtgctgggat tacaggcatg
    10081 agccaccgtg cccggcctat atacccttat tcttgattat ttcttttttc atcttttcaa
    10141 tcctgcttac ttttatcctc acttttcttt ctgccatgaa aactgcacct aatttaccac
    10201 acttaagatt ggcaattttt gattcattga tgggagaagt acagtagaaa ggccctgcag
    10261 tttagaatta agttgtgttt gtttatttac atgtatgccc atttcttcta aattaaatct
    10321 agaatgtgag actttgacat ataaaagcat gataagtatt ttcttaaaaa ataagactat
    10381 tgatacataa tgaaaccacc attggtaatt gaattttaaa atgatatgca aaaatattta
    10441 gaaatccagt tgggaaatgt gtttttgcat atgtcaccag atacacatta ggcagtacta
    10501 caaatgttaa ttcttaaaca atactgtggt gatggcaatc agtaatttat ttctttgtcc
    10561 tgtaacttat cattcttgtc ttttgtaatg tcttacacag tattaacata actgtacctt
    10621 ttttttgttc ttggtatcca tacattttaa gatggaaaat cagttcatag ttgatatgat
    10681 attgtatatg ggcaaaatgt ccgttaaact aaaattcagt aaaaaaggta atataaactg
    10741 gcttgattta taaaagatgt tttgtttggc agttatcagt cattataagc aattatcttc
    10801 aaagacaaaa aaactggact aatttgttgc cattctttat gggatgttta caataaaatt
    10861 ccaagttgtt tggaatcaat tgcactcttg ctgctttatg ccttaattta tgtaccagag
    10921 aaaaattaac cagaagaaag aaatatggag ttacctattc agctttagag attgtaacat
    10981 gtaactctta ggtctttctt gtttctttgt catagaatat tttattacta ttacttttta
    11041 atctgagaaa ctaggatgct tcttcctatc aaagaaaagg ttttgttttt tgttttcatc
    11101 ttagacattg caaatattct ttgggtcact tttaggataa taaatatgat gtttacactt
    11161 taaatgtggg ctgcttggtg cattcaataa cagcctgcaa agcatttgtc aacattttgt
    11221 tttgcagagc ttttcaaaat gaatagatct ctaacatatt tatgacttac aacttttaac
    11281 agctgagtta tatgtacctg acattttaaa atgtatagta agattaccta cattgtaaat
    11341 ggtgctttaa ttcagtgtaa gtgtaggaga gagagaagtg aggtgagatg atctgaatgc
    11401 tctaacagga acattcataa ctatatagtt acccagaatt tgtctcccag tggcaaacat
    11461 tccactaggt tcaagataaa taagctggcc aaagactgga ctgtatcttt gatatatata
    11521 tactgtgtat tttgtgtatt tagaataaaa aaaatgcatt taggaaaaaa gtagactgat
    11581 tttttacaat attcagagat tgaagtggag ataagttgtt tggtattttt gtttagttgc
    11641 ttaattggtt agagatagcc ctctttaagg atataaaaat cttacattaa aaatttttgg
    11701 ttaaggccag gcacagtgac tcacgtttat aatctcagca ttttgggaag ccatggtggg
    11761 aggattattt gagcccagga gttcaagacc agcctgggca gcatagtgag acaccgtatc
    11821 tacaaaacaa tttttttttt aattagctgg gcatggttgt gtgtgcctgt aagtcccagg
    11881 tacttgggag acaggtggga ggatcactcg agcctgggag gtcaaggctg cagtgagctg
    11941 tgatcatgcc actgcactcc agcctgggga tccatttttt ttccaagttg agaaggtcaa
    12001 gaaaaaggtg ctctccatcc tctctcaatt atatgttctt gacaatttaa agctacttta
    12061 ccaaaatgtg caaaataaaa ccaatatatt gagcctgtga gttgatcttt tgaatgagat
    12121 ttttggtggg atagttaagc ctatacgctt acagttgctt tctcaggtca tttatataaa
    12181 tacttaaggg ctttttaatg ctacaaaaca caggtagatc aaacaataat attaaatgaa
    12241 gtaaactttt tacggtatcg atttttcccc caaagttcta gggaaacatt ttcctttcct
    12301 ttctatgtaa ctttaataga tttttctttg ccatctgtga caattgcctt aatgaagttc
    12361 ttatctacag attataaaca tctaattata attataaaat cttataattt taattattct
    12421 agacatctag ttttaacagt tattaattaa caaattgata tttaatttga tgttggagac
    12481 ctaaaagtct ttctgaatct agtattaatt ttgaattgcc accttgcctg gtcagcatct
    12541 ttgcagttct cttcaatttt ataagttttg taagtaaata tatgaagaaa taaaaacatt
    12601 ttaaattctt taatttaggt gactaatatt aattgatgga gcttattcat ttttaaggat
    12661 ttttgtggtt gatttttgtc atgttgcaat tctagttaga atttgtataa caacatgtta
    12721 atttgtattg gcaattttgt atagtctgtt aagtaattta agtcaaggaa actgctaacg
    12781 tgttccctcc tcccttggct tttaaaaaaa agcttacaat atgtttaaat gaaatttgca
    12841 taacaaattg tgtaatagat catttgaaaa gtactgtttt gttacccttg agtattattc
    12901 atctaaaata ttaataatga a
//
