LOCUS       NM_033656              17728 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens bromodomain and WD repeat domain containing 1 (BRWD1),
            transcript variant 2, mRNA.
ACCESSION   NM_033656
VERSION     NM_033656.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 17728)
  AUTHORS   Guo,T., Tu,C.F., Yang,D.H., Ding,S.Z., Lei,C., Wang,R.C., Liu,L.,
            Kang,X., Shen,X.Q., Yang,Y.F., Tan,Z.P., Tan,Y.Q. and Luo,H.
  TITLE     Bi-allelic BRWD1 variants cause male infertility with
            asthenoteratozoospermia and likely primary ciliary dyskinesia
  JOURNAL   Hum Genet 140 (5), 761-773 (2021)
   PUBMED   33389130
  REMARK    GeneRIF: Bi-allelic BRWD1 variants cause male infertility with
            asthenoteratozoospermia and likely primary ciliary dyskinesia.
REFERENCE   2  (bases 1 to 17728)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 17728)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 17728)
  AUTHORS   Mandal,M., Maienschein-Cline,M., Maffucci,P., Veselits,M.,
            Kennedy,D.E., McLean,K.C., Okoreeh,M.K., Karki,S.,
            Cunningham-Rundles,C. and Clark,M.R.
  TITLE     BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis
  JOURNAL   Nat Commun 9 (1), 3888 (2018)
   PUBMED   30250168
  REMARK    GeneRIF: Study data indicate that, in both mice and humans, BRWD1
            is a master orchestrator of enhancer accessibility that cooperates
            with transcription factor networks to drive late B-cell
            development.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 17728)
  AUTHORS   Alves da Silva,A.F., Machado,F.B., Pavarino,E.C.,
            Biselli-Perico,J.M., Zampieri,B.L., da Silva Francisco Junior,R.,
            Mozer Rodrigues,P.T., Terra Machado,D., Santos-Reboucas,C.B., Gomes
            Fernandes,M., Chuva de Sousa Lopes,S.M., Lopes Rios,A.F. and
            Medina-Acosta,E.
  TITLE     Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and
            -Independent Manners
  JOURNAL   PLoS One 11 (4), e0154108 (2016)
   PUBMED   27100087
  REMARK    GeneRIF: RNA-seq evidence of biallelic expression of BRWD1 and 10
            neighboring genes in at least one primary human tissue tested
            indicates that the expression of BRWD1 is uncoupled from the
            control of the maternally inherited 5mCpG imprints at the WRB
            differentially methylated region (DMR) in disomic controls or
            trisomy (Down syndrome) individuals.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 17728)
  AUTHORS   Philipps,D.L., Wigglesworth,K., Hartford,S.A., Sun,F.,
            Pattabiraman,S., Schimenti,K., Handel,M., Eppig,J.J. and
            Schimenti,J.C.
  TITLE     The dual bromodomain and WD repeat-containing mouse protein BRWD1
            is required for normal spermiogenesis and the oocyte-embryo
            transition
  JOURNAL   Dev Biol 317 (1), 72-82 (2008)
   PUBMED   18353305
REFERENCE   7  (bases 1 to 17728)
  AUTHORS   Hu,Y.H., Warnatz,H.J., Vanhecke,D., Wagner,F., Fiebitz,A.,
            Thamm,S., Kahlem,P., Lehrach,H., Yaspo,M.L. and Janitz,M.
  TITLE     Cell array-based intracellular localization screening reveals novel
            functional features of human chromosome 21 proteins
  JOURNAL   BMC Genomics 7, 155 (2006)
   PUBMED   16780588
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 17728)
  AUTHORS   Huang,H., Rambaldi,I., Daniels,E. and Featherstone,M.
  TITLE     Expression of the Wdr9 gene and protein products during mouse
            development
  JOURNAL   Dev Dyn 227 (4), 608-614 (2003)
   PUBMED   12889071
REFERENCE   9  (bases 1 to 17728)
  AUTHORS   Ramos,V.C., Vidal-Taboada,J., Bergonon,S., Egeo,A., Fisher,E.M.,
            Scartezzini,P. and Oliva,R.
  TITLE     Characterisation and expression analysis of the WDR9 gene, located
            in the Down critical region-2 of the human chromosome 21
  JOURNAL   Biochim Biophys Acta 1577 (3), 377-383 (2002)
   PUBMED   12359327
  REMARK    GeneRIF: isolation and characterization of the gene located in the
            Down Syndrome critical region-2 of chromosome 21
REFERENCE   10 (bases 1 to 17728)
  AUTHORS   Vidal-Taboada,J.M., Bergonon,S., Sanchez,M., Lopez-Acedo,C.,
            Groet,J., Nizetic,D., Egeo,A., Scartezzini,P., Katsanis,N.,
            Fisher,E.M., Delabar,J.M. and Oliva,R.
  TITLE     High resolution physical mapping and identification of transcribed
            sequences in the Down syndrome region-2
  JOURNAL   Biochem Biophys Res Commun 243 (2), 572-578 (1998)
   PUBMED   9480850
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA792365.1, AJ238214.2,
            AK125906.1 and AF129408.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_033656.3.
            
            Summary: This gene encodes a member of the WD repeat protein
            family. WD repeats are minimally conserved regions of approximately
            40 amino acids typically bracketed by gly-his and trp-asp (GH-WD)
            residues which may facilitate formation of heterotrimeric or
            multiprotein complexes. Members of this family are involved in a
            variety of cellular processes including cell cycle progression,
            signal transduction, apoptosis, and gene regulation. This protein
            contains 2 bromodomains and multiple WD repeats. This gene is
            located within the Down syndrome region-2 on chromosome 21.
            Alternative splicing of this gene generates multiple transcript
            variants encoding distinct isoforms. In mouse, this gene encodes a
            nuclear protein that has a polyglutamine-containing region that
            functions as a transcriptional activation domain which may regulate
            chromatin remodelling and associates with a component of the
            SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun
            2011].
            
            Transcript Variant: This variant (2) has an alternate 3' sequence,
            as compared to variant 1. The encoded isoform B has a shorter and
            distinct C-terminus, as compared to isoform A.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ238214.2, AB080586.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000342449.8/ ENSP00000344333.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                DA792365.1         188-229
            43-4034             AJ238214.2         1-3992
            4035-4134           AK125906.1         2141-2240
            4135-5236           AJ238214.2         4093-5194
            5237-5429           AK125906.1         3343-3535
            5430-7538           AJ238214.2         5388-7496
            7539-17728          AF129408.4         22757-32946         c
FEATURES             Location/Qualifiers
     source          1..17728
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.2"
     gene            1..17728
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /note="bromodomain and WD repeat domain containing 1"
                     /db_xref="GeneID:54014"
                     /db_xref="HGNC:HGNC:12760"
                     /db_xref="MIM:617824"
     exon            1..190
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..6951
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /note="isoform B is encoded by transcript variant 2;
                     transcriptional unit N143; WD repeat protein WDR9-form2;
                     WD repeat-containing protein 9"
                     /codon_start=1
                     /product="bromodomain and WD repeat-containing protein 1
                     isoform B"
                     /protein_id="NP_387505.1"
                     /db_xref="CCDS:CCDS13663.1"
                     /db_xref="GeneID:54014"
                     /db_xref="HGNC:HGNC:12760"
                     /db_xref="MIM:617824"
                     /translation="MAEPSSARRPVPLIESELYFLIARYLSAGPCRRAAQVLVQELEQ
                     YQLLPKRLDWEGNEHNRSYEELVLSNKHVAPDHLLQICQRIGPMLDKEIPPSISRVTS
                     LLGAGRQSLLRTAKDCRHTVWKGSAFAALHRGRPPEMPVNYGSPPNLVEIHRGKQLTG
                     CSTFSTAFPGTMYQHIKMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNG
                     RLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSL
                     QFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSV
                     GGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTA
                     RIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAWNQNDSIVVTAVNDHVL
                     KVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIFIWDITKGTKMKHYF
                     NMIEGQGHGAVFDCKFSQDGQHFACTDSHGHLLIFGFGCSKPYEKIPDQMFFHTDYRP
                     LIRDSNNYVLDEQTQQAPHLMPPPFLVDVDGNPHPTKYQRLVPGRENSADEHLIPQLG
                     YVATSDGEVIEQIISLQTNDNDERSPESSILDGMIRQLQQQQDQRMGADQDTIPRGLS
                     NGEETPRRGFRRLSLDIQSPPNIGLRRSGQVEGVRQMHQNAPRSQIATERDLQAWKRR
                     VVVPEVPLGIFRKLEDFRLEKGEEERNLYIIGRKRKTLQLSHKSDSVVLVSQSRQRTC
                     RRKYPNYGRRNRSWRELSSGNESSSSVRHETSCDQSEGSGSSEEDEWRSDRKSESYSE
                     SSSDSSSRYSDWTADAGINLQPPLRTSCRRRITRFCSSSEDEISTENLSPPKRRRKRK
                     KENKPKKENLRRMTPAELANMEHLYEFHPPVWITDTTLRKSPFVPQMGDEVIYFRQGH
                     EAYIEAVRRNNIYELNPNKEPWRKMDLRDQELVKIVGIRYEVGPPTLCCLKLAFIDPA
                     TGKLMDKSFSIRYHDMPDVIDFLVLRQFYDEARQRNWQSCDRFRSIIDDAWWFGTVLS
                     QEPYQPQYPDSHFQCYIVRWDNTEIEKLSPWDMEPIPDNVDPPEELGASISVTTDELE
                     KLLYKPQAGEWGQKSRDEECDRIISGIDQLLNLDIAAAFAGPVDLCTYPKYCTVVAYP
                     TDLYTIRMRLVNRFYRRLSALVWEVRYIEHNARTFNEPESVIARSAKKITDQLLKFIK
                     NQHCTNISELSNTSENDEQNAEDLDDSDLPKTSSGRRRVHDGKKSIRATNYVESNWKK
                     QCKELVNLIFQCEDSEPFRQPVDLVEYPDYRDIIDTPMDFGTVRETLDAGNYDSPLEF
                     CKDIRLIFSNAKAYTPNKRSKIYSMTLRLSALFEEKMKKISSDFKIGQKFNEKLRRSQ
                     RFKQRQNCKGDSQPNKSIRNLKPKRLKSQTKIIPELVGSPTQSTSSRTAYLGTHKTSA
                     GISSGVTSGDSSDSAESSERRKRNRPITNGSTLSESEVEDSLATSLSSSASSSSEESK
                     ESSRARESSSRSGLSRSSNLRVTRTRAAQRKTGPVSLANGCGRKATRKRVYLSDSDNN
                     SLETGEILKARAGNNRKVLRKCAAVAANKIKLMSDVEENSSSESVCSGRKLPHRNASA
                     VARKKLLHNSEDEQSLKSEIEEEELKDENQLLPVSSSHTAQSNVDESENRDSESESDL
                     RVARKNWHANGYKSHTPAPSKTKFLKIESSEEDSKSHDSDHACNRTAGPSTSVQKLKA
                     ESISEEADSEPGRSGGRKYNTFHKNASFFKKTKILSDSEDSESEEQDREDGKCHKMEM
                     NPISGNLNCDPIAMSQCSSDHGCETDLDSDDDKIEKPNNFMKDSASQDNGLSRKISRK
                     RVCSSDSDSSLQVVKKSSKARTGLLRITRRCAATAANKIKLMSDVEDVSLENVHTRSK
                     NGRKKPLHLACTTAKKKLSDCEGSVHCEVPSEQYACEGKPPDPDSEGSTKVLSQALNG
                     DSDSEDMLNSEHKHRHTNIHKIDAPSKRKSSSVTSSGEDSKSHIPGSETDRTFSSEST
                     LAQKATAENNFEVELNYGLRRWNGRRLRTYGKAPFSKTKVIHDSQETAEKEVKRKRSH
                     PELENVKISETTGNSKFRPDTSSKSSDLGSVTESDIDCTDNTKTKRRKTKGKAKVVRK
                     GKTFTANISKTVRRQRQSKRPRLSVDDNDWEDLDYAKSKRVLRRSKIKTRNQGRRTVR
                     YHDGDDDRSLENVLDFNGCTL"
     exon            191..249
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            250..279
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            280..339
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            340..490
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            491..589
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            590..750
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            751..972
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1073
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1144
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1245
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1286
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1385
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1536
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1671
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1800
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..2026
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2212
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2396
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2397..2490
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..2622
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2717
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2718..2907
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2908..3033
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            3034..3141
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            3142..3266
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            3267..3349
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            3350..3461
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            3462..3523
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            3524..3679
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            3680..3800
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            3801..3926
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            3927..3999
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            4000..4041
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            4042..4185
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            4186..4338
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            4339..4505
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            4506..4726
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            4727..4894
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            4895..5794
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     exon            5795..17728
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      17294..17299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /note="hexamer: ATTAAA"
     polyA_site      17317
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /note="major polyA site"
     regulatory      17708..17713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /note="hexamer: AATAAA"
     polyA_site      17728
                     /gene="BRWD1"
                     /gene_synonym="C21orf107; CILD51; DCAF19; N143; WDR9;
                     WRD9"
                     /note="major polyA site"
ORIGIN      
        1 aggcggcgcg cacggtatgg cggcggcggc ggcggcggcg gcgcgcgcct gagaagaggg
       61 gacgccagcc cggtcaggcc tcggcgcggc ctacacgctc cgctcgctcg ctcgctcccg
      121 cctcccgccc cgcgcccggc catggcggag ccgtcgtccg cccgacgccc ggtgcctctc
      181 atcgagtcgg agctgtactt ccttatcgcc cggtacctat cggcgggccc gtgtcggaga
      241 gcggcccagg tgctggtgca ggagctggag cagtaccagt tgttgccgaa gagattggac
      301 tgggagggca acgagcacaa caggagctac gaggagttgg tcttgtccaa taagcatgtg
      361 gctcctgatc atcttttgca aatctgccag cgcatcggtc ctatgttgga taaagaaatt
      421 ccacccagta tttcaagagt cacttcttta cttggtgcag gaaggcagtc tttgctacgt
      481 acagcaaaag actgcaggca cacagtttgg aagggctctg cctttgctgc tcttcataga
      541 ggaagacctc ctgaaatgcc agtgaattat ggttccccac caaatcttgt ggagatacat
      601 cgaggaaaac aactcacagg gtgttccact tttagtacag catttccagg aactatgtat
      661 cagcatataa aaatgcacag aaggattctc ggacatctat ctgctgttta ctgtgtagca
      721 tttgatagga caggacatag aatctttaca ggttcagatg actgtttggt aaagatttgg
      781 tcaacacata atggccgctt gttatctaca ttaagaggtc attctgcaga aatttcagat
      841 atggcagtaa actatgagaa tacaatgatt gctgcgggga gctgtgataa aattattaga
      901 gtgtggtgct tgagaacttg tgccccagtt gctgtgctcc aaggacacac aggatcaatt
      961 acatctttac agtttagccc gatggccaaa ggctctcaaa gatacatggt ttccactggt
     1021 gctgatggga cagtttgctt ttggcaatgg gatttagaat ccttaaaatt tagcccacgt
     1081 cccctgaagt tcactgaaaa gcctaggcca ggcgttcaaa tgctttgttc ttcttttagt
     1141 gttggtggta tgtttttagc cacaggtagt actgatcatg taatcagaat gtattttttg
     1201 ggttttgaag cacccgaaaa aatcgcagaa cttgaaagcc acactgataa agtagatagt
     1261 atccaatttt gtaacaatgg tgatcggttc ctaagtggta gcagagatgg aacagcacgg
     1321 atttggagat ttgagcagtt agaatggagg agcattttat tggatatggc taccagaatc
     1381 tcaggggact tatcttccga agaggaaagg tttatgaaac ctaaagtaac aatgatagct
     1441 tggaatcaaa atgatagcat tgttgtcaca gctgtgaatg atcatgtcct caaagtgtgg
     1501 aattcttaca ctggacaact gcttcataac ttaatgggac atgctgatga agtatttgtt
     1561 ctggagacac atccctttga ttccagaatt atgttatctg caggacatga tggcagcata
     1621 tttatatggg atattacaaa aggtaccaag atgaaacatt attttaatat gattgaagga
     1681 caaggacatg gagctgtgtt tgactgtaag ttttcacagg atggacagca ttttgcctgt
     1741 acagattctc atgggcacct tctgatattt ggttttggat gcagcaaacc atatgaaaag
     1801 attcctgatc agatgttctt ccatactgac tatcgaccac ttattagaga ttctaataat
     1861 tatgtcttag atgagcaaac tcagcaggct cctcatctta tgcctccacc attcttggta
     1921 gatgtagatg gaaatcctca tccaaccaag tatcagagat tagtaccagg ccgagaaaat
     1981 tctgcagatg aacatttgat tccacagctg ggctatgtgg caacaagtga tggagaggtg
     2041 attgaacaaa ttataagcct gcaaaccaat gataatgatg aacgcagccc agaatcgagt
     2101 attcttgatg gaatgataag acagttgcag cagcagcaag atcagagaat gggagcagat
     2161 caggatacta ttccaagagg actttcaaat ggtgaagaaa caccccggag aggttttaga
     2221 aggctgagct tagacattca gtcccctcca aatattggtc tgcgtcgtag tggacaagtt
     2281 gaaggtgttc gtcagatgca tcaaaacgct ccacgcagtc agattgctac agaacgtgac
     2341 ctgcaggctt ggaaacgaag agtggttgta ccagaggtac cactaggcat atttaggaag
     2401 ctggaagact tccgattaga gaaaggtgaa gaggaaagaa atctttatat aataggaaga
     2461 aaaagaaaga ctcttcagct ctcacataag tcggattcag tggttttggt atcacagtct
     2521 agacaaagga catgtaggcg taaatatcca aattatggta gaagaaatcg tagctggcgt
     2581 gagttatctt ctggaaatga gtcttcaagc tctgtaagac atgagacttc ctgtgatcag
     2641 agtgaaggtt ctggttcttc agaagaggat gaatggagaa gtgacagaaa aagtgagagt
     2701 tacagcgaaa gttcaagtga ctcttcatct agatattccg attggacagc tgatgcgggc
     2761 atcaatttgc agcctccttt aagaacatca tgtcgtcgac gaattactcg attttgtagt
     2821 agttcagaag atgaaatatc tactgagaat ttatctcctc caaaaagaag acgaaagaga
     2881 aagaaagaaa ataagcctaa gaaggagaat ttgcggagga tgactccagc agagcttgca
     2941 aatatggagc atttatatga atttcaccct ccagtttgga ttactgacac cacacttaga
     3001 aaatctcctt ttgttcctca aatgggtgat gaggtaatat attttcgaca gggtcatgaa
     3061 gcttatattg aggctgtaag aagaaataat atttatgaac tgaaccctaa taaggagcca
     3121 tggagaaaaa tggatcttag ggatcaagaa ttggttaaaa tagttggaat acgatatgaa
     3181 gttgggcccc ctacactctg ttgcctaaaa ctagcattta tagatccagc aactggaaaa
     3241 cttatggaca aatctttctc tattagatat catgatatgc cagatgttat tgactttctt
     3301 gtattgcgtc aattttatga tgaagcaaga cagaggaatt ggcagtcttg tgacagattc
     3361 cgctctatta ttgatgatgc ttggtggttt ggaacagtgt taagtcaaga gccatatcaa
     3421 ccacagtatc ctgatagtca tttccagtgt tatattgtta ggtgggataa tactgaaatt
     3481 gaaaaactta gcccatggga catggaacca attcctgata atgttgatcc acctgaagaa
     3541 ttaggagcta gtatttctgt cacaacagat gagctagaga aattgctcta taaaccacaa
     3601 gctggtgaat ggggtcagaa atcaagagat gaagaatgtg atagaattat cagtggtata
     3661 gatcaacttt tgaatcttga tatagcagca gcttttgcag gccctgttga tttgtgtaca
     3721 tacccgaagt actgtactgt agtagcttat ccaaccgatc tttacacaat tcgaatgaga
     3781 cttgttaatc gattttacag gaggctgtct gcgttagttt gggaagtcag atatatagaa
     3841 cataatgcca gaacatttaa cgaacctgag agtgtaattg caagatcagc taaaaagata
     3901 actgaccaac ttttaaaatt tatcaagaat caacactgta caaatatctc agaactttct
     3961 aacacatctg aaaatgatga gcaaaatgct gaggatttgg atgatagtga tcttcctaaa
     4021 acatcttctg gaaggaggag agtccatgat gggaaaaaaa gcatcagagc tacgaactat
     4081 gttgaaagca actggaagaa acagtgtaag gaactagtga acttaatttt tcagtgtgaa
     4141 gattctgaac catttagaca acctgttgat ttggttgaat atccagacta cagagatatt
     4201 atagataccc caatggattt tggaacagta agggaaactc tagatgcggg aaattatgac
     4261 agccctttgg agttttgcaa agacatccgg ctgatattta gcaatgcaaa agcgtataca
     4321 ccaaacaaaa gatcaaagat ttatagtatg accttgagat tatctgcctt atttgaagaa
     4381 aaaatgaaga aaatctcttc tgattttaaa attggtcaaa aattcaatga aaaacttcga
     4441 agaagccaga ggttcaagca acggcaaaat tgtaaaggtg acagtcagcc taacaaaagt
     4501 atcagaaacc tcaagccgaa gaggttaaaa tctcagacaa aaataattcc tgagttggta
     4561 ggttctccta cccagtctac ctcaagtagg acagcttatc ttggaaccca caagacaagt
     4621 gctggtatct cttcaggtgt tacttctggt gactcttcag attcagcaga atcatcagaa
     4681 aggaggaaaa gaaatagacc tataacaaat ggttctacat tatctgaaag tgaagtggaa
     4741 gattctttag ctacctcttt gtcatcgtca gcttccagta gttctgagga aagcaaagag
     4801 agttccagag ctcgtgaatc ctcctcacgc agtgggctat ccagaagcag caatctcagg
     4861 gtaaccagaa ctagagctgc tcaaagaaaa actggtcccg tttcattagc aaatggatgt
     4921 ggcagaaaag ccactcgaaa gagagtctat ttaagtgatt ctgataacaa ttcattggag
     4981 actggtgaaa ttctaaaagc cagagctgga aataaccgaa aagtcttaag gaagtgtgct
     5041 gctgtggctg ccaataaaat aaagctaatg agtgatgtag aagagaattc tagctctgaa
     5101 agtgtctgtt ctggtcggaa gctgcctcac cgcaatgctt ctgctgtagc tagaaaaaag
     5161 ttattacata attctgaaga tgaacagagc ttaaagtcag aaattgaaga agaggagcta
     5221 aaagatgaaa atcaactatt accagtgtcc agttctcaca ctgcccagag caatgttgat
     5281 gaatctgaaa acagagactc agagtcagaa agtgatttgc gggtagcccg gaaaaattgg
     5341 catgctaatg gttacaagtc ccatactcca gcaccttcaa agacaaaatt tcttaaaata
     5401 gagtcttctg aggaagactc taaaagtcat gattcagatc atgcatgtaa cagaactgct
     5461 ggcccatcaa cgtctgtgca gaaacttaag gcagagagca tctcagagga agcagattct
     5521 gaaccaggaa gatctggtgg taggaaatac aatacatttc acaagaatgc gagtttcttt
     5581 aaaaaaacca agattctgag tgactcagaa gactctgaat ctgaagagca agatagagaa
     5641 gatgggaaat gtcataaaat ggaaatgaac ccaatttcag gaaatctgaa ctgtgaccct
     5701 attgctatgt cccagtgttc ctcagatcat ggatgtgaaa ctgatttaga ttcagatgat
     5761 gacaaaatag aaaaaccaaa caattttatg aaagattctg catcacaaga caatggacta
     5821 agcagaaaaa tttccaggaa aagggtctgt tccagtgact cagacagtag tttacaggtg
     5881 gttaagaaat catcaaaagc cagaacaggt ctcctgagga ttactcgaag atgtgcagct
     5941 acggctgcca ataagatcaa gctcatgagt gatgtagaag atgtcagttt agaaaatgtg
     6001 cacactagaa gcaaaaatgg aaggaaaaaa cctctccatc ttgcttgtac tacagctaag
     6061 aagaaattga gtgattgtga aggaagtgta cattgtgaag taccaagtga acagtatgcc
     6121 tgtgaaggca agccacctga tcctgactcc gaaggtagta caaaagtgct tagtcaggct
     6181 ctaaatggag actcagactc tgaagatatg ttgaattcag aacacaagca caggcatacc
     6241 aatattcaca aaatagatgc accttctaaa agaaaaagtt cctctgttac atcttcagga
     6301 gaagattcaa aaagtcatat tccagggagt gagactgata ggacattttc ttcagagtca
     6361 accttggcac aaaaagctac tgcagagaat aattttgaag tggaactgaa ttatgggctg
     6421 cgcaggtgga atggcagaag actcaggacc tatggaaagg ctccttttag taagacaaaa
     6481 gtgattcatg attcacagga aacagcagag aaggaagtaa aaaggaagag atcgcatcct
     6541 gaattggaaa atgtgaaaat ctctgaaaca actgggaatt caaagtttag acctgatact
     6601 agttccaaat catcagattt gggatctgta actgaatcag atattgactg tactgataat
     6661 acaaaaacca aaaggaggaa aacgaaagga aaagcaaaag tagttagaaa aggtaaaact
     6721 tttacagcta acatatctaa aactgtgaga cgtcaaagac aaagcaaacg ccctaggtta
     6781 agtgtggatg ataatgactg ggaggatttg gactatgcaa aatctaaaag agttcttcga
     6841 cgttcaaaaa taaaaacgag aaatcagggt agaaggactg tgagatacca tgatggggat
     6901 gatgacagaa gtttagaaaa tgtgttagat ttcaatggtt gcaccttatg accttgaggg
     6961 aaagccagtt catttaagag gaaatggact ggcatttatg gtgaaagctg gctgttaaaa
     7021 ttattttttt gtcttacaat tcagggaata tatttatatt tttctatgaa aagttatgaa
     7081 tgtgactaaa tcatgactgt tatttttatt tgcacttgct ggtctttgta gcagcattca
     7141 gcacaggtgc caaaatatgc ttcattttgg gggcagatct attttgacag tatttgacta
     7201 catatagcaa gagtttgaaa tatgttaaac actagacatc ctggttatca aaaccaatga
     7261 gcattacttt catggcagca agtgtcatgc agttattttc tgaatttgtc aaagaggcag
     7321 tagtttctaa cccctgttct atagtagtta caacaatttc acaacctatg tttacagatt
     7381 cttcataaat acatgcatac tgacactata atcatgggag gtgtaaccat gattagtagg
     7441 cgaggtacct accacttttt tttttttctt cccctggcta cttgagtaga atgcattata
     7501 ccagatctgg tcactttcat tgaaatggtt tctaattttc ttcccaagtg ctgttgggtt
     7561 tttttcttct taaggaaaac gttgtcactt ttatgttata aacttgaatt tataaagtgc
     7621 tggtaaatta tttttaatga tttgagtgca tgttttaaac ctctaggacc agagcatagt
     7681 cagagcattt tcttttaaat tgtgcactaa caaaatgcta tataatctgt cttctgtcca
     7741 agatctcctg gtttccattg taagggattt aaccaaaatc ttgctcttcc ataatcttac
     7801 tctgtgaaat agaggaattc gtgtgcctta gatttagaag tgtgttcttt aatagagtgt
     7861 acagggctaa aagagtattt aagttaatat gtaggtttcc cccatctgta ttccaattgt
     7921 agaggtgagt tttgttaaga gtacaattgc aaatcttatc tatataggaa aatagctaaa
     7981 tgtcattctc catctctttg ttttagttta ctgcttccat gtgcaatcct aagcattctt
     8041 tgctggggca actaaatgta tctttattag tgacttctag tccaaatata agaaactgtc
     8101 atgttttgtg ggaaaataat tttataatcc atttaaagtg aaagtttatc acacaaatag
     8161 tacacttatt ttctaaccaa atacttgata ggttatgcta ctccagtgta gatggccatt
     8221 cctaacttgt ttgtgcctga agatggactt gattcaaatg gtttacatat ttagtgggta
     8281 agggatatgt tacagtaccc cacctgtaag ttatttatta gccctaattg tgtttgattt
     8341 cagacaaaat taaccctttt ctcctgtgta tctttgaagt ggcagataag gtgaagcatc
     8401 agactggtat caatattaga caatgttatt tattagccct aattgtgttt ggtttcagac
     8461 aaaacctttt ctcctgtgta tctttgaagt ggcagacaag gcgaagcatc agactggtat
     8521 taatgttaga gaatgttctg aagtgttcct attttgtagt tatctattcc atttgacata
     8581 gtagaaggta cattttcttt ctactctgat gcatggggaa ggatgttttt ggacattatc
     8641 aactgagata ggtgggaaac ctcctctcat ttgtggctta gagagctatc accatttcag
     8701 aactatgatg cttttcttct cagaacttgt gttaagtaga tagtaaacag attgattcat
     8761 gataattgtc cttgactaag actgaaaaga ctaatgggat gccttttact ttgctaattt
     8821 taaaaactgg tgatagatgt caaatccatt aatttattta aactcttctt aaccttctct
     8881 tttataatct gttctcaggt tttaactcca tgtttaccat catttgcaaa aaggtaccaa
     8941 aaaaatccat aaataaatat ggaatacatt cataagtaca tacattcttt tggtataaaa
     9001 caatattttg acagtttagg cttcattaat agaactattc tgattatttg gactgcatta
     9061 attggtcatt gactggccat ccaattacca ttttttcttt cagtccaaaa tagttagacc
     9121 cttgcataca gaagtggtat tttggttttt aatcagattt ggtttcatca gaagcagcaa
     9181 gaatggacct gatgtcttta aaagcatagc cgacaatggt agcttctcaa gttatgaaat
     9241 aaaactgaga gataatggag aaaataattt ttatgggttt ttttggttat ggtgctattc
     9301 ctaaggttaa ctttgaatat gtgacacaca cactcctaag tacctttaag gaaaattaat
     9361 aaatcattaa tagttaaaat gtttacattg agcactagaa catgtttggc cttttttttc
     9421 tacgttatgc aaaatgccca gggatttaat gcacaggtgt actttaatgt ttagggtcag
     9481 tttgtagtat tcttgagaaa aagataaagg gttataattt gaatgtgaac tgatccagaa
     9541 ataagtgctg tacctttcca ctgcacttga agttcaactt aatggtgtat gtgaaaaaca
     9601 aaaactactt tggttgtgta tgtccaaagt cctatggttt tattcattta tggttttaca
     9661 ggctttgaag tactcagatt tgatttttgc tttcttggaa agactcactt taccaagcat
     9721 ataaaggaaa aatgatttca aacattgaca agatagatga gtgttaacaa agctttcttt
     9781 tttcgtgtcc tccttattta aaaaggtata cttacaatgt gaagtaactt atgaataaaa
     9841 ggaaaagttt atcccatatt caaataattc ctaaggtcag cctccctttt tgtaagtggc
     9901 aaatatctga ttaaatcatt tctcagttta ttaatccttg gaaacaatga tatagcagtt
     9961 actcacagct tgtaaattac aacagaaagg ttcctttcaa atagtagagc tgcacctaaa
    10021 gaggaaattg ggtttataag aaaatggagg caaagaactt aagttttaag aaaaagcact
    10081 tcaaaacaga agggcaaatg gaaaagggga atataaaaca aaccaataaa aataccatct
    10141 gagggtgtta ctgtccaaaa gtaaagaata agatgcatca ctaagccctt tgcactcgtt
    10201 atgacctcgt aagtaaaaat tatcacttag aataaggggt gcacactaca ttccctctgt
    10261 cttctagact tttttttttg tagaagaatc agaaaacaat ttactaacct ccctgtttga
    10321 tattaaaaat aggaagaatt ttaatatttt ctgttagtac aagttgaact tgattgtgcc
    10381 aactgaaacc ccagaggttt gtatatcagt agaatgcaag aacattgtta aaggtgctta
    10441 cgatcttttt tgttttcctt tccactccat tgtatcaatt ttttgagtaa cttttaaatg
    10501 gctagaaaat ggtctttttg ctttgccctt ttaaagctga aataaccagc tccattcttt
    10561 tcatgaatag taagttgata tatttattta tcaggtatct tgcagttgtc accaaatact
    10621 gtagttttct tatgttgtat ggaaattata gttcaattat tttaatgtga tagagtgcaa
    10681 caagtcattg tagaactttt cacctgttaa tgttgaagtt atacctctga atttctgctg
    10741 tggatatcaa ggaaataata aagcagaaac cccaagaaat ttgcaactta acagtttgag
    10801 actgtctctt atcctagtat ttgggaagag aaggaataaa tttgtcaaaa ctaggtgaga
    10861 aaatagagca ttgtgggaaa aactgagtcc aactagatta gcaaatgtta attcctagct
    10921 caaactgtga atagtaagga ttgaaaagta aagtatgtaa tgctaagggc tgtgttgtct
    10981 tttcttacga ttttaagttt taaaggctgt taaattacag agatgttgcc caaggataca
    11041 tggggattct caaaagtaag agatttttac ctttttcata atctgccaag ctggttccta
    11101 atatattgtt aaattggtag aaaaatatct ttaaattggt gtctgctcaa gaattgcttt
    11161 tctagatttg atggagggag ggggagagtc acatcatttg gattctacca atctgcaggc
    11221 tctatctttg gcaacatgta aataattaga ctatacatct gtttctcaag tatggcaaga
    11281 ccaatagttt gaatttaatt atcaatgcta tggtatactt tctggtcata ttttagttat
    11341 gtcagtttta aggtaagttt tttcatttat taaagccctt aaatgagatt ttagactgcc
    11401 aaagagaaga ggcagtccaa ttgacctaac tgaaatgaga tgaccagtat atagagccta
    11461 gatggactgt agcagctcta cccctttgtt ttacaaggta aatcatttta aaaattacct
    11521 tttttgatca gtgggtaaaa gttaaaggga tctttaattt ttgatatatt caagttaatt
    11581 ttctaaatgt gaatcagtcc ttggactgca actatatatt cacctacaaa atcccaatca
    11641 aaaaattaca tgagcctgtc aagcagatct ttagttttcc acttcacata agatcgttaa
    11701 tgttctaaat taatctattc atttagatga tttttgtcag ttcttaaatg ggatataata
    11761 aatttagcat tttcatctta acaagcaaaa gagttaaaaa acaaaacaaa acactactcc
    11821 aagccaaata cattctagct ggttaattcc agacttgtcc caagtggttc cccaacctct
    11881 tttccactgg taatttcttt tcatgcaggc agaatatagg ggtgcgagcg ctgtgagttt
    11941 tacatatgag cttggatagg ggaactgaag cgagtcagga gccctgctgg aaaaggggtt
    12001 tgccattgga ttgtctgtgg cctggtttct ttccagtagt acagtaatag ggtagattga
    12061 aaacaagtat ttacttctga ttctgcctgc atttagtgtg aaatgctctt aaggtattgc
    12121 ttctaaaaag caaattaagc agttaagtat aaagtccctg aattcatatt tcaaaataag
    12181 gcttttatga gatttttatt aaaaattgca atagccatca caaatctgag tttttctagg
    12241 ggtgagagaa aactgtattg tgatgagcta gattagttgt agttccagaa taagaacaaa
    12301 aattcagagt tgtgtggtgc ccatcattga gtaaatgaac cctaaaaatg aataagctaa
    12361 tgaactagtt catggaatta tttctgatgg tcttttgacc tgatgctgcc atactgcagt
    12421 gttaccagct ccccctagaa aacggaactg tttaaaaaca cagcaagtta cagaaaccat
    12481 tttattctac agccattggg gtacttcagt ttatgggatg tttttggaaa cttctgcttt
    12541 gggagggatg aagatcattg ataaatgtta tttgctttct gagttttggg gtcatttcat
    12601 tgcttatcaa tgaagggcag acagaggaga gaatatctca agtcttttct gataaaaggc
    12661 ttgcttgagg gagcttataa cttgcaccta gagggtttac ccactttgtg gatttgattt
    12721 atccaccaac cacagcaacc aataatgtca agattctagg agtttatgaa agaggctagt
    12781 atgttttcat tttgagtcag acattctttt ctcattctca aatctgtttt aaatgctcca
    12841 attttaaaaa tgccaatgaa aattttataa tgcttctgta gtaaccatat gcagtttact
    12901 ttgaatttag gaaaacagtt ttgtatgatg aaatattgtg cagaatctgt aaataaggta
    12961 gcttaaaaat taaaaaaaag tctaattaga atatgattaa tccttgaaat gtagaaacta
    13021 gagattgtgt tgagtcagaa ctgttatgtt tgtatccagg tttctattca ccacatatac
    13081 catcttagaa tacacacata tctgtgagtt ataatttaaa gtggtcatcc agggaaatga
    13141 tcatggagtg ctactacaga tgtacagttt tacactactg atgtgttctt gccataccca
    13201 agtagggaat cacttccagg aaaacaagtc ctcaagcact caatgacttt gtaaacccat
    13261 gactgaaaca agactcatct gaggcagtag gactggtggg attctactga cttcttagta
    13321 tcacatggca ccatcacaaa tgcattgtta gagcagcaac atccagagtt cttaagcttg
    13381 taccctaaca cacaaatttg acttctaacc ctgaaatatc ctatatatat ttctaaaact
    13441 gtttgtagtt ttcttgagaa aaagcacttt ataatttact cagttttcag taataaaatt
    13501 aacactgact tgaatgtatt taaaaaaatt ctccacagtt ttgtcttcct cagattgttt
    13561 ttatccttat tctctgaaat tcctgtttta ttgtctaaga cttaagagat tcagctttat
    13621 caagttagag tacagtgtaa ttcaaattct ccctcccttg ggcatagtta ctgaagttca
    13681 aatttcctta agtatttttt aaaaacctga ttttagtttt ttttttcctg cagaatctta
    13741 acttttccat tattctggat gacaaataaa catttattaa aatgtgttag aattagtatt
    13801 tactaggttc ctaaattgtc agtataggta ctttgatcac acatcaaaat ggaatttctg
    13861 caacttaaag cattttgtta caaattgtag ttgaaataga attttatcta tttgtctgga
    13921 tgaataggtt gttgggaatg aaccagttat ctgttctttt cttccaaatg caaatggtgc
    13981 agctagttga taatagtata ttctcatcct actataaagt gcaaatttca ccttaatttt
    14041 gcatatttta aaatttttgt ttaccctttg tagcatattt acattttagc atttgctaac
    14101 attgatttaa tgtgttaaag attcattttg gatatagggt tgacttgttg gagatactag
    14161 ttcataattt taaaattccc aagagaagtg tctttgaagt ggtaaacaca gtgcacttta
    14221 agccacttct cttcccacag agtccagctg aaggaggtaa gggcatgctg catgagagta
    14281 atgccgtgat gagtgtctta ctctggtaaa atgccattta caatgcctgg agactgaaca
    14341 ctgaacaaaa catagtgccc ttagaatttc actggaaaaa catgtgaatc acataagtta
    14401 gttggcaaaa ggaactgatg tgtatgtggt ggggttgctt tgaataaagt atttcctaac
    14461 ctattctggg gagaacgctc aactgatctt agagaagtgt gaaatcagtt tcatagactt
    14521 agggaaaaat ctgaagtgct tgcactgtga gggcagaggc ctgcctcatt agtctagctg
    14581 tatgaacatg tcagtccaca gaagcagttt ttacctgtac tcatctgccc ttcagtcagc
    14641 tttgtgacag aagggcaaac atcttcacag aagaaaaagt tcagaaggtt ggcattggtg
    14701 gtttcattgc tacagaataa tagtgttact tgatagtatc tgactaaaag agctctcatt
    14761 ttctagtact tagtagtaaa aagaatgtgg tggagtcctc cagatgtcta gtgtgggtgg
    14821 aggatatcaa ctggttattt cagtgatcta cagccttacc ttttgaatgc taaatgtctg
    14881 gaaacttcag gcagggtcct acaaaacaaa ctgccatcaa gattggtgtg taccatgaag
    14941 gcagttttag atagtttgac tgttcatggc tgcaagaaag acctaaaatt caagggcccg
    15001 tgaacttcag atacgtaaaa ggaatatcac ttctgttcta gaagagtact aattagactt
    15061 gtttgtgaaa tttgaaaatt tggctttgag acactggtaa caaacatatc tgagccctcc
    15121 taagtttggt cagcacggag tagtagctct ggcatcatgt ggctgtgtag agctccagtg
    15181 tgatttcaag ccccctctaa aaactgcctt agtctgcatg aagtagttaa ctctccaaag
    15241 tgctttttgt ctggcaaatc ccttcacaat tttcacctct cgtctaaaag cttccttaaa
    15301 ggaagccttc cttgatccct taggctaggt taggtttcca gtctgtgttc tcatagcact
    15361 ctgcactttt tggttcctta aagcaactct gtgttatttt ttagaatttt aatctgaatc
    15421 tcgtgtgtca catacctagg tcagaaaata ctggaacaat gaagttaaga tttagtaatt
    15481 caaattatgt aaaatgctca tatatatgtt tttagattag cagctttatg atgccgatgc
    15541 tgaaggaact tttcacccca ttcttacaag tctgctactg ttttaagtga catccttata
    15601 gttgtagata agcaaatgta aggttatatc aatgtgaaga agcccttagt atcacatttt
    15661 aaaatttatc atttagcaat atgactttta aatttattgt ttccgaatga gtgttgttga
    15721 ggaatgttag cagtagtaaa atcttgtgtt acaagatttt tgcatttaca tgaactttca
    15781 ctcatttttc agaatttgtt cctagagaca gagaacccaa tacaaaagtg agaacatgta
    15841 tgcataatca gaaggatgca gtgcagatgc ctagtgaaac tctgaaagca aaaatggtac
    15901 ctgagaaagt tccccgcaga tgtgctactg ttgctgcaaa taaaataaag ataatgagta
    15961 atctaaaaga aacgatctca ggaccagaaa atgtctggat taggaagagt agcagaaaac
    16021 tgccccatcg aaatgcttct gctgcggcta agaaaaaatt actgaatgtt tataaagagg
    16081 atgatacaac cataaattct gaaagtgaaa aagagctaga agatattaat agaaaaatgc
    16141 tttttttaag ggggttcaga tcctggaaag aaaatgcaca atagtgacta tgagaatgta
    16201 gaagtggcat ctgaaaacaa ttggtacaca agtaaactgg cagttacatt ctgctcccag
    16261 ctctaaaatt actcccttat tggcatcttt ggaggaattt tctaaaagcc ataatccagt
    16321 gggttcctcc cagtcagctc ttgtacagac atgtgctctg gggaattctg aggaggaaat
    16381 aaattgcaga gtctgtaggt ggagaggtgg aaagaaaaga caaatggcct gctataagac
    16441 tactattcct ttccagaatg caaggccttg aagacatgat tccttagagg aagaatataa
    16501 tgggaagtgt acaggctagg aagaacttga agtgaacaaa tttcaaaatc ttaacctgat
    16561 gctaattttc agggttctcc attacagtgt aaaaattcag accacgacaa ctatggtgtc
    16621 atgaggaaaa aaaatcaggc atttttccaa aggaagtgct aatgggccta tttgacttct
    16681 gagtgaagca aaaactaccc agatccattc cctacaattc acatccccaa aggtcaaaaa
    16741 caaactagga ggacctggga atttcagctg gagatactga ttattgagtt ctgaagtaga
    16801 gtgttggaaa taggcaatta gagaaagtcc attgatgtca ttttgtttat aatattgcag
    16861 ttcatactga atgaccactt gatatgacta attcagggaa tatatatttt tctatgaaag
    16921 ctatgaatgt tactatcacg gcttttcctt atttttactt gtatgtagca gcatttacag
    16981 aaatgccaaa aatgtgcctc attaagaggc aggtcttaat cagttagata aaaataaaat
    17041 gtatagctta agatcaaaac agtcatattt ttagatacag tgaaatcttt tatgtttctc
    17101 tacagcacct taaaaattag aacttgaata ctttgagtaa acttactaca atctcatccc
    17161 aacaaacttt aatggtagca tgtttggcct atttcattgt ggcctgtact aggattagaa
    17221 aatttggtcg tggtataaca aagaagtgta tttacaatag gatttaattt gttgttaata
    17281 tgtatttgtt gaaattaaaa ttgccagatt aaatgaatat actgtcgcat ctttttaaca
    17341 tagtaacgtg ttactggaaa aattaagttg ttgaaagtaa gttgttttcc catttaaaaa
    17401 tatctgaata tatgatttgc atgtgtaaat ctgaaaaact aaactacaga aacctagggt
    17461 tttctatttc ttttttaagt caaatgcatt tttttttttt tgttatacag atgaaccaag
    17521 tgtctaaaat acttgagaaa tttgtggttg catgtctgtt ttaaaaaaaa ggctttttgt
    17581 tttttagcat aagccagaat attctaacct actaagtctg tgtcctttgc tccttttgta
    17641 gtatactttc atctaaatta ctgatcccca atatgttgat acacaggtga gaaagggaag
    17701 aattcctaat aaactgctat tactttta
//
