LOCUS       NM_001256627            4528 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens BR serine/threonine kinase 2 (BRSK2), transcript
            variant 1, mRNA.
ACCESSION   NM_001256627
VERSION     NM_001256627.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4528)
  AUTHORS   Xu,R., Wang,K., Yao,Z., Zhang,Y., Jin,L., Pang,J., Zhou,Y.,
            Wang,K., Liu,D., Zhang,Y., Sun,P., Wang,F., Chang,X., Liu,T.,
            Wang,S., Zhang,Y., Lin,S., Hu,C., Zhu,Y. and Han,X.
  TITLE     BRSK2 in pancreatic beta cells promotes hyperinsulinemia-coupled
            insulin resistance and its genetic variants are associated with
            human type 2 diabetes
  JOURNAL   J Mol Cell Biol 15 (5) (2023)
   PUBMED   37188647
  REMARK    GeneRIF: BRSK2 in pancreatic beta cells promotes
            hyperinsulinemia-coupled insulin resistance and its genetic
            variants are associated with human type 2 diabetes.
REFERENCE   2  (bases 1 to 4528)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 4528)
  AUTHORS   Zhang,C., Wang,X., Fang,D., Xu,P., Mo,X., Hu,C., Abdelatty,A.,
            Wang,M., Xu,H., Sun,Q., Zhou,G., She,J., Xia,J., Hui,K.M. and
            Xia,H.
  TITLE     STK39 is a novel kinase contributing to the progression of
            hepatocellular carcinoma by the PLK1/ERK signaling pathway
  JOURNAL   Theranostics 11 (5), 2108-2122 (2021)
   PUBMED   33500714
  REMARK    GeneRIF: STK39 is a novel kinase contributing to the progression of
            hepatocellular carcinoma by the PLK1/ERK signaling pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4528)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4528)
  AUTHORS   Hiatt,S.M., Thompson,M.L., Prokop,J.W., Lawlor,J.M.J., Gray,D.E.,
            Bebin,E.M., Rinne,T., Kempers,M., Pfundt,R., van Bon,B.W.,
            Mignot,C., Nava,C., Depienne,C., Kalsner,L., Rauch,A., Joset,P.,
            Bachmann-Gagescu,R., Wentzensen,I.M., McWalter,K. and Cooper,G.M.
  TITLE     Deleterious Variation in BRSK2 Associates with a Neurodevelopmental
            Disorder
  JOURNAL   Am J Hum Genet 104 (4), 701-708 (2019)
   PUBMED   30879638
  REMARK    GeneRIF: damaging variation in BRSK2 is a source of
            neurodevelopmental disease
REFERENCE   6  (bases 1 to 4528)
  AUTHORS   Lu,R., Niida,H. and Nakanishi,M.
  TITLE     Human SAD1 kinase is involved in UV-induced DNA damage checkpoint
            function
  JOURNAL   J Biol Chem 279 (30), 31164-31170 (2004)
   PUBMED   15150265
REFERENCE   7  (bases 1 to 4528)
  AUTHORS   Lizcano,J.M., Goransson,O., Toth,R., Deak,M., Morrice,N.A.,
            Boudeau,J., Hawley,S.A., Udd,L., Makela,T.P., Hardie,D.G. and
            Alessi,D.R.
  TITLE     LKB1 is a master kinase that activates 13 kinases of the AMPK
            subfamily, including MARK/PAR-1
  JOURNAL   EMBO J 23 (4), 833-843 (2004)
   PUBMED   14976552
REFERENCE   8  (bases 1 to 4528)
  AUTHORS   Stanchi,F., Bertocco,E., Toppo,S., Dioguardi,R., Simionati,B.,
            Cannata,N., Zimbello,R., Lanfranchi,G. and Valle,G.
  TITLE     Characterization of 16 novel human genes showing high similarity to
            yeast sequences
  JOURNAL   Yeast 18 (1), 69-80 (2001)
   PUBMED   11124703
REFERENCE   9  (bases 1 to 4528)
  AUTHORS   Miura,K., Miyoshi,O., Yun,K., Inazawa,J., Miyamoto,T., Hayashi,H.,
            Masuzaki,H., Yoshimura,S., Niikawa,N., Jinno,Y. and Ishimaru,T.
  TITLE     Repeat-directed isolation of a novel gene preferentially expressed
            from the maternal allele in human placenta
  JOURNAL   J Hum Genet 44 (1), 1-9 (1999)
   PUBMED   9929968
REFERENCE   10 (bases 1 to 4528)
  AUTHORS   Miura,K., Masuzaki,H., Ishimaru,T., Niikawa,N. and Jinno,Y.
  TITLE     A HhaI/BstUI polymorphism in a novel gene at human chromosome
            11p15.5
  JOURNAL   J Hum Genet 43 (4), 283-284 (1998)
   PUBMED   9852686
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC136297.6, AF533879.1, AK131534.1 and AC091196.6.
            
            On Nov 22, 2018 this sequence version replaced NM_001256627.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF533879.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000528841.6/ ENSP00000432000.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               AC136297.6         61372-61709         c
            339-1102            AF533879.1         372-1135
            1103-1836           AK131534.1         1143-1876
            1837-2741           AF533879.1         1870-2774
            2742-4528           AC091196.6         69641-71427
FEATURES             Location/Qualifiers
     source          1..4528
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..4528
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /note="BR serine/threonine kinase 2"
                     /db_xref="GeneID:9024"
                     /db_xref="HGNC:HGNC:11405"
                     /db_xref="MIM:609236"
     exon            1..442
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /inference="alignment:Splign:2.1.0"
     CDS             352..2562
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.26"
                     /note="isoform 1 is encoded by transcript variant 1;
                     brain-selective kinase 2; BR serine/threonine-protein
                     kinase 2; protein kinase SAD1B; serine/threonine-protein
                     kinase 29; serine/threonine-protein kinase SAD-A;
                     brain-specific serine/threonine-protein kinase 2;
                     serine/threonine-protein kinase BRSK2; testicular tissue
                     protein Li 30"
                     /codon_start=1
                     /product="serine/threonine-protein kinase BRSK2 isoform 1"
                     /protein_id="NP_001243556.1"
                     /db_xref="CCDS:CCDS58107.1"
                     /db_xref="GeneID:9024"
                     /db_xref="HGNC:HGNC:11405"
                     /db_xref="MIM:609236"
                     /translation="MTSTGKDGGAQHAQYVGPYRLEKTLGKGQTGLVKLGVHCVTCQK
                     VAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGE
                     LFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDEKNNIRIADF
                     GMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDD
                     DNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNE
                     PEPEQPIPRKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSEEENQEKMIY
                     FLLLDRKERYPSQEDEDLPPRNEIDPPRKRVDSPMLNRHGKRRPERKSMEVLSVTDGG
                     SPVPARRAIEMAQHGQRSRSISGASSGLSTSPLSSPRVTPHPSPRGSPLPTPKGTPVH
                     TPKESPAGTPNPTPPSSPSVGGVPWRARLNSIKNSFLGSPRFHRRKLQVPTPEEMSNL
                     TPESSPELAKKSWFGNFISLEKEEQIFVVIKDKPLSSIKADIVHAFLSIPSLSHSVIS
                     QTSFRAEYKATGGPAVFQKPVKFQVDITYTEGGEAQKENGIYSVTFTLLSGPSRRFKR
                     VVETIQAQLLSTHDPPAAQHLSDTTNCMEMMTGRLSKCGSPLSNFFDVIKQLFSDEKN
                     GQAAQAPSTPAKRSAHGPLGDSAAAGPGPGGDAEYPTGKDTAKMGPPTARREQP"
     exon            443..537
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /inference="alignment:Splign:2.1.0"
     exon            538..623
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /inference="alignment:Splign:2.1.0"
     exon            624..764
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /inference="alignment:Splign:2.1.0"
     exon            765..881
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /inference="alignment:Splign:2.1.0"
     exon            882..915
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /inference="alignment:Splign:2.1.0"
     exon            916..984
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1131
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1163
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1328
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1426
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1577
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1638
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1846
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1895
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2019
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2200
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2290
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2338
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..4528
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3584
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /note="major polyA site"
     regulatory      4506..4511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /note="hexamer: AATAAA"
     polyA_site      4528
                     /gene="BRSK2"
                     /gene_synonym="C11orf7; PEN11B; SAD-A; SAD1; SADA; STK29"
                     /note="major polyA site"
ORIGIN      
        1 ggctcggctc ggctgcgcgg ccgctgacgg gcgtgcgctg ggggcgcggg gcgcggggcg
       61 cgggcctcgg cggcggcggc ggcggcggcg gcggaagcca ggtgcccccg cccgccctgt
      121 cctctcgacg aggcggaggc gtcgccgcgg gccaggcctc ggactgccgc gtcggagtgg
      181 acgcgggggg cggcggcgcg ggcggacgcg ggcggcgcga agcagcgggg cccgcggggg
      241 cgccccggcc gggtcggcgc ggacggcact cggcggacgc gggcggacgc tgggcggccc
      301 ctccctgccc gcgcgcccgg gcgcccctgg ccggcgccgg gccccagagc gatgacatcg
      361 acggggaagg acggcggcgc gcagcacgcg cagtatgttg ggccctaccg gctggagaag
      421 acgctgggca aggggcagac aggtctggtg aagctggggg ttcactgcgt cacctgccag
      481 aaggtggcca tcaagatcgt caaccgtgag aagctcagcg agtcggtgct gatgaaggtg
      541 gagcgggaga tcgcgatcct gaagctcatt gagcaccccc acgtcctaaa gctgcacgac
      601 gtttatgaaa acaaaaaata tttgtacctg gtgctagaac acgtgtcagg tggtgagctc
      661 ttcgactacc tggtgaagaa ggggaggctg acgcctaagg aggctcggaa gttcttccgg
      721 cagatcatct ctgcgctgga cttctgccac agccactcca tatgccacag ggatctgaaa
      781 cctgaaaacc tcctgctgga cgagaagaac aacatccgca tcgcagactt tggcatggcg
      841 tccctgcagg ttggcgacag cctgttggag accagctgtg ggtcccccca ctacgcctgc
      901 cccgaggtga tccgggggga gaagtatgac ggccggaagg cggacgtgtg gagctgcggc
      961 gtcatcctgt tcgccttgct ggtgggggct ctgcccttcg acgatgacaa cttgcgacag
     1021 ctgctggaga aggtgaagcg gggcgtgttc cacatgccgc actttatccc gcccgactgc
     1081 cagagtctgc tacggggcat gatcgaggtg gacgccgcac gccgcctcac gctagagcac
     1141 attcagaaac acatatggta tatagggggc aagaatgagc ccgaaccaga gcagcccatt
     1201 cctcgcaagg tgcagatccg ctcgctgccc agcctggagg acatcgaccc cgacgtgctg
     1261 gacagcatgc actcactggg ctgcttccga gaccgcaaca agctgctgca ggacctgctg
     1321 tccgaggagg agaaccagga gaagatgatt tacttcctcc tcctggaccg gaaagaaagg
     1381 tacccgagcc aggaggatga ggacctgccc ccccggaacg agatagaccc tccccggaag
     1441 cgtgtggact ccccgatgct gaaccggcac ggcaagcggc ggccagaacg caaatccatg
     1501 gaggtgctca gcgtgacgga cggcggctcc ccggtgcctg cgcggcgggc cattgagatg
     1561 gcccagcacg gccagaggtc tcggtccatc agcggtgcct cctcaggcct ttccaccagc
     1621 ccactcagca gcccccgggt gacccctcac ccctcaccaa ggggcagtcc cctccccacc
     1681 cccaagggga cacctgtcca cacgccaaag gagagcccgg ctggcacgcc caaccccacg
     1741 cccccgtcca gccccagcgt cggaggggtg ccctggaggg cgcggctcaa ctccatcaag
     1801 aacagctttc tgggctcacc ccgcttccac cgccggaaac tgcaagttcc gacgccggag
     1861 gagatgtcca acctgacacc agagtcgtcc ccagagctgg cgaagaagtc ctggtttggg
     1921 aacttcatca gcctggagaa ggaggagcag atcttcgtgg tcatcaaaga caaacctctg
     1981 agctccatca aggctgacat cgtgcacgcc ttcctgtcga ttcccagtct cagccacagc
     2041 gtcatctccc aaacgagctt ccgggccgag tacaaggcca cgggggggcc agccgtgttc
     2101 cagaagccgg tcaagttcca ggttgatatc acctacacgg agggtgggga ggcgcagaag
     2161 gagaacggca tctactccgt caccttcacc ctgctctcag gccccagccg tcgcttcaag
     2221 agggtggtgg agaccatcca ggcccagctg ctgagcacac acgacccgcc tgcggcccag
     2281 cacttgtcag acaccactaa ctgtatggaa atgatgacgg ggcggctttc caaatgtggc
     2341 agcccattga gtaacttctt tgacgtaatt aaacaacttt tttcagacga gaagaacggg
     2401 caggcggccc aggcccccag cacgcccgcc aagcggagtg cccacggccc actcggtgac
     2461 tccgcggccg ctggccctgg ccccggaggg gacgccgagt acccaacggg caaggacacg
     2521 gccaagatgg gcccgcccac cgcccgccgc gagcagcctt agacacacta gccccccccc
     2581 ccagcacagc actgacagcg gctgcctcgc cgcccgccgc ccgccctgcc ccgagtggac
     2641 ccgcggccgc gccgcccgtc cgtccagact gttctcagag cctgggagga aaggaaaggg
     2701 gcgttggggc cggcctgtgg gctgcgccac ccgcgcccgc tctcttttct ctctgtctct
     2761 gcctctgcct gtctctgaca gcatcgcttg tttccactct gataccagga attatcccga
     2821 aaagttaaca tgtcacctcc acgaggccat cctctgtgac cgaaggcagc tgctgcggac
     2881 ccgccctccc tccgctcctg ctgttgctgc cgggcagtga ggcccagccc agcgccccgt
     2941 ccaccccgcg gcagctcctc gcctcagctc cgcacggccc gtgggaggaa ggccaggctc
     3001 gggggagcct cctccagccc ggccgacccg gactcccggt cacctgaccc ctcagcaaga
     3061 acagcctgcc tggtggcctt ctggggccag gacccctggt gggcaacgta gccacaggaa
     3121 caggccccgt ccaccgcctc cacgccgcac ctggaggcct cctcgcaggc ccgtgccccg
     3181 cctccctggc tgcgccgcct ccgtgtagtc ttggcctcct caggctgcct cccgtcctct
     3241 cgtctcaccc gcgcctccct tgcctcatct ggggcggctg tgggctctgg cgctcctctc
     3301 tggctgaggt ggaaacagag acaccctgcg gcaccagagc cttcccagca ggccaggccg
     3361 ctgggctggg atcagtgtta tttatttgcc gttttaattt atggattctc cgcacctctg
     3421 ttcagggaag ggcggcggcc acatcccctg ccgtctgcgt gtctcaggca gtgggggggc
     3481 tggggccagg gcgccctctg aggacagagc tggtggggcg cgggggggct ggcgagctac
     3541 tgtaaacttt aaagaattcc tgcaagatat ttttataaac ttttttttct tggtggtttt
     3601 tggaaaaggg tgtgggggtg ggggcgccgc tggggcaggg ccaggttttg tgttttagtc
     3661 ccttgctcct gcttctttct acacacacat ctaaagacgg tgcggctcgc tctgtcatgg
     3721 gttccgtctc tctgtggaga agcagctcca cctctggggg ggctcggggc agaggggcgg
     3781 tgtcttgtag cgggcggcag cgccagcgcc cctctgtcag gctggggcaa tcttggtttt
     3841 gtgtccaaag gtgaaggggt aggaggaggg ccctcagctg gccctcccca cacacaggac
     3901 ggcaggggca ctgtgaggct tttcttatta aaatgaaaaa attgaaaaaa aaggacaaag
     3961 agtcggtggc gctcctctgc agggcgttct gtgcagagcg aggcccaggg cgcagccctc
     4021 agagggctgc aggcccaccc tgcccagtgc ccgccgccgt gcttcacccc agctccagct
     4081 tctgtgttcc cttccgccca tgtgcccagc cctcccaggc gggcacagcc cgggtgcggc
     4141 ggccgtgggg gacggcgggt ctgatgcatg cctctgccat ggagtcgtct gtctgcttcg
     4201 gtgcctgccc ctgcctccca cccacctcgt gtatagattt taacgcttct gttaacatta
     4261 gacctctgcc acaggctggg atttctatac ataagaacaa aagcaaacac ctaggacagc
     4321 aaacgccagg cggtacaggc gggaaggggc tctccacgga gatcgaggac acgaagcaaa
     4381 ctgcctcttg cttgccttcc ccttttgtgc ttcggacaca cgcggactcc agcaggcgcc
     4441 acggaaatgg gcaagcccct gcagtgtacc cctgtcataa ctgtgagcag ctgcagctcc
     4501 ggaacaataa atcccttccg caaagaca
//
