LOCUS       NM_015695               6052 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens bromodomain and PHD finger containing 3 (BRPF3), mRNA.
ACCESSION   NM_015695 XM_166450
VERSION     NM_015695.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6052)
  AUTHORS   Poh,J., Ponsford,A.H., Boyd,J., Woodsmith,J., Stelzl,U., Wanker,E.,
            Harper,N., MacEwan,D. and Sanderson,C.M.
  TITLE     A functionally defined high-density NRF2 interactome reveals new
            conditional regulators of ARE transactivation
  JOURNAL   Redox Biol 37, 101686 (2020)
   PUBMED   32911434
REFERENCE   2  (bases 1 to 6052)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 6052)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 6052)
  AUTHORS   Feng,Y., Vlassis,A., Roques,C., Lalonde,M.E., Gonzalez-Aguilera,C.,
            Lambert,J.P., Lee,S.B., Zhao,X., Alabert,C., Johansen,J.V.,
            Paquet,E., Yang,X.J., Gingras,A.C., Cote,J. and Groth,A.
  TITLE     BRPF3-HBO1 regulates replication origin activation and histone
            H3K14 acetylation
  JOURNAL   EMBO J 35 (2), 176-192 (2016)
   PUBMED   26620551
REFERENCE   5  (bases 1 to 6052)
  AUTHORS   Gong,F., Chiu,L.Y., Cox,B., Aymard,F., Clouaire,T., Leung,J.W.,
            Cammarata,M., Perez,M., Agarwal,P., Brodbelt,J.S., Legube,G. and
            Miller,K.M.
  TITLE     Screen identifies bromodomain protein ZMYND8 in chromatin
            recognition of transcription-associated DNA damage that promotes
            homologous recombination
  JOURNAL   Genes Dev 29 (2), 197-211 (2015)
   PUBMED   25593309
REFERENCE   6  (bases 1 to 6052)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   7  (bases 1 to 6052)
  AUTHORS   Doyon,Y., Cayrou,C., Ullah,M., Landry,A.J., Cote,V., Selleck,W.,
            Lane,W.S., Tan,S., Yang,X.J. and Cote,J.
  TITLE     ING tumor suppressor proteins are critical regulators of chromatin
            acetylation required for genome expression and perpetuation
  JOURNAL   Mol Cell 21 (1), 51-64 (2006)
   PUBMED   16387653
REFERENCE   8  (bases 1 to 6052)
  AUTHORS   Coppinger,J.A., Cagney,G., Toomey,S., Kislinger,T., Belton,O.,
            McRedmond,J.P., Cahill,D.J., Emili,A., Fitzgerald,D.J. and
            Maguire,P.B.
  TITLE     Characterization of the proteins released from activated platelets
            leads to localization of novel platelet proteins in human
            atherosclerotic lesions
  JOURNAL   Blood 103 (6), 2096-2104 (2004)
   PUBMED   14630798
REFERENCE   9  (bases 1 to 6052)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   10 (bases 1 to 6052)
  AUTHORS   Gogstad,G.O., Hagen,I., Korsmo,R. and Solum,N.O.
  TITLE     Characterization of the proteins of isolated human platelet
            alpha-granules. Evidence for a separate alpha-granule-pool of the
            glycoproteins IIb and IIIa
  JOURNAL   Biochim Biophys Acta 670 (2), 150-162 (1981)
   PUBMED   6457647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z84485.1, AB033112.1 and BC039615.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015695.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB033112.1, SRR1803611.249300.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357641.10/ ENSP00000350267.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                Z84485.1           49672-49700         c
            30-3475             AB033112.1         1-3446
            3476-6052           BC039615.1         348-2924
FEATURES             Location/Qualifiers
     source          1..6052
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.31"
     gene            1..6052
                     /gene="BRPF3"
                     /note="bromodomain and PHD finger containing 3"
                     /db_xref="GeneID:27154"
                     /db_xref="HGNC:HGNC:14256"
                     /db_xref="MIM:616856"
     exon            1..227
                     /gene="BRPF3"
                     /inference="alignment:Splign:2.1.0"
     exon            228..1701
                     /gene="BRPF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..3871
                     /gene="BRPF3"
                     /codon_start=1
                     /product="bromodomain and PHD finger-containing protein 3"
                     /protein_id="NP_056510.2"
                     /db_xref="CCDS:CCDS34437.1"
                     /db_xref="GeneID:27154"
                     /db_xref="HGNC:HGNC:14256"
                     /db_xref="MIM:616856"
                     /translation="MRKPRRKSRQNAEGRRSPSPYSLKCSPTRETLTYAQAQRIVEVD
                     IDGRLHRISIYDPLKIITEDELTAQDITECNSNKENSEQPQFPGKSKKPSSKGKKKES
                     CSKHASGTSFHLPQPSFRMVDSGIQPEAPPLPAAYYRYIEKPPEDLDAEVEYDMDEED
                     LAWLDMVNEKRRVDGHSLVSADTFELLVDRLEKESYLESRSSGAQQSLIDEDAFCCVC
                     LDDECHNSNVILFCDICNLAVHQECYGVPYIPEGQWLCRCCLQSPSRPVDCILCPNKG
                     GAFKQTSDGHWAHVVCAIWIPEVCFANTVFLEPIEGIDNIPPARWKLTCYICKQKGLG
                     AAIQCHKVNCYTAFHVTCAQRAGLFMKIEPMRETSLNGTIFTVRKTAYCEAHSPPGAA
                     TARRKGDSPRSISETGDEEGLKEGDGEEEEEEEVEEEEQEAQGGVSGSLKGVPKKSKM
                     SLKQKIKKEPEEAGQDTPSTLPMLAVPQIPSYRLNKICSGLSFQRKNQFMQRLHNYWL
                     LKRQARNGVPLIRRLHSHLQSQRNAEQREQDEKTSAVKEELKYWQKLRHDLERARLLI
                     ELIRKREKLKREQVKVQQAAMELELMPFNVLLRTTLDLLQEKDPAHIFAEPVNLSEVP
                     DYLEFISKPMDFSTMRRKLESHLYRTLEEFEEDFNLIVTNCMKYNAKDTIFHRAAVRL
                     RDLGGAILRHARRQAENIGYDPERGTHLPESPKLEDFYRFSWEDVDNILIPENRAHLS
                     PEVQLKELLEKLDLVSAMRSSGARTRRVRLLRREINALRQKLAQPPPPQPPSLNKTVS
                     NGELPAGPQGDAAVLEQALQEEPEDDGDRDDSKLPPPPTLEPTGPAPSLSEQESPPEP
                     PTLKPINDSKPPSRFLKPRKVEEDELLEKSPLQLGNEPLQRLLSDNGINRLSLMAPDT
                     PAGTPLSGVGRRTSVLFKKAKNGVKLQRSPDRVLENGEDHGVAGSPASPASIEEERHS
                     RKRPRSRSCSESEGERSPQQEEETGMTNGFGKHTESGSDSECSLGLSGGLAFEACSGL
                     TPPKRSRGKPALSRVPFLEGVNGDSDYNGSGRSLLLPFEDRGDLEPLELVWAKCRGYP
                     SYPALIIDPKMPREGLLHNGVPIPVPPLDVLKLGEQKQAEAGEKLFLVLFFDNKRTWQ
                     WLPRDKVLPLGVEDTVDKLKMLEGRKTSIRKSVQVAYDRAMIHLSRVRGPHSFVTSSY
                     L"
     exon            1702..1858
                     /gene="BRPF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1859..1990
                     /gene="BRPF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2119
                     /gene="BRPF3"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2432
                     /gene="BRPF3"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2735
                     /gene="BRPF3"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..3242
                     /gene="BRPF3"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..3336
                     /gene="BRPF3"
                     /inference="alignment:Splign:2.1.0"
     exon            3337..3434
                     /gene="BRPF3"
                     /inference="alignment:Splign:2.1.0"
     exon            3435..3532
                     /gene="BRPF3"
                     /inference="alignment:Splign:2.1.0"
     exon            3533..3687
                     /gene="BRPF3"
                     /inference="alignment:Splign:2.1.0"
     exon            3688..6052
                     /gene="BRPF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6030..6035
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRPF3"
                     /note="hexamer: AATAAA"
     polyA_site      6052
                     /gene="BRPF3"
                     /note="major polyA site"
ORIGIN      
        1 gtggcggcag cggcagcagc ggcggctcca ttccccctcc tcccccggga gcggcggcgg
       61 cggccgggcc ggggccccag cgcgggccgg gagggggcac ggcggaggcc acggaggcag
      121 gcgcgggaga agaccgcgct ccgcttcccg ggccgcgccg acctgctcgg cggcctgccc
      181 gcccgcgccc aggggccccg aacggtgggg ccgggcaggc ggctgaggcc tgtcccctca
      241 gttcccaggt gccatgagga agcctcgtcg gaagtcccgg cagaatgccg agggccggcg
      301 ttccccgtcc ccctacagtc tcaagtgctc acccacccgg gagaccctga catatgccca
      361 ggcccagcgg attgtcgagg tagacattga tggacgcctg catcgtatca gcatctatga
      421 cccactcaaa atcattactg aagatgagct aactgcccag gatatcaccg aatgcaatag
      481 taacaaggaa aacagtgaac agcctcagtt ccctggcaag tccaagaaac cctcatccaa
      541 gggcaaaaag aaggaatcct gctccaagca tgcatctggt acttccttcc acctcccaca
      601 gcccagcttc cgtatggtgg actcaggcat ccagccagaa gcacccccgc tgcctgctgc
      661 ctactaccgc tacattgaga agccacctga agacctggat gcagaggtag agtatgacat
      721 ggatgaggag gaccttgcct ggctggacat ggtgaatgaa aaacggcgag tagatgggca
      781 cagtttggtg tctgcagata cctttgagct gctggtagac cggcttgaga aagagtcata
      841 cttggagagt cgcagcagtg gggcccaaca gtcactcatc gatgaagacg ctttctgctg
      901 tgtgtgcctg gatgatgaat gtcacaatag caatgttatt ctcttctgtg acatctgcaa
      961 cctggctgta caccaggagt gctatggcgt cccatacatc cctgagggcc agtggctatg
     1021 ccgctgctgc ctgcagtctc cctcccggcc tgtggattgc atcctttgcc ccaataaggg
     1081 tggcgccttc aaacagacca gtgatgggca ctgggcccat gtggtgtgtg ccatctggat
     1141 ccctgaagtc tgctttgcta acaccgtgtt cttggaacct attgagggca ttgacaatat
     1201 cccgcctgcc cgctggaaac taacctgcta tatctgcaag cagaaagggc taggtgcagc
     1261 catccagtgc cataaggtga actgctacac agcattccat gtgacatgtg cacagcgggc
     1321 tgggctcttc atgaagattg agcccatgcg cgaaaccagc ctcaatggca ccatctttac
     1381 agtgcgcaag actgcctact gtgaggccca ctcgccacca ggtgcggcca ctgctaggag
     1441 gaagggcgac tcccctagaa gcatcagtga gactggcgat gaggaagggc tgaaggaggg
     1501 tgatggagag gaggaagaag aggaagaggt ggaggaagaa gagcaggaag ctcaaggcgg
     1561 ggtgagtggc tccctcaagg gagtgcccaa gaaaagcaag atgagtttga agcagaagat
     1621 caagaaggag ccagaggaag caggccaaga cacaccctcc actctcccca tgcttgctgt
     1681 cccacagata ccctcttaca ggttgaacaa gatctgtagt ggtctctcct ttcagaggaa
     1741 aaaccagttt atgcagcggc ttcacaatta ttggctgttg aagcggcagg cacggaatgg
     1801 tgtccctctt atccggcgct tgcactccca tctgcagtcc caaagaaacg ctgagcagcg
     1861 agagcaggat gagaagacaa gtgcagtgaa ggaggagctg aagtattggc agaagctccg
     1921 gcatgacttg gagcgggcgc ggctgctgat tgagctgatt cggaagagag agaagctcaa
     1981 acgagagcag gtcaaagtcc agcaggctgc catggagctg gagctgatgc cattcaatgt
     2041 tctgttgagg acaacactgg acctgctgca ggagaaggat cctgcacaca tcttcgcaga
     2101 accagtcaac ttgagtgagg ttccagatta cctggaattc atatccaagc caatggattt
     2161 ttctactatg aggcggaagc tggagtccca cctgtaccgc accttggagg agtttgagga
     2221 ggactttaac cttatagtta ccaactgcat gaagtataat gctaaagaca caattttcca
     2281 ccgagcagct gtccgcctgc gggacctggg aggggccatc ctacggcacg cccggcggca
     2341 ggcagagaac atcggctatg accccgagag gggcactcac ctgcccgagt cacccaaatt
     2401 ggaagacttt taccgcttct cctgggaaga cgtggacaac atcctcatcc cagagaaccg
     2461 ggcccatttg tccccagagg tgcagctgaa ggagctgctg gagaaactgg acctggtgag
     2521 cgccatgcgg tccagtgggg cccgcacccg tcgtgtccgc ctgctacgcc gggagatcaa
     2581 tgcccttcgg cagaagctgg cacagccacc accaccacag ccaccatcac tcaacaagac
     2641 agtatccaat ggggagctgc cagcagggcc ccagggggat gcagctgtgc tggagcaggc
     2701 cttgcaggag gagccagaag acgatgggga cagagatgac tccaaactgc ctcctccgcc
     2761 aaccctggag cccactgggc ctgcaccttc cttgtctgag caagaatccc ccccggagcc
     2821 ccctactctg aaacccatta atgatagcaa acctccaagc aggttcctaa agcccagaaa
     2881 ggtggaagaa gatgagctct tggaaaaatc accactgcag ctagggaatg agcctttgca
     2941 acgcttgctc agtgacaatg gcatcaacag actatccctc atggcccctg acaccccggc
     3001 cggtacccca cttagtggtg tgggtcgccg cacatcagtc ctcttcaaga aggccaagaa
     3061 tggggttaag ctacagagaa gcccagacag ggtcctggag aatggcgagg accatggtgt
     3121 ggcaggctct cctgcctctc cagccagcat cgaggaagag cgccactccc ggaagcggcc
     3181 aaggagcagg agctgtagtg agagcgaagg ggagaggtcc ccccagcagg aggaagagac
     3241 aggcatgacc aacggctttg gaaaacacac cgaaagcggg tctgactctg aatgtagttt
     3301 gggtctcagt ggtggactgg catttgaagc ttgcagtggt ctgacgcccc ccaaacgcag
     3361 ccgtgggaag ccagccctgt ctcgagtgcc cttcctggaa ggtgtgaacg gagactctga
     3421 ctacaatggc tcaggcagaa gcctcctgct gccctttgaa gaccgcggag acctggagcc
     3481 cttggagctg gtgtgggcca agtgccgagg ctacccctcc taccctgcct tgatcatcga
     3541 tcccaagatg ccccgggagg gcctcctgca caatggcgtt cccatccctg tccccccgct
     3601 ggacgtgctg aagctgggag agcagaaaca ggcagaggct ggagagaagc tcttccttgt
     3661 cctcttcttt gacaacaagc gcacctggca gtggcttcca agggacaaag tcctgccctt
     3721 gggtgtggaa gacaccgtgg acaagctcaa gatgctggaa ggccgcaaga ccagcatccg
     3781 caagtcagtg caggtggcct atgaccgtgc gatgatccac ctgagcagag tccgggggcc
     3841 ccactccttc gtcacttcca gctacctgta agggcagggc tgggcctgca tccgcttgcc
     3901 ctgcctccat cccgcagggc acagagaagc ctcttctgcc cctgccagat gtatggccgg
     3961 cagcttcccc ctctcatggt aggccaggga ctgggctttc tccccactaa gggcaaggcc
     4021 ccagttttga ccaatcgcat ggttctcctg gcaggcctgc tgtgtgccaa aaactcccac
     4081 ccaaggtccc tcaggggata tttcactgaa gaaccagtta gaagtagaaa cagctgtggg
     4141 gcttgggccc agcttaggag attgcccaga tggcaagagg tcctgggctc cttcttgagg
     4201 ggctgcctgg cccgctccat cctactccca ctaactacac ctcagggcgg gtgaggttcc
     4261 gacactgatc ccagagatgc cgtggatacg ccagggtccc agggggaatc tccccaagct
     4321 cacactctct cccgcttatc gcctattctc acacctcttc tcggtcccat cttctgcacc
     4381 cattgcccag tcttgctttc tctttcccat attccttttc tttttctctt gtgccaaact
     4441 gacagaaacc gtcaccacac tggtcttttt ctttaatgtc tcattcccct tgaggccagc
     4501 tgctatgcca ggtggtgtct ctgccaggct cctcaggccc agacagaggc cagcccacaa
     4561 cctatgaccc cctcccccag gacaccacct cccacccaca gaccttccct ttagctgttg
     4621 acacaacttc ccagctctgc aagtgtgccc cctggatcaa ggcgggtccc ctcttgtttt
     4681 tttctttgct gccacgaggt ggtccaagcc ttcagggtgg gctcctatca ggctgggtgt
     4741 gcgagtgtcc atctgtccac atggatgtcg agggtggttt gtgtggagct gtgctcgtca
     4801 gctgggtctg ccctcttccc ccttttctcc ttcttctctc ctcatggact ttttctgcaa
     4861 ttgcagtctt aagcttcact ctccaccacc tggatggcat ggcgcctgcc accaaacatc
     4921 ttcctggcct gcgctctgcc ctgccctgcc tagcctctgc tactcccact tcccaactcc
     4981 agggaatgca ttacttttat ttcaaaccct ctgcctcctt ccttctttct cttcaacccc
     5041 ctccccacct tcaccttctc aaaaatggaa ggaaaaaaaa actgtgaatg gggaatgctg
     5101 actgacaaac caacacaact ttcagaggct tcagtgtctg ttctctggac atttcttttc
     5161 acctcctgag caccaaagtc gcagggccag ttgcaggccg ctgattgcca tgttgatttt
     5221 taacctgata ttctttttaa ttgttttaaa tttttcatag gggagttttg gacaaaacag
     5281 tcactgggga gatcactgcc atttttacac acttgacttt ttaaaaatac aaccaaccaa
     5341 ccaccacaac ttcttataca tttgggacat gagccagagt ttaaaaggga accaacaaaa
     5401 cactataact taaaaggatg gggttttgga ttttgtataa taataaaaac aatacagcat
     5461 atggctaggg aaggacatgg tgtatataat tgtaaaatac tgttctaaat tattcaggcc
     5521 tatagtttcc attactggag tcctccattg tgtggccaca cagtgtcgtt gatttaaagg
     5581 agccagtgct tcccctctcc ccaggtagtt ggtcagctgt ggactctgtg acctttgtct
     5641 aaacctgtgt tgtaagatct tgggacttcc tctctttcta tgtctatctc ttccccccaa
     5701 cactttctct tcttagtctc tctctttatt tttcaatctc tgaatatttt agtctctctc
     5761 tgagtctcat tttttaaaat gctcttttag aacgggaaac ggctcagatc ctgctgtggc
     5821 acggggccta tgtgtctctg tcgcgtctgc tgtgaagcac atgatgctct atttattgta
     5881 gagagtgact ttatttgctt tctagaattg tttataacag atggtataag agaggtaata
     5941 aacagagaaa aatctatgct tgtaaagaat acaaaagtta attttaccta ctataatatg
     6001 actgtctgaa acttattttc tctctgagaa ataaatgttc taatgggcag ta
//
