LOCUS       NM_032352               2637 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens BRMS1 like transcriptional repressor (BRMS1L), mRNA.
ACCESSION   NM_032352
VERSION     NM_032352.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2637)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2637)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2637)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2637)
  AUTHORS   Cao,P., Zhao,S., Sun,Z., Jiang,N., Shang,Y., Wang,Y., Gu,J. and
            Li,S.
  TITLE     BRMS1L suppresses ovarian cancer metastasis via inhibition of the
            beta-catenin-wnt pathway
  JOURNAL   Exp Cell Res 371 (1), 214-221 (2018)
   PUBMED   30118697
  REMARK    GeneRIF: BRMS1L suppresses ovarian cancer metastasis via inhibition
            of the beta-catenin-WNT pathway.
REFERENCE   5  (bases 1 to 2637)
  AUTHORS   Lv,J., Yang,H., Wang,X., He,R., Ding,L. and Sun,X.
  TITLE     Decreased BRMS1L expression is correlated with glioma grade and
            predicts poor survival in glioblastoma via an invasive phenotype
  JOURNAL   Cancer Biomark 22 (2), 311-316 (2018)
   PUBMED   29660900
  REMARK    GeneRIF: low levels of BRMS1L is associated with glioma progression
            and plays as an independent poor prognosis biomarker. The
            up-regulation of BRMS1L suppresses glioma cells' invasion. All of
            those indicate that BRMS1L is a novel prognostic biomarker with
            potential anti-invasion therapeutic implications in GBM.
REFERENCE   6  (bases 1 to 2637)
  AUTHORS   Gong,C., Qu,S., Lv,X.B., Liu,B., Tan,W., Nie,Y., Su,F., Liu,Q.,
            Yao,H. and Song,E.
  TITLE     BRMS1L suppresses breast cancer metastasis by inducing epigenetic
            silence of FZD10
  JOURNAL   Nat Commun 5, 5406 (2014)
   PUBMED   25406648
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2637)
  AUTHORS   Smith,K.T., Sardiu,M.E., Martin-Brown,S.A., Seidel,C.,
            Mushegian,A., Egidy,R., Florens,L., Washburn,M.P. and Workman,J.L.
  TITLE     Human family with sequence similarity 60 member A (FAM60A) protein:
            a new subunit of the Sin3 deacetylase complex
  JOURNAL   Mol Cell Proteomics 11 (12), 1815-1828 (2012)
   PUBMED   22984288
REFERENCE   8  (bases 1 to 2637)
  AUTHORS   Munoz,I.M., MacArtney,T., Sanchez-Pulido,L., Ponting,C.P., Rocha,S.
            and Rouse,J.
  TITLE     Family with sequence similarity 60A (FAM60A) protein is a cell
            cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase
            complex
  JOURNAL   J Biol Chem 287 (39), 32346-32353 (2012)
   PUBMED   22865885
REFERENCE   9  (bases 1 to 2637)
  AUTHORS   Nikolaev,A.Y., Papanikolaou,N.A., Li,M., Qin,J. and Gu,W.
  TITLE     Identification of a novel BRMS1-homologue protein p40 as a
            component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex
  JOURNAL   Biochem Biophys Res Commun 323 (4), 1216-1222 (2004)
   PUBMED   15451426
REFERENCE   10 (bases 1 to 2637)
  AUTHORS   Zhang,Y., Sun,Z.W., Iratni,R., Erdjument-Bromage,H., Tempst,P.,
            Hampsey,M. and Reinberg,D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162311.5, BU507838.1 and
            AA836514.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032352.3.
            
            Summary: The protein encoded by this gene shows sequence similarity
            to the human breast carcinoma metastasis suppressor (BRMS1) protein
            and the mammalian Sds3 (suppressor of defective silencing 3)
            proteins. This protein is a component of the mSin3a family of
            histone deacetylase complexes (HDAC). [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.414428.1,
                                           SRR3476690.829117.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216807.12/ ENSP00000216807.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AL162311.5         111706-111758       c
            54-93               BU507838.1         45-84
            94-321              AL162311.5         111438-111665       c
            322-412             AL162311.5         106596-106686       c
            413-540             AL162311.5         104991-105118       c
            541-620             AL162311.5         103173-103252       c
            621-717             AL162311.5         75410-75506         c
            718-801             AL162311.5         74143-74226         c
            802-866             AL162311.5         73097-73161         c
            867-906             AL162311.5         72335-72374         c
            907-1033            AL162311.5         70064-70190         c
            1034-2573           AL162311.5         66197-67736         c
            2574-2637           AA836514.1         21-84               c
FEATURES             Location/Qualifiers
     source          1..2637
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q13.2"
     gene            1..2637
                     /gene="BRMS1L"
                     /gene_synonym="BRMS1; p40"
                     /note="BRMS1 like transcriptional repressor"
                     /db_xref="GeneID:84312"
                     /db_xref="HGNC:HGNC:20512"
                     /db_xref="MIM:618514"
     exon            1..321
                     /gene="BRMS1L"
                     /gene_synonym="BRMS1; p40"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..1151
                     /gene="BRMS1L"
                     /gene_synonym="BRMS1; p40"
                     /note="BRMS1-like protein p40; BRMS1-homolog protein p40;
                     breast cancer metastasis-suppressor 1 like"
                     /codon_start=1
                     /product="breast cancer metastasis-suppressor 1-like
                     protein"
                     /protein_id="NP_115728.2"
                     /db_xref="CCDS:CCDS32066.1"
                     /db_xref="GeneID:84312"
                     /db_xref="HGNC:HGNC:20512"
                     /db_xref="MIM:618514"
                     /translation="MPVHSRGDKKETNHHDEMEVDYAENEGSSSEDEDTESSSVSEDG
                     DSSEMDDEDCERRRMECLDEMSNLEKQFTDLKDQLYKERLSQVDAKLQEVIAGKAPEY
                     LEPLATLQENMQIRTKVAGIYRELCLESVKNKYECEIQASRQHCESEKLLLYDTVQSE
                     LEEKIRRLEEDRHSIDITSELWNDELQSRKKRKDPFSPDKKKPVVVSGPYIVYMLQDL
                     DILEDWTTIRKAMATLGPHRVKTEPPVKLEKHLHSARSEEGRLYYDGEWYIRGQTICI
                     DKKDECPTSAVITTINHDEVWFKRPDGSKSKLYISQLQKGKYSIKHS"
     exon            322..412
                     /gene="BRMS1L"
                     /gene_synonym="BRMS1; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            413..540
                     /gene="BRMS1L"
                     /gene_synonym="BRMS1; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            541..620
                     /gene="BRMS1L"
                     /gene_synonym="BRMS1; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            621..717
                     /gene="BRMS1L"
                     /gene_synonym="BRMS1; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            718..801
                     /gene="BRMS1L"
                     /gene_synonym="BRMS1; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            802..866
                     /gene="BRMS1L"
                     /gene_synonym="BRMS1; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            867..906
                     /gene="BRMS1L"
                     /gene_synonym="BRMS1; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1033
                     /gene="BRMS1L"
                     /gene_synonym="BRMS1; p40"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..2637
                     /gene="BRMS1L"
                     /gene_synonym="BRMS1; p40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2613..2618
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRMS1L"
                     /gene_synonym="BRMS1; p40"
                     /note="hexamer: AATAAA"
     polyA_site      2637
                     /gene="BRMS1L"
                     /gene_synonym="BRMS1; p40"
                     /note="major polyA site"
ORIGIN      
        1 agagctccca tcgcagagcc tgcgggttag gttgtgaggc ccgggccggg ggcggggagg
       61 agccaagggg gcgagcaagc tcggtggctg ggtgggttgg ggcgttccgc gcgcccttca
      121 ttgaagcggc ggtggccggg ctgggcgccg gtagtggaaa gcgacggcgc ggctggaaaa
      181 tgccagtcca ttcccgaggg gataagaagg agaccaacca tcacgatgag atggaggtgg
      241 actacgccga aaatgagggg agcagctccg aggacgagga cactgagagc tcgtcggtct
      301 ccgaggatgg agatagctca gaaatggatg atgaagactg tgaaagaaga agaatggaat
      361 gtttggatga aatgtccaat cttgaaaaac agtttaccga tctcaaagat caactttata
      421 aagaacgatt aagtcaggtg gatgcaaaac tacaagaagt catagctgga aaagcaccag
      481 aatacttgga accgctggca actttacagg aaaatatgca aattcgtaca aaggtagcag
      541 gaatctatag agagctctgc ttagaatctg taaagaacaa atatgaatgt gaaattcaag
      601 cttctcgcca gcattgtgag agcgaaaagc tgttgctata tgatacagtc cagagtgaac
      661 tagaggagaa gataagaagg cttgaagagg ataggcacag cattgatatt acctcagagc
      721 tgtggaatga tgagcttcag tcaagaaaaa agaggaagga tcctttcagt cctgacaaaa
      781 agaagccagt tgttgtttca ggtccatata tagtttatat gctacaagat cttgatattc
      841 ttgaagactg gacaacaatt aggaaggcaa tggctacatt ggggccacac agagtgaaaa
      901 cggaaccacc tgtgaaactg gaaaaacatc tgcacagtgc tagatctgaa gagggaagac
      961 tatattatga tggtgaatgg tatatacgtg gacaaacaat atgtattgat aaaaaagatg
     1021 aatgtcctac aagtgctgta attacaacaa ttaaccatga tgaagtttgg tttaagaggc
     1081 ctgatggaag caaatctaag ctttacattt cacagctaca gaaaggaaaa tattcaatta
     1141 aacattcata atcatgattt aagtgttatc taaatttacc ttattagtgt taccaaatgt
     1201 aagtgccatg agagtaaaaa aatgtattca ataacttaat attctcactg aatcatgaga
     1261 gaatgtgtat ttgtaggtag tactctaaat agatctcatt gatatgttat taaaagaaac
     1321 agtaataaaa attttatcac gatccttacg ttgatttgcc tcttaggtcc gatgaccaat
     1381 aggtattctg tatatggtag gggtttcttt ctaaacattt ttctttggtt ttaaaaaaag
     1441 ttatgcaaat ttgtcttatc tttagtaaac tatgactaca tttatctgca atttttaaaa
     1501 ttttccatat ctttgtcatt cattgtgtgt ttgtaaataa ggccgataga atgtttccta
     1561 taaatggttt gtactagtac attagtgtta aaccagaact gaaatttaaa catatatata
     1621 tatgaggatg tatatatggc atcatcagct tatttagaac tgatggccat accttacaat
     1681 cttgttttac ccaaaattaa gctattgggg ttgaaagcta aaaggagcac ttttgtagaa
     1741 tagcaacttt tcttttcctc tttcttgatt gtatggtggg gtggtgacct atttttacaa
     1801 attataccta atgagtaaaa ttagtgtaaa gtgataacat gcttctacct gtatttctag
     1861 tgacccttta gcggcaggta tttatacctg gtatttatga tgcagtatat aagtggtgaa
     1921 caataactga cagtattgtg cttgctgtac atgtctggtc ttttgaaaca gattttagta
     1981 agcattttcc agaggtaaaa ctgtgtcctt attctaattt tattcctagg gcaaagtaga
     2041 cagggattat ttccttgaat ctatttccaa attaatattt ttttctttgg tatttctaca
     2101 ctttaaggcc atttggtgca atttagaaag tgttggcctc ccttccgcta gccacattca
     2161 aaattaactt ccaaaacctc aggaacagta caaagaattg aaaccctcaa tatggcagca
     2221 cagccggctg tagtgtatat ttagggtaca ccaaatcagg tattcctggt ggtcttgtgc
     2281 actttaattt ctgttacaat gagttaagag gatgaggaag aaatctactt attaacactt
     2341 actgcagaaa tgtctgcatt attccgtttg ttttcttatt attttacctc tccaaacatc
     2401 ttcctgtgca gatcactact tcatagttgc caaattttaa aacacttaac tgctgaaatt
     2461 cagtgtcagc aaagtgatat tacgttgttc tgtttctaat taaccttagc aaatgtacat
     2521 aatgtcaaaa cccaatagta tttgacagta cttatgtata caatgtttga taagcatttt
     2581 taataagatt tgtattttta aatttagtat ataataaaaa gatgtgtttc agtgtga
//
