LOCUS       NM_015399               1424 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens BRMS1 transcriptional repressor and anoikis regulator
            (BRMS1), transcript variant 1, mRNA.
ACCESSION   NM_015399
VERSION     NM_015399.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1424)
  AUTHORS   Babu,D., Chintal,R., Panigrahi,M. and Phanithi,P.B.
  TITLE     Distinct expression and function of breast cancer metastasis
            suppressor 1 in mutant P53 glioblastoma
  JOURNAL   Cell Oncol (Dordr) 45 (6), 1451-1465 (2022)
   PUBMED   36284039
  REMARK    GeneRIF: Distinct expression and function of breast cancer
            metastasis suppressor 1 in mutant P53 glioblastoma.
REFERENCE   2  (bases 1 to 1424)
  AUTHORS   Liu,Y., Chudgar,N., Mastrogiacomo,B., He,D., Lankadasari,M.B.,
            Bapat,S., Jones,G.D., Sanchez-Vega,F., Tan,K.S., Schultz,N.,
            Mukherjee,S., Offit,K., Bao,Y., Bott,M.J., Rekhtman,N.,
            Adusumilli,P.S., Li,B.T., Mayo,M.W. and Jones,D.R.
  TITLE     A germline SNP in BRMS1 predisposes patients with lung
            adenocarcinoma to metastasis and can be ameliorated by targeting
            c-fos
  JOURNAL   Sci Transl Med 14 (665), eabo1050 (2022)
   PUBMED   36197962
  REMARK    GeneRIF: A germline SNP in BRMS1 predisposes patients with lung
            adenocarcinoma to metastasis and can be ameliorated by targeting
            c-fos.
REFERENCE   3  (bases 1 to 1424)
  AUTHORS   Zimmermann,R.C., Sardiu,M.E., Manton,C.A., Miah,M.S., Banks,C.A.S.,
            Adams,M.K., Koestler,D.C., Hurst,D.R., Edmonds,M.D., Washburn,M.P.
            and Welch,D.R.
  TITLE     Perturbation of BRMS1 interactome reveals pathways that impact
            metastasis
  JOURNAL   PLoS One 16 (11), e0259128 (2021)
   PUBMED   34788285
  REMARK    GeneRIF: Perturbation of BRMS1 interactome reveals pathways that
            impact metastasis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1424)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1424)
  AUTHORS   Zhou,C., Zhang,Z., Zhu,X., Qian,G., Zhou,Y., Sun,Y., Yu,W.,
            Wang,J., Lu,H., Lin,F., Shen,Z. and Zheng,S.
  TITLE     N6-Methyladenosine modification of the TRIM7 positively regulates
            tumorigenesis and chemoresistance in osteosarcoma through
            ubiquitination of BRMS1
  JOURNAL   EBioMedicine 59, 102955 (2020)
   PUBMED   32853985
  REMARK    GeneRIF: N6-Methyladenosine modification of the TRIM7 positively
            regulates tumorigenesis and chemoresistance in osteosarcoma through
            ubiquitination of BRMS1.
REFERENCE   6  (bases 1 to 1424)
  AUTHORS   Janneau,J.L., Maldonado-Estrada,J., Tachdjian,G., Miran,I.,
            Motte,N., Saulnier,P., Sabourin,J.C., Cote,J.F., Simon,B.,
            Frydman,R., Chaouat,G. and Bellet,D.
  TITLE     Transcriptional expression of genes involved in cell invasion and
            migration by normal and tumoral trophoblast cells
  JOURNAL   J Clin Endocrinol Metab 87 (11), 5336-5339 (2002)
   PUBMED   12414911
REFERENCE   7  (bases 1 to 1424)
  AUTHORS   Shevde,L.A., Samant,R.S., Goldberg,S.F., Sikaneta,T.,
            Alessandrini,A., Donahue,H.J., Mauger,D.T. and Welch,D.R.
  TITLE     Suppression of human melanoma metastasis by the metastasis
            suppressor gene, BRMS1
  JOURNAL   Exp Cell Res 273 (2), 229-239 (2002)
   PUBMED   11822878
  REMARK    GeneRIF: BRMS1 functions as a metastasis suppressor in more than
            one tumor type(i.e., breast carcinoma and cutaneous melanoma)by
            modifying several metastasis-associated phenotypes.
REFERENCE   8  (bases 1 to 1424)
  AUTHORS   Samant,R.S., Debies,M.T., Shevde,L.A., Verderame,M.F. and
            Welch,D.R.
  TITLE     Identification and characterization of the murine ortholog (brms1)
            of breast-cancer metastasis suppressor 1 (BRMS1)
  JOURNAL   Int J Cancer 97 (1), 15-20 (2002)
   PUBMED   11774238
REFERENCE   9  (bases 1 to 1424)
  AUTHORS   Seraj,M.J., Samant,R.S., Verderame,M.F. and Welch,D.R.
  TITLE     Functional evidence for a novel human breast carcinoma metastasis
            suppressor, BRMS1, encoded at chromosome 11q13
  JOURNAL   Cancer Res 60 (11), 2764-2769 (2000)
   PUBMED   10850410
REFERENCE   10 (bases 1 to 1424)
  AUTHORS   Zhang,Y., Sun,Z.W., Iratni,R., Erdjument-Bromage,H., Tempst,P.,
            Hampsey,M. and Reinberg,D.
  TITLE     SAP30, a novel protein conserved between human and yeast, is a
            component of a histone deacetylase complex
  JOURNAL   Mol Cell 1 (7), 1021-1031 (1998)
   PUBMED   9651585
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB130346.1, AP001107.5 and
            BU734281.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015399.3.
            
            Summary: This gene reduces the metastatic potential, but not the
            tumorogenicity, of human breast cancer and melanoma cell lines. The
            protein encoded by this gene localizes primarily to the nucleus and
            is a component of the mSin3a family of histone deacetylase
            complexes (HDAC). The protein contains two coiled-coil motifs and
            several imperfect leucine zipper motifs. Alternative splicing
            results in two transcript variants encoding different isoforms.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest and
            more abundant transcript and encodes isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009834.2, AF159141.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359957.8/ ENSP00000353042.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                CB130346.1         14-29
            17-133              AP001107.5         85228-85344         c
            134-279             AP001107.5         82352-82497         c
            280-370             AP001107.5         81789-81879         c
            371-498             AP001107.5         81462-81589         c
            499-578             AP001107.5         81223-81302         c
            579-675             AP001107.5         81030-81126         c
            676-768             AP001107.5         80377-80469         c
            769-833             AP001107.5         78977-79041         c
            834-873             AP001107.5         78499-78538         c
            874-1396            AP001107.5         77623-78145         c
            1397-1424           BU734281.1         25-52               c
FEATURES             Location/Qualifiers
     source          1..1424
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..1424
                     /gene="BRMS1"
                     /note="BRMS1 transcriptional repressor and anoikis
                     regulator"
                     /db_xref="GeneID:25855"
                     /db_xref="HGNC:HGNC:17262"
                     /db_xref="MIM:606259"
     exon            1..133
                     /gene="BRMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            134..279
                     /gene="BRMS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..881
                     /gene="BRMS1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     breast cancer metastasis suppressor 1"
                     /codon_start=1
                     /product="breast cancer metastasis-suppressor 1 isoform 1"
                     /protein_id="NP_056214.1"
                     /db_xref="CCDS:CCDS8135.1"
                     /db_xref="GeneID:25855"
                     /db_xref="HGNC:HGNC:17262"
                     /db_xref="MIM:606259"
                     /translation="MPVQPPSKDTEEMEAEGDSAAEMNGEEEESEEERSGSQTESEEE
                     SSEMDDEDYERRRSECVSEMLDLEKQFSELKEKLFRERLSQLRLRLEEVGAERAPEYT
                     EPLGGLQRSLKIRIQVAGIYKGFCLDVIRNKYECELQGAKQHLESEKLLLYDTLQGEL
                     QERIQRLEEDRQSLDLSSEWWDDKLHARGSSRSWDSLPPSKRKKAPLVSGPYIVYMLQ
                     EIDILEDWTAIKKARAAVSPQKRKSDGP"
     exon            280..370
                     /gene="BRMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..498
                     /gene="BRMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            499..578
                     /gene="BRMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            579..675
                     /gene="BRMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            676..768
                     /gene="BRMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            769..833
                     /gene="BRMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..873
                     /gene="BRMS1"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1424
                     /gene="BRMS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1406..1411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRMS1"
                     /note="hexamer: ATTAAA"
     polyA_site      1424
                     /gene="BRMS1"
                     /note="major polyA site"
ORIGIN      
        1 gataggctct gcctcccgaa gaaaagggag ccgcgcagcg cctacgggag tccggcggca
       61 gcagccggta ccggcaacca cgggcagctc tcagggaatc tccgtcgtga ggccagaggc
      121 tccagtcccc gcgagtccag atgcctgtcc agcctccaag caaagacaca gaagagatgg
      181 aagcagaggg tgattctgct gctgagatga atggggagga ggaagagagt gaggaggagc
      241 ggagcggcag ccagacagag tcagaagagg agagctccga gatggatgat gaggactatg
      301 agcgacgccg cagcgagtgt gtcagtgaga tgctggacct agagaagcag ttctcggagc
      361 taaaggagaa gttgttcagg gaacgactga gtcagctgcg gttgcggctg gaggaagtgg
      421 gggctgagag agcccctgaa tacacggagc cccttggggg gctgcagcgg agcctcaaga
      481 ttcgcattca ggtggcaggg atctacaagg gcttctgtct ggatgtgatc aggaataagt
      541 acgaatgtga gctgcaggga gccaaacagc acctggagag tgagaagctg ctgctctatg
      601 acacgctgca gggggagctg caggagcgga tccagaggct ggaggaggac cgccagagcc
      661 tggacctcag ctctgaatgg tgggatgaca aactgcacgc cagaggcagc tccaggtctt
      721 gggactccct gccgcccagc aagaggaaga aggcacctct ggtttctggc ccatacatcg
      781 tgtacatgct tcaagagatc gacatcctgg aggactggac agccatcaaa aaggctaggg
      841 cagctgtgtc ccctcagaag agaaaatcgg atggaccttg accctgctgt tcacagccag
      901 ggggaccctc agagcagctg gcactgcacc caggattctc gtcttcctcc tgcagacagg
      961 cggacccaca ggcccctcag ggtctgccca gccaggctcc tgtggtgctg ctgggccctc
     1021 ccactccatc tggcactggc ctggactcct cctctgccct cctcgaggcc tgcacagctg
     1081 tggccgtgga gctgacctga ccaggcaagg ctgctgtctc catccctgag ccgcctgcca
     1141 cctcccactc ctgaagatcc atctcttggg gctcccctga cagagaagac agccgaagtc
     1201 aaagccacat cctcttgctg atgttggatg caggctgtcc ggcctcaggg ccagggagcc
     1261 agtttccact gtgcgggaac tctgagtcag acgtgattat ctgggggtct gtccaccctg
     1321 gctggatctg gaggcaagat gccaggcccc ccaggtgttc tcagggcagt tcttggtgtc
     1381 tgcttctcag attccaagga ctggaattaa aacctttcct ggga
//
