LOCUS       NM_001345843            2885 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens break repair meiotic recombinase recruitment factor 1
            (BRME1), transcript variant 1, mRNA.
ACCESSION   NM_001345843
VERSION     NM_001345843.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2885)
  AUTHORS   Felipe-Medina,N., Caburet,S., Sanchez-Saez,F., Condezo,Y.B., de
            Rooij,D.G., Gomez-H,L., Garcia-Valiente,R., Todeschini,A.L.,
            Duque,P., Sanchez-Martin,M.A., Shalev,S.A., Llano,E., Veitia,R.A.
            and Pendas,A.M.
  TITLE     A missense in HSF2BP causing primary ovarian insufficiency affects
            meiotic recombination by its novel interactor C19ORF57/BRME1
  JOURNAL   Elife 9, e56996 (2020)
   PUBMED   32845237
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2885)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2885)
  AUTHORS   Shang,Y., Huang,T., Liu,H., Liu,Y., Liang,H., Yu,X., Li,M.,
            Zhai,B., Yang,X., Wei,Y., Wang,G., Chen,Z., Wang,S. and Zhang,L.
  TITLE     MEIOK21: a new component of meiotic recombination bridges required
            for spermatogenesis
  JOURNAL   Nucleic Acids Res 48 (12), 6624-6639 (2020)
   PUBMED   32463460
REFERENCE   4  (bases 1 to 2885)
  AUTHORS   Takemoto,K., Tani,N., Takada-Horisawa,Y., Fujimura,S., Tanno,N.,
            Yamane,M., Okamura,K., Sugimoto,M., Araki,K. and Ishiguro,K.I.
  TITLE     Meiosis-Specific C19orf57/4930432K21Rik/BRME1 Modulates
            Localization of RAD51 and DMC1 to DSBs in Mouse Meiotic
            Recombination
  JOURNAL   Cell Rep 31 (8), 107686 (2020)
   PUBMED   32460033
REFERENCE   5  (bases 1 to 2885)
  AUTHORS   Zhang,J., Gurusaran,M., Fujiwara,Y., Zhang,K., Echbarthi,M.,
            Vorontsov,E., Guo,R., Pendlebury,D.F., Alam,I., Livera,G.,
            Emmanuelle,M., Wang,P.J., Nandakumar,J., Davies,O.R. and Shibuya,H.
  TITLE     The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and
            impairs the mitotic BRCA2-RAD51 function in cancer cells
  JOURNAL   Nat Commun 11 (1), 2055 (2020)
   PUBMED   32345962
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2885)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   7  (bases 1 to 2885)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2885)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2885)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   10 (bases 1 to 2885)
  AUTHORS   Ranes-Goldberg,M.G., Hori,T., Mohan-Peterson,S. and Spits,H.
  TITLE     Identification of human pre-T/NK cell-associated genes
  JOURNAL   J Immunol 151 (10), 5810-5821 (1993)
   PUBMED   8228263
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020916.8.
            
            On Feb 24, 2021 this sequence version replaced NM_001345843.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Variants 1, 7, and
            8 all encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.2069961.1,
                                           SRR14038196.1248373.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: lack of evidence for use of
                                                upstream AUG
            MANE Ensembl match               :: ENST00000586783.6/
                                                ENSP00000465822.1
            RefSeq Select criteria           :: based on manual assertion,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-403               AC020916.8         118855-119257       c
            404-455             AC020916.8         118002-118053       c
            456-630             AC020916.8         108512-108686       c
            631-712             AC020916.8         106282-106363       c
            713-817             AC020916.8         105926-106030       c
            818-2092            AC020916.8         102328-103602       c
            2093-2187           AC020916.8         99101-99195         c
            2188-2280           AC020916.8         96448-96540         c
            2281-2885           AC020916.8         95488-96092         c
FEATURES             Location/Qualifiers
     source          1..2885
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..2885
                     /gene="BRME1"
                     /gene_synonym="C19orf57; MEIOK21"
                     /note="break repair meiotic recombinase recruitment factor
                     1"
                     /db_xref="GeneID:79173"
                     /db_xref="HGNC:HGNC:28153"
                     /db_xref="MIM:619276"
     exon            1..403
                     /gene="BRME1"
                     /gene_synonym="C19orf57; MEIOK21"
                     /inference="alignment:Splign:2.1.0"
     exon            404..455
                     /gene="BRME1"
                     /gene_synonym="C19orf57; MEIOK21"
                     /inference="alignment:Splign:2.1.0"
     CDS             425..2431
                     /gene="BRME1"
                     /gene_synonym="C19orf57; MEIOK21"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pre-T/NK cell associated protein (3B3); uncharacterized
                     protein C19orf57; BRCA2 and MEILB2-associating protein 1;
                     meiosis-specific 4930432K21RIK"
                     /codon_start=1
                     /product="break repair meiotic recombinase recruitment
                     factor 1 isoform 1"
                     /protein_id="NP_001332772.2"
                     /db_xref="CCDS:CCDS92536.1"
                     /db_xref="GeneID:79173"
                     /db_xref="HGNC:HGNC:28153"
                     /db_xref="MIM:619276"
                     /translation="MTKRKKLRTSGEGLCPPKPLKNPRLGDFYGDPQSSMLGCLHHPE
                     EPEGKLGPVPSTQQHGEEPGKAVSSSPDEETGSPCRLLRQPEKEPAPLPPSQNSFGRF
                     VPQFAKSRKTVTRKEEMKDEDRGSGAFSLETIAESSAQSPGCQLLVETLGVPLQEATE
                     LGDPTQADSARPEQSSQSPVQAVPGSGDSQPDDPPDRGTGLSASQRASQDHLSEQGAD
                     DSKPETDRVPGDGGQKEHLPSIDSEGEKPDRGAPQEGGAQRTAGAGLPGGPQEEGDGV
                     PCTPASAPTSGPAPGLGPASWCLEPGSVAQGSPDPQQTPSRMGREGEGTHSSLGCSSL
                     GMVVIADLSTDPTELEERALEVAGPDGQASAISPASPRRKAADGGHRRALPGCTSLTG
                     ETTGESGEAGQDGKPPGDVLVGPTASLALAPGSGESMMGAGDSGHASPDTGPCVNQKQ
                     EPGPAQEEAELGGQNLERDLEGFRVSPQASVVLEHREIADDPLQEPGAQQGIPDTTSE
                     LAGQRDHLPHSADQGTWADSLAVELDFLLDSQIQDALDASDFEAPPEQLFPSGNKPGP
                     CWPGPSSHANGDPVAVAKAQPRTFVGIQASEASRMEDATNVVRGLIVELSNLNRLIMG
                     THRDLEAFKRLNYRKTKLGGKAPLPYPSKGPGNIPRGDPPWREL"
     exon            456..630
                     /gene="BRME1"
                     /gene_synonym="C19orf57; MEIOK21"
                     /inference="alignment:Splign:2.1.0"
     exon            631..712
                     /gene="BRME1"
                     /gene_synonym="C19orf57; MEIOK21"
                     /inference="alignment:Splign:2.1.0"
     exon            713..817
                     /gene="BRME1"
                     /gene_synonym="C19orf57; MEIOK21"
                     /inference="alignment:Splign:2.1.0"
     exon            818..2092
                     /gene="BRME1"
                     /gene_synonym="C19orf57; MEIOK21"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2187
                     /gene="BRME1"
                     /gene_synonym="C19orf57; MEIOK21"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2280
                     /gene="BRME1"
                     /gene_synonym="C19orf57; MEIOK21"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2885
                     /gene="BRME1"
                     /gene_synonym="C19orf57; MEIOK21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2858..2863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRME1"
                     /gene_synonym="C19orf57; MEIOK21"
                     /note="hexamer: AATAAA"
     polyA_site      2885
                     /gene="BRME1"
                     /gene_synonym="C19orf57; MEIOK21"
                     /note="major polyA site"
ORIGIN      
        1 gtcgctcatg cgcggggcgg gacctcgcgg ggcgcgggaa agaggcagag cgcgcgcagg
       61 tgtgaggggc ggcgacatct gtggggttca gagcgtctgt cagtcaccga cgggctccgg
      121 cttcacgtgg gctctcggcc tgtggagtcc tcacttctcg gtggtcggcg tagtgtcagt
      181 gtggggcttg tcaccgggag cggggtctac agcgcccacc ctcaggcctt tccatctttc
      241 acctccggac tcgaggcctc cagcgttctg tgagggccaa tttggccatt tattttttcc
      301 aaaaagagta acgcggataa ttcaagcgac ttattcccaa ctgatccagg cagagctcgt
      361 ttctgataag gacagagggt cctcaacgac ttctgtggcc cagatttctc aaggggaaga
      421 taaaatgact aagaggaaga agctgcggac ctcaggagag ggactctgtc ctccaaaacc
      481 cctaaagaac ccaaggctag gagacttcta tggggacccc cagagttcca tgttgggctg
      541 tttacatcac cctgaggagc cagagggcaa attgggacct gttccctcta cacagcagca
      601 cggggaggaa ccaggaaagg ccgtctccag ctcccctgat gaggaaacag gatctccctg
      661 ccggctcctc cgtcaaccag aaaaggagcc agctcccctt cctccttccc agaactcatt
      721 cgggaggttt gttccccagt ttgcaaaatc caggaagaca gtgacaagaa aagaagagat
      781 gaaggatgag gaccgtggga gtggggcctt tagcctggaa acaatcgcag agtccagcgc
      841 ccagagtcca ggatgccagc tgctagtgga gaccctgggg gtccccctcc aggaggccac
      901 ggagctgggg gacccaacgc aggcagacag tgcccgccct gagcagagca gccagagccc
      961 tgtgcaggcg gtgcccggca gtggggattc tcagcctgat gaccctccag acagggggac
     1021 ggggttgtcc gcctcacaga gggccagcca agaccacctg tcagaacaag gggccgatga
     1081 cagcaagcct gagacagaca gggttccagg tgacggtggc caaaaggaac acctaccaag
     1141 cattgattct gaaggggaga agccagacag aggagccccc caggagggag gggcccaaag
     1201 gacagcaggg gctggcctgc ctggagggcc ccaggaggag ggagacggtg tcccctgtac
     1261 cccagcatca gctcctacct caggccctgc tccaggactg ggccctgcct cttggtgcct
     1321 ggaacccggg tctgtggccc agggctcccc tgacccccag cagaccccca gcaggatggg
     1381 tagggaaggg gaagggactc atagcagcct gggatgctcc tccctcggga tggttgtcat
     1441 cgcagacctg agcacagacc ccactgagct ggaagagagg gctctggagg tggctgggcc
     1501 cgatgggcag gccagtgcca tatcacctgc ctctcccagg aggaaggccg ctgatggagg
     1561 ccacaggagg gccttgccag gctgcacctc gctcactggg gaaaccacag gagaaagtgg
     1621 ggaggcaggg caggatggca agccccccgg cgatgtccta gtgggcccta cagcctccct
     1681 ggctctggca cctgggagcg gagagtccat gatgggtgct ggagattccg gtcatgcatc
     1741 cccggacaca ggtccatgtg tcaatcagaa gcaggagcca ggtcctgctc aagaggaagc
     1801 cgagttaggt ggccagaacc tcgaacgaga cctcgagggg ttccgtgtgt ccccgcaagc
     1861 ctctgttgtg ctggaacaca gagaaatagc agacgaccct ctccaggagc ccggggctca
     1921 gcagggcatt ccagacacca cctcagagct ggcagggcag cgagaccacc tgcctcattc
     1981 tgcagaccag ggcacctggg cagactcttt agctgtggaa ctcgacttcc tgctggacag
     2041 ccagatacag gatgccctgg acgcctctga cttcgaagcc ccacctgagc agctctttcc
     2101 ttcggggaac aagccgggcc cttgctggcc gggccccagc tcacatgcca atggagaccc
     2161 tgttgcagtg gccaaggccc agccgaggac cttcgtgggg atccaggcct ctgaggcctc
     2221 caggatggag gatgccacca acgtcgtgcg tggcctcatc gttgagctct ccaacctgaa
     2281 ccggctgatc atgggcaccc accgggacct ggaagctttc aagcgcctta actaccggaa
     2341 gacaaagctg ggaggcaaag cccccctgcc ttacccttcc aaggggcctg ggaatatccc
     2401 tcgaggggac ccaccctgga gggagttgta ggccactttg aggtctgtgt ttcctttgcc
     2461 acccagcccc catgtccgca gacctcctcc aagatgctcc agggggtcct agtggaccct
     2521 acaaacctcc cttcagttgc ccggaagttg gtcttccatg gacaacacaa aggaggccgt
     2581 gaggtcctgg cctcacctgg ccagggtcaa ggtcatttgc cacccttggc ttcagggagg
     2641 gaaactgtgt ctcccacagc cccagtgact tcaagcgggc ctgggctcca ggaagctggc
     2701 cacctctgag cagggcccat cctgtccgga tttgcaaatt ttagggtcct gagccaagta
     2761 tggatggttc agaatttgtt tctttcctgg aggagaagag agctcccttt gttttctttc
     2821 tccccatttc cattttattt cttctgggaa gacccataat aaatgattct gtagaggccc
     2881 cgtga
//
