LOCUS       NM_018321               1591 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens biogenesis of ribosomes BRX1 (BRIX1), mRNA.
ACCESSION   NM_018321
VERSION     NM_018321.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1591)
  AUTHORS   Jiang,C., Sun,L., Wen,S., Tian,Y., Xu,C., Xu,Q. and Xue,H.
  TITLE     BRIX1 promotes ribosome synthesis and enhances glycolysis by
            selected translation of GLUT1 in colorectal cancer
  JOURNAL   J Gene Med 26 (1), e3632 (2024)
   PUBMED   38282151
  REMARK    GeneRIF: BRIX1 promotes ribosome synthesis and enhances glycolysis
            by selected translation of GLUT1 in colorectal cancer.
REFERENCE   2  (bases 1 to 1591)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1591)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1591)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1591)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   6  (bases 1 to 1591)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   7  (bases 1 to 1591)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   8  (bases 1 to 1591)
  AUTHORS   Wehner,K.A. and Baserga,S.J.
  TITLE     The sigma(70)-like motif: a eukaryotic RNA binding domain unique to
            a superfamily of proteins required for ribosome biogenesis
  JOURNAL   Mol Cell 9 (2), 329-339 (2002)
   PUBMED   11864606
REFERENCE   9  (bases 1 to 1591)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   10 (bases 1 to 1591)
  AUTHORS   Kaser,A., Bogengruber,E., Hallegger,M., Doppler,E.,
            Lepperdinger,G., Jantsch,M., Breitenbach,M. and Kreil,G.
  TITLE     Brix from xenopus laevis and brx1p from yeast define a new family
            of proteins involved in the biogenesis of large ribosomal subunits
  JOURNAL   Biol Chem 382 (12), 1637-1647 (2001)
   PUBMED   11843177
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026801.7 and BC001546.1.
            
            On May 17, 2019 this sequence version replaced NM_018321.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036741.1, SRR1803617.49822.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336767.6/ ENSP00000338862.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC026801.7         157849-157852
            5-1277              BC001546.1         1-1273
            1278-1591           AC026801.7         167821-168134
FEATURES             Location/Qualifiers
     source          1..1591
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.2"
     gene            1..1591
                     /gene="BRIX1"
                     /gene_synonym="BRIX; BXDC2"
                     /note="biogenesis of ribosomes BRX1"
                     /db_xref="GeneID:55299"
                     /db_xref="HGNC:HGNC:24170"
                     /db_xref="MIM:618466"
     exon            1..187
                     /gene="BRIX1"
                     /gene_synonym="BRIX; BXDC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..1090
                     /gene="BRIX1"
                     /gene_synonym="BRIX; BXDC2"
                     /note="brix domain containing 2; brix domain-containing
                     protein 2; BRX1, biogenesis of ribosomes, homolog"
                     /codon_start=1
                     /product="ribosome biogenesis protein BRX1 homolog"
                     /protein_id="NP_060791.3"
                     /db_xref="CCDS:CCDS34143.1"
                     /db_xref="GeneID:55299"
                     /db_xref="HGNC:HGNC:24170"
                     /db_xref="MIM:618466"
                     /translation="MAATKRKRRGGFAVQAKKPKRNEIDAEPPAKRHATAEEVEEEER
                     DRIPGPVCKGKWKNKERILIFSSRGINFRTRHLMQDLRMLMPHSKADTKMDRKDKLFV
                     INEVCEMKNCNKCIYFEAKKKQDLYMWLSNSPHGPSAKFLVQNIHTLAELKMTGNCLK
                     GSRPLLSFDPAFDELPHYALLKELLIQIFSTPRYHPKSQPFVDHVFTFTILDNRIWFR
                     NFQIIEEDAALVEIGPRFVLNLIKIFQGSFGGPTLYENPHYQSPNMHRRVIRSITAAK
                     YREKQQVKDVQKLRKKEPKTLLPHDPTADVFVTPAEEKPIEIQWVKPEPKVDLKARKK
                     RIYKRQRKMKQRMDSGKTK"
     exon            188..299
                     /gene="BRIX1"
                     /gene_synonym="BRIX; BXDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            300..343
                     /gene="BRIX1"
                     /gene_synonym="BRIX; BXDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            344..414
                     /gene="BRIX1"
                     /gene_synonym="BRIX; BXDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            415..464
                     /gene="BRIX1"
                     /gene_synonym="BRIX; BXDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            465..538
                     /gene="BRIX1"
                     /gene_synonym="BRIX; BXDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            539..589
                     /gene="BRIX1"
                     /gene_synonym="BRIX; BXDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            590..691
                     /gene="BRIX1"
                     /gene_synonym="BRIX; BXDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            692..820
                     /gene="BRIX1"
                     /gene_synonym="BRIX; BXDC2"
                     /inference="alignment:Splign:2.1.0"
     exon            821..1591
                     /gene="BRIX1"
                     /gene_synonym="BRIX; BXDC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1248..1253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRIX1"
                     /gene_synonym="BRIX; BXDC2"
                     /note="hexamer: AATAAA"
     polyA_site      1277
                     /gene="BRIX1"
                     /gene_synonym="BRIX; BXDC2"
                     /note="major polyA site"
     regulatory      1559..1564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRIX1"
                     /gene_synonym="BRIX; BXDC2"
                     /note="hexamer: ATTAAA"
     polyA_site      1591
                     /gene="BRIX1"
                     /gene_synonym="BRIX; BXDC2"
ORIGIN      
        1 aggccaagag cgcgggcggc gaggcaagat ggcggcaacc aagaggaaac ggcgtggagg
       61 ctttgcagtt caggcgaaga agccaaaaag aaacgaaata gatgcggagc cgccagctaa
      121 gcggcacgcc acagcagagg aggtggagga agaagagagg gaccggatcc caggccccgt
      181 ttgcaaggga aagtggaaaa ataaggaacg gattctcatc ttttcttcca gaggaataaa
      241 ttttagaaca agacatttaa tgcaggactt gagaatgttg atgcctcatt ctaaagcaga
      301 tactaaaatg gatcgtaagg ataagctatt tgtgattaac gaggtttgtg aaatgaagaa
      361 ctgtaataaa tgcatctatt ttgaagctaa gaaaaaacag gatctctata tgtggctttc
      421 aaattcacct cacggaccat ctgctaaatt ccttgttcaa aatattcata ccctcgctga
      481 actgaagatg actggaaact gtttgaaagg ttctcggccc cttttgtctt ttgaccctgc
      541 ttttgatgaa ttaccacatt atgctttgtt aaaagaactc ttaattcaga tctttagtac
      601 accacggtat catcccaaaa gccaaccatt tgtggaccac gtgtttactt tcaccatttt
      661 ggataatagg atatggtttc ggaactttca gatcatagaa gaagatgctg ctcttgtaga
      721 aataggacct cgttttgtct taaatctcat aaagattttc cagggaagtt ttggaggacc
      781 aactttatat gaaaatcctc actaccagtc accaaacatg catcggcgtg tcataagatc
      841 catcacagct gcaaaataca gagagaaaca gcaagtgaaa gatgtgcaaa aactgagaaa
      901 gaaagagccg aagactcttc ttccacatga tcccactgca gatgtttttg taacaccagc
      961 tgaggagaaa ccaatagaaa tacagtgggt aaaaccagag ccaaaagttg atttgaaagc
     1021 aagaaagaaa cggatttaca aaaggcaaag aaaaatgaaa cagaggatgg acagtgggaa
     1081 aacaaaataa gtcaatggaa acctgatttg tttttcagtt actttatatt tattttgtat
     1141 tcaatgtgta aatactttta ttatctaata ctatcttacg tctaattagt gtagcattta
     1201 caagaaagaa aaattaagat cttaaaatca gtgattatct ttttctaaat aaaatatcac
     1261 cagaattcat cagttaattt ctgatttctt tttgaagttt gtgttgctaa aaatgtagca
     1321 cacttaatgt agcctgttct cttgggttgg aatttttggt ttagcaaagc tgaaattcag
     1381 acatttatta ggtcatatta tttgtaaaag cattcaacac ttcaagagca tcggttgtgg
     1441 atggtaaagt aggagtagac tggtagaaag gaaggcatct cactgaagtt tactcagtca
     1501 tcagttaatg aagccatgga agaaccaacc cctgatctgt cacttcaaaa aagagtatat
     1561 taaaatgttg aggttttgag aatcaaatgc a
//
