LOCUS       NM_032043               8182 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens BRCA1 interacting DNA helicase 1 (BRIP1), mRNA.
ACCESSION   NM_032043
VERSION     NM_032043.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8182)
  AUTHORS   Cong,K., MacGilvary,N., Lee,S., MacLeod,S.G., Calvo,J., Peng,M.,
            Nedergaard Kousholt,A., Day,T.A. and Cantor,S.B.
  TITLE     FANCJ promotes PARP1 activity during DNA replication that is
            essential in BRCA1 deficient cells
  JOURNAL   Nat Commun 15 (1), 2599 (2024)
   PUBMED   38521768
  REMARK    GeneRIF: FANCJ promotes PARP1 activity during DNA replication that
            is essential in BRCA1 deficient cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8182)
  AUTHORS   Yang,X., Ren,S., Yang,J., Pan,Y., Zhou,Z., Chen,Q., Fang,Y.,
            Shang,L., Zhang,F., Zhang,X. and Wu,Y.
  TITLE     Rare variants in FANCJ induce premature ovarian insufficiency in
            humans and mice
  JOURNAL   J Genet Genomics 51 (2), 252-255 (2024)
   PUBMED   37062450
  REMARK    GeneRIF: Rare variants in FANCJ induce premature ovarian
            insufficiency in humans and mice.
REFERENCE   3  (bases 1 to 8182)
  AUTHORS   Mukhana,L., Aissa,A.A., Ahmed,A.A.M., Saakyan,S.V., Tsygankov,A.Y.,
            Blagonravov,M.L. and Azova,M.M.
  TITLE     Association of BARD1 and BRIP1 Gene Polymorphisms with the Risk of
            Uveal Melanoma
  JOURNAL   Bull Exp Biol Med 175 (3), 399-403 (2023)
   PUBMED   37561379
  REMARK    GeneRIF: Association of BARD1 and BRIP1 Gene Polymorphisms with the
            Risk of Uveal Melanoma.
REFERENCE   4  (bases 1 to 8182)
  AUTHORS   Long,G., Hu,K., Zhang,X., Zhou,L. and Li,J.
  TITLE     Spectrum of BRCA1 interacting helicase 1 aberrations and potential
            prognostic and therapeutic implication: a pan cancer analysis
  JOURNAL   Sci Rep 13 (1), 4435 (2023)
   PUBMED   36932143
  REMARK    GeneRIF: Spectrum of BRCA1 interacting helicase 1 aberrations and
            potential prognostic and therapeutic implication: a pan cancer
            analysis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8182)
  AUTHORS   Karppinen,S.M., Vuosku,J., Heikkinen,K., Allinen,M. and Winqvist,R.
  TITLE     No evidence of involvement of germline BACH1 mutations in Finnish
            breast and ovarian cancer families
  JOURNAL   Eur J Cancer 39 (3), 366-371 (2003)
   PUBMED   12565990
REFERENCE   6  (bases 1 to 8182)
  AUTHORS   Luo,L., Lei,H., Du,Q., von Wachenfeldt,A., Kockum,I., Luthman,H.,
            Vorechovsky,I. and Lindblom,A.
  TITLE     No mutations in the BACH1 gene in BRCA1 and BRCA2 negative
            breast-cancer families linked to 17q22
  JOURNAL   Int J Cancer 98 (4), 638-639 (2002)
   PUBMED   11920628
REFERENCE   7  (bases 1 to 8182)
  AUTHORS   Menichini,P. and Linial,M.
  TITLE     SUVi and BACH1: a new subfamily of mammalian helicases?
  JOURNAL   Mutat Res 487 (1-2), 67-71 (2001)
   PUBMED   11595410
REFERENCE   8  (bases 1 to 8182)
  AUTHORS   Cantor,S.B., Bell,D.W., Ganesan,S., Kass,E.M., Drapkin,R.,
            Grossman,S., Wahrer,D.C., Sgroi,D.C., Lane,W.S., Haber,D.A. and
            Livingston,D.M.
  TITLE     BACH1, a novel helicase-like protein, interacts directly with BRCA1
            and contributes to its DNA repair function
  JOURNAL   Cell 105 (1), 149-160 (2001)
   PUBMED   11301010
REFERENCE   9  (bases 1 to 8182)
  AUTHORS   Scott,D.A.
  TITLE     Esophageal Atresia / Tracheoesophageal Fistula Overview - RETIRED
            CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301753
REFERENCE   10 (bases 1 to 8182)
  AUTHORS   Mehta,P.A. and Ebens,C.
  TITLE     Fanconi Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301575
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC060798.10, AF360549.1 and
            AC002994.3.
            
            On Aug 31, 2019 this sequence version replaced NM_032043.2.
            
            Summary: The protein encoded by this gene is a member of the RecQ
            DEAH helicase family and interacts with the BRCT repeats of breast
            cancer, type 1 (BRCA1). The bound complex is important in the
            normal double-strand break repair function of breast cancer, type 1
            (BRCA1). This gene may be a target of germline cancer-inducing
            mutations. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF360549.1, BC101472.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259008.7/ ENSP00000259008.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               AC060798.10        49005-49138         c
            135-2911            AF360549.1         1-2777
            2912-3180           AC002994.3         25403-25671
            3181-8182           AC002994.3         27367-32368
FEATURES             Location/Qualifiers
     source          1..8182
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.2"
     gene            1..8182
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /note="BRCA1 interacting DNA helicase 1"
                     /db_xref="GeneID:83990"
                     /db_xref="HGNC:HGNC:20473"
                     /db_xref="MIM:605882"
     exon            1..245
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /inference="alignment:Splign:2.1.0"
     exon            246..368
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..4025
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /EC_number="5.6.2.3"
                     /note="BRCA1/BRCA2-associated helicase 1; BRCA1-binding
                     helicase-like protein BACH1; BRCA1-associated C-terminal
                     helicase 1; ATP-dependent RNA helicase BRIP1; FANCJ
                     helicase; BRCA1 interacting helicase 1; BRCA1 interacting
                     protein C-terminal helicase 1; DNA 5'-3' helicase FANCJ"
                     /codon_start=1
                     /product="Fanconi anemia group J protein"
                     /protein_id="NP_114432.2"
                     /db_xref="CCDS:CCDS11631.1"
                     /db_xref="GeneID:83990"
                     /db_xref="HGNC:HGNC:20473"
                     /db_xref="MIM:605882"
                     /translation="MSSMWSEYTIGGVKIYFPYKAYPSQLAMMNSILRGLNSKQHCLL
                     ESPTGSGKSLALLCSALAWQQSLSGKPADEGVSEKAEVQLSCCCACHSKDFTNNDMNQ
                     GTSRHFNYPSTPPSERNGTSSTCQDSPEKTTLAAKLSAKKQASIYRDENDDFQVEKKR
                     IRPLETTQQIRKRHCFGTEVHNLDAKVDSGKTVKLNSPLEKINSFSPQKPPGHCSRCC
                     CSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMTIL
                     SSRDHTCVHPEVVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKA
                     WDIEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQIRESMDLNLKEQVVIL
                     DEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLE
                     ANAEYLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIY
                     GKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFADDYKIAIQQTYSWTNQIDISD
                     KNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFS
                     SELGVTFTIQLEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLS
                     VCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEPQGGEKTNFDELLQ
                     VYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKR
                     QYNDHHSKLRGLLPGRQWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRY
                     ISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSL
                     KYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKNDPV
                     FLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKATPELGSSENSA
                     SSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKIDATLTRKNH
                     SEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEK
                     NDLAETDRGNRLANNSDCILAKDLFEIRTIKEVDSAREVKAEDCIDTKLNGILHIEES
                     KIDDIDGNVKTTWINELELGKTHEIEIKNFKPSPSKNKGMFPGFK"
     exon            369..480
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /inference="alignment:Splign:2.1.0"
     exon            481..654
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /inference="alignment:Splign:2.1.0"
     exon            655..782
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /inference="alignment:Splign:2.1.0"
     exon            783..902
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1193
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1415
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1615
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1748
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1903
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2069
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2210
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2372
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2532
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /inference="alignment:Splign:2.1.0"
     exon            2533..2654
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2767
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2850
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..3180
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /inference="alignment:Splign:2.1.0"
     exon            3181..8182
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6024..6029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /note="hexamer: AATAAA"
     polyA_site      6050
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /note="major polyA site"
     regulatory      7694..7699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /note="hexamer: AATAAA"
     polyA_site      7717
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
     regulatory      7912..7917
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /note="hexamer: AATAAA"
     polyA_site      7935
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
     regulatory      7952..7957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /note="hexamer: ATTAAA"
     polyA_site      7974
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
     regulatory      8163..8168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
                     /note="hexamer: ATTAAA"
     polyA_site      8182
                     /gene="BRIP1"
                     /gene_synonym="BACH1; FANCJ; OF"
ORIGIN      
        1 aggcgggaat tcgtctcggg ttgtgtggtt gaggggtctg gtgggtcgag gaaaggtaac
       61 ggcggcccca gtcctgcaca caaggccggg gaagtagcag cacccccagg aagagggagg
      121 aggaagggct cgtgcccttt cttctcttcc agggctccgc tttatttgct ctcagaagtc
      181 ggtttccttt ccttttcttc agtgaatcgg agctcagagc gttgcttcgg tttccctcca
      241 gacagttagg aatctgaaat aaacaggaaa gcactatgtc ttcaatgtgg tctgaatata
      301 caattggtgg ggtgaagatt tactttcctt ataaagctta cccgtcacag cttgctatga
      361 tgaattctat tctcagagga ttaaacagca agcaacattg tttgttggag agtcccacag
      421 gaagtggaaa aagcttagcc ttactttgtt ctgctttagc atggcaacaa tctcttagtg
      481 ggaaaccagc agatgagggc gtaagtgaaa aagctgaagt acaattgtca tgttgttgtg
      541 catgccattc aaaggatttt acaaacaatg acatgaacca aggaacttca cgtcatttca
      601 actatccaag cacaccacct tctgaaagaa atggcacttc atcaacttgt caagactccc
      661 ctgaaaaaac cactctggct gcaaagttat ctgctaagaa acaggcatcc atatacagag
      721 atgaaaatga tgattttcaa gtagagaaga aaagaattcg acccttagaa actacacagc
      781 agattagaaa acgtcattgc tttggaacag aagtacacaa tttggatgca aaagttgatt
      841 caggaaagac tgtaaaactc aactctccac tggaaaagat aaactccttt tcgccacaga
      901 aaccccctgg ccactgttct aggtgctgtt gttctactaa acaaggaaac agtcaagagt
      961 catcgaatac cattaagaag gatcatacag ggaaatccaa gatacccaaa atatattttg
     1021 ggacacgcac acacaagcag attgctcaga ttactagaga gctccggagg acggcatatt
     1081 caggggttcc aatgactatt ctttccagca gggatcatac ttgtgtccat cctgaggtag
     1141 tcggtaactt caacagaaat gagaagtgca tggaattgct agatgggaaa aacggaaaat
     1201 cctgctattt ttatcatgga gttcataaaa ttagtgatca gcacacatta cagactttcc
     1261 aagggatgtg caaagcctgg gatatagaag aacttgtcag cctggggaag aaactaaagg
     1321 cctgtccata ttacacagcc cgagaactaa tacaagatgc tgacatcata ttttgtccct
     1381 acaactatct tctagatgca caaataaggg aaagtatgga tttaaatctg aaagaacagg
     1441 ttgtcatttt agatgaagct cataacatcg aggactgtgc tcgggaatca gcaagttaca
     1501 gtgtaacaga agttcagctt cggtttgctc gggatgaact agatagtatg gtcaacaata
     1561 atataaggaa gaaagatcat gaacccctac gagctgtgtg ctgtagcctc attaattggt
     1621 tagaagcaaa cgctgaatat cttgtagaaa gagattatga atcagcttgt aaaatatgga
     1681 gtggaaatga aatgctctta actttacaca aaatgggtat caccactgct acttttccca
     1741 ttttgcaggg acatttttct gctgttcttc aaaaagagga aaaaatctca ccaatttatg
     1801 gtaaagagga ggcaagagaa gtacctgtta ttagtgcatc aactcaaata atgcttaaag
     1861 gactttttat ggtacttgac tatcttttta ggcaaaatag cagatttgca gatgattata
     1921 aaattgcgat tcaacagact tactcctgga caaatcagat tgatatttca gacaaaaatg
     1981 ggttgttggt tctaccaaaa aataagaaac gttcacgaca gaaaactgca gttcatgtgc
     2041 taaacttttg gtgcttaaat ccagctgtgg ccttttcaga tattaatggc aaagttcaga
     2101 ccattgtttt gacatctggt acattatcac caatgaaatc cttttcgtca gaacttggtg
     2161 ttacatttac tatccagctg gaggctaatc atatcattaa aaattcacag gtttgggttg
     2221 gtaccattgg gtcaggcccc aagggtcgga atctctgtgc taccttccag aatactgaaa
     2281 catttgagtt ccaagatgaa gtgggagcac ttttgttatc tgtgtgccag actgtgagcc
     2341 aaggaatttt gtgtttcttg ccatcttaca agttattaga aaaattaaaa gaacgttggc
     2401 tctctactgg tttatggcat aatctggagt tggtgaagac agtcattgta gaaccacagg
     2461 gaggagaaaa aacaaatttt gatgaattac tgcaggtgta ctatgacgca atcaaataca
     2521 aaggagagaa agatggagct ctcctggtag cagtttgtcg tggtaaagtg agtgagggtc
     2581 tggatttctc agatgacaat gcccgtgctg tcataacaat aggaattcct tttccaaatg
     2641 tgaaagatct acaggttgaa ctaaaacgac aatacaatga ccaccattca aaattgagag
     2701 gtcttctacc tggccgtcag tggtatgaaa ttcaagcata cagggcctta aaccaggccc
     2761 ttggtagatg tattagacac agaaatgatt ggggagctct tattctagtg gatgatcgct
     2821 ttaggaataa cccaagtcgc tatatatctg gactttctaa atgggtacgg cagcagattc
     2881 agcaccattc aacctttgaa agtgcactgg aatccttggc tgaattttcc aaaaagcatc
     2941 aaaaagttct taatgtatcc ataaaggaca gaaccaatat acaggacaat gagtctacac
     3001 ttgaagtgac ctctttaaag tacagtacct caccttattt actggaagca gcaagtcatc
     3061 tatcaccaga aaattttgtg gaagatgaag caaagatatg tgtccaggaa ctacagtgtc
     3121 ctaaaattat taccaaaaat tcacctctac caagtagcat tatctccaga aaggagaaaa
     3181 atgatccagt attcctggaa gaagcaggga aagcagaaaa aattgtgatt tccagatcca
     3241 caagcccaac tttcaacaaa caaacaaaga gagttagctg gtcaagcttt aattctttgg
     3301 gacagtattt tactggtaaa ataccgaagg caacacctga gctcgggtca tcagagaata
     3361 gtgcctctag tcctccccgt ttcaaaacag agaagatgga aagtaaaact gttttgccct
     3421 tcactgataa atgtgaatcc tcaaatctga cagtaaacac atcgtttgga tcatgccctc
     3481 aatcagaaac cattatttca tcattaaaga ttgatgccac ccttactaga aaaaatcatt
     3541 ctgaacatcc gctctgttct gaagaagccc tggatccaga cattgaattg tctctagtaa
     3601 gtgaagaaga taaacagtcc acttcaaata gagattttga aacagaagca gaagatgaat
     3661 ctatctattt tacacctgaa ctttatgatc ctgaagatac agatgaagaa aaaaatgacc
     3721 tagctgaaac tgatagagga aatagattgg ctaacaattc agattgcatt ttagctaaag
     3781 acctttttga aattagaact ataaaagaag tagattcagc cagagaagtg aaagctgagg
     3841 attgcataga tacaaagttg aatggaattc tgcatattga agaaagtaaa attgatgaca
     3901 ttgatggtaa tgtaaaaaca acttggataa atgaactgga actgggaaaa actcatgaaa
     3961 tagaaataaa gaactttaaa ccatctcctt ccaaaaataa aggcatgttt cctggtttta
     4021 agtaataata cttaactctc aagctaagta aaaatatgtc atcatgctta tgttaaactc
     4081 tgttgtaagt aataatttgt aaattgaata agtggcatac tttttaaaaa actattttat
     4141 gttcagaaat gtaaatgtta ttattcttga gtttttgggt tttttttttt gagacagagt
     4201 cttggtctgt tgcccaggct ggaatgcagt ggtgtgctct gggctcactg caaccttcac
     4261 ctccaggttc aagtgattct cctgcctcag ccttctgagt agctgggact acaggtgtgc
     4321 accaccatgc ccagctagtt tttgtatttt tagtagagat ggggtttcac catgttggcc
     4381 aggctggtct cgaactcctg gcctcgtgat ctgcccttct ctgcctccct aagttgctgg
     4441 gattacaggt gtgagccaca gtgcctggcc cattcttgag ttttgataaa gtaattcata
     4501 caaagtactg tcctcaaata agtcttcctt agctaaatgc aatttaaaat tattcaaaga
     4561 tcctagggca cttctagttt cacgtaaata ttcatattag gtggttctct tcatccattt
     4621 gttttcacac tgatacataa aaattaacag cagtctaatc tagtgacacc tcagtcatat
     4681 ttcgctatag attttacctc aaatcagtcc aagacttttt cagagatcac catttgtctt
     4741 gaaaggttta tttcgttatt aaactgccta cttataagta attaagagaa attaagaaag
     4801 tagtatgcat ttttaattga aattgtttta cattctttgt ataataaacc taaaaccaaa
     4861 catgtcataa acaaattgac gtaaagatat aaaatgccaa atgaagtatt ccaaattttc
     4921 tattctaatt atttagcttc accatcattg tggaaaaaaa tactagatcc tgcttagtat
     4981 tatatatttt tcctagtgga tcagtgagta ataagtacca aacactagac tagaaggtaa
     5041 tttctacatt gtttagaaag ggtgaaacaa tttatcccct ctggtattgt tctagcataa
     5101 gctttagtta tacaatgatt aagatagaaa acttcatata taaatttgat aagcaaaccc
     5161 acatttatag ctgcagctaa aatatgtttc cttagggcac agtaatcctt tctgtgaatt
     5221 ttgaccttgt ttgtgttttt gtgaatgaag ctatatgtct aatcaaaaat gattataaaa
     5281 gaggctcatc tctgacatca ttccaaaaat acattcattg atctcttttt aagaaacatc
     5341 tgttattcac tgggcattgg gactttttgt gagtaatttg aattgaaatt ttatgagcta
     5401 tccaagaatt ctgtatggtc tattattttc aagtcaaaat ttccagtaag gatttacttt
     5461 acatttcatt tggataaatg aatcattata taggtatgtc tttgcttcca ttttgagaca
     5521 tttagatttt tacagcctgt ttctatagca tttgatgtta caactctaag cgtagttcaa
     5581 agacatttaa attgacaagt taccagttaa agaatttaga atatattaga tcccatctag
     5641 tattatatat tttttctagt tgatcattga gcagtaaata ccaaatactc gattagaagg
     5701 taatttttac attgttttga aagggtgaaa caatttatct cctctggtat tattcttaaa
     5761 ccacagatag ggatagtagg gtagtgaaac gaataaatac ctggtagaag acaagagact
     5821 tgggctctac acctggctct gccactgatt tgctaagtca tattggcaat caccacaccc
     5881 ttcagggaat tagtttcatc tgtaaaatgc agcggttagt actataaaat catacaaatt
     5941 tctttgtgct ttgagaatct ataaaggaat gtctgttgat attctgagtc gattttcatt
     6001 tgcttttgtt ccagaacggt taaaataaag catattattt catttaaaaa gtaaagtggc
     6061 tcttactcat ttacatttag ggaacgatgg tgacgtggtt tggctatgtc cccagccaga
     6121 tctcatcttg aattgtagtt cccataatcc cgacgtgttg tgggaaggac ccagtgggag
     6181 gtaattgaat cgtgggggcg gttaccctca tgcggttctc gtgatactga gttcttatga
     6241 gacctgatga ttttataagg agcttttccc tgcttcactc tcattcttct ctcctgctgc
     6301 cctgtgaaaa gttgccttcc gccatgattg taagtttctt gaggcctcct cagtcatgca
     6361 gaactgtgag tcaattaaac ctctttcctt tataaattac ccagtcttgg gtatgacttt
     6421 attagcagca tgagaacaga ctgacacaga tggtatatgt gcataataac ttggaaagct
     6481 agatatttat tttcgcaatg ctacaattaa aacattttga ggacttttaa aattaccttt
     6541 agggccaggc gcggtggctc acgcctgtaa tcccagcact ttgggaggcc gaggcgggcg
     6601 gatcacgagg tcaggagatc gagaccatcc tggttaacac ggtgaaaccc cgtctctact
     6661 aaaaatacaa aaaattagcc aggcgtggtg gcgggcgcct gtagtcccag ctactcagga
     6721 ggctgaggca ggagaatggc gtgaacccgg gaggtggagc ttgcagtgag ccgagattgc
     6781 gccactgcac tccagcctgg gcgacagagc gggactccgt ctcaaaaaaa aaaaaaaaaa
     6841 gaaattacct ttagaattgg taaactacat gagaaaatta agcatattat tcatatctta
     6901 gtgttattac ccaacttcat ctccaatact ttcccctttc cctagctaga tatgtttttg
     6961 tttgtttgtt ttagacagtc ttgctctgtc gctcaggctg gagtgcaaag gcacgatctt
     7021 ggctcactgc aacctctgcc tcgcaggtta aagcgattct catgtctcag cctcctgcgt
     7081 agctgggatt acaggtgtac accactgcac ccagctaatt tttttttttt ttttttttta
     7141 agtatcgaca gggtttcacc atgttggcca ggctggtctc aaactcctga cctcaagtga
     7201 tctgcccacc tcggcctccc aaagtgttgg gattacaggc gtgagccacc atgcctggcc
     7261 tagatatttt ttattctttc caaaatttaa ttctccctga agttaaaaat tttcattact
     7321 gagaatgtac atagagatgt gtcacaaccc tttagtaatt ccaaaaggtg tttcaaaaat
     7381 tttatacaat gataatcact gttgaaacag gtgtatattc tcctcagatc atgactgacc
     7441 aagatgatat tccaagaagt aaactactgg cctttataga gtaggatgta ggccattttc
     7501 attactgata acatactttt aaaagaaatg tttacagatt taaataagtt aaaacatcta
     7561 aatgctttta aaagagcacc tggcacattg caagttattc attattaatt agtagatgaa
     7621 tcatatatct ggagtgcacc cttgctctat atgaaagctt ccctaactat agatatatag
     7681 gtgatagact gacaataaag atttgaggaa agaaaaatta tttggctggc ttatttttta
     7741 agcttttgag atgtataagg tagagattgt ttatcaaata atttatgtga cacattcaat
     7801 gcatatgaaa taattatcta atactgaatt tattcaagga ctgaaagtat atagagcaca
     7861 caggctgcaa accaggaaaa ctaccagtta gagacagggc tttattcttg gaataaaggt
     7921 acaatgtaaa gagtagatgt ttcatgactt gattaaatta tttaaaactg tctagaattg
     7981 tgttataaaa ctattactat gtttctatgc acttagttat tacatgggtt taaatttggc
     8041 actgtttcta agtttctata aggctttgtt gttaagatct ttctattcaa aacattaatt
     8101 ttaacaaaaa gcttttcccc gttatttttc tgcaactgga cttttttgta ttactttcct
     8161 atattaaaac gcatttaaaa ta
//
