LOCUS       NM_021165               4097 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens BMP/retinoic acid inducible neural specific 2
            (BRINP2), mRNA.
ACCESSION   NM_021165
VERSION     NM_021165.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4097)
  AUTHORS   Kawano,H., Nakatani,T., Mori,T., Ueno,S., Fukaya,M., Abe,A.,
            Kobayashi,M., Toda,F., Watanabe,M. and Matsuoka,I.
  TITLE     Identification and characterization of novel developmentally
            regulated neural-specific proteins, BRINP family
  JOURNAL   Brain Res Mol Brain Res 125 (1-2), 60-75 (2004)
   PUBMED   15193423
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL021398.1, DA118275.1, AB051534.1, AB161694.1 and AL022143.1.
            
            On Nov 22, 2018 this sequence version replaced NM_021165.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.171083.1,
                                           SRR1660807.54570.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361539.5/ ENSP00000354481.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-430               AL021398.1         51632-52061         c
            431-449             DA118275.1         1-19
            450-1450            AB051534.1         13-1013
            1451-3438           AB161694.1         1014-3001
            3439-3439           AL022143.1         41569-41569         c
            3440-4097           AB161694.1         3003-3660
FEATURES             Location/Qualifiers
     source          1..4097
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.2"
     gene            1..4097
                     /gene="BRINP2"
                     /gene_synonym="DBCCR1L2; FAM5B"
                     /note="BMP/retinoic acid inducible neural specific 2"
                     /db_xref="GeneID:57795"
                     /db_xref="HGNC:HGNC:13746"
                     /db_xref="MIM:619359"
     exon            1..775
                     /gene="BRINP2"
                     /gene_synonym="DBCCR1L2; FAM5B"
                     /inference="alignment:Splign:2.1.0"
     exon            776..1120
                     /gene="BRINP2"
                     /gene_synonym="DBCCR1L2; FAM5B"
                     /inference="alignment:Splign:2.1.0"
     CDS             852..3203
                     /gene="BRINP2"
                     /gene_synonym="DBCCR1L2; FAM5B"
                     /note="BMP/retinoic acid-inducible neural-specific protein
                     2; DBCCR1-like2; DBCCR1-like protein 2; protein FAM5B;
                     bone morphogenetic protein/retinoic acid inducible
                     neural-specific 2; family with sequence similarity 5,
                     member B; bone morphogenic protein/retinoic acid inducible
                     neural-specific 2"
                     /codon_start=1
                     /product="BMP/retinoic acid-inducible neural-specific
                     protein 2 precursor"
                     /protein_id="NP_066988.1"
                     /db_xref="CCDS:CCDS1320.1"
                     /db_xref="GeneID:57795"
                     /db_xref="HGNC:HGNC:13746"
                     /db_xref="MIM:619359"
                     /translation="MRWQCGTRFRGLRPAVAPWTALLALGLPGWVLAVSATAAAVVPE
                     QHASVAGQHPLDWLLTDRGPFHRAQEYADFMERYRQGFTTRYRIYREFARWKVNNLAL
                     ERKDFFSLPLPLAPEFIRNIRLLGRRPNLQQVTENLIKKYGTHFLLSATLGGEESLTI
                     FVDKQKLGRKTETTGGASIIGGSGNSTAVSLETLHQLAASYFIDRESTLRRLHHIQIA
                     TGAIKVTETRTGPLGCSNYDNLDSVSSVLVQSPENKVQLLGLQVLLPEYLRERFVAAA
                     LSYITCSSEGELVCKENDCWCKCSPTFPECNCPDADIQAMEDSLLQIQDSWATHNRQF
                     EESEEFQALLKRLPDDRFLNSTAISQFWAMDTSLQHRYQQLGAGLKVLFKKTHRILRR
                     LFNLCKRCHRQPRFRLPKERSLSYWWNRIQSLLYCGESTFPGTFLEQSHSCTCPYDQS
                     SCQGPIPCALGEGPACAHCAPDNSTRCGSCNPGYVLAQGLCRPEVAESLENFLGLETD
                     LQDLELKYLLQKQDSRIEVHSIFISNDMRLGSWFDPSWRKRMLLTLKSNKYKPGLVHV
                     MLALSLQICLTKNSTLEPVMAIYVNPFGGSHSESWFMPVNEGSFPDWERTNVDAAAQC
                     QNWTITLGNRWKTFFETVHVYLRSRIKSLDDSSNETIYYEPLEMTDPSKNLGYMKINT
                     LQVFGYSLPFDPDAIRDLILQLDYPYTQGSQDSALLQLIELRDRVNQLSPPGKVRLDL
                     FSCLLRHRLKLANNEVGRIQSSLRAFNSKLPNPVEYETGKLCS"
     exon            1121..1311
                     /gene="BRINP2"
                     /gene_synonym="DBCCR1L2; FAM5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1520
                     /gene="BRINP2"
                     /gene_synonym="DBCCR1L2; FAM5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1626
                     /gene="BRINP2"
                     /gene_synonym="DBCCR1L2; FAM5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1863
                     /gene="BRINP2"
                     /gene_synonym="DBCCR1L2; FAM5B"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2086
                     /gene="BRINP2"
                     /gene_synonym="DBCCR1L2; FAM5B"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..4097
                     /gene="BRINP2"
                     /gene_synonym="DBCCR1L2; FAM5B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3998..4003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRINP2"
                     /gene_synonym="DBCCR1L2; FAM5B"
                     /note="hexamer: AACAAA"
     polyA_site      4018
                     /gene="BRINP2"
                     /gene_synonym="DBCCR1L2; FAM5B"
                     /note="major polyA site"
     regulatory      4072..4077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRINP2"
                     /gene_synonym="DBCCR1L2; FAM5B"
                     /note="hexamer: AGTAAA"
     polyA_site      4097
                     /gene="BRINP2"
                     /gene_synonym="DBCCR1L2; FAM5B"
ORIGIN      
        1 gagtctgcag gtgacactgc ttaggtacgg agcgcggagt cggagcgggg acgcgccggg
       61 ctgcagctct gggatgcaat ccgcctgcct cgcaagctgc tcgccgctgc gctggcagcg
      121 cttacgctga gctcggagga tcccattagg acttgcccgg ggatgtgcac ctgccgtgcg
      181 ctccgaggtc agtggcaggt ctgcaggcag ccgagggagc ggtgaagccg gaagacctgt
      241 ctctgcccat gtgcaaggca gtgatttcgg gtgagagagc gggtgggtga gtctctttag
      301 agttggaaag aaggcaaaat cttgggtttc tcctcggcgg agggacaggg gactccccca
      361 gttgggtctt gcacttccct tacctctccc accccgcgtg cgccccggcc cagtgccgaa
      421 gccccacttc aaagatgctc tgggagaccg ggatcctggc tgctcagcgg gaaggcagca
      481 ggcaagtggt ctaacgttgg cggcggtggc ggtggcggcg gcggcggcac cgacagtaaa
      541 gcggggagca agagaatttg aaaagagaca tccgctccct ctcacacgct gagggggagg
      601 cattcgcgtt tccccaaatg agaaagaacc acaagaaatc atgaagtaaa aactttggaa
      661 agctgccact ggagatgttg cacaaaaacc tggaatcttt taggagtctc ctcccagtcg
      721 ttgaaggttt ggggagcagc tgatacagca aggagggctc ttgcaaggat tcaagctccg
      781 agccctggag gagcagcacg gagcgggaga gcgtggcgag agaatgaaga aaccaatcgc
      841 ccgggagaag catgaggtgg cagtgtggca ctcggtttag agggcttcgg ccggcggtgg
      901 ccccatggac agccctgctg gcactgggcc tgcctggctg ggtgttggct gtctcagcca
      961 cggcggctgc tgtggtcccc gagcagcatg cctccgtagc tggccagcat cccctggact
     1021 ggctgctcac agaccggggc cccttccacc gcgctcagga gtatgctgac ttcatggagc
     1081 ggtaccgcca gggtttcacc accaggtaca ggatttatag ggagtttgcc cgttggaagg
     1141 tgaacaactt ggctctggaa aggaaggact tcttcagttt gccattgcct cttgccccag
     1201 agtttatccg gaacattcgc ctccttggaa ggagacccaa tctgcaacag gttacagaaa
     1261 atctgattaa aaagtacggc actcatttct tactttctgc cacccttgga ggagaagagt
     1321 ccctgaccat ttttgtggac aagcagaaac tgggaagaaa gacagagaca acaggaggtg
     1381 cctctataat cgggggcagt gggaacagca cagctgtgtc cctggagacc ctgcaccagc
     1441 tggccgcctc ctacttcatc gacagagaga gcacgctgcg acggctgcac catatccaga
     1501 tagccacggg ggccatcaag gtcaccgaga ccaggaccgg tcctctgggc tgcagcaact
     1561 atgacaatct ggactcagtc agttctgtct tggtacagag tccagagaac aaagtacagt
     1621 tacttggcct tcaggtgctg ctgcctgagt atctgcgtga gcgctttgta gctgcagcac
     1681 tcagctacat cacatgcagc tctgagggtg agctcgtctg caaggagaat gactgctggt
     1741 gcaagtgcag ccccaccttc cctgaatgca actgccctga tgctgacatc caggccatgg
     1801 aggacagcct gctgcagatc caggactcct gggccactca caaccggcag tttgaagagt
     1861 cagaagagtt ccaggccctg ctgaaaaggc tgcccgatga ccggttcctg aactccacag
     1921 ctatctccca gttctgggcc atggacacca gccttcagca ccgctaccag cagctgggag
     1981 ctggcttgaa agtgctgttc aaaaagaccc atcggatcct acgccggctc ttcaacctct
     2041 gcaagcgctg ccatcgccag cctcgcttcc gcctgcccaa ggagaggtcc ttgtcctact
     2101 ggtggaaccg aatccagtcc ctcctctact gtggggaaag cacctttcct ggcactttcc
     2161 tggaacagag ccacagctgc acctgcccct atgaccaatc ttcctgccag ggccccatcc
     2221 catgtgcctt gggcgaaggg cccgcgtgtg cccactgtgc tccagacaat agcacacgct
     2281 gtgggagctg caacccgggc tatgtgctgg cccaggggct gtgccggcca gaggtggccg
     2341 agtccctgga aaactttctt gggctggaga cagacttgca ggacctggag ctaaagtacc
     2401 tgctgcagaa gcaggatagc cgcattgagg tacactccat cttcatcagc aatgacatgc
     2461 ggctgggcag ctggtttgac ccttcctgga ggaagcgcat gctgctcacc ctgaagagca
     2521 acaagtacaa gcctgggctg gtgcacgtga tgttggcctt gtccttgcag atctgtctca
     2581 ccaagaacag caccctggag cctgtcatgg ccatctacgt caaccccttt gggggcagcc
     2641 actctgagag ctggttcatg cctgtgaatg agggcagctt tcctgactgg gaaaggacta
     2701 acgtggatgc agctgcccag tgccaaaact ggactatcac cttggggaat aggtggaaga
     2761 ctttctttga gacagttcat gtttacctac ggagccgaat caagtccctg gatgacagct
     2821 ccaatgagac aatctactat gagcccctgg agatgactga tccctctaag aatttgggtt
     2881 acatgaaaat taacaccttg caggtctttg gctacagcct gccctttgac ccagatgcta
     2941 tccgggactt aattctccag ttggactacc catatactca aggttcccag gactctgcac
     3001 tcttgcagct cattgagctc agggaccggg tgaaccagct ttctccacct ggcaaagtcc
     3061 gacttgacct tttctcctgc ttgctccggc atcggcttaa gctggccaac aatgaggtgg
     3121 gcaggatcca gtcctccctg agggctttca attctaagct gccaaaccct gtggaatatg
     3181 agaccggcaa actctgtagc taatgggcgg cccacttcag cactgggcaa ggaggggatc
     3241 catgaatctg gggtacaaag ataatctaag ccctcacctt agtgccaaca gggtgtgctc
     3301 ccacgagact ttcagcatcc agtagatggg acctcgaggc tcgagctgaa gcaggcgaga
     3361 gagaaacagc tactgcgtgc gtgcgcgcac gcatacacac acacacacac acactggcac
     3421 agggaggcta caactaagca gcctcagatc tgtaaagttg attggtgctt tctaaaatga
     3481 atgcaattga aagaaaggag ccaaggaaga gattaagaaa aagaaccagc tgaaccatga
     3541 aacaaacaaa aatcctaaaa gtgattcttg tcattcaaga aagcaagagg ggacaacaat
     3601 gggaggggtc ggagctcttc cttcccctct gtggagtcac ttttgtattc tttttaacca
     3661 gatttcttaa aatgttgttg ttttgtgaat cctgacattg gttcttactt ttgtatgctg
     3721 cctcctctgt gccctcccag acgctgactg ggaaacacaa gaagtacaac caacaggaac
     3781 cagcgccaag ggcaggcagc ggcctccttg ctcccctccc ttactcctcc ctctgctgcc
     3841 tcctcccccc accaagtttc agggccctgg attgttccca gttcccattg tggtcccttc
     3901 agagctcctt tccaacagca tctctctgtc gaagaaagaa gctctgtcaa gttagagaga
     3961 gacaatgtgt aggaaatgtt cttttttaaa aaaaaataac aaaaacaaaa caaaactatt
     4021 tattttgtga ttgttttcct tgttaatctg ctccaaccac ctgaacatct aagtaaacat
     4081 ttatctggtt taatata
//
