LOCUS       NM_014618               3171 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens BMP/retinoic acid inducible neural specific 1
            (BRINP1), mRNA.
ACCESSION   NM_014618
VERSION     NM_014618.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3171)
  AUTHORS   Zhou,G., Ye,J., Fang,Y., Zhang,Z., Zhang,J., Sun,L. and Feng,J.
  TITLE     Identification of DBCCR1 as a suppressor in the development of lung
            cancer that is associated with increased DNA methyltransferase 1
  JOURNAL   Oncotarget 8 (20), 32821-32832 (2017)
   PUBMED   28427182
  REMARK    GeneRIF: Results found that the expression of DBCCR1 is
            significantly lower in the lung cancer tissues compared with
            adjacent non-tumor tissues of patients, and correlates with more
            advanced stages of cancer, and shorter survival of patients.
            Interestingly, DBCCR1 attenuates the expression of DNMT1,
            suggesting a reciprocal regulation between genetic silencing of
            cancer suppressor genes and activating DNA methylation.
REFERENCE   2  (bases 1 to 3171)
  AUTHORS   Chini,C.C., Escande,C., Nin,V. and Chini,E.N.
  TITLE     DBC1 (Deleted in Breast Cancer 1) modulates the stability and
            function of the nuclear receptor Rev-erbalpha
  JOURNAL   Biochem J 451 (3), 453-461 (2013)
   PUBMED   23398316
  REMARK    GeneRIF: DBC1 modulates the stability and function of the nuclear
            receptor Rev-erb-alpha.
REFERENCE   3  (bases 1 to 3171)
  AUTHORS   Raynes,R., Pombier,K.M., Nguyen,K., Brunquell,J., Mendez,J.E. and
            Westerheide,S.D.
  TITLE     The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the
            heat shock response
  JOURNAL   PLoS One 8 (1), e54364 (2013)
   PUBMED   23349863
  REMARK    GeneRIF: we found that the SIRT1 modulators AROS and DBC1 have an
            impact on hsp70 transcription, HSF1 acetylation status, and HSF1
            recruitment to the hsp70 promoter
REFERENCE   4  (bases 1 to 3171)
  AUTHORS   Yuan,J., Luo,K., Liu,T. and Lou,Z.
  TITLE     Regulation of SIRT1 activity by genotoxic stress
  JOURNAL   Genes Dev 26 (8), 791-796 (2012)
   PUBMED   22465953
  REMARK    GeneRIF: the stress-induced DBC1-SIRT1 interaction is important for
            cell fate determination following genotoxic stress.
REFERENCE   5  (bases 1 to 3171)
  AUTHORS   Close,P., East,P., Dirac-Svejstrup,A.B., Hartmann,H., Heron,M.,
            Maslen,S., Chariot,A., Soding,J., Skehel,M. and Svejstrup,J.Q.
  TITLE     DBIRD complex integrates alternative mRNA splicing with RNA
            polymerase II transcript elongation
  JOURNAL   Nature 484 (7394), 386-389 (2012)
   PUBMED   22446626
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3171)
  AUTHORS   Nishiyama,H., Gill,J.H., Pitt,E., Kennedy,W. and Knowles,M.A.
  TITLE     Negative regulation of G(1)/S transition by the candidate bladder
            tumour suppressor gene DBCCR1
  JOURNAL   Oncogene 20 (23), 2956-2964 (2001)
   PUBMED   11420708
REFERENCE   7  (bases 1 to 3171)
  AUTHORS   Nishiyama,H., Takahashi,T., Kakehi,Y., Habuchi,T. and Knowles,M.A.
  TITLE     Homozygous deletion at the 9q32-33 candidate tumor suppressor locus
            in primary human bladder cancer
  JOURNAL   Genes Chromosomes Cancer 26 (2), 171-175 (1999)
   PUBMED   10469456
REFERENCE   8  (bases 1 to 3171)
  AUTHORS   Nishiyama,H., Hornigold,N., Davies,A.M. and Knowles,M.A.
  TITLE     A sequence-ready 840-kb PAC contig spanning the candidate tumor
            suppressor locus DBC1 on human chromosome 9q32-q33
  JOURNAL   Genomics 59 (3), 335-338 (1999)
   PUBMED   10444335
REFERENCE   9  (bases 1 to 3171)
  AUTHORS   Habuchi,T., Luscombe,M., Elder,P.A. and Knowles,M.A.
  TITLE     Structure and methylation-based silencing of a gene (DBCCR1) within
            a candidate bladder cancer tumor suppressor region at 9q32-q33
  JOURNAL   Genomics 48 (3), 277-288 (1998)
   PUBMED   9545632
REFERENCE   10 (bases 1 to 3171)
  AUTHORS   Habuchi,T., Yoshida,O. and Knowles,M.A.
  TITLE     A novel candidate tumour suppressor locus at 9q32-33 in bladder
            cancer: localization of the candidate region within a single 840 kb
            YAC
  JOURNAL   Hum Mol Genet 6 (6), 913-919 (1997)
   PUBMED   9175739
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL138894.11, BC065196.1, Z41452.1 and AL353773.9.
            
            On Nov 22, 2018 this sequence version replaced NM_014618.2.
            
            Summary: This gene is located within a chromosomal region that
            shows loss of heterozygosity in some bladder cancers.  It contains
            a 5' CpG island that may be a frequent target of hypermethylation,
            and it may undergo hypermethylation-based silencing in some bladder
            cancers. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.100445.1,
                                           SRR1803617.54931.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145544, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265922.8/ ENSP00000265922.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-343               AL138894.11        139476-139818       c
            344-1047            BC065196.1         323-1026
            1048-1048           AL138894.11        9105-9105           c
            1049-2890           BC065196.1         1028-2869
            2891-3170           Z41452.1           1-280               c
            3171-3171           AL353773.9         28781-28781         c
FEATURES             Location/Qualifiers
     source          1..3171
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q33.1"
     gene            1..3171
                     /gene="BRINP1"
                     /gene_synonym="DBC1; DBCCR1; FAM5A"
                     /note="BMP/retinoic acid inducible neural specific 1"
                     /db_xref="GeneID:1620"
                     /db_xref="HGNC:HGNC:2687"
                     /db_xref="MIM:602865"
     exon            1..380
                     /gene="BRINP1"
                     /gene_synonym="DBC1; DBCCR1; FAM5A"
                     /inference="alignment:Splign:2.1.0"
     exon            381..648
                     /gene="BRINP1"
                     /gene_synonym="DBC1; DBCCR1; FAM5A"
                     /inference="alignment:Splign:2.1.0"
     CDS             431..2716
                     /gene="BRINP1"
                     /gene_synonym="DBC1; DBCCR1; FAM5A"
                     /note="deleted in bladder cancer chromosome region
                     candidate 1; deleted in bladder cancer protein 1; bone
                     morphogenetic protein/retinoic acid inducible
                     neural-specific 1; bA574M5.1 (deleted in bladder cancer
                     chromosome region candidate 1 (IB3089A)); deleted in
                     bladder cancer 1; bone morphogenic protein/retinoic acid
                     inducible neural-specific 1; BMP/retinoic acid-inducible
                     neural-specific protein 1"
                     /codon_start=1
                     /product="BMP/retinoic acid-inducible neural-specific
                     protein 1 precursor"
                     /protein_id="NP_055433.2"
                     /db_xref="CCDS:CCDS6822.1"
                     /db_xref="GeneID:1620"
                     /db_xref="HGNC:HGNC:2687"
                     /db_xref="MIM:602865"
                     /translation="MNWRFVELLYFLFIWGRISVQPSHQEPAGTDQHVSKEFDWLISD
                     RGPFHHSRSYLSFVERHRQGFTTRYKIYREFARWKVRNTAIERRDLVRHPVPLMPEFQ
                     RSIRLLGRRPTTQQFIDTIIKKYGTHLLISATLGGEEALTMYMDKSRLDRKSGNATQS
                     VEALHQLASSYFVDRDGTMRRLHEIQISTGAIKVTETRTGPLGCNSYDNLDSVSSVLL
                     QSTESKLHLQGLQIIFPQYLQEKFVQSALSYIMCNGEGEYLCQNSQCRCQCAEEFPQC
                     NCPITDIQIMEYTLANMAKSWAEAYKDLENSDEFKSFMKRLPSNHFLTIGSIHQHWGN
                     DWDLQNRYKLLQSATEAQRQKIQRTARKLFGLSVRCRHNPNHQLPRERTIQQWLARVQ
                     SLLYCNENGFWGTFLESQRSCVCHGSTTLCQRPIPCVIGGNNSCAMCSLANISLCGSC
                     NKGYKLYRGRCEPQNVDSERSEQFISFETDLDFQDLELKYLLQKMDSRLYVHTTFISN
                     EIRLDTFFDPRWRKRMSLTLKSNKNRMDFIHMVIGMSMRICQMRNSSLDPMFFVYVNP
                     FSGSHSEGWNMPFGEFGYPRWEKIRLQNSQCYNWTLLLGNRWKTFFETVHIYLRSRTR
                     LPTLLRNETGQGPVDLSDPSKRQFYIKISDVQVFGYSLRFNADLLRSAVQQVNQSYTQ
                     GGQFYSSSSVMLLLLDIRDRINRLAPPVAPGKPQLDLFSCMLKHRLKLTNSEIIRVNH
                     ALDLYNTEILKQSDQMTAKLC"
     exon            649..839
                     /gene="BRINP1"
                     /gene_synonym="DBC1; DBCCR1; FAM5A"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1009
                     /gene="BRINP1"
                     /gene_synonym="DBC1; DBCCR1; FAM5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1115
                     /gene="BRINP1"
                     /gene_synonym="DBC1; DBCCR1; FAM5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1352
                     /gene="BRINP1"
                     /gene_synonym="DBC1; DBCCR1; FAM5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1575
                     /gene="BRINP1"
                     /gene_synonym="DBC1; DBCCR1; FAM5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..3171
                     /gene="BRINP1"
                     /gene_synonym="DBC1; DBCCR1; FAM5A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3140..3145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRINP1"
                     /gene_synonym="DBC1; DBCCR1; FAM5A"
                     /note="hexamer: GATAAA"
     polyA_site      3171
                     /gene="BRINP1"
                     /gene_synonym="DBC1; DBCCR1; FAM5A"
                     /note="major polyA site"
ORIGIN      
        1 attcgccagc cgcctcgctc ccggacccca cggctgcaaa ctgatctggc gcgcggggag
       61 gaggagagcg caggcgagcg aacccgcgag agagggagag agcgagcgag caacagcgag
      121 agcgagagcg agagagccgg gaggcagagg gagtagtgac cgccttccgg agccgggatt
      181 catgcctgtc ctcgggacca gcgaagggga ctttacggct gagtatgagc caggctgcta
      241 ggagccaggt acccccacgc ctgcagtccc cgcgccgtgc ccggaatgcg agctgcacgc
      301 agggctctcc caagttccca ccgagccgaa taaaaagcgt cctcccgcag ctctccgcca
      361 aagacggaca ttgactccag gactccacag aatggagcaa gaatgagagg aaaaaggccg
      421 gcagaaaagc atgaactgga ggtttgttga gctcctctac ttcctgttta tatggggccg
      481 tatctcagtg cagccctccc accaggaacc agctgggaca gaccaacatg tctccaagga
      541 atttgattgg ctcatttcag acagggggcc tttccaccac tccaggagct acctatcctt
      601 tgtggaaaga caccgtcaag gatttacaac cagatataaa atatacaggg agtttgcccg
      661 ttggaaggtg aggaacacag ccatcgagag gagagatctg gtccgccatc cagtgcccct
      721 catgccggag tttcaaagga gcatccgcct gcttggcagg agacctacca ctcagcagtt
      781 catcgatacc atcatcaaaa agtacggcac ccacctgctc atctcagcca cattgggagg
      841 ggaggaggct ttgaccatgt atatggacaa aagtcgcctc gacaggaagt cagggaatgc
      901 cactcaaagt gttgaagctc tgcaccagct cgcatcatcc tactttgttg accgtgatgg
      961 taccatgagg aggcttcatg agatccagat atcaactgga gcaatcaagg tcacagagac
     1021 acgcactggg cctctgggct gtaacagcta tgacaatctg gactctgtga gttccgtcct
     1081 tctgcaaagc acggagagca aactgcacct tcaaggtctt cagataatct ttcctcagta
     1141 tctgcaagag aagtttgtcc agtcggcctt gagctatatc atgtgcaatg gggaggggga
     1201 gtacctgtgc cagaacagcc agtgtcgctg ccaatgtgcc gaggagtttc cgcagtgcaa
     1261 ctgccccatc acggacatcc agatcatgga gtacacgctg gccaacatgg ccaagtcttg
     1321 ggccgaagct tataaggacc tggagaattc agatgagttt aaatcattta tgaagcgcct
     1381 ccccagcaac cacttcctga ccatcggaag catccatcag cactggggca atgactggga
     1441 cctgcagaac cgctacaagc tcctgcagag tgccacggag gcacagagac aaaagatcca
     1501 acgcactgcc cgcaagcttt tcggcctcag tgtacgctgt cgccacaatc ccaaccacca
     1561 gctgcctaga gagaggacaa ttcagcagtg gcttgcaagg gtccagtcac tcctctactg
     1621 taatgagaat gggttttggg gaaccttcct ggagagccag cggagctgcg tgtgccacgg
     1681 cagcaccacg ctgtgccagc gccccatccc ctgcgtgata ggcgggaaca acagctgcgc
     1741 catgtgcagc ctggccaaca tctccctctg cggctcctgc aacaagggct acaagctgta
     1801 tcgaggccgc tgtgaaccac agaacgtgga ctcggagcgg agcgagcagt tcatcagctt
     1861 tgagactgac ctggacttcc aggacctgga gctgaagtac ctgctgcaga agatggactc
     1921 acgcctctac gtccacacca ccttcatcag caacgagatc cgcctcgaca ccttctttga
     1981 ccctcggtgg cgcaagcgca tgtccctcac tctcaagagc aacaagaacc gcatggactt
     2041 catccacatg gtgatcggca tgtccatgcg catctgccag atgcgcaaca gcagcctgga
     2101 ccccatgttc tttgtctatg tcaacccctt tagcgggagc cattcggagg gctggaacat
     2161 gcccttcggg gaatttggct acccacgctg ggagaagatc cgtctccaaa acagccagtg
     2221 ctacaactgg actcttttgc tgggcaatcg gtggaaaaca tttttcgaga cggtccacat
     2281 ctacctacgt agtcggactc ggctacctac cctactgcga aatgagactg gccagggccc
     2341 cgtggacctg tcggatccct ccaagaggca gttctacatc aagatctcag acgtgcaggt
     2401 gtttgggtat agcctgaggt tcaacgccga cctcctgcgc agtgcagtgc agcaggtcaa
     2461 ccagtcctac acacagggcg gccagttcta ttcctcttcg tcagtgatgc tcctcttgtt
     2521 ggatattcgg gaccgaatta atcgcctggc ccctcctgtg gccccgggga aaccccagct
     2581 ggacttgttc tcctgtatgc tgaaacaccg cctgaaactg accaacagcg agatcatcag
     2641 ggtgaaccac gccttggacc tgtacaacac ggagatcctc aaacagtcgg accagatgac
     2701 agccaaactc tgctaacccg ggactccttg ccatggactt ttcctgttgt tgtacacaca
     2761 caacagaaca aaatgaagca aaacaaaaca aaaaaaccca caaaaatttg taaaatgtaa
     2821 ttaatattca aagaaaagga ggaaaatctt catttgttgg aaatgaaaac gttctagcaa
     2881 ctgtataaaa gcgttgggca tgtttgttat ttctatactc actctgtcat gaagaagggt
     2941 ctcagccttt tgtggagcat tgagggagtt gcttcttagg cctcaggtgc tgtattgggg
     3001 gagaagggag aaagcatatg caatgaattg taaagatctc tgctgtgcag gtgctaagat
     3061 taaacactaa aaagaaagag agatatatgt aatgtacaac tgacactgcc atttttcctt
     3121 tttggaggaa atggacatag ataaagaaga tatttcttcg gttaagattt a
//
