LOCUS       NM_015379                790 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens brain protein I3 (BRI3), transcript variant 1, mRNA.
ACCESSION   NM_015379
VERSION     NM_015379.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 790)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 790)
  AUTHORS   Yasukawa,T., Tsutsui,A., Tomomori-Sato,C., Sato,S., Saraf,A.,
            Washburn,M.P., Florens,L., Terada,T., Shimizu,K., Conaway,R.C.,
            Conaway,J.W. and Aso,T.
  TITLE     NRBP1-Containing CRL2/CRL4A Regulates Amyloid beta Production by
            Targeting BRI2 and BRI3 for Degradation
  JOURNAL   Cell Rep 30 (10), 3478-3491 (2020)
   PUBMED   32160551
  REMARK    GeneRIF: NRBP1-Containing CRL2/CRL4A Regulates Amyloid beta
            Production by Targeting BRI2 and BRI3 for Degradation.
REFERENCE   3  (bases 1 to 790)
  AUTHORS   Akiva,I. and Birgul Iyison,N.
  TITLE     Identification of IFITM3 and MGAT1 as novel interaction partners of
            BRI3 by yeast two-hybrid screening
  JOURNAL   Turk J Biol 42 (6), 463-470 (2018)
   PUBMED   30983867
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 790)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   5  (bases 1 to 790)
  AUTHORS   Kavak,E., Najafov,A., Ozturk,N., Seker,T., Cavusoglu,K., Aslan,T.,
            Duru,A.D., Saygili,T., Hoxhaj,G., Hiz,M.C., Unal,D.O.,
            Birgul-Iyison,N., Ozturk,M. and Koman,A.
  TITLE     Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide
            microarray and promoter analysis: Identification of BRI3 and HSF2
            as novel targets
  JOURNAL   Cell Signal 22 (10), 1523-1535 (2010)
   PUBMED   20538055
  REMARK    GeneRIF: In the context of hepatocellular carcinoma cells, BRI3 is
            a target of WNT signaling.
REFERENCE   6  (bases 1 to 790)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 790)
  AUTHORS   Wickham,L., Benjannet,S., Marcinkiewicz,E., Chretien,M. and
            Seidah,N.G.
  TITLE     Beta-amyloid protein converting enzyme 1 and brain-specific type II
            membrane protein BRI3: binding partners processed by furin
  JOURNAL   J Neurochem 92 (1), 93-102 (2005)
   PUBMED   15606899
REFERENCE   8  (bases 1 to 790)
  AUTHORS   Wu,H., Liu,G., Li,C. and Zhao,S.
  TITLE     bri3, a novel gene, participates in tumor necrosis
            factor-alpha-induced cell death
  JOURNAL   Biochem Biophys Res Commun 311 (2), 518-524 (2003)
   PUBMED   14592447
REFERENCE   9  (bases 1 to 790)
  AUTHORS   Lin,L., Wu,Y., Li,C. and Zhao,S.
  TITLE     Cloning, tissue expression pattern, and chromosome location of a
            novel human gene BRI3BP
  JOURNAL   Biochem Genet 39 (11-12), 369-377 (2001)
   PUBMED   11860200
REFERENCE   10 (bases 1 to 790)
  AUTHORS   Matoba,R., Okubo,K., Hori,N., Fukushima,A. and Matsubara,K.
  TITLE     The addition of 5'-coding information to a 3'-directed cDNA library
            improves analysis of gene expression
  JOURNAL   Gene 146 (2), 199-207 (1994)
   PUBMED   8076819
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ083249.1, BC062370.1, BQ018487.1 and AC093169.3.
            
            On May 17, 2019 this sequence version replaced NM_015379.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD101728.1, HY026844.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297290.4/ ENSP00000297290.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BQ083249.1         20-36
            18-767              BC062370.1         1-750
            768-772             BQ018487.1         19-23               c
            773-790             AC093169.3         1552-1569
FEATURES             Location/Qualifiers
     source          1..790
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.3"
     gene            1..790
                     /gene="BRI3"
                     /gene_synonym="I3"
                     /note="brain protein I3"
                     /db_xref="GeneID:25798"
                     /db_xref="HGNC:HGNC:1109"
                     /db_xref="MIM:615628"
     exon            1..252
                     /gene="BRI3"
                     /gene_synonym="I3"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..488
                     /gene="BRI3"
                     /gene_synonym="I3"
                     /note="isoform a is encoded by transcript variant 1;
                     pRGR2; membrane protein BRI3"
                     /codon_start=1
                     /product="membrane protein BRI3 isoform a"
                     /protein_id="NP_056194.1"
                     /db_xref="CCDS:CCDS5656.1"
                     /db_xref="GeneID:25798"
                     /db_xref="HGNC:HGNC:1109"
                     /db_xref="MIM:615628"
                     /translation="MDHKPLLQERPPAYNLEAGQGDYACGPHGYGAIPAAPPPPPYPY
                     LVTGIPTHHPRVYNIHSRTVTRYPANSIVVVGGCPVCRVGVLEDCFTFLGIFLAIILF
                     PFGFICCFALRKRRCPNCGATFA"
     exon            253..355
                     /gene="BRI3"
                     /gene_synonym="I3"
                     /inference="alignment:Splign:2.1.0"
     exon            356..790
                     /gene="BRI3"
                     /gene_synonym="I3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      748..753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRI3"
                     /gene_synonym="I3"
                     /note="hexamer: AATAAA"
     polyA_site      769
                     /gene="BRI3"
                     /gene_synonym="I3"
                     /note="major polyA site"
ORIGIN      
        1 agaggggccc gagccacccg gtccgccgcg tccccgccgc cgccgccgcg tcccccgccg
       61 gggccgaccg agccgagccg ggccggagcg gcgggcgcgg ccgggccgcc atggaccaca
      121 agccgctgct gcaggagcgg ccgcccgcct acaacctgga ggccggccag ggcgactacg
      181 cgtgcggccc gcacggctac ggcgccatcc ccgccgcgcc cccgccgccg ccctacccct
      241 acctcgtcac agggataccc acccaccatc ccagggtcta caacatccac agccggaccg
      301 tcacccgcta tcctgccaac tctatcgtgg tcgtaggagg ctgtcctgtc tgcagggttg
      361 gggtgctgga ggactgcttc accttcctgg gcatcttcct ggccatcatc ctcttcccct
      421 ttgggttcat ttgctgtttt gccttgagga agcgacgatg ccccaactgt ggagccacct
      481 tcgcttaaag ggaacaccag gcccggcttt cctacaccca gctctctttt tctaatgtaa
      541 atgttgtgta caataatttt atttgattaa gcttcaggac tgttttgtaa agcgaggtgg
      601 gaccgatgtg gcacacgcca gctgcggttt cccggagcgt ggagaggcag tgctgctgct
      661 cccgcccgag gctcatgaca actcaataaa gcactgcttt tattttttgc agtcttcaat
      721 ttgagaaagg tgagaaataa tgttttcaat aaatgagatt cataccattg ttgacctggt
      781 gctgcttact
//
