LOCUS       NM_139199               4028 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens bromodomain containing 8 (BRD8), transcript variant 2,
            mRNA.
ACCESSION   NM_139199
VERSION     NM_139199.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4028)
  AUTHORS   Yamaguchi,K., Nakagawa,S. and Furukawa,Y.
  TITLE     Understanding the role of BRD8 in human carcinogenesis
  JOURNAL   Cancer Sci 115 (9), 2862-2870 (2024)
   PUBMED   38965933
  REMARK    GeneRIF: Understanding the role of BRD8 in human carcinogenesis.
            Review article
REFERENCE   2  (bases 1 to 4028)
  AUTHORS   Sun,X., Klingbeil,O., Lu,B., Wu,C., Ballon,C., Ouyang,M., Wu,X.S.,
            Jin,Y., Hwangbo,Y., Huang,Y.H., Somerville,T.D.D., Chang,K.,
            Park,J., Chung,T., Lyons,S.K., Shi,J., Vogel,H., Schulder,M.,
            Vakoc,C.R. and Mills,A.A.
  TITLE     BRD8 maintains glioblastoma by epigenetic reprogramming of the p53
            network
  JOURNAL   Nature 613 (7942), 195-202 (2023)
   PUBMED   36544023
  REMARK    GeneRIF: BRD8 maintains glioblastoma by epigenetic reprogramming of
            the p53 network.
REFERENCE   3  (bases 1 to 4028)
  AUTHORS   Browne,J.A., NandyMazumdar,M., Paranjapye,A., Leir,S.H. and
            Harris,A.
  TITLE     The Bromodomain Containing 8 (BRD8) transcriptional network in
            human lung epithelial cells
  JOURNAL   Mol Cell Endocrinol 524, 111169 (2021)
   PUBMED   33476703
  REMARK    GeneRIF: The Bromodomain Containing 8 (BRD8) transcriptional
            network in human lung epithelial cells.
REFERENCE   4  (bases 1 to 4028)
  AUTHORS   Yu,Z., Chen,T., Mo,H., Guo,C. and Liu,Q.
  TITLE     BRD8, which is negatively regulated by miR-876-3p, promotes the
            proliferation and apoptosis resistance of hepatocellular carcinoma
            cells via KAT5
  JOURNAL   Arch Biochem Biophys 693, 108550 (2020)
   PUBMED   32860757
  REMARK    GeneRIF: BRD8, which is negatively regulated by miR-876-3p,
            promotes the proliferation and apoptosis resistance of
            hepatocellular carcinoma cells via KAT5.
REFERENCE   5  (bases 1 to 4028)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4028)
  AUTHORS   Cai,Y., Jin,J., Tomomori-Sato,C., Sato,S., Sorokina,I.,
            Parmely,T.J., Conaway,R.C. and Conaway,J.W.
  TITLE     Identification of new subunits of the multiprotein mammalian
            TRRAP/TIP60-containing histone acetyltransferase complex
  JOURNAL   J Biol Chem 278 (44), 42733-42736 (2003)
   PUBMED   12963728
REFERENCE   7  (bases 1 to 4028)
  AUTHORS   Lai,F., Godley,L.A., Joslin,J., Fernald,A.A., Liu,J., Espinosa,R.
            3rd, Zhao,N., Pamintuan,L., Till,B.G., Larson,R.A., Qian,Z. and Le
            Beau,M.M.
  TITLE     Transcript map and comparative analysis of the 1.5-Mb commonly
            deleted segment of human 5q31 in malignant myeloid diseases with a
            del(5q)
  JOURNAL   Genomics 71 (2), 235-245 (2001)
   PUBMED   11161817
REFERENCE   8  (bases 1 to 4028)
  AUTHORS   Monden,T., Kishi,M., Hosoya,T., Satoh,T., Wondisford,F.E.,
            Hollenberg,A.N., Yamada,M. and Mori,M.
  TITLE     p120 acts as a specific coactivator for 9-cis-retinoic acid
            receptor (RXR) on peroxisome proliferator-activated
            receptor-gamma/RXR heterodimers
  JOURNAL   Mol Endocrinol 13 (10), 1695-1703 (1999)
   PUBMED   10517671
REFERENCE   9  (bases 1 to 4028)
  AUTHORS   Monden,T., Wondisford,F.E. and Hollenberg,A.N.
  TITLE     Isolation and characterization of a novel ligand-dependent thyroid
            hormone receptor-coactivating protein
  JOURNAL   J Biol Chem 272 (47), 29834-29841 (1997)
   PUBMED   9368056
REFERENCE   10 (bases 1 to 4028)
  AUTHORS   Nielsen,M.S., Petersen,C.M., Gliemann,J. and Madsen,P.
  TITLE     Cloning and sequencing of a human cDNA encoding a putative
            transcription factor containing a bromodomain
  JOURNAL   Biochim Biophys Acta 1306 (1), 14-16 (1996)
   PUBMED   8611617
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC109442.3 and AC113382.2.
            
            On Jun 2, 2019 this sequence version replaced NM_139199.1.
            
            Summary: The protein encoded by this gene interacts with thyroid
            hormone receptor in a ligand-dependent manner and enhances thyroid
            hormone-dependent activation from thyroid response elements. This
            protein contains a bromodomain and is thought to be a nuclear
            receptor coactivator. Multiple alternatively spliced transcript
            variants that encode distinct isoforms have been identified.
            [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (2) has multiple coding region
            differences, compared to variant 1. The resulting isoform (2) has a
            longer, and a different C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136823.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000254900.10/ ENSP00000254900.5
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AC109442.3         42996-43030         c
            36-132              AC109442.3         41971-42067         c
            133-202             AC109442.3         36465-36534         c
            203-252             AC109442.3         35761-35810         c
            253-375             AC113382.2         144-266
            376-456             AC113382.2         392-472
            457-521             AC113382.2         895-959
            522-658             AC113382.2         1946-2082
            659-803             AC113382.2         3226-3370
            804-1013            AC113382.2         4577-4786
            1014-1294           AC113382.2         5196-5476
            1295-1747           AC113382.2         6138-6590
            1748-1841           AC113382.2         6891-6984
            1842-1888           AC113382.2         7171-7217
            1889-2103           AC113382.2         7960-8174
            2104-2196           AC113382.2         9158-9250
            2197-2265           AC113382.2         9440-9508
            2266-2443           AC113382.2         10236-10413
            2444-2548           AC113382.2         11131-11235
            2549-2593           AC113382.2         11705-11749
            2594-2872           AC113382.2         18544-18822
            2873-3136           AC113382.2         20296-20559
            3137-3294           AC113382.2         21507-21664
            3295-3384           AC113382.2         25426-25515
            3385-3453           AC113382.2         26059-26127
            3454-3631           AC113382.2         30422-30599
            3632-4028           AC113382.2         31138-31534
FEATURES             Location/Qualifiers
     source          1..4028
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.2"
     gene            1..4028
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /note="bromodomain containing 8"
                     /db_xref="GeneID:10902"
                     /db_xref="HGNC:HGNC:19874"
                     /db_xref="MIM:602848"
     exon            1..35
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..3724
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     bromodomain-containing protein 8; skeletal muscle abundant
                     protein 2; trCP120; thyroid hormone receptor coactivating
                     protein of 120 kDa"
                     /codon_start=1
                     /product="bromodomain-containing protein 8 isoform 2"
                     /protein_id="NP_631938.2"
                     /db_xref="CCDS:CCDS4198.1"
                     /db_xref="GeneID:10902"
                     /db_xref="HGNC:HGNC:19874"
                     /db_xref="MIM:602848"
                     /translation="MATGTGKHKLLSTGPTEPWSIREKLCLASSVMRSGDQNWVSVSR
                     AIKPFAEPGRPPDWFSQKHCASQYSELLETTETPKRKRGEKGEVVETVEDVIVRKLTA
                     ERVEELKKVIKETQERYRRLKRDAELIQAGHMDSRLDELCNDIATKKKLEEEEAEVKR
                     KATDAAYQARQAVKTPPRRLPTVMVRSPIDSASPGGDYPLGDLTPTTMEEATSGVNES
                     EMAVASGHLNSTGVLLEVGGVLPMIHGGEIQQTPNTVAASPAASGAPTLSRLLEAGPT
                     QFTTPLASFTTVASEPPVKLVPPPVESVSQATIVMMPALPAPSSAPAVSTTESVAPVS
                     QPDNCVPMEAVGDPHTVTVSMDSSEISMIINSIKEECFRSGVAEAPVGSKAPSIDGKE
                     ELDLAEKMDIAVSYTGEELDFETVGDIIAIIEDKVDDHPEVLDVAAVEAALSFCEEND
                     DPQSLPGPWEHPIQQERDKPVPLPAPEMTVKQERLDFEETENKGIHELVDIREPSAEI
                     KVEPAEPEPVISGAEIVAGVVPATSMEPPELRSQDLDEELGSTAAGEIVEADVAIGKG
                     DETPLTNVKTEASPESMLSPSHGSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIK
                     DAPGEDEEEDGVSEAASLEEPKEEDQGEGYLSEMDNEPPVSESDDGFSIHNATLQSHT
                     LADSIPSSPASSQFSVCSEDQEAIQAQKIWKKAIMLVWRAAANHRYANVFLQPVTDDI
                     APGYHSIVQRPMDLSTIKKNIENGLIRSTAEFQRDIMLMFQNAVMYNSSDHDVYHMAV
                     EMQRDVLEQIQQFLATQLIMQTSESGISAKSLRGRDSTRKQDASEKDSVPMGSPAFLL
                     SLFMGHEWVWLDSEQDHPNDSELSNDCRSLFSSWDSSLDLDVGNWRETEDPEAEELEE
                     SSPEREPSELLVGDGGSEESQEAARKASHQNLLHFLSEVAYLMEPLCISSNESSEGCC
                     PPSGTRQEGREIKASEGERELCRETEELSAKGDPLVAEKPLGENGKPEVASAPSVICT
                     VQGLLTESEEGEAQQESKGEDQGEVYVSEMEDQPPSGECDDAFNIKETPLVDTLFSHA
                     TSSKLTDLSQDDPVQDHLLFKKTLLPVWKMIASHRFSSPFLKPVSERQAPGYKDVVKR
                     PMDLTSLKRNLSKGRIRTMAQFLRDLMLMFQNAVMYNDSDHHVYHMAVEMRQEVLEQI
                     QVLNIWLDKRKGSSSLEGEPANPVDDGKPVF"
     exon            36..132
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            133..202
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            203..252
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            253..375
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            376..456
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            457..521
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            522..658
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            659..803
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            804..1013
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1294
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1747
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1841
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1888
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..2103
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2196
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2265
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2443
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2444..2548
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2593
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2872
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2873..3136
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3137..3294
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3295..3384
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3385..3453
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3454..3631
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3632..4028
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4008..4013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /note="hexamer: AATAAA"
     polyA_site      4028
                     /gene="BRD8"
                     /gene_synonym="p120; SMAP; SMAP2"
                     /note="major polyA site"
ORIGIN      
        1 agacttcggg gccaagatgg cgacgggaac gggcaaacac aagctgctaa gcactggccc
       61 cacagagcca tggtccatcc gagagaagct atgtttagca tcttctgtca tgagaagtgg
      121 cgatcaaaat tgggtatcag ttagcagagc aatcaagccc tttgcagaac ctggccgccc
      181 tccagactgg ttctctcaaa aacattgtgc ttcccagtac tcggagcttt tagagaccac
      241 tgagacacca aaacggaaac gaggtgaaaa gggagaagtg gtggaaactg ttgaagatgt
      301 tattgttcgg aaattgactg ctgagcgagt tgaagaacta aagaaagtga taaaggaaac
      361 ccaggagaga tatagacggc taaagagaga tgcagaacta attcaagctg gacacatgga
      421 cagcagactg gatgagcttt gcaatgacat tgcaacgaaa aagaaattgg aagaagagga
      481 ggctgaagta aagaggaagg ctacagatgc tgcataccag gctcgtcaag cagtaaaaac
      541 acccccccgg aggttaccca ctgtgatggt tcgctctcct atagattctg cctccccagg
      601 aggtgattat ccacttgggg acttgactcc aaccactatg gaagaggcta cctctggggt
      661 caatgagagt gaaatggctg tggcttctgg ccacctgaac agtacaggtg tcctcctgga
      721 ggtaggcggg gtccttccca tgatacatgg tggggagata cagcaaacac ccaatactgt
      781 tgcagcctcc cctgctgcat caggtgctcc cactctttcc cggcttttag aagctggtcc
      841 tacacagttc accacacctc ttgcttcctt cactactgtt gccagtgagc ctccagttaa
      901 acttgtgcca ccccctgtag agtctgtgtc ccaagctacc attgtcatga tgcctgcgct
      961 gccagcacca tcctctgctc cggctgtctc cactactgaa agtgtagctc cagtgagtca
     1021 acccgacaac tgtgttccca tggaggctgt gggggatcca catactgtga ctgtttccat
     1081 ggacagcagt gaaatatcca tgatcatcaa ttctatcaaa gaagagtgtt ttcgatcagg
     1141 ggtagcagag gctcctgttg gatcaaaggc tcccagcata gatgggaagg aagaattaga
     1201 tctggctgag aagatggata ttgctgtgtc ttacacaggt gaagagctgg attttgagac
     1261 tgttggagac atcattgcca tcattgagga caaggtagat gatcatcctg aagtgctgga
     1321 tgtggcagca gtggaagcag cactgtcatt ttgtgaagaa aatgatgatc ctcagtccct
     1381 gcctggcccc tgggagcatc ctatccagca ggagcgggac aagccagtac ctctccctgc
     1441 accagaaatg acggtcaagc aagagagact ggactttgag gaaacggaaa acaagggaat
     1501 acatgaactg gtggacatca gggagcccag tgcagagatc aaggtggaac ctgcagaacc
     1561 agagccagtc atttcaggag ccgaaatagt agctggagtt gttccagcca caagtatgga
     1621 gccaccagaa ctcaggagtc aggacttaga tgaggaactg ggaagtactg cagctggaga
     1681 gattgttgaa gcagatgttg ccattgggaa aggcgatgag actccactta caaatgtgaa
     1741 gacagaggca tcccctgaaa gcatgttgtc tccatcacat ggctcaaatc ccattgaaga
     1801 tcctttagag gcagagactc agcacaagtt tgaaatgtca gactcattga aagaagaatc
     1861 agggactatt tttggaagcc agataaagga tgccccaggt gaggatgagg aggaagatgg
     1921 tgtcagtgaa gcggccagcc tagaggagcc taaggaagag gatcaaggag aaggctactt
     1981 gtcagaaatg gataatgaac ctcctgtgag cgagagtgat gatggcttca gcatacacaa
     2041 tgctacactg cagtcacaca cactggcaga ctccatcccc agcagccctg cttcttcaca
     2101 gttctctgtc tgtagtgagg atcaggaagc tattcaggca cagaaaattt ggaagaaagc
     2161 catcatgctt gtatggagag ctgcagctaa tcataggtat gccaatgtct tcctgcagcc
     2221 tgttacagat gacatagcac ctggctacca cagcattgtg cagaggccta tggatttgtc
     2281 aactattaag aaaaacatag aaaatggact gatccgaagc acagctgaat ttcagcgtga
     2341 cattatgctg atgtttcaga atgctgtaat gtacaatagc tcagaccatg atgtctatca
     2401 catggcagtg gagatgcagc gagatgtctt ggaacagatc cagcaattct tggccacgca
     2461 gttgattatg caaacatccg agtctgggat cagtgctaaa agtcttcgag ggagagattc
     2521 tacccgcaaa caggatgctt cagagaagga cagtgtccca atgggctctc ctgccttcct
     2581 tctctctctc tttatgggac acgagtgggt ttggctggat tctgaacaag atcatcccaa
     2641 tgactctgag ttgagcaatg actgcaggtc cctcttcagc tcatgggact ccagtctgga
     2701 tcttgatgtg ggcaactgga gggaaactga ggatccagag gctgaggaac tagaggaaag
     2761 cagcccggag agagaaccta gtgaactgct tgttggggat ggaggcagtg aggaatctca
     2821 ggaagcggca aggaaagcca gccaccagaa cctcctccac tttctctctg aggtagctta
     2881 tttaatggag cccttgtgca tcagcagcaa cgaatcaagt gaaggctgct gccctccatc
     2941 tggtaccaga caagaaggaa gggaaattaa agctagcgaa ggagaaaggg agctctgcag
     3001 agagactgaa gagctttcag ctaaaggaga ccccttagta gctgaaaagc cactgggaga
     3061 aaatggaaag ccagaggtgg cttcagctcc ctcagttatt tgtacagttc agggactact
     3121 cacagagagt gaagaggggg aggctcagca agaatccaaa ggggaggacc agggtgaagt
     3181 atatgtgtca gagatggaag accagccccc ttcaggcgag tgtgatgatg cctttaacat
     3241 taaggagact cccttggtgg atacactttt cagccatgct acctcctcaa agctgactga
     3301 tctaagccag gatgaccctg ttcaggatca tttgctattt aagaagactc tcctgccagt
     3361 ctggaagatg attgccagtc acaggttcag cagtccattt ctgaagcctg tgtcagaaag
     3421 gcaggcccca gggtacaagg atgtggtgaa aagacccatg gacttaacta gcctgaagag
     3481 aaatctctct aagggtcgga ttcgcaccat ggcccaattc ctgcgagacc tgatgctgat
     3541 gttccaaaat gctgtaatgt acaatgactc tgatcatcat gtataccata tggctgtgga
     3601 gatgcggcaa gaagtcctgg agcagattca ggtactgaat atctggttag acaaaagaaa
     3661 aggctcaagt agtctggaag gagaaccagc taacccagtg gatgatggaa aacctgtttt
     3721 ctaacctgga gctgctatcc tgactttttc tagagtttga atctctcccg gaactctgac
     3781 ctagagagga tcctggtact tctttgccat gtcctcattt tcttttccaa caagaataat
     3841 accttaactc acaaccaacg agtcaaagat gcatgtggac ataatataaa gaaaaaaagg
     3901 ggaagctgag gtttggattt atgccataaa tgttgcccac atctttgttc catcggcttg
     3961 atttaaagac aattccatta gatcttttct aagcctttta ctctataaat aaatgtattt
     4021 acacaata
//
