LOCUS       NM_013263               5424 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens bromodomain containing 7 (BRD7), transcript variant 2,
            mRNA.
ACCESSION   NM_013263
VERSION     NM_013263.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5424)
  AUTHORS   Xue,C., Meng,H., Niu,W., Li,M., Wei,J., Chen,S., Zheng,L., Duan,Y.,
            Deng,H., Tang,F., Fan,S., Tan,M., Xiong,W. and Zhou,M.
  TITLE     TRIM28 promotes tumor growth and metastasis in breast cancer by
            targeting the BRD7 protein for ubiquitination and degradation
  JOURNAL   Cell Oncol (Dordr) 47 (5), 1973-1993 (2024)
   PUBMED   39222175
  REMARK    GeneRIF: TRIM28 promotes tumor growth and metastasis in breast
            cancer by targeting the BRD7 protein for ubiquitination and
            degradation.
REFERENCE   2  (bases 1 to 5424)
  AUTHORS   Huang,K., Wu,Y., Fan,W., Zhao,Y., Xue,M., Liu,H., Tang,Y. and Li,J.
  TITLE     Identification of BRD7 by whole-exome sequencing as a predictor for
            intermediate-stage hepatocellular carcinoma in patients undergoing
            TACE
  JOURNAL   J Cancer Res Clin Oncol 149 (13), 11247-11261 (2023)
   PUBMED   37365429
  REMARK    GeneRIF: Identification of BRD7 by whole-exome sequencing as a
            predictor for intermediate-stage hepatocellular carcinoma in
            patients undergoing TACE.
REFERENCE   3  (bases 1 to 5424)
  AUTHORS   Li,M., Wei,Y., Liu,Y., Wei,J., Zhou,X., Duan,Y., Chen,S., Xue,C.,
            Zhan,Y., Zheng,L., Deng,H., Tang,F., Fan,S., Xiong,W., Li,G.,
            Tan,M. and Zhou,M.
  TITLE     BRD7 inhibits enhancer activity and expression of BIRC2 to suppress
            tumor growth and metastasis in nasopharyngeal carcinoma
  JOURNAL   Cell Death Dis 14 (2), 121 (2023)
   PUBMED   36788209
  REMARK    GeneRIF: BRD7 inhibits enhancer activity and expression of BIRC2 to
            suppress tumor growth and metastasis in nasopharyngeal carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5424)
  AUTHORS   Agbo,L., Loehr,J., Kougnassoukou Tchara,P.E. and Lambert,J.P.
  TITLE     Characterization of the Functional Interplay between the BRD7 and
            BRD9 Homologues in mSWI/SNF Complexes
  JOURNAL   J Proteome Res 22 (1), 78-90 (2023)
   PUBMED   36484504
  REMARK    GeneRIF: Characterization of the Functional Interplay between the
            BRD7 and BRD9 Homologues in mSWI/SNF Complexes.
REFERENCE   5  (bases 1 to 5424)
  AUTHORS   Li,S., Sun,J., Ma,J., Zhou,C., Yang,X., Zhang,S., Huang,L., Jia,H.,
            Shao,Y., Zhang,E., Zheng,M., Zhao,Q. and Zang,L.
  TITLE     LncRNA LENGA acts as a tumor suppressor in gastric cancer through
            BRD7/TP53 signaling
  JOURNAL   Cell Mol Life Sci 80 (1), 5 (2022)
   PUBMED   36477655
  REMARK    GeneRIF: LncRNA LENGA acts as a tumor suppressor in gastric cancer
            through BRD7/TP53 signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5424)
  AUTHORS   Zhang,H.S., Gavin,M., Dahiya,A., Postigo,A.A., Ma,D., Luo,R.X.,
            Harbour,J.W. and Dean,D.C.
  TITLE     Exit from G1 and S phase of the cell cycle is regulated by
            repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF
  JOURNAL   Cell 101 (1), 79-89 (2000)
   PUBMED   10778858
REFERENCE   7  (bases 1 to 5424)
  AUTHORS   Cuppen,E., van Ham,M., Pepers,B., Wieringa,B. and Hendriks,W.
  TITLE     Identification and molecular characterization of BP75, a novel
            bromodomain-containing protein
  JOURNAL   FEBS Lett 459 (3), 291-298 (1999)
   PUBMED   10526152
REFERENCE   8  (bases 1 to 5424)
  AUTHORS   Phelan,M.L., Sif,S., Narlikar,G.J. and Kingston,R.E.
  TITLE     Reconstitution of a core chromatin remodeling complex from SWI/SNF
            subunits
  JOURNAL   Mol Cell 3 (2), 247-253 (1999)
   PUBMED   10078207
REFERENCE   9  (bases 1 to 5424)
  AUTHORS   Reyes,J.C., Muchardt,C. and Yaniv,M.
  TITLE     Components of the human SWI/SNF complex are enriched in active
            chromatin and are associated with the nuclear matrix
  JOURNAL   J Cell Biol 137 (2), 263-274 (1997)
   PUBMED   9128241
REFERENCE   10 (bases 1 to 5424)
  AUTHORS   Wang,W., Xue,Y., Zhou,S., Kuo,A., Cairns,B.R. and Crabtree,G.R.
  TITLE     Diversity and specialization of mammalian SWI/SNF complexes
  JOURNAL   Genes Dev 10 (17), 2117-2130 (1996)
   PUBMED   8804307
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007493.7, DA645362.1,
            AF152604.1, AW615116.1 and AC007597.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_013263.4.
            
            Summary: This gene encodes a protein which is a member of the
            bromodomain-containing protein family. The product of this gene has
            been identified as a component of one form of the SWI/SNF chromatin
            remodeling complex, and as a protein which interacts with p53 and
            is required for p53-dependent oncogene-induced senescence which
            prevents tumor growth. Pseudogenes have been described on
            chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. The
            resulting isoform (2) lacks one internal residue, compared to
            isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF152604.1, AJ271881.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394688.8/ ENSP00000378180.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               AC007493.7         25297-25450         c
            155-162             DA645362.1         1-8
            163-2351            AF152604.1         2-2190
            2352-2363           AW615116.1         19-30               c
            2364-5424           AC007597.3         7041-10101
FEATURES             Location/Qualifiers
     source          1..5424
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q12.1"
     gene            1..5424
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
                     /note="bromodomain containing 7"
                     /db_xref="GeneID:29117"
                     /db_xref="HGNC:HGNC:14310"
                     /db_xref="MIM:618489"
     exon            1..263
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..2170
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein CELTIX-1; 75 kDa bromodomain protein"
                     /codon_start=1
                     /product="bromodomain-containing protein 7 isoform 2"
                     /protein_id="NP_037395.2"
                     /db_xref="CCDS:CCDS10742.1"
                     /db_xref="GeneID:29117"
                     /db_xref="HGNC:HGNC:14310"
                     /db_xref="MIM:618489"
                     /translation="MGKKHKKHKSDKHLYEEYVEKPLKLVLKVGGNEVTELSTGSSGH
                     DSSLFEDKNDHDKHKDRKRKKRKKGEKQIPGEEKGRKRRRVKEDKKKRDRDRVENEAE
                     KDLQCHAPVRLDLPPEKPLTSSLAKQEEVEQTPLQEALNQLMRQLQRKDPSAFFSFPV
                     TDFIAPGYSMIIKHPMDFSTMKEKIKNNDYQSIEELKDNFKLMCTNAMIYNKPETIYY
                     KAAKKLLHSGMKILSQERIQSLKQSIDFMADLQKTRKQKDGTDTSQSGEDGGCWQRER
                     EDSGDAEAHAFKSPSKENKKKDKDMLEDKFKSNNLEREQEQLDRIVKESGGKLTRRLV
                     NSQCEFERRKPDGTTTLGLLHPVDPIVGEPGYCPVRLGMTTGRLQSGVNTLQGFKEDK
                     RNKVTPVLYLNYGPYSSYAPHYDSTFANISKDDSDLIYSTYGEDSDLPSDFSIHEFLA
                     TCQDYPYVMADSLLDVLTKGGHSRTLQEMEMSLPEDEGHTRTLDTAKEMEITEVEPPG
                     RLDSSTQDRLIALKAVTNFGVPVEVFDSEEAEIFQKKLDETTRLLRELQEAQNERLST
                     RPPPNMICLLGPSYREMHLAEQVTNNLKELAQQVTPGDIVSTYGVRKAMGISIPSPVM
                     ENNFVDLTEDTEEPKKTDVAECGPGGS"
     exon            264..472
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
                     /inference="alignment:Splign:2.1.0"
     exon            473..602
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
                     /inference="alignment:Splign:2.1.0"
     exon            603..660
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
                     /inference="alignment:Splign:2.1.0"
     exon            661..805
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
                     /inference="alignment:Splign:2.1.0"
     exon            806..916
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1101
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1225
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1301
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1409
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1545
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1657
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1714
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1826
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1970
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2114
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..5424
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2271..2276
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
                     /note="hexamer: ATTAAA"
     polyA_site      2291
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
                     /note="major polyA site"
     regulatory      2326..2331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
                     /note="hexamer: AATAAA"
     polyA_site      2359
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
                     /note="major polyA site"
     regulatory      3364..3369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
                     /note="hexamer: AATAAA"
     polyA_site      3384
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
     regulatory      3800..3805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
                     /note="hexamer: AATAAA"
     polyA_site      3818
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
     regulatory      5278..5283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
                     /note="hexamer: AACAAA"
     polyA_site      5307
                     /gene="BRD7"
                     /gene_synonym="BP75; CELTIX1; NAG4; SMARCI1"
ORIGIN      
        1 gccccccccg ccgccgctct cgggctccgg ccgggtctcg cgcgccgtct tctcgagagg
       61 ggcatcgcgc cgcccggcgc gcgccgcccc cctgcctcgc ggcgcggggt ctcgcgggcc
      121 ccgctcccgc cctccgctcg cctggcccgg accggaagcg gcgccgcacg gcctgggcct
      181 ggcgcggggg gcgggcaccg gggcccggtc ggacatgggc aagaagcaca agaagcacaa
      241 gtcggacaaa cacctctacg aggagtatgt agagaagccc ttgaagctgg tcctcaaagt
      301 aggagggaac gaagtcaccg aactctccac gggcagctcg gggcacgact ccagcctctt
      361 cgaagacaaa aacgatcatg acaaacacaa ggacagaaag cggaaaaaga gaaagaaagg
      421 agagaagcag attccagggg aagaaaaggg gagaaaacgg agaagagtta aggaggataa
      481 aaagaagcga gatcgagacc gggtggagaa tgaggcagaa aaagatctcc agtgtcacgc
      541 ccctgtgaga ttagacttgc ctcctgagaa gcctctcaca agctctttag ccaaacaaga
      601 agaagtagaa cagacacccc ttcaagaagc tttgaatcaa ctgatgagac aattgcagag
      661 aaaagatcca agtgctttct tttcatttcc tgtgactgat tttattgctc ctggctactc
      721 catgatcatt aaacacccaa tggattttag taccatgaaa gaaaagatca agaacaatga
      781 ctatcagtcc atagaagaac taaaggataa cttcaaacta atgtgtacta atgccatgat
      841 ttacaataaa ccagagacca tttattataa agctgcaaag aagctgttgc actcaggaat
      901 gaaaattctt agccaggaaa gaattcagag cctgaagcag agcatagact tcatggctga
      961 cttgcagaaa actcgaaagc agaaagatgg aacagacacc tcacagagtg gggaggacgg
     1021 aggctgctgg cagagagaga gagaggactc tggagatgcc gaagcacacg ccttcaagag
     1081 tcccagcaaa gaaaataaaa agaaagacaa agatatgctt gaagataagt ttaaaagcaa
     1141 taatttagag agagagcagg agcagcttga ccgcatcgtg aaggaatctg gaggaaagct
     1201 gaccaggcgg cttgtgaaca gtcagtgcga atttgaaaga agaaaaccag atggaacaac
     1261 gacgttggga cttctccatc ctgtggatcc cattgtagga gagccaggct actgccctgt
     1321 gagactggga atgacaactg gaagacttca gtctggagtg aatactttgc aggggttcaa
     1381 agaggataaa aggaacaaag tcactccagt gttatatttg aattatgggc cctacagttc
     1441 ttatgcaccg cattatgact ccacatttgc aaatatcagc aaggatgatt ctgatttaat
     1501 ctattcaacc tatggggaag actctgatct tccaagtgat ttcagcatcc atgagttttt
     1561 ggccacgtgc caagattatc cgtatgtcat ggcagatagt ttactggatg ttttaacaaa
     1621 aggagggcat tccaggaccc tacaagagat ggagatgtca ttgcctgaag atgaaggcca
     1681 tactaggaca cttgacacag caaaagaaat ggagattaca gaagtagagc caccagggcg
     1741 tttggactcc agtactcaag acaggctcat agcgctgaaa gcagtaacaa attttggcgt
     1801 tccagttgaa gtttttgact ctgaagaagc tgaaatattc cagaagaaac ttgatgagac
     1861 caccagattg ctcagggaac tccaggaagc ccagaatgaa cgtttgagca ccagaccccc
     1921 tccgaacatg atctgtctct tgggtccctc atacagagaa atgcatcttg ctgaacaagt
     1981 gaccaataat cttaaagaac ttgcacagca agtaactcca ggtgatatcg taagcacgta
     2041 tggagttcga aaagcaatgg ggatttccat tccttccccc gtcatggaaa acaactttgt
     2101 ggatttgaca gaagacactg aagaacctaa aaagacggat gttgctgagt gtggacctgg
     2161 tggaagttga ggctgcctgg tatttgatta tatattatgt acatactttt tcattcttaa
     2221 cttagaaatg cttttcagaa gatattaaat atttgtaaat tgtgttttta attaaacttt
     2281 ggaacagcga atttggatgt tccagaggtt ggacttgtat taggtaataa agctggacct
     2341 gggactcgtg aggaaggaat gtgcttgggg ctgttgccat acctgtgcag cattctttca
     2401 aaatagtgcc ttccaatgct tcttccttat gtcccacaga caggatcatc actaagaagc
     2461 gttcttaaaa cggccccatc cagtgagatt ttccgttata cgaacatact tgaaataatt
     2521 ttagaattta ctactgtggt tctgcccctg catacccagt gggaatgatg cccttgtatg
     2581 ggtaattagg cacctcccac ccacccctga caaaagcaca ctgggagttt tatagcactg
     2641 tcacatggct agtgttcttt tttggttttt tccgtttttt aaagaaagag gagttactta
     2701 gtactatagc aaagtaataa gccaaataag ataaactaag tcatccttga atagatcagg
     2761 gaattaccag attaccaaaa ggtgacattt ctactttact tactgtttat ctgaaataca
     2821 aaggtcaagt acccaaggag ttgaactcta agtaggagac cacaagattc atggccccct
     2881 tttatcagca agctgagata aatggtgatt ttgctgaatc ggtatagaac ctgttataca
     2941 caagggaaaa aaatcaggat ggagatagat agatagatag ccttgttcag tgaacaaatt
     3001 aagtttgaag gcccttatac aatccttcta taaatcaccc aggcaggaag ccatttgatt
     3061 tctattattt tcctgacttt gaaaattaat tagtatttag gaagaacaaa tagggtaaag
     3121 gaaaattaat tccctcaaaa gacttaaaat cttatgctaa aagagtcaaa ttttcaagtt
     3181 gtttgagtct acttttaatc tctagtgagt tcatgaggac cacgaaaata aaataccttc
     3241 agatatttga gtttttcaaa ttgctaattt aatgtataaa aagcagctaa acactggtac
     3301 tttataaaaa tgaaacagca ttttgaaaca aatgttacag atctataaat attcattata
     3361 tagaataaac cctagttact tgcatgcacc acctcaaatc atatttcttt acactgacct
     3421 attatataca caaagtatac agtggttaat gatcttctct tctgtttgtt tgtttgtttg
     3481 tttgttagga aatttcctca ataagccaga aaaccttagg tattattttc acaaaagtta
     3541 actcaggaga aattgtaagg aagtccttga cccatggaga aggtcactgt ttgtttgttt
     3601 gttagatacg tgtgtctgtc ataaaacaaa atgacaccag taattacttg gtaatttaaa
     3661 aacaagttca taaaaagaaa atacctgcag gtaattttta tggtcagtta tattctataa
     3721 cctgaacact gaaaactaaa aacttttact tacaaactat tattatctga gcacagcaca
     3781 gtgctttgct ttaattggaa ataaaaatgc atgagtgagt ggtagtcagt tatttgttaa
     3841 actcccaact ggggtttctg ttgttactga agaaaaaaac aaatattcca agagtacaaa
     3901 tatgctgacc tcagagaggc ccagtgcact aatgtgtttc tatgttatat tagcaacaga
     3961 aaccttcctg acttgccagg agagcccccg ccgggcagcc ctggtcactg ctagatcttg
     4021 agagcacaga tttcagtata gtattcatgt gaaaccagcc cttcatgtaa aaagttttgg
     4081 tgtgtaaaaa aggcaactta agcgaggcta attgccctta ccagcattgt tgccatgaaa
     4141 ttcctttata cagcaagttc ttctattcat actgattcca cttatgtgca gcacatgaga
     4201 gctgccacta gtctacccag cacctttgtg caaattagaa tacacctgcc cttcctcggg
     4261 ctgataaagc cacacgacac agcacaggca gacaggttca attttcgttc cctccaccgc
     4321 cacccccgca cttagctgta ctcttaattt gcagcccggg gcaactcatc ccaggacccc
     4381 aacaagtctg gtcagtcacc caatctgcaa ccctgtataa tcatcttgta aaggctcctg
     4441 tatgcaagac tttgtgtaga actttacggg gttcatgggg acacctagct aagaatccct
     4501 gctatgtagg gaaactgagt gcattagaaa tcctggcgat gctctggtga tgaggccacc
     4561 ggttaagtct tccggttatg aagtccattc agaaaaagtc acgggcagtt tggtcatttc
     4621 tcaccctgtt gttacagtta ggttgacttt caattccttg ggaagttgaa gcacagtaag
     4681 acacatcccc aaaacctggc tttttgcatt tgccttgact cacgcagttt cagagcaaga
     4741 acggctcagc atttgtgagg gggcgggctt cccagatcca ggagcctctg catgcaccca
     4801 tgcggagtag atccttctag ttttgaagct ctccagagtt agctgtgaag actaaaggaa
     4861 agaagagatg cactcacagg ttgtccaagt tgtctctaaa cagactccat tcctttctgg
     4921 taagaaaagt aagatacagt tgaaggacgg caggggagaa cgcaaagatg tgtgagtaat
     4981 caaggaagag gtgaaaggcc gcaccttact ttcaaagcac ctctctccag aatgcttgcc
     5041 tcacaagctg cctcattcaa aggcaaggct ctgctgctcc ccgccttctt gctgtgacca
     5101 cattcctcag gactctatcc ccacagccag ctgaccccat aagctgatgc tagacagtag
     5161 tcctccttac atgtcagtgg ttaaaaaggc agagcataca ctggagggaa gagatttatg
     5221 tctagtgtct gaaaagtcat tcaaaaggat aaaaacccca ttaatgtatt catttaaaac
     5281 aaacatgcca gacaaggcaa aaagtaacag tgttaattgt ggtgtttttc tctctacctg
     5341 tttgaaaccg tttacagatg taaaacaccc ctttcagctt catttaccag aatgcctctg
     5401 tgagaaatgc tgtcattgcc aggc
//
