LOCUS       NM_001379291            7231 bp    mRNA    linear   PRI 11-MAR-2025
DEFINITION  Homo sapiens bromodomain containing 4 (BRD4), transcript variant 4,
            mRNA.
ACCESSION   NM_001379291 XM_011527854
VERSION     NM_001379291.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7231)
  AUTHORS   Yang,Y.H., Yan,F., Yuan,W., Shi,P.S., Wu,S.M. and Cui,D.J.
  TITLE     High-altitude hypoxia promotes BRD4-mediated activation of the
            Wnt/beta-catenin pathway and disruption of intestinal barrier
  JOURNAL   Cell Signal 120, 111187 (2024)
   PUBMED   38648894
  REMARK    GeneRIF: High-altitude hypoxia promotes BRD4-mediated activation of
            the Wnt/beta-catenin pathway and disruption of intestinal barrier.
REFERENCE   2  (bases 1 to 7231)
  AUTHORS   Chen,F., Li,S., Liu,M., Qian,C., Shang,Z., Song,X., Jiang,W. and
            Tu,C.
  TITLE     Targeting BRD4 mitigates hepatocellular lipotoxicity by suppressing
            the NLRP3 inflammasome activation and GSDMD-mediated hepatocyte
            pyroptosis
  JOURNAL   Cell Mol Life Sci 81 (1), 295 (2024)
   PUBMED   38977508
  REMARK    GeneRIF: Targeting BRD4 mitigates hepatocellular lipotoxicity by
            suppressing the NLRP3 inflammasome activation and GSDMD-mediated
            hepatocyte pyroptosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7231)
  AUTHORS   Strom,A.R., Eeftens,J.M., Polyachenko,Y., Weaver,C.J.,
            Watanabe,H.F., Bracha,D., Orlovsky,N.D., Jumper,C.C., Jacobs,W.M.
            and Brangwynne,C.P.
  TITLE     Interplay of condensation and chromatin binding underlies BRD4
            targeting
  JOURNAL   Mol Biol Cell 35 (6), ar88 (2024)
   PUBMED   38656803
  REMARK    GeneRIF: Interplay of condensation and chromatin binding underlies
            BRD4 targeting.
REFERENCE   4  (bases 1 to 7231)
  AUTHORS   Xu,X., Qiao,D. and Brasier,A.R.
  TITLE     Cooperative interaction of interferon regulatory factor -1 and
            bromodomain-containing protein 4 on RNA polymerase activation for
            intrinsic innate immunity
  JOURNAL   Front Immunol 15, 1366235 (2024)
   PUBMED   38601157
  REMARK    GeneRIF: Cooperative interaction of interferon regulatory factor -1
            and bromodomain-containing protein 4 on RNA polymerase activation
            for intrinsic innate immunity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7231)
  AUTHORS   Padmanabhan,A., de Soysa,T.Y., Pelonero,A., Sapp,V., Shah,P.P.,
            Wang,Q., Li,L., Lee,C.Y., Sadagopan,N., Nishino,T., Ye,L., Yang,R.,
            Karnay,A., Poleshko,A., Bolar,N., Linares-Saldana,R., Ranade,S.S.,
            Alexanian,M., Morton,S.U., Jain,M., Haldar,S.M., Srivastava,D. and
            Jain,R.
  TITLE     A genome-wide CRISPR screen identifies BRD4 as a regulator of
            cardiomyocyte differentiation
  JOURNAL   Nat Cardiovasc Res 3 (3), 317-331 (2024)
   PUBMED   39196112
  REMARK    GeneRIF: A genome-wide CRISPR screen identifies BRD4 as a regulator
            of cardiomyocyte differentiation.
REFERENCE   6  (bases 1 to 7231)
  AUTHORS   Maruyama,T., Farina,A., Dey,A., Cheong,J., Bermudez,V.P.,
            Tamura,T., Sciortino,S., Shuman,J., Hurwitz,J. and Ozato,K.
  TITLE     A Mammalian bromodomain protein, brd4, interacts with replication
            factor C and inhibits progression to S phase
  JOURNAL   Mol Cell Biol 22 (18), 6509-6520 (2002)
   PUBMED   12192049
  REMARK    GeneRIF: brd4 binds to replication factor C and inhibits
            progression to S phase
REFERENCE   7  (bases 1 to 7231)
  AUTHORS   French,C.A., Miyoshi,I., Aster,J.C., Kubonishi,I., Kroll,T.G., Dal
            Cin,P., Vargas,S.O., Perez-Atayde,A.R. and Fletcher,J.A.
  TITLE     BRD4 bromodomain gene rearrangement in aggressive carcinoma with
            translocation t(15;19)
  JOURNAL   Am J Pathol 159 (6), 1987-1992 (2001)
   PUBMED   11733348
REFERENCE   8  (bases 1 to 7231)
  AUTHORS   Duarte,M., Graham,K., Daher,A., Battisti,P.L., Bannwarth,S.,
            Segeral,E., Jeang,K.T. and Gatignol,A.
  TITLE     Characterization of TRBP1 and TRBP2. Stable stem-loop structure at
            the 5' end of TRBP2 mRNA resembles HIV-1 TAR and is not found in
            its processed pseudogene
  JOURNAL   J Biomed Sci 7 (6), 494-506 (2000)
   PUBMED   11060498
REFERENCE   9  (bases 1 to 7231)
  AUTHORS   Dey,A., Ellenberg,J., Farina,A., Coleman,A.E., Maruyama,T.,
            Sciortino,S., Lippincott-Schwartz,J. and Ozato,K.
  TITLE     A bromodomain protein, MCAP, associates with mitotic chromosomes
            and affects G(2)-to-M transition
  JOURNAL   Mol Cell Biol 20 (17), 6537-6549 (2000)
   PUBMED   10938129
REFERENCE   10 (bases 1 to 7231)
  AUTHORS   Deardorff,M.A., Noon,S.E. and Krantz,I.D.
  TITLE     Cornelia de Lange Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301283
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005776.1, AC004798.1 and
            AC004257.1.
            
            On Mar 27, 2020 this sequence version replaced XM_011527854.2.
            
            Summary: The protein encoded by this gene is homologous to the
            murine protein MCAP, which associates with chromosomes during
            mitosis, and to the human RING3 protein, a serine/threonine kinase.
            Each of these proteins contains two bromodomains, a conserved
            sequence motif which may be involved in chromatin targeting. This
            gene has been implicated as the chromosome 19 target of
            translocation t(15;19)(q13;p13.1), which defines an upper
            respiratory tract carcinoma in young people. Two alternatively
            spliced transcript variants have been described. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR4352443.827898.1,
                                           ERR4368409.43771.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000679869.1/ ENSP00000506350.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               AC005776.1         21224-21473         c
            251-569             AC004798.1         37751-38069         c
            570-707             AC004798.1         33841-33978         c
            708-843             AC004798.1         32352-32487         c
            844-1133            AC004798.1         30290-30579         c
            1134-1496           AC004798.1         29340-29702         c
            1497-1625           AC004798.1         28356-28484         c
            1626-1835           AC004798.1         21900-22109         c
            1836-2035           AC004798.1         21000-21199         c
            2036-2331           AC004798.1         20233-20528         c
            2332-2442           AC004798.1         19088-19198         c
            2443-2495           AC004798.1         9646-9698           c
            2496-2865           AC004798.1         9167-9536           c
            2866-3453           AC004798.1         7836-8423           c
            3454-3566           AC004798.1         4846-4958           c
            3567-3729           AC004798.1         4595-4757           c
            3730-3860           AC004798.1         4328-4458           c
            3861-4066           AC004798.1         3995-4200           c
            4067-4304           AC004798.1         3679-3916           c
            4305-6955           AC004798.1         731-3381            c
            6956-7231           AC004257.1         42829-43104         c
FEATURES             Location/Qualifiers
     source          1..7231
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..7231
                     /gene="BRD4"
                     /gene_synonym="CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP"
                     /note="bromodomain containing 4"
                     /db_xref="GeneID:23476"
                     /db_xref="HGNC:HGNC:13575"
                     /db_xref="MIM:608749"
     exon            1..250
                     /gene="BRD4"
                     /gene_synonym="CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            251..569
                     /gene="BRD4"
                     /gene_synonym="CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..4373
                     /gene="BRD4"
                     /gene_synonym="CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP"
                     /EC_number="3.1.1.31"
                     /note="isoform long is encoded by transcript variant 4;
                     chromosome-associated protein; bromodomain-containing
                     protein 4; mitotic chromosome-associated protein; female
                     sterile homeotic related gene 4"
                     /codon_start=1
                     /product="bromodomain-containing protein 4 isoform long"
                     /protein_id="NP_001366220.1"
                     /db_xref="CCDS:CCDS12328.1"
                     /db_xref="GeneID:23476"
                     /db_xref="HGNC:HGNC:13575"
                     /db_xref="MIM:608749"
                     /translation="MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTN
                     PPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIK
                     TPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQK
                     INELPTEETEIMIVQAKGRGRGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPV
                     QATPHPFPAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIA
                     ATPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKD
                     VPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCD
                     IIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVF
                     EMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERA
                     QRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAK
                     EPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYESEEEDKCKPMSYEEKRQLSLDINK
                     LPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQ
                     AEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHH
                     HHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPP
                     PFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPEHSTPPHLNQHAV
                     VSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVLLE
                     DEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHPSVQQQLQQ
                     QPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPPHPPPGQQPPP
                     PQPAKPQQVIQHHHSPRHHKSDPYSTGHLREAPSPLMIHSPQMSQFQSLTHQSPPQQN
                     VQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPESIKAPVHL
                     PQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMGSWAS
                     LVQKHPTTPSSTAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERMRS
                     REDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSM
                     LDQQRELARKREQERRRREAMAATIDMNFQSDLLSIFEENLF"
     exon            570..707
                     /gene="BRD4"
                     /gene_synonym="CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            708..843
                     /gene="BRD4"
                     /gene_synonym="CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1133
                     /gene="BRD4"
                     /gene_synonym="CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1496
                     /gene="BRD4"
                     /gene_synonym="CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1625
                     /gene="BRD4"
                     /gene_synonym="CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1835
                     /gene="BRD4"
                     /gene_synonym="CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..2035
                     /gene="BRD4"
                     /gene_synonym="CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2331
                     /gene="BRD4"
                     /gene_synonym="CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2442
                     /gene="BRD4"
                     /gene_synonym="CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2495
                     /gene="BRD4"
                     /gene_synonym="CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2865
                     /gene="BRD4"
                     /gene_synonym="CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..3453
                     /gene="BRD4"
                     /gene_synonym="CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3454..3566
                     /gene="BRD4"
                     /gene_synonym="CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3567..3729
                     /gene="BRD4"
                     /gene_synonym="CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3730..3860
                     /gene="BRD4"
                     /gene_synonym="CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3861..4066
                     /gene="BRD4"
                     /gene_synonym="CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4067..4304
                     /gene="BRD4"
                     /gene_synonym="CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4305..7231
                     /gene="BRD4"
                     /gene_synonym="CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5888..5893
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRD4"
                     /gene_synonym="CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP"
                     /note="hexamer: AATAAA"
     polyA_site      5912
                     /gene="BRD4"
                     /gene_synonym="CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP"
                     /note="major polyA site"
     regulatory      7203..7208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRD4"
                     /gene_synonym="CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP"
                     /note="hexamer: AATAAA"
     polyA_site      7231
                     /gene="BRD4"
                     /gene_synonym="CAP; CDLS6; FSHRG4; HUNK1; HUNKI; MCAP"
ORIGIN      
        1 agtgcgctgg cggcggcggc ggcggcggcg gcggcggctg ggctgtttgt tctggtctcc
       61 cgcagccgag gagccgaagc agtggcggcg gcagcggctg cggcggctgc cggcggtgcc
      121 cgcgggcgag cgcggcctgt gagctcggca gagcggcggg cgggccccgg cgccgcgcag
      181 gcagctcggg gagggggcgg cggcagcggg cggacggccg gcgggggcgg cgtgcggcct
      241 agcgtctcag agtgcctggt gaagaatgtg atgggatcac tagcatgtct gcggagagcg
      301 gccctgggac gagattgaga aatctgccag taatggggga tggactagaa acttcccaaa
      361 tgtctacaac acaggcccag gcccaacccc agccagccaa cgcagccagc accaaccccc
      421 cgcccccaga gacctccaac cctaacaagc ccaagaggca gaccaaccaa ctgcaatacc
      481 tgctcagagt ggtgctcaag acactatgga aacaccagtt tgcatggcct ttccagcagc
      541 ctgtggatgc cgtcaagctg aacctccctg attactataa gatcattaaa acgcctatgg
      601 atatgggaac aataaagaag cgcttggaaa acaactatta ctggaatgct caggaatgta
      661 tccaggactt caacactatg tttacaaatt gttacatcta caacaagcct ggagatgaca
      721 tagtcttaat ggcagaagct ctggaaaagc tcttcttgca aaaaataaat gagctaccca
      781 cagaagaaac cgagatcatg atagtccagg caaaaggaag aggacgtggg aggaaagaaa
      841 cagggacagc aaaacctggc gtttccacgg taccaaacac aactcaagca tcgactcctc
      901 cgcagaccca gacccctcag ccgaatcctc ctcctgtgca ggccacgcct caccccttcc
      961 ctgccgtcac cccggacctc atcgtccaga cccctgtcat gacagtggtg cctccccagc
     1021 cactgcagac gcccccgcca gtgccccccc agccacaacc cccacccgct ccagctcccc
     1081 agcccgtaca gagccaccca cccatcatcg cggccacccc acagcctgtg aagacaaaga
     1141 agggagtgaa gaggaaagca gacaccacca cccccaccac cattgacccc attcacgagc
     1201 caccctcgct gcccccggag cccaagacca ccaagctggg ccagcggcgg gagagcagcc
     1261 ggcctgtgaa acctccaaag aaggacgtgc ccgactctca gcagcaccca gcaccagaga
     1321 agagcagcaa ggtctcggag cagctcaagt gctgcagcgg catcctcaag gagatgtttg
     1381 ccaagaagca cgccgcctac gcctggccct tctacaagcc tgtggacgtg gaggcactgg
     1441 gcctacacga ctactgtgac atcatcaagc accccatgga catgagcaca atcaagtcta
     1501 aactggaggc ccgtgagtac cgtgatgctc aggagtttgg tgctgacgtc cgattgatgt
     1561 tctccaactg ctataagtac aaccctcctg accatgaggt ggtggccatg gcccgcaagc
     1621 tccaggatgt gttcgaaatg cgctttgcca agatgccgga cgagcctgag gagccagtgg
     1681 tggccgtgtc ctccccggca gtgccccctc ccaccaaggt tgtggccccg ccctcatcca
     1741 gcgacagcag cagcgatagc tcctcggaca gtgacagttc gactgatgac tctgaggagg
     1801 agcgagccca gcggctggct gagctccagg agcagctcaa agccgtgcac gagcagcttg
     1861 cagccctctc tcagccccag cagaacaaac caaagaaaaa ggagaaagac aagaaggaaa
     1921 agaaaaaaga aaagcacaaa aggaaagagg aagtggaaga gaataaaaaa agcaaagcca
     1981 aggaacctcc tcctaaaaag acgaagaaaa ataatagcag caacagcaat gtgagcaaga
     2041 aggagccagc gcccatgaag agcaagcccc ctcccacgta tgagtcggag gaagaggaca
     2101 agtgcaagcc tatgtcctat gaggagaagc ggcagctcag cttggacatc aacaagctcc
     2161 ccggcgagaa gctgggccgc gtggtgcaca tcatccagtc acgggagccc tccctgaaga
     2221 attccaaccc cgacgagatt gaaatcgact ttgagaccct gaagccgtcc acactgcgtg
     2281 agctggagcg ctatgtcacc tcctgtttgc ggaagaaaag gaaacctcaa gctgagaaag
     2341 ttgatgtgat tgccggctcc tccaagatga agggcttctc gtcctcagag tcggagagct
     2401 ccagtgagtc cagctcctct gacagcgaag actccgaaac agagatggct ccgaagtcaa
     2461 aaaagaaggg gcaccccggg agggagcaga agaagcacca tcatcaccac catcagcaga
     2521 tgcagcaggc cccggctcct gtgccccagc agccgccccc gcctccccag cagcccccac
     2581 cgcctccacc tccgcagcag caacagcagc cgccaccccc gcctccccca ccctccatgc
     2641 cgcagcaggc agccccggcg atgaagtcct cgcccccacc cttcattgcc acccaggtgc
     2701 ccgtcctgga gccccagctc ccaggcagcg tctttgaccc catcggccac ttcacccagc
     2761 ccatcctgca cctgccgcag cctgagctgc cccctcacct gccccagccg cctgagcaca
     2821 gcactccacc ccatctcaac cagcacgcag tggtctctcc tccagctttg cacaacgcac
     2881 taccccagca gccatcacgg cccagcaacc gagccgctgc cctgcctccc aagcccgccc
     2941 ggcccccagc cgtgtcacca gccttgaccc aaacacccct gctcccacag ccccccatgg
     3001 cccaaccccc ccaagtgctg ctggaggatg aagagccacc tgccccaccc ctcacctcca
     3061 tgcagatgca gctgtacctg cagcagctgc agaaggtgca gccccctacg ccgctactcc
     3121 cttccgtgaa ggtgcagtcc cagcccccac cccccctgcc gcccccaccc cacccctctg
     3181 tgcagcagca gctgcagcag cagccgccac cacccccacc accccagccc cagcctccac
     3241 cccagcagca gcatcagccc cctccacggc ccgtgcactt gcagcccatg cagttttcca
     3301 cccacatcca acagcccccg ccaccccagg gccagcagcc cccccatccg cccccaggcc
     3361 agcagccacc cccgccgcag cctgccaagc ctcagcaagt catccagcac caccattcac
     3421 cccggcacca caagtcggac ccctactcaa ccggtcacct ccgcgaagcc ccctccccgc
     3481 ttatgataca ttccccccag atgtcacagt tccagagcct gacccaccag tctccacccc
     3541 agcaaaacgt ccagcctaag aaacaggagc tgcgtgctgc ctccgtggtc cagccccagc
     3601 ccctcgtggt ggtgaaggag gagaagatcc actcacccat catccgcagc gagcccttca
     3661 gcccctcgct gcggccggag ccccccaagc acccggagag catcaaggcc cccgtccacc
     3721 tgccccagcg gccggaaatg aagcctgtgg atgtcgggag gcctgtgatc cggcccccag
     3781 agcagaacgc accgccacca ggggcccctg acaaggacaa acagaaacag gagccgaaga
     3841 ctccagttgc gcccaaaaag gacctgaaaa tcaagaacat gggctcctgg gccagcctag
     3901 tgcagaagca tccgaccacc ccctcctcca cagccaagtc atccagcgac agcttcgagc
     3961 agttccgccg cgccgctcgg gagaaagagg agcgtgagaa ggccctgaag gctcaggccg
     4021 agcacgctga gaaggagaag gagcggctgc ggcaggagcg catgaggagc cgagaggacg
     4081 aggatgcgct ggagcaggcc cggcgggccc atgaggaggc acgtcggcgc caggagcagc
     4141 agcagcagca gcgccaggag caacagcagc agcagcaaca gcaagcagct gcggtggctg
     4201 ccgccgccac cccacaggcc cagagctccc agccccagtc catgctggac cagcagaggg
     4261 agttggcccg gaagcgggag caggagcgaa gacgccggga agccatggca gctaccattg
     4321 acatgaattt ccagagtgat ctattgtcaa tatttgaaga aaatcttttc tgagcgcacc
     4381 taggtggctt ctgactttga ttttctggca aaacattgac tttccatagt gttaggggcg
     4441 gtggtggagg tgggatcagc ggccagggga tgcctcaggg cctggccctc ctgcatgcta
     4501 tgcccggggc aggcctgacg ggcagctgag gattgcagag cctgtctgcc ttacggccag
     4561 tcggacagac gtcccgccac ccaccacccc tcacaggacg tccgctcagc acacgccttg
     4621 ttacgagcaa gtgccggctg gacccaagcc ctgcatcccc acatgcgggg cagaggccct
     4681 tctctccgcc aaatgtctac acagtataca caggacatcg ttgctgccgc cgtgactggt
     4741 tttctgtccc caagaacgtg acgttcgtga tgtcctgccc gccgggagtc tttccccaca
     4801 ccccagccat cgccgcccgc tcccaggagg ccagggcagg cctgcgtggg ctggaggcgg
     4861 gcgaggccgg cccaccccct cgctggcact gactttgcct tgaacagacc ccccgaccct
     4921 cccccacaag cctttaattg agagccgctc tctgtaagtg tttgcttgtg caaaagggaa
     4981 tagtgccgtg gaggtgtgtg tgtccatggc atccggagcg aggcgactgt cctgcgtggg
     5041 tagccctcgg ccggggagtg aggccaccaa ccaaagtcag ttccttccca cctgtgtttc
     5101 tgtttcgttt ttttttttct tttttttcta tatatatttt ttgttgaatt ctattttatt
     5161 tttaattctc tcttctcctc cagacacaat ggcactgctt atctccgaaa tggtgtgatc
     5221 gtctcctcat tgagcagcgg ctgccaccgc gctgtgggta gtgtgtgacc gtggctgtac
     5281 tgtatagtga acatagttgg catatctttg tttgaagttt gttggtgact ccaccaaact
     5341 ggtgtgaaaa aagaaaaaag ctcaaaaaaa tccacaaaaa gacaaaacac acaaaaaaaa
     5401 tcctgcctat attttactca gtttcaaact ttattagtct atttttaatt ataaaaccag
     5461 aaagctacaa tttcttttct ttcccctcca cccccccccc ccccacccat ttgttggctt
     5521 ttttgttttt taatgtcaga tctgttgagt tggttttttt ggttttggtt tttgtttttg
     5581 tttttgtttt ttactgagaa aggaagggcc aagggatgag gtgggaaccg ggccctgggg
     5641 gcgccacaga ctaaggcaga gactccccta cctggcgccc agccccaacc agctggccgc
     5701 tcctgcccat gctttttttt tttttttttt ttaattttta taattggagc ccctggtgag
     5761 gttacgcgtg ccatgagaac ccactctaca ccacgacgct ggtgcctcag tgttggccaa
     5821 actctggagt cactgactgg tttgactttc atacggtgaa tatgcatttg gtctgtactg
     5881 atcatggaat aaacacatct ctcttttttt aatgctggcg tctccctgac atttctttgt
     5941 gaaccaactg ttgcctaggc taggcccagg ggaccccctg gaccccagac cacctctgta
     6001 caggaactac tgccagggat tacctagccc ctctcctgtg acctgtccct gtctgccctg
     6061 ggcgggagcc acgcagactc atagcaacca ccccaagctg aagctgtgac gcagagcccg
     6121 gtacccatcc ttgtggaccc tggctgaggt ggagggtgtg ctctagcaga accctggcca
     6181 gactccagac agtattcttc ccctccaccc tactccatcc tgtcccccct actccatcct
     6241 gtccccccac tcaccaaagg acttgggcca cttctcccac cttgcctgcc tcaacctaac
     6301 tcctcctttc atttaagctc agggttaacc agatactctt agatataagt ctacatcccc
     6361 caaaatagga tcctcacccc ccatgcacat acacacacat tcctgtccaa gaaagcccac
     6421 aggtggctgc tctgcctgtg tgtccacttg tgtatgtaca tgccccagcc acaaggcacg
     6481 ggtgacgccc aagaagagcc cctaagatgt aagatacaag tatataattt atatgtatgc
     6541 agagacaaac tgattgaaac atttctagca ctgtttattc tcctacatcc cctctttttg
     6601 acctgaaagg tcctttattg tctttggatc tgccaaacct ccctgtgagg gtgtggttca
     6661 ggcatccagc cagaggtccc cccacttctt cgatgtccat gcccactcag gcactttctc
     6721 atataccact gtgccacttc aagtgtgacg tatttaggtt ctttggggtt tcttccatct
     6781 catcccaccc actcattttt gttccttgtt ttgttcagac acttccccag cctgggtcca
     6841 actgctgagc tggatagttt tctctgcagc ttcctgctga agatttaact cagccatggc
     6901 cttctccaca cctccctgat gggtgtctct ctacctgggt tgtaattaga actgggatct
     6961 atttaatttc tccagccatt tcccaaccct tcccacagta ctagaaatct tagtcctata
     7021 ccagagtaag aggtgtgtac aagcccccac tgtactgtat gcacggatcg cttggccaat
     7081 aattatgtca gtgaatctga gacttgtatt aaacacttta gacatttgta gaagggaatt
     7141 cgtagacttt tcacttacat acgaaaggtt tttttttttt tttgtgcagt tctcattgca
     7201 aaaataaaca tttgtactga gtataaagtt a
//
