LOCUS       NM_001355256            5682 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens BRD3 opposite strand (BRD3OS), transcript variant 1,
            mRNA.
ACCESSION   NM_001355256 NR_015427 XR_041460 XR_041461 XR_041462
VERSION     NM_001355256.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5682)
  AUTHORS   Piipponen,M., Riihila,P., Knuutila,J.S., Kallajoki,M., Kahari,V.M.
            and Nissinen,L.
  TITLE     Super Enhancer-Regulated LINC00094 (SERLOC) Upregulates the
            Expression of MMP-1 and MMP-13 and Promotes Invasion of Cutaneous
            Squamous Cell Carcinoma
  JOURNAL   Cancers (Basel) 14 (16), 3980 (2022)
   PUBMED   36010973
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5682)
  AUTHORS   Li,S., Sun,X., Miao,S., Liu,J. and Jiao,W.
  TITLE     Differential protein-coding gene and long noncoding RNA expression
            in smoking-related lung squamous cell carcinoma
  JOURNAL   Thorac Cancer 8 (6), 672-681 (2017)
   PUBMED   28949095
  REMARK    GeneRIF: Results identified LINC00094 to be downregulated in the
            lung squamous cell carcinoma tissues of smoking patients and may
            play an important role in diagnosis and prognosis.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL445931.29.
            
            On Nov 22, 2018 this sequence version replaced NM_001355256.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.89709.1,
                                           SRR1803612.167071.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000603928.3/ ENSP00000490916.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AL445931.29        138687-138742
            57-302              AL445931.29        139051-139296
            303-5682            AL445931.29        139414-144793
FEATURES             Location/Qualifiers
     source          1..5682
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.2"
     gene            1..5682
                     /gene="BRD3OS"
                     /gene_synonym="LINC00094; LP2477; NCRNA00094; SERLOC"
                     /note="BRD3 opposite strand"
                     /db_xref="GeneID:266655"
                     /db_xref="HGNC:HGNC:24742"
     exon            1..56
                     /gene="BRD3OS"
                     /gene_synonym="LINC00094; LP2477; NCRNA00094; SERLOC"
                     /inference="alignment:Splign:2.1.0"
     exon            57..302
                     /gene="BRD3OS"
                     /gene_synonym="LINC00094; LP2477; NCRNA00094; SERLOC"
                     /inference="alignment:Splign:2.1.0"
     exon            303..5682
                     /gene="BRD3OS"
                     /gene_synonym="LINC00094; LP2477; NCRNA00094; SERLOC"
                     /inference="alignment:Splign:2.1.0"
     CDS             843..1097
                     /gene="BRD3OS"
                     /gene_synonym="LINC00094; LP2477; NCRNA00094; SERLOC"
                     /note="long intergenic non-protein coding RNA 94; BRD3
                     opposite strand protein; Super enhancer and ERK1/2
                     Regulated Long Intergenic non-protein coding transcript
                     Overexpressed in Carcinomas"
                     /codon_start=1
                     /product="putative uncharacterized protein BRD3OS"
                     /protein_id="NP_001342185.1"
                     /db_xref="CCDS:CCDS87707.1"
                     /db_xref="GeneID:266655"
                     /db_xref="HGNC:HGNC:24742"
                     /translation="MSGRVPLAEKALSEGYARLRYRDTSLLIWQQQQQKLESVPPGTY
                     LSRSRSMWYSQYGNEAILVRDKNKLEVSRDTGQSKFCTIM"
     regulatory      2174..2179
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRD3OS"
                     /gene_synonym="LINC00094; LP2477; NCRNA00094; SERLOC"
                     /note="hexamer: AATAAA"
     polyA_site      2193
                     /gene="BRD3OS"
                     /gene_synonym="LINC00094; LP2477; NCRNA00094; SERLOC"
                     /note="major polyA site"
     regulatory      4534..4539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRD3OS"
                     /gene_synonym="LINC00094; LP2477; NCRNA00094; SERLOC"
                     /note="hexamer: AATAAA"
     polyA_site      4555
                     /gene="BRD3OS"
                     /gene_synonym="LINC00094; LP2477; NCRNA00094; SERLOC"
     regulatory      5563..5568
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRD3OS"
                     /gene_synonym="LINC00094; LP2477; NCRNA00094; SERLOC"
                     /note="hexamer: ATTAAA"
     polyA_site      5585
                     /gene="BRD3OS"
                     /gene_synonym="LINC00094; LP2477; NCRNA00094; SERLOC"
     regulatory      5661..5666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRD3OS"
                     /gene_synonym="LINC00094; LP2477; NCRNA00094; SERLOC"
                     /note="hexamer: ATTAAA"
     polyA_site      5682
                     /gene="BRD3OS"
                     /gene_synonym="LINC00094; LP2477; NCRNA00094; SERLOC"
ORIGIN      
        1 gggagccccg cagtgcgtcg cgccgctgcc cgcatctccg aggcccgcga cgagcggggc
       61 ctcacgggag ctggatgctc ggagcagcaa ggcggccctg ggggcccctt ccggtcccgg
      121 ggctgacgcc tggcggcgtc tccgggaacc cgcgcccttt caagcgccgc tggctcctgt
      181 ttcacagatg gagaccctga agccccaaca agcagcctcc ccagcacctc ccagtgactg
      241 aaaaagctgg cactgggcgc ccgtctcact ctccacccag ctcccaggct gccccacggg
      301 accagcacct ttggggagag acgagacctg aacaaacgct ggggctggat ccccagggtg
      361 ggtcagaaca gccgttgccc tgaaagctgg cccggacaga tgcgtgcggg gcgtgccacc
      421 ggagctcctt ccagcttgcg tctggggcca ccatgtccct tcctcagggc actggatcca
      481 tctcttcaag ctcagtggtc caggccatgg tggcagaatc accccccagg gtgtgacgcc
      541 tcgtccctgt caattccaca cagctgcacc cggaagagct gtggccgggc gccgctctga
      601 cctgtgtgcg gtcccctgaa tgggtctcag gtgtcttcag aatggtgagg ccgcctcatt
      661 tcctcaccac acaaccctcc tgaggacgtt gcctgcaaat gggcggaatt cctaatttct
      721 accattcagt taaacgaggg atccttaagc cccaaagctg ggaaagctgt ccgttaattt
      781 agtgcgcgtg ggccgtctca gaacagcagg gttcccagga gtccagcggg acgggggagg
      841 ggatgagtgg ccgtgtcccc ctggcagaga aggccttgtc tgaaggctac gcccgcctcc
      901 ggtacaggga cacctccttg ctcatctggc agcagcaaca gcagaagttg gagtcggtgc
      961 cacctgggac gtacctgagc aggagccgaa gcatgtggta ctcacagtat ggaaatgagg
     1021 ccatcttggt ccgagacaaa aacaagctcg aggtctctag ggacacaggg cagtccaagt
     1081 tttgcacaat tatgtaattc cgatgtgagc acctgaaccc aggaccacac tttgaggaaa
     1141 acagacctga gtttcattca gttgtcttgt tgatttccaa tccttgctgg aagattttga
     1201 ataatgaacg tgaagatcaa actgtggtgt aagaacccaa gaagcgcaga attggccccc
     1261 gaacccctca gcacagccgc ggtgtgactg gtgcacagga cacttcccct ctagagtccc
     1321 ctccgtggtc agctgttgtg acatttgaat tctccaggtg ctgctaggga cagcataggc
     1381 ccgggcactg ctagatgctt ggtttaaacc aggccaagag taaccctccc atccccatta
     1441 caaaccacct tttcaagttt tttaggtttt agttttttgt ttttagcata aatggcggag
     1501 tagcagcagc atctcaccag gagctttgtc gcattacatt ttgtattttg cttttttgag
     1561 acggggtctc actctgttac ccaggctgga atacagtggc acaatcacag ctcactgtag
     1621 gctctatctc ctgggctcag gtgatcctcc caaactcagc ctcccaggta gctgtggctc
     1681 caggcgaact actgtatata gagacagggt ttccctatgt tgcccaggct ggtctggtct
     1741 tatagtcctg ggctcaagcc tcccagagtg ctgggattac aggcatgggt caccgcacca
     1801 agcccgcatt tatattttga gttaccaaaa tgatcatcat ctgtgaagca tcatggtagc
     1861 ttccaagcat ttgcggccca ctggccagtg catccaaaac acattcagga aacccgagag
     1921 ttgtaagttg cacatgtgtg gcctacagtg acttccatgt agtaacaggg ctgagcaagg
     1981 caggctctcc accagactta aagcattcaa ccactctgcc cccaggccga cactgacatg
     2041 tgttcactgt cgctgccaca gctggccacc tgtgttcagt ctccatgaag gattcacctt
     2101 ctgctctcac tgacatctcc ttggctacac aaatgtgcag gtgtctcttg tcaaagctaa
     2161 tttttctttt ctaaataaac atcctttaat acactcctcc ccttcctcac acttattttt
     2221 atccttgttc gtaatatcct acttggcttc ccatttttta tagcagtaat atgtaattga
     2281 ttgctaaaga ctgcaataca caaaggcata aagcaaagca caagtgctct ccgtggggag
     2341 aacccggccg gcagctgggg atgcgtccca cagctcctca gcatgcacac acggtcacgt
     2401 gattctgacg gcctcatcct gcaccatgcc tcttgtatcc gccattttct ttcttgctca
     2461 actgtacaga ctgggcattc acttaatgct tttctttttt tttaagagag tctcactctg
     2521 ttgcccaggc tggagtgcaa tggcacaatc tcagctcact gcaacctctg cctcctgggt
     2581 tcaggcgatt ctcctgcctc agcctcctga gtagctggaa ttacaggtgc ctgccaccac
     2641 gcctggctaa tttttctatt tttaatagag acaaggtttc accatgttgg ccaggctggt
     2701 ctcgaactgc caatctcagg tgatctgccc acctcggcct cccaaagtac tgggattaca
     2761 ggcgtgagcc accgcacccg gcccacttca tgcttttaac ctctgactcg cagctctccc
     2821 gtgagcccac agacgggcac agtgacagca tccaggttgt catctgtgca aacagcatgt
     2881 tctgaatgtg cctgtactct gttcgtgctt ctctttgcag ctgtgcaagt tcattcgcaa
     2941 acgtcctaga agtggaactg ctgggtcaaa gtgcattccc caaatgtcct gccagaggcc
     3001 tggtcggcag cagcctcctg cacagcccga gtcccttctg cgagagtcct ggcttgtttg
     3061 cagcctgcag ctgggagatt tgaagtcaga cttccaggat tgccgcatgg agctgcagag
     3121 ggagtgagca tggggctgga ggacctgccc cgccggctga cactcccaca gcaaggcggg
     3181 cccgccaagg aagcactcca catccgctag gtagggtttg tctgcatctt ttcagttctt
     3241 cagtttaagt cctgcctggg aagaaagcaa actccagagg caaatctgga atgcctgtgt
     3301 gccaccttct caccgcacca cagactcccc tgaggacggg ttgtggcggg gttggcccca
     3361 agcatgggag gcagcgcaga catgcagaat ggggtctgag gtcacgttgc aacgctggca
     3421 ggatgtgtgc tcaagggcca gtctctgcag gggtcagggc gtgtgggcca cgcacaagga
     3481 gctggcacta agccgcttag gctgcaggaa gacaccatct gcctggggcg gacaaggccc
     3541 catgtccgtc ctcaaggagg ctggtctgga tgagaagggt cacagtctgg ccaggagtgt
     3601 caccgtgccc cctgacccca tctggggtcg ggctggacag gtcctcaggc ctagacgtgg
     3661 gcccagccag aaccttctcc cctggcatgt ctcttccagg cctagttcca gagctgtcat
     3721 tcttcggcga gccgcgctgc acgccagcct ccagtctggc agttaaacct cactatgaaa
     3781 atctgctttt gggattttat ttgcatttcc attagactga gcgcatcaca agccacttca
     3841 ggatagactg aggtgcagag ggaggggaca agcggccagg ttgactagaa gagcacagaa
     3901 cctggctgtc tcgaagaggg cagcttgttc cagggaacca atgaactgtc agtaaagggg
     3961 attgtggctt cctagtgagg caagaaatga tgctcccttc atcctgccag ggctcaggac
     4021 aagagctact taatggtttg attattatta ttttttaaga gatgttgtcc aggctggagt
     4081 gcagtgatgc aatcatggct tactgcagcc tcaaactcct ggcctcaggc catcctcctg
     4141 cctcagcctc ccaaagtgct gtgatcacag gcacgagcca ctgcatcctg cctttaaatg
     4201 gttttttggg gccccttttg gatgctctgg gtgtttttgc caagagttac aggatgtcaa
     4261 gtgtggggag ctcagcaccc ttgctgtgga ccagtgaagg ctgttccaga ccaggtgctt
     4321 ccagacattt ccaggctcca ggagagaggc tgggagcccc cacagaaagc acaggaaaat
     4381 gcaaaaaaaa aaaacagtct tttttttttt tttttttttt gctttttatt atgaaaacaa
     4441 aacaaatgcc ccaggagaag ggtccatgat taccagaaac atcaaagagt actttctacc
     4501 atttttattc tgttgtgttg aggccagcat tgcaataaac aagctaaact acttacattg
     4561 gactcatttt cagtaactga catttacagg aatatactag aaacggcact aaaaagttta
     4621 agaaaagtta cggtaaactt gcatgcacat catacagaaa agtaacattt taaatataaa
     4681 aaagaaaaac ttcctggaag cattatgcca gtattaagga acagtgctac tctggatgtg
     4741 acaaattctg tatgtgggtg ttactctttc ccaaaagact gtcagaggcg tgagtgctgc
     4801 aaaagaacaa caacaaaaac aaacacacaa aaaaatgtgt cttacagttt gtaagcaaga
     4861 tgacactgcc caacacaaag aggggtctgg agttcagttc acgcccgaag cctgccccct
     4921 cggcctccag gggtcattca gagtgttctc aaatccaatt ccgacacacg acttgtcact
     4981 actcctctcc ccttgaaaaa agcatgttag aagctgccct acaggtctca gcagtgggac
     5041 aatctaattg aatcaccgca gccttctaat acagaagaaa cggacgtgac tgtcaccctc
     5101 agcccgccag caagggcgct gaggaagtca ttaatccttc gaaactctga aaagaaacca
     5161 gtgttgaagt ctggacagaa agccttaaaa aagtgacagc accaatgcag ctgctcagtg
     5221 tacccgccgt gggctgtcag ggtcagtggc ttctttctag atgaaaggag cagaggcgag
     5281 ccgacgccac cgtcacagag aaccagccga gaaggaaagg ccccacgatg ctcctgctgc
     5341 gctgccccca cagccggccg ctcccccgac ggctcacaca ggcagcacct cactgccctg
     5401 tggctggagg ggcattgcaa ggagcgcccc ccagccccag gcacccccgg cttagggtgt
     5461 acgtatcacc cagccctgtg ctggcagcac gttaccaacc agcctgcgtg aagacctgtc
     5521 aactgtcgtg tgtgaattcc ttaaattcgg tttaaatagt ccattaaaga tctgtttaga
     5581 aaataccttt gaaaacgagg gtaactttaa aaaatggaaa ctttcaaatc catttatatt
     5641 tttattataa acaaaactta attaaaagtt taacaaactg gc
//
