LOCUS       NM_007371               5661 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens bromodomain containing 3 (BRD3), mRNA.
ACCESSION   NM_007371
VERSION     NM_007371.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5661)
  AUTHORS   Hashimoto,M., Masuda,T., Nakano,Y., Tobo,T., Saito,H., Koike,K.,
            Takahashi,J., Abe,T., Ando,Y., Ozato,Y., Hosoda,K., Higuchi,S.,
            Hisamatsu,Y., Toshima,T., Yonemura,Y., Hata,T., Uemura,M.,
            Eguchi,H., Doki,Y., Mori,M. and Mimori,K.
  TITLE     Tumor suppressive role of the epigenetic master regulator BRD3 in
            colorectal cancer
  JOURNAL   Cancer Sci 115 (6), 1866-1880 (2024)
   PUBMED   38494600
  REMARK    GeneRIF: Tumor suppressive role of the epigenetic master regulator
            BRD3 in colorectal cancer.
REFERENCE   2  (bases 1 to 5661)
  AUTHORS   Hsu,P.L., Chien,C.W., Tang,Y.A., Lin,B.W., Lin,S.C., Lin,Y.S.,
            Chen,S.Y., Sun,H.S. and Tsai,S.J.
  TITLE     Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer
            metastasis
  JOURNAL   Sci Adv 9 (15), eade3422 (2023)
   PUBMED   37043564
  REMARK    GeneRIF: Targeting BRD3 eradicates nuclear TYRO3-induced colorectal
            cancer metastasis.
            Erratum:[Sci Adv. 2023 Nov 10;9(45):eadl3229. doi:
            10.1126/sciadv.adl3229.. PMID: 37948531]
REFERENCE   3  (bases 1 to 5661)
  AUTHORS   Wang,C., Chan,D.W. and Hendrickson,E.A.
  TITLE     Kinome-wide screening uncovers a role for Bromodomain Protein 3 in
            DNA double-stranded break repair
  JOURNAL   DNA Repair (Amst) 122, 103445 (2023)
   PUBMED   36608404
  REMARK    GeneRIF: Kinome-wide screening uncovers a role for Bromodomain
            Protein 3 in DNA double-stranded break repair.
REFERENCE   4  (bases 1 to 5661)
  AUTHORS   Lee,J.H., Yoo,S.S., Hong,M.J., Choi,J.E., Kang,H.G., Do,S.K.,
            Lee,W.K., Choi,S.H., Lee,Y.H., Seo,H., Lee,J., Lee,S.Y., Cha,S.I.,
            Kim,C.H., Lee,E.B., Cho,S., Jheon,S. and Park,J.Y.
  TITLE     Epigenetic readers and lung cancer: the rs2427964C>T variant of the
            bromodomain and extraterminal domain gene BRD3 is associated with
            poorer survival outcome in NSCLC
  JOURNAL   Mol Oncol 16 (3), 750-763 (2022)
   PUBMED   34605158
  REMARK    GeneRIF: Epigenetic readers and lung cancer: the rs2427964C>T
            variant of the bromodomain and extraterminal domain gene BRD3 is
            associated with poorer survival outcome in NSCLC.
REFERENCE   5  (bases 1 to 5661)
  AUTHORS   Aiyer,S., Swapna,G.V.T., Ma,L.C., Liu,G., Hao,J., Chalmers,G.,
            Jacobs,B.C., Montelione,G.T. and Roth,M.J.
  TITLE     A common binding motif in the ET domain of BRD3 forms polymorphic
            structural interfaces with host and viral proteins
  JOURNAL   Structure 29 (8), 886-898 (2021)
   PUBMED   33592170
  REMARK    GeneRIF: A common binding motif in the ET domain of BRD3 forms
            polymorphic structural interfaces with host and viral proteins.
REFERENCE   6  (bases 1 to 5661)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   7  (bases 1 to 5661)
  AUTHORS   Zhou,M., Peng,C., Nie,X.M., Zhang,B.C., Zhu,S.G., Yu,Y., Li,X.L.
            and Li,G.Y.
  TITLE     [Expression of BRD7-interacting proteins,BRD2 and BRD3, in
            nasopharyngeal carcinoma tissues]
  JOURNAL   Ai Zheng 22 (2), 123-127 (2003)
   PUBMED   12600283
REFERENCE   8  (bases 1 to 5661)
  AUTHORS   Kaneko,H., Inoue,R., Teramoto,T., Morimoto,W., Isogai,K.,
            Kasahara,K. and Kondo,N.
  TITLE     Detection of the genes induced in activated lymphocytes by modified
            differential display
  JOURNAL   J Investig Allergol Clin Immunol 12 (2), 86-90 (2002)
   PUBMED   12371535
  REMARK    GeneRIF: Activated lymphocytes induced by mitogens or antigens
            express various sets of genes, including those involved in the
            expression of cytokines, surface molecules, and nuclear proteins.
REFERENCE   9  (bases 1 to 5661)
  AUTHORS   Thorpe,K.L., Gorman,P., Thomas,C., Sheer,D., Trowsdale,J. and
            Beck,S.
  TITLE     Chromosomal localization, gene structure and transcription pattern
            of the ORFX gene, a homologue of the MHC-linked RING3 gene
  JOURNAL   Gene 200 (1-2), 177-183 (1997)
   PUBMED   9373153
REFERENCE   10 (bases 1 to 5661)
  AUTHORS   Thorpe,K.L., Abdulla,S., Kaufman,J., Trowsdale,J. and Beck,S.
  TITLE     Phylogeny and structure of the RING3 gene
  JOURNAL   Immunogenetics 44 (5), 391-396 (1996)
   PUBMED   8781126
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL591386.19, BI545861.1,
            D26362.1, BC010699.1, AA766480.1, DW413353.1, AK123322.1 and
            AK026880.1.
            
            On May 17, 2019 this sequence version replaced NM_007371.3.
            
            Summary: This gene was identified based on its homology to the gene
            encoding the RING3 protein, a serine/threonine kinase. The gene
            localizes to 9q34, a region which contains several major
            histocompatibility complex (MHC) genes. The function of the encoded
            protein is not known. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.79752.1, D26362.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303407.12/ ENSP00000305918.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AL591386.19        8193-8199           c
            8-56                BI545861.1         9-57
            57-1130             D26362.1           1-1074
            1131-2108           BC010699.1         1094-2071
            2109-3084           D26362.1           2053-3028
            3085-3125           AA766480.1         176-216             c
            3126-3257           DW413353.1         181-312
            3258-4469           AK123322.1         1-1212
            4470-5661           AK026880.1         519-1710
FEATURES             Location/Qualifiers
     source          1..5661
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.2"
     gene            1..5661
                     /gene="BRD3"
                     /gene_synonym="FSHRG2; ORFX; RING3L"
                     /note="bromodomain containing 3"
                     /db_xref="GeneID:8019"
                     /db_xref="HGNC:HGNC:1104"
                     /db_xref="MIM:601541"
     exon            1..82
                     /gene="BRD3"
                     /gene_synonym="FSHRG2; ORFX; RING3L"
                     /inference="alignment:Splign:2.1.0"
     exon            83..408
                     /gene="BRD3"
                     /gene_synonym="FSHRG2; ORFX; RING3L"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..2376
                     /gene="BRD3"
                     /gene_synonym="FSHRG2; ORFX; RING3L"
                     /note="RING3-like protein; female sterile homeotic related
                     gene 2"
                     /codon_start=1
                     /product="bromodomain-containing protein 3"
                     /protein_id="NP_031397.1"
                     /db_xref="CCDS:CCDS6980.1"
                     /db_xref="GeneID:8019"
                     /db_xref="HGNC:HGNC:1104"
                     /db_xref="MIM:601541"
                     /translation="MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQN
                     VVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECM
                     QDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPA
                     AGAQSAGTQQVAAVSSVSPATPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAA
                     PPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVV
                     ARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPF
                     YKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNP
                     PDHEVVAMARKLQDVFEMRFAKMPDEPVEAPALPAPAAPMVSKGAESSRSSEESSSDS
                     GSSDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKEKKEKEKKKKDKEKEK
                     EKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKANSTTTAGRQLKKGGKQASASYDSEEE
                     EEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPT
                     TLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEELAQEKKKELEKRLQDVSGQLSSS
                     KKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSSDSSDSE"
     exon            409..546
                     /gene="BRD3"
                     /gene_synonym="FSHRG2; ORFX; RING3L"
                     /inference="alignment:Splign:2.1.0"
     exon            547..694
                     /gene="BRD3"
                     /gene_synonym="FSHRG2; ORFX; RING3L"
                     /inference="alignment:Splign:2.1.0"
     exon            695..909
                     /gene="BRD3"
                     /gene_synonym="FSHRG2; ORFX; RING3L"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1281
                     /gene="BRD3"
                     /gene_synonym="FSHRG2; ORFX; RING3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1410
                     /gene="BRD3"
                     /gene_synonym="FSHRG2; ORFX; RING3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1602
                     /gene="BRD3"
                     /gene_synonym="FSHRG2; ORFX; RING3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1838
                     /gene="BRD3"
                     /gene_synonym="FSHRG2; ORFX; RING3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..2131
                     /gene="BRD3"
                     /gene_synonym="FSHRG2; ORFX; RING3L"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2260
                     /gene="BRD3"
                     /gene_synonym="FSHRG2; ORFX; RING3L"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..5661
                     /gene="BRD3"
                     /gene_synonym="FSHRG2; ORFX; RING3L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5552..5557
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRD3"
                     /gene_synonym="FSHRG2; ORFX; RING3L"
                     /note="hexamer: AATAAA"
     polyA_site      5571
                     /gene="BRD3"
                     /gene_synonym="FSHRG2; ORFX; RING3L"
                     /note="major polyA site"
ORIGIN      
        1 attatgctgc cggggccggc gagccaaaga ggagccggcc gcgcgggccg ggaggggacg
       61 gccgccggag ccgcgaggcc aactgtcgcc tggttgggcc cggaaatggg acgtcgcgct
      121 ttctcaggga gcgtagaagc agccagggcc tctccaagcc gctgctgtga cagaaagtga
      181 gtgagctgcc ggaggatgtc caccgccacg acagtcgccc ccgcggggat cccggcgacc
      241 ccgggccctg tgaacccacc ccccccggag gtctccaacc ccagcaagcc cggccgcaag
      301 accaaccagc tgcagtacat gcagaatgtg gtggtgaaga cgctctggaa acaccagttc
      361 gcctggccct tctaccagcc cgtggacgca atcaaattga acctgccgga ttatcataaa
      421 ataattaaaa acccaatgga tatggggact attaagaaga gactagaaaa taattattat
      481 tggagtgcaa gcgaatgtat gcaggacttc aacaccatgt ttacaaattg ttacatttat
      541 aacaagccca cagatgacat agtgctaatg gcccaagctt tagagaaaat ttttctacaa
      601 aaagtggccc agatgcccca agaggaagtt gaattattac cccctgctcc aaagggcaaa
      661 ggtcggaagc cggctgcggg agcccagagc gcaggtacac agcaagtggc ggccgtgtcc
      721 tctgtctccc cagcgacccc ctttcagagc gtgcccccca ccgtctccca gacgcccgtc
      781 atcgctgcca cccctgtacc aaccatcact gcaaacgtca cgtcggtccc agtcccccca
      841 gctgccgccc cacctcctcc tgccacaccc atcgtccccg tggtccctcc tacgccgcct
      901 gtcgtcaaga aaaagggcgt gaagcggaaa gcagacacaa ccactcccac gacgtcggcc
      961 atcactgcca gccggagtga gtcgcccccg ccgttgtcag accccaagca ggccaaagtg
     1021 gtggcccggc gggagagtgg tggccgcccc atcaagcctc ccaagaagga cctggaggac
     1081 ggcgaggtgc cccagcacgc aggcaagaag ggcaagctgt cggagcacct acgctactgc
     1141 gacagcatcc tcagggagat gctatccaag aagcacgcgg cctacgcctg gcccttctac
     1201 aagccagtgg atgccgaggc cctggagctg cacgactacc acgacatcat caagcacccg
     1261 atggacctca gcaccgtgaa aaggaagatg gatggccgag agtacccaga cgcacagggc
     1321 tttgctgctg atgtccggct gatgttctcg aattgctaca aatacaatcc cccagaccac
     1381 gaggttgtgg ccatggcccg gaagctccag gacgtgtttg agatgaggtt tgccaagatg
     1441 ccagatgagc ccgtggaggc accggcgctg cctgcccccg cggcccccat ggtgagcaag
     1501 ggcgctgaga gcagccgtag cagtgaggag agctcttcgg actcaggcag ctcggactcg
     1561 gaggaggagc gggccaccag gctggcggag ctgcaggagc agctgaaggc cgtgcacgag
     1621 cagctggccg ccctgtctca ggccccagta aacaaaccaa agaagaagaa ggagaagaag
     1681 gagaaggaga agaagaagaa ggacaaggag aaggagaagg agaagcacaa agtgaaggcc
     1741 gaggaagaga agaaggccaa ggtggctccg cctgccaagc aggctcagca gaagaaggct
     1801 cctgccaaga aggccaacag cacgaccacg gccggcagac agctgaagaa aggcggcaag
     1861 caggcatctg cctcctacga ctcagaggaa gaggaggagg gcctgcccat gagctacgat
     1921 gaaaagcgcc agcttagcct ggacatcaac cggctgcccg gggagaagct gggccgggta
     1981 gtgcacatca tccaatctcg ggagccctcg ctcagggact ccaaccccga cgagatagaa
     2041 attgactttg agactctgaa acccaccact ttgcgggaac tggagagata tgtcaagtct
     2101 tgtttacaga aaaagcaaag gaaaccgttc tcagcaagcg ggaagaaaca ggcagccaag
     2161 tcgaaagagg agctagctca ggaaaagaag aaggagctgg aaaagcgtct gcaggatgtc
     2221 agcgggcagc tgagcagcag caagaagccc gcccggaaag agaagcccgg ctcagcaccc
     2281 tcagggggcc cgtccaggct cagcagcagc agctcctccg agtctgggag cagcagctcc
     2341 agcgggtcca gctctgacag cagtgactca gaatgaactg gcttcggaca gaacaggaca
     2401 gatggatgtc gcacacgccg agactctgcc gtacccctct gtggttcata ttactacttc
     2461 tgttccatgg tgtgcaggtc tgcttcttaa ttcagtgtta tgatatcttc cagtttttgc
     2521 tttcataggt cagagatcta tcttgtgtgt gcgttagact tgatgagaag gtgtgaactc
     2581 tgcagaaagt ctcttcttca tcactgaatt cagtcacttg gagatgacaa cttcaaatgc
     2641 taacccgatg accccagaaa accgtgtgag attcgtaccg aagaaccttg tggaatccct
     2701 ttgcttaggc ccaacctggt cgatagctcg agaaagaatt ttttccaagg aaatgtctcg
     2761 gatatgggta ctgtatttga aagctgttag ctttgtcaac acgcattgtc cttgtcattt
     2821 gggccccgag ctctgaccct cgtgtctgac gcggccacct ctttctggag gggctgagga
     2881 cagatgtgcc tgcttgtgga gaccaggctg ggcctaagcg aagggtcatc gcagccccag
     2941 cccggagcgt ggagcccttg gggggtggtc gggtgggatg tgcgttctcc gctcgtggtg
     3001 atgtcaggag ctcctcggag ggaacagagc ggctgtgtat gcagcctgca ggtttccata
     3061 cactgaagct tttacctcaa ctttaaaaaa aaaaaaagaa gaaaagattt aaaaaaaaaa
     3121 aaaaaggaga ctttttttgt aaggttcggc aattttctac ggaagtccag cccgctgtga
     3181 gtccccgcct ggctagcgct gcccctgctg ctgctgccgc gccacccttg ggaaccactt
     3241 cccgagctta tgtgtatata aatagttatt tattaacatc attggtcatt tttaaaaaaa
     3301 agaaaataag aaaaaaccgc agaagaaatg cattcacaca gtcgcagaga tgcaggcctt
     3361 gccagtggtg tgccgggcgc gggtcctgtc tggcggcggc ctgtcgtctc caggtgctaa
     3421 ctcctgccac cgcgcggtgc tcacccacgt ctgttcgcgc gctcgcccct gggtttgttg
     3481 ggttttttgg tttttttctt tgtggttttt tttttttttt ttttttgtat gaaacttgga
     3541 ggcttacagg tatagacagc tttcagctac agcacattct aattttttat tttgtttagt
     3601 tcttttgtat tcacttctgg tctctttaag actgttttaa aagaaatcaa tttagggaac
     3661 cccagttata taatataaac tttgtaatct gagagaaaaa atgtatagta aatctaagtc
     3721 ttgattttta actttctatt gtaaaaaata ataatataca gagtttaata gaaggtgatg
     3781 ttttggtttt gttttcccag aggctgccat atggtctttg agtacgggga tgtcccaaac
     3841 tggcccacca atgagcatgg cggctccggc caggaatgcc agagttagcc tcccaggctt
     3901 gcgggtggac atgcctgctc cctgccagcc tccagtggcc tggccaggcc ctcccgagcc
     3961 tgtctgccct ccccaggggt ggaggagtct ctgggcccca ggaggattcc ctcccggaga
     4021 ctcgcacggt gctccctgct cacgcgttgt cacagttagt ccggaaatga ctgaaaccag
     4081 gcattctccc ggacctcagc gtgggggagc ctccaggcag acgctgggta tggagctgtg
     4141 gtgtggtctg tcctgtatgg tggccagtgc tttctgccag catttctgga tggatatagg
     4201 gactatcatt agtatcctaa tacacggtga ttttaaaaca accataaaat tgattcagag
     4261 tccactgacc cttacagatg taggtatacc cttactggag agggaactct gatgaggaga
     4321 tgctggtaaa ttatcatttt ttaaattgct ggtgagtctg acacttggtg agttttcagc
     4381 cagtttgtta aacttttaat taagttttgt ttataataaa aatataaatg gatttgaaag
     4441 tttccatttt ttaaagttac cctcgttttc aaaggtattt tctaaacaga tctttaatgg
     4501 actatttaaa ccgaatttaa ggaattcaca cacgacagtt gacaggtctt cacgcaggct
     4561 ggttggtaac gtgctgccag cacagggctg ggtgatacgt acaccctaag ccgggggtgc
     4621 ctggggctgg ggggcgctcc ttgcaatgcc cctccagcca cagggcagtg aggtgctgcc
     4681 tgtgtgagcc gtcgggggag cggccggctg tgggggcagc gcagcaggag catcgtgggg
     4741 cctttccttc tcggctggtt ctctgtgacg gtggcgtcgg ctcgcctctg ctcctttcat
     4801 ctagaaagaa gccactgacc ctgacagccc acggcgggta cactgagcag ctgcattggt
     4861 gctgtcactt ttttaaggct ttctgtccag acttcaacac tggtttcttt tcagagtttc
     4921 gaaggattaa tgacttcctc agcgcccttg ctggcgggct gagggtgaca gtcacgtccg
     4981 tttcttctgt attagaaggc tgcggtgatt caattagatt gtcccactgc tgagacctgt
     5041 agggcagctt ctaacatgct tttttcaagg ggagaggagt agtgacaagt cgtgtgtcgg
     5101 aattggattt gagaacactc tgaatgaccc ctggaggccg agggggcagg cttcgggcgt
     5161 gaactgaact ccagacccct ctttgtgttg ggcagtgtca tcttgcttac aaactgtaag
     5221 acacattttt ttgtgtgttt gtttttgttg ttgttctttt gcagcactca cgcctctgac
     5281 agtcttttgg gaaagagtaa cacccacata cagaatttgt cacatccaga gtagcactgt
     5341 tccttaatac tggcataatg cttccaggaa gtttttcttt tttatattta aaatgttact
     5401 tttctgtatg atgtgcatgc aagtttaccg taacttttct taaacttttt agtgccgttt
     5461 ctagtatatt cctgtaaatg tcagttactg aaaatgagtc caatgtaagt agtttagctt
     5521 gtttattgca atgctggcct caacacaaca gaataaaaat ggtagaaagt actctttgat
     5581 gtttctggta atcatggacc cttctcctgg ggcatttgtt ttgttttcat aataaaaagc
     5641 aaaaaaaaaa aaaaaaaaaa a
//
