LOCUS       NM_005104               4956 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens bromodomain containing 2 (BRD2), transcript variant 1,
            mRNA.
ACCESSION   NM_005104 XM_005249264
VERSION     NM_005104.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4956)
  AUTHORS   Kang,J.H., Splinter,P.L., Trussoni,C.E., Pirius,N.E., Gores,G.J.,
            LaRusso,N.F. and O'Hara,S.P.
  TITLE     The Epigenetic Reader, Bromodomain Containing 2, Mediates
            Cholangiocyte Senescence via Interaction With ETS Proto-Oncogene 1
  JOURNAL   Gastroenterology 165 (1), 228-243 (2023)
   PUBMED   37059338
  REMARK    GeneRIF: The Epigenetic Reader, Bromodomain Containing 2, Mediates
            Cholangiocyte Senescence via Interaction With ETS Proto-Oncogene 1.
REFERENCE   2  (bases 1 to 4956)
  AUTHORS   Xie,L., Dong,P., Qi,Y., Hsieh,T.S., English,B.P., Jung,S., Chen,X.,
            De Marzio,M., Casellas,R., Chang,H.Y., Zhang,B., Tjian,R. and
            Liu,Z.
  TITLE     BRD2 compartmentalizes the accessible genome
  JOURNAL   Nat Genet 54 (4), 481-491 (2022)
   PUBMED   35410381
REFERENCE   3  (bases 1 to 4956)
  AUTHORS   Bhola,N.E., Njatcha,C., Hu,L., Lee,E.D., Shiah,J.V., Kim,M.O.,
            Johnson,D.E. and Grandis,J.R.
  TITLE     PD-L1 is upregulated via BRD2 in head and neck squamous cell
            carcinoma models of acquired cetuximab resistance
  JOURNAL   Head Neck 43 (11), 3364-3373 (2021)
   PUBMED   34346116
  REMARK    GeneRIF: PD-L1 is upregulated via BRD2 in head and neck squamous
            cell carcinoma models of acquired cetuximab resistance.
REFERENCE   4  (bases 1 to 4956)
  AUTHORS   Galea,G.L., Paradise,C.R., Meakin,L.B., Camilleri,E.T.,
            Taipaleenmaki,H., Stein,G.S., Lanyon,L.E., Price,J.S., van
            Wijnen,A.J. and Dudakovic,A.
  TITLE     Mechanical strain-mediated reduction in RANKL expression is
            associated with RUNX2 and BRD2
  JOURNAL   Gene 763S, 100027 (2020)
   PUBMED   34493364
  REMARK    GeneRIF: Mechanical strain-mediated reduction in RANKL expression
            is associated with RUNX2 and BRD2.
REFERENCE   5  (bases 1 to 4956)
  AUTHORS   Shen,H., Li,J., Xie,X., Yang,H., Zhang,M., Wang,B., Kent,K.C.,
            Plutzky,J. and Guo,L.W.
  TITLE     BRD2 regulation of sigma-2 receptor upon cholesterol deprivation
  JOURNAL   Life Sci Alliance 4 (1), e201900540 (2020)
   PUBMED   33234676
  REMARK    GeneRIF: BRD2 regulation of sigma-2 receptor upon cholesterol
            deprivation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4956)
  AUTHORS   Denis,G.V. and Green,M.R.
  TITLE     A novel, mitogen-activated nuclear kinase is related to a
            Drosophila developmental regulator
  JOURNAL   Genes Dev 10 (3), 261-271 (1996)
   PUBMED   8595877
  REMARK    GeneRIF: The BRD2 gene is homologous to the mammalian cell cycle
            regulator TAFII250 and the Drosophila trithorax group gene female
            sterile homeotic; the gene encodes a nuclear-localized kinase with
            signal transduction activity.
REFERENCE   7  (bases 1 to 4956)
  AUTHORS   Thorpe,K.L., Abdulla,S., Kaufman,J., Trowsdale,J. and Beck,S.
  TITLE     Phylogeny and structure of the RING3 gene
  JOURNAL   Immunogenetics 44 (5), 391-396 (1996)
   PUBMED   8781126
REFERENCE   8  (bases 1 to 4956)
  AUTHORS   Haynes,S.R., Dollard,C., Winston,F., Beck,S., Trowsdale,J. and
            Dawid,I.B.
  TITLE     The bromodomain: a conserved sequence found in human, Drosophila
            and yeast proteins
  JOURNAL   Nucleic Acids Res 20 (10), 2603 (1992)
   PUBMED   1350857
REFERENCE   9  (bases 1 to 4956)
  AUTHORS   Beck,S., Hanson,I., Kelly,A., Pappin,D.J. and Trowsdale,J.
  TITLE     A homologue of the Drosophila female sterile homeotic (fsh) gene in
            the class II region of the human MHC
  JOURNAL   DNA Seq 2 (4), 203-210 (1992)
   PUBMED   1352711
REFERENCE   10 (bases 1 to 4956)
  AUTHORS   Okamoto,N., Ando,A., Kawai,J., Yoshiwara,T., Tsuji,K. and Inoko,H.
  TITLE     Orientation of HLA-DNA gene and identification of a CpG
            island-associated gene adjacent to DNA in human major
            histocompatibility complex class II region
  JOURNAL   Hum Immunol 32 (3), 221-228 (1991)
   PUBMED   1663500
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL645941.11, D42040.1,
            DA127395.1, BP271262.1, DC379337.1, AL832722.1, AI983495.1 and
            H11588.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005104.3.
            
            Summary: This gene encodes a transcriptional regulator that belongs
            to the BET (bromodomains and extra terminal domain) family of
            proteins. This protein associates with transcription complexes and
            with acetylated chromatin during mitosis, and it selectively binds
            to the acetylated lysine-12 residue of histone H4 via its two
            bromodomains. The gene maps to the major histocompatability complex
            (MHC) class II region on chromosome 6p21.3, but sequence comparison
            suggests that the protein is not involved in the immune response.
            This gene has been implicated in juvenile myoclonic epilepsy, a
            common form of epilepsy that becomes apparent in adolescence.
            Multiple alternatively spliced variants have been described for
            this gene. [provided by RefSeq, Dec 2010].
            
            Transcript Variant: This variant (1) and variant 2 encode the same
            predominant isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D42040.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374825.9/ ENSP00000363958.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                AL645941.11        46031-46096
            67-324              D42040.1           1-258
            325-671             DA127395.1         30-376
            672-985             BP271262.1         270-583
            986-994             DC379337.1         569-577
            995-1860            AL832722.1         777-1642
            1861-4481           D42040.1           1795-4415
            4482-4765           AI983495.1         2-285               c
            4766-4956           H11588.1           18-208              c
FEATURES             Location/Qualifiers
     source          1..4956
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.32"
     gene            1..4956
                     /gene="BRD2"
                     /gene_synonym="BRD2-IT1; D6S113E; FSH; FSHRG1; FSRG1; NAT;
                     O27.1.1; RING3; RNF3"
                     /note="bromodomain containing 2"
                     /db_xref="GeneID:6046"
                     /db_xref="HGNC:HGNC:1103"
                     /db_xref="MIM:601540"
     exon            1..463
                     /gene="BRD2"
                     /gene_synonym="BRD2-IT1; D6S113E; FSH; FSHRG1; FSRG1; NAT;
                     O27.1.1; RING3; RNF3"
                     /inference="alignment:Splign:2.1.0"
     exon            464..1796
                     /gene="BRD2"
                     /gene_synonym="BRD2-IT1; D6S113E; FSH; FSHRG1; FSRG1; NAT;
                     O27.1.1; RING3; RNF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             1768..4173
                     /gene="BRD2"
                     /gene_synonym="BRD2-IT1; D6S113E; FSH; FSHRG1; FSRG1; NAT;
                     O27.1.1; RING3; RNF3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     female sterile homeotic-related gene 1; really interesting
                     new gene 3 protein; BRD2 intronic transcript 1"
                     /codon_start=1
                     /product="bromodomain-containing protein 2 isoform 1"
                     /protein_id="NP_005095.1"
                     /db_xref="CCDS:CCDS4762.1"
                     /db_xref="GeneID:6046"
                     /db_xref="HGNC:HGNC:1103"
                     /db_xref="MIM:601540"
                     /translation="MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFE
                     SPTMASVPALQLTPANPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQP
                     VDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTD
                     DIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAV
                     SSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKK
                     KGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDS
                     QQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKH
                     PMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRY
                     AKMPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESE
                     SSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGR
                     AGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAP
                     PALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPE
                     EIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVGKTKEELALEKKRELEKRL
                     QDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDS
                     DSG"
     exon            1797..2100
                     /gene="BRD2"
                     /gene_synonym="BRD2-IT1; D6S113E; FSH; FSHRG1; FSRG1; NAT;
                     O27.1.1; RING3; RNF3"
                     /inference="alignment:Splign:2.1.0"
     exon            2101..2238
                     /gene="BRD2"
                     /gene_synonym="BRD2-IT1; D6S113E; FSH; FSHRG1; FSRG1; NAT;
                     O27.1.1; RING3; RNF3"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2377
                     /gene="BRD2"
                     /gene_synonym="BRD2-IT1; D6S113E; FSH; FSHRG1; FSRG1; NAT;
                     O27.1.1; RING3; RNF3"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2592
                     /gene="BRD2"
                     /gene_synonym="BRD2-IT1; D6S113E; FSH; FSHRG1; FSRG1; NAT;
                     O27.1.1; RING3; RNF3"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2967
                     /gene="BRD2"
                     /gene_synonym="BRD2-IT1; D6S113E; FSH; FSHRG1; FSRG1; NAT;
                     O27.1.1; RING3; RNF3"
                     /inference="alignment:Splign:2.1.0"
     exon            2968..3096
                     /gene="BRD2"
                     /gene_synonym="BRD2-IT1; D6S113E; FSH; FSHRG1; FSRG1; NAT;
                     O27.1.1; RING3; RNF3"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3345
                     /gene="BRD2"
                     /gene_synonym="BRD2-IT1; D6S113E; FSH; FSHRG1; FSRG1; NAT;
                     O27.1.1; RING3; RNF3"
                     /inference="alignment:Splign:2.1.0"
     exon            3346..3608
                     /gene="BRD2"
                     /gene_synonym="BRD2-IT1; D6S113E; FSH; FSHRG1; FSRG1; NAT;
                     O27.1.1; RING3; RNF3"
                     /inference="alignment:Splign:2.1.0"
     exon            3609..3913
                     /gene="BRD2"
                     /gene_synonym="BRD2-IT1; D6S113E; FSH; FSHRG1; FSRG1; NAT;
                     O27.1.1; RING3; RNF3"
                     /inference="alignment:Splign:2.1.0"
     exon            3914..4036
                     /gene="BRD2"
                     /gene_synonym="BRD2-IT1; D6S113E; FSH; FSHRG1; FSRG1; NAT;
                     O27.1.1; RING3; RNF3"
                     /inference="alignment:Splign:2.1.0"
     exon            4037..4956
                     /gene="BRD2"
                     /gene_synonym="BRD2-IT1; D6S113E; FSH; FSHRG1; FSRG1; NAT;
                     O27.1.1; RING3; RNF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4749..4754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRD2"
                     /gene_synonym="BRD2-IT1; D6S113E; FSH; FSHRG1; FSRG1; NAT;
                     O27.1.1; RING3; RNF3"
                     /note="hexamer: AAGAAA"
     polyA_site      4765
                     /gene="BRD2"
                     /gene_synonym="BRD2-IT1; D6S113E; FSH; FSHRG1; FSRG1; NAT;
                     O27.1.1; RING3; RNF3"
                     /note="major polyA site"
     regulatory      4936..4941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRD2"
                     /gene_synonym="BRD2-IT1; D6S113E; FSH; FSHRG1; FSRG1; NAT;
                     O27.1.1; RING3; RNF3"
                     /note="hexamer: AGTAAA"
     polyA_site      4956
                     /gene="BRD2"
                     /gene_synonym="BRD2-IT1; D6S113E; FSH; FSHRG1; FSRG1; NAT;
                     O27.1.1; RING3; RNF3"
ORIGIN      
        1 gtgttcctgg tctgcggcag ccatgctgaa ctcgtatgga gaggcgagtg ggggggacag
       61 agtccaggac tgcgggatag gaagctgggg atatggacaa gcagcagcgt tatagcgctc
      121 tgggtttcgg gacataggcc tgggccatgc ggcccccttg gccccttggc gcgaccccca
      181 ggaacgttcg gaaagctggt cctcgtggct gggggaaagg cggggggtgg gggggaagcg
      241 ggcacgtgac cccggtcagc caatctgggt gctgctgacg tggccgcgcg gccccgatgc
      301 tctccccacc cccccagccc gttcgggaag ggaggggctg ggggctacgc cccctccccc
      361 agcacggctt cgttttctgg gggggggttg acaccccgga ttacataccc cgtaccaagc
      421 cgagggcaac tttggaggcc ccctggaagg ctttaggatc cagattcttc gctgctgctg
      481 ccttaccgcc gagaaccacc acccgccagg cgtcttgcgg ccacacccct ggcgggttca
      541 ggcaggctac gcccacgcga cccctcccgt ttccctgctt tggccaatgg aggagctacg
      601 aatggcacga cctgctcgag cttggcagtc tccagttggg ctgtgcatgg aagcttggga
      661 agactttgtt ggaaggggag gcggggagag agtgctggag gctctggggc gatggcttcc
      721 gcacctcttc caaccaccct ctttccctgg agtcggcgga ccacagctca gccaattggc
      781 ttggagatgt ggcgggttgc cacttccctg tgggtctctg cggcactctt ctgcctggtg
      841 actgacacct tggaaatgaa gtttatgacg tcatcgttgc ggctggccaa tagaaaaagc
      901 tcccgcggag aggtgttcct tccccttcga ctcagcttct tcacccgcgt gagcgagcgc
      961 gcgcgcgcgg agggggtggg gaaaagctca agcagggtgg cgcgcatgag cggcgaagct
     1021 cctcctcccc gcctatatat aaagggctgg cgcggggctc ggcggcgcca tttcgtgctg
     1081 gagtggagca gcctctagaa cgagctggag gattctgcct accgatacag agccttcgag
     1141 tcgtccgggg ccgccattac aatccacctc catccgcttg gaaatggcct tcgtcccggc
     1201 ctatgactgg tcccagcggg cagtacagac cccctagaag cccctggagc tccccttttt
     1261 cgggccccgc ccaatcctcg gagtctgtcc accccctcta ctccgccctc aagaggattt
     1321 caaagatgga ggcggcggct ccctaaacca cttttcgtgt tcatccgcct ccatccgaga
     1381 tcgaaacggg acctcgtcgg ccccgtaggg gcccgacaag aagagggaat ccctgcagac
     1441 caacagcggg ctatattgac gacggtgtct gagatcgggg accgtctttt gaagagtcag
     1501 tccctcctta gttgcccgcc tcagctgagg ccgccgccat tttcttgctg tccgccgtct
     1561 gcagagcgcg ccaagctgcc cggagctctc cgagaggccc caaagagact gctttcgtgc
     1621 cggccaggca gggggtttgt cgcctggagg cccaagagga acggcctccc cccaacttag
     1681 cgggttatgc tggaccgggc ggtgagggga accgaggcca cccggacttt ccgcggctga
     1741 gggcagcgcc ggttccttgc ggtcaagatg ctgcaaaacg tgactcccca caataagctc
     1801 cctggggaag ggaatgcagg gttgctgggg ctgggcccag aagcagcagc accagggaag
     1861 aggattcgaa aaccctctct cttgtatgag ggctttgaga gccccacaat ggcttcggtg
     1921 cctgctttgc aacttacccc tgccaaccca ccacccccgg aggtgtccaa tcccaaaaag
     1981 ccaggacgag ttaccaacca gctgcaatac ctacacaagg tagtgatgaa ggctctgtgg
     2041 aaacatcagt tcgcatggcc attccggcag cctgtggatg ctgtcaaact gggtctaccg
     2101 gattatcaca aaattataaa acagcctatg gacatgggta ctattaagag gagacttgaa
     2161 aacaattatt attgggctgc ttcagagtgt atgcaagatt ttaataccat gttcaccaac
     2221 tgttacattt acaacaagcc cactgatgat attgtcctaa tggcacaaac gctggaaaag
     2281 atattcctac agaaggttgc atcaatgcca caagaagaac aagagctggt agtgaccatc
     2341 cctaagaaca gccacaagaa gggggccaag ttggcagcgc tccagggcag tgttaccagt
     2401 gcccatcagg tgcctgccgt ctcttctgtg tcacacacag ccctgtatac tcctccacct
     2461 gagataccta ccactgtcct caacattccc cacccatcag tcatttcctc tccacttctc
     2521 aagtccttgc actctgctgg acccccgctc cttgctgtta ctgcagctcc tccagcccag
     2581 ccccttgcca agaaaaaagg cgtaaagcgg aaagcagata ctaccacccc tacacctaca
     2641 gccatcttgg ctcctggttc tccagctagc cctcctggga gtcttgagcc taaggcagca
     2701 cggcttcccc ctatgcgtag agagagtggt cgccccatca agcccccacg caaagacttg
     2761 cctgactctc agcaacaaca ccagagctct aagaaaggaa agctttcaga acagttaaaa
     2821 cattgcaatg gcattttgaa ggagttactc tctaagaagc atgctgccta tgcttggcct
     2881 ttctataaac cagtggatgc ttctgcactt ggcctgcatg actaccatga catcattaag
     2941 caccccatgg acctcagcac tgtcaagcgg aagatggaga accgtgatta ccgggatgca
     3001 caggagtttg ctgctgatgt acggcttatg ttctccaact gctataagta caatccccca
     3061 gatcacgatg ttgtggcaat ggcacgaaag ctacaggatg tatttgagtt ccgttatgcc
     3121 aagatgccag atgaaccact agaaccaggg cctttaccag tctctactgc catgccccct
     3181 ggcttggcca aatcgtcttc agagtcctcc agtgaggaaa gtagcagtga gagctcctct
     3241 gaggaagagg aggaggaaga tgaggaggac gaggaggaag aagagagtga aagctcagac
     3301 tcagaggaag aaagggctca tcgcttagca gaactacagg aacagcttcg ggcagtacat
     3361 gaacaactgg ctgctctgtc ccagggtcca atatccaagc ccaagaggaa aagagagaaa
     3421 aaagagaaaa agaagaaacg gaaggcagag aagcatcgag gccgagctgg ggccgatgaa
     3481 gatgacaagg ggcctagggc accccgccca cctcaaccta agaagtccaa gaaagcaagt
     3541 ggcagtgggg gtggcagtgc tgctttaggc ccttctggct ttggaccttc tggaggaagt
     3601 ggcaccaagc tccccaaaaa ggccacaaag acagccccac ctgccctgcc tacaggttat
     3661 gattcagagg aggaggaaga gagcaggccc atgagttacg atgagaagcg gcagctgagc
     3721 ctggacatca acaaattacc tggggagaag ctgggccgag ttgtgcatat aatccaagcc
     3781 agggagccct ctttacgtga ttcaaaccca gaagagattg agattgattt tgaaacactc
     3841 aagccatcca cacttagaga gcttgagcgc tatgtccttt cctgcctacg taagaaaccc
     3901 cggaagccct acaccattaa gaagcctgtg ggaaagacaa aggaggaact ggctttggag
     3961 aaaaagcggg aattagaaaa gcggttacaa gatgtcagcg gacagctcaa ttctactaaa
     4021 aagcccccca agaaagcgaa tgagaaaaca gagtcatcct ctgcacagca agtagcagtg
     4081 tcacgcctta gcgcttccag ctccagctca gattccagct cctcctcttc ctcgtcgtcg
     4141 tcttcagaca ccagtgattc agactcaggc taaggggtca ggccagatgg ggcaggaagg
     4201 ctccgcagga ccggacccct agaccaccct gccccacctg ccccttcccc ctttgctgtg
     4261 acacttcttc atctcacccc cccccgcccc cctctaggag agctggctct gcagtggggg
     4321 agggatgcag ggacatttac tgaaggaggg acatggacaa aacaacattg aattcccagc
     4381 cccattgggg agtgatctct tggacacaga gcccccattc aaaatggggc agggcaaggg
     4441 tgggagtgtg caaagccctg atctggagtt acctgaggcc acagctgccc tattcacttc
     4501 taagggccct gttttgagat tgtttgttct aatttatttt aagctaggta aggctggggg
     4561 gagggtgggg ccgtggtccc ctcagcctcc atggggaggg aagaaggggg agctcttttt
     4621 ttacgttgat tttttttttt ctactctgtt ttcccttttt ccttccgctc catttggggc
     4681 cctgggggtt tcagtcatct ccccatttgg tcccctggac tgtctttgtt gattctaact
     4741 tgtaaataaa gaaaatatta ttcaagtttt gagttacctt aatatttgct tttgtagtgt
     4801 ttcaaaagga acatcataag aattgtcttg ataattttga gggaaatatt actgcagtga
     4861 gaaaaggcaa tagctaacct ataattggat tgtcttaatt tttaaaccag taggcttttg
     4921 ctgtgttttt aataaagtaa atatgacttt tgtaaa
//
