LOCUS       NM_001394549            4890 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens bromodomain containing 1 (BRD1), transcript variant
            10, mRNA.
ACCESSION   NM_001394549
VERSION     NM_001394549.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4890)
  AUTHORS   Paternoster,V., Comert,C., Kirk,L.S., la Cour,S.H., Fryland,T.,
            Fernandez-Guerra,P., Stougaard,M., Nyengaard,J.R., Qvist,P.,
            Bross,P., Borglum,A.D. and Christensen,J.H.
  TITLE     The psychiatric risk gene BRD1 modulates mitochondrial
            bioenergetics by transcriptional regulation
  JOURNAL   Transl Psychiatry 12 (1), 319 (2022)
   PUBMED   35941107
  REMARK    GeneRIF: The psychiatric risk gene BRD1 modulates mitochondrial
            bioenergetics by transcriptional regulation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4890)
  AUTHORS   Xiao,Y., Li,W., Yang,H., Pan,L., Zhang,L., Lu,L., Chen,J., Wei,W.,
            Ye,J., Li,J., Li,G., Zhang,Y., Tan,M., Ding,J. and Wong,J.
  TITLE     HBO1 is a versatile histone acyltransferase critical for promoter
            histone acylations
  JOURNAL   Nucleic Acids Res 49 (14), 8037-8059 (2021)
   PUBMED   34259319
  REMARK    GeneRIF: HBO1 is a versatile histone acyltransferase critical for
            promoter histone acylations.
REFERENCE   3  (bases 1 to 4890)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4890)
  AUTHORS   Zhang,M., Lei,M., Qin,S., Dong,A., Yang,A., Li,Y., Loppnau,P.,
            Hughes,T.R., Min,J. and Liu,Y.
  TITLE     Crystal structure of the BRPF2 PWWP domain in complex with DNA
            reveals a different binding mode than the HDGF family of PWWP
            domains
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (3), 194688 (2021)
   PUBMED   33556623
  REMARK    GeneRIF: Crystal structure of the BRPF2 PWWP domain in complex with
            DNA reveals a different binding mode than the HDGF family of PWWP
            domains.
REFERENCE   5  (bases 1 to 4890)
  AUTHORS   Li,Z., Wang,J., Ji,Y. and Song,F.
  TITLE     Expression Characteristics and Clinical Correlations of BRD1 in
            Colorectal Cancer Samples
  JOURNAL   Technol Cancer Res Treat 20, 15330338211039678 (2021)
   PUBMED   34482774
  REMARK    GeneRIF: Expression Characteristics and Clinical Correlations of
            BRD1 in Colorectal Cancer Samples.
REFERENCE   6  (bases 1 to 4890)
  AUTHORS   Ullah,M., Pelletier,N., Xiao,L., Zhao,S.P., Wang,K., Degerny,C.,
            Tahmasebi,S., Cayrou,C., Doyon,Y., Goh,S.L., Champagne,N., Cote,J.
            and Yang,X.J.
  TITLE     Molecular architecture of quartet MOZ/MORF histone
            acetyltransferase complexes
  JOURNAL   Mol Cell Biol 28 (22), 6828-6843 (2008)
   PUBMED   18794358
  REMARK    Erratum:[Mol Cell Biol. 2009 Feb;29(3):942]
REFERENCE   7  (bases 1 to 4890)
  AUTHORS   Severinsen,J.E., Bjarkam,C.R., Kiaer-Larsen,S., Olsen,I.M.,
            Nielsen,M.M., Blechingberg,J., Nielsen,A.L., Holm,I.E.,
            Foldager,L., Young,B.D., Muir,W.J., Blackwood,D.H., Corydon,T.J.,
            Mors,O. and Borglum,A.D.
  TITLE     Evidence implicating BRD1 with brain development and susceptibility
            to both schizophrenia and bipolar affective disorder
  JOURNAL   Mol Psychiatry 11 (12), 1126-1138 (2006)
   PUBMED   16924267
REFERENCE   8  (bases 1 to 4890)
  AUTHORS   Doyon,Y., Cayrou,C., Ullah,M., Landry,A.J., Cote,V., Selleck,W.,
            Lane,W.S., Tan,S., Yang,X.J. and Cote,J.
  TITLE     ING tumor suppressor proteins are critical regulators of chromatin
            acetylation required for genome expression and perpetuation
  JOURNAL   Mol Cell 21 (1), 51-64 (2006)
   PUBMED   16387653
REFERENCE   9  (bases 1 to 4890)
  AUTHORS   McCullagh,P., Chaplin,T., Meerabux,J., Grenzelias,D.,
            Lillington,D., Poulsom,R., Gregorini,A., Saha,V. and Young,B.D.
  TITLE     The cloning, mapping and expression of a novel gene, BRL, related
            to the AF10 leukaemia gene
  JOURNAL   Oncogene 18 (52), 7442-7452 (1999)
   PUBMED   10602503
REFERENCE   10 (bases 1 to 4890)
  AUTHORS   Haynes,S.R., Dollard,C., Winston,F., Beck,S., Trowsdale,J. and
            Dawid,I.B.
  TITLE     The bromodomain: a conserved sequence found in human, Drosophila
            and yeast proteins
  JOURNAL   Nucleic Acids Res 20 (10), 2603 (1992)
   PUBMED   1350857
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z98885.1.
            
            Summary: This gene encodes a bromodomain-containing protein that
            localizes to the nucleus and can interact with DNA and histone
            tails. The encoded protein is a component of the MOZ/MORF
            acetyltransferase complex and can stimulate acetylation of histones
            H3 and H4, thereby potentially playing a role in gene activation.
            Variation in this gene is associated with schizophrenia and bipolar
            disorder in some study populations. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Mar 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-377               Z98885.1           68602-68978         c
            378-1758            Z98885.1           64056-65436         c
            1759-1915           Z98885.1           45309-45465         c
            1916-2047           Z98885.1           40093-40224         c
            2048-2155           Z98885.1           39678-39785         c
            2156-2468           Z98885.1           38910-39222         c
            2469-2729           Z98885.1           35139-35399         c
            2730-3227           Z98885.1           28495-28992         c
            3228-3363           Z98885.1           18783-18918         c
            3364-3491           Z98885.1           18139-18266         c
            3492-3601           Z98885.1           17155-17264         c
            3602-3756           Z98885.1           16696-16850         c
            3757-4890           Z98885.1           14388-15521         c
FEATURES             Location/Qualifiers
     source          1..4890
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     gene            1..4890
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /note="bromodomain containing 1"
                     /db_xref="GeneID:23774"
                     /db_xref="HGNC:HGNC:1102"
                     /db_xref="MIM:604589"
     exon            1..377
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            378..1758
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             392..3940
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /note="isoform 7 is encoded by transcript variant 10;
                     bromodomain-containing protein 1; BR140-like protein;
                     bromodomain and PHD finger-containing protein 2"
                     /codon_start=1
                     /product="bromodomain-containing protein 1 isoform 7"
                     /protein_id="NP_001381478.1"
                     /db_xref="GeneID:23774"
                     /db_xref="HGNC:HGNC:1102"
                     /db_xref="MIM:604589"
                     /translation="MRRKGRCHRGSAARHPSSPCSVKHSPTRETLTYAQAQRMVEIEI
                     EGRLHRISIFDPLEIILEDDLTAQEMSECNSNKENSERPPVCLRTKRHKNNRVKKKNE
                     ALPSAHGTPASASALPEPKVRIVEYSPPSAPRRPPVYYKFIEKSAEELDNEVEYDMDE
                     EDYAWLEIVNEKRKGDCVPAVSQSMFEFLMDRFEKESHCENQKQGEQQSLIDEDAVCC
                     ICMDGECQNSNVILFCDMCNLAVHQECYGVPYIPEGQWLCRHCLQSRARPADCVLCPN
                     KGGAFKKTDDDRWGHVVCALWIPEVGFANTVFIEPIDGVRNIPPARWKLTCYLCKQKG
                     VGACIQCHKANCYTAFHVTCAQKAGLYMKMEPVKELTGGGTTFSVRKTAYCDVHTPPG
                     CTRRPLNIYGDVEMKNGVCRKESSVKTVRSTSKVRKKAKKAKKALAEPCAVLPTVCAP
                     YIPPQRLNRIANQVAIQRKKQFVERAHSYWLLKRLSRNGAPLLRRLQSSLQSQRSSQQ
                     RENDEEMKAAKEKLKYWQRLRHDLERARLLIELLRKREKLKREQVEQVAMELRLTPLT
                     VLLRSVLDQLQDKDPARIFAQPVPDYLDHIKHPMDFATMRKRLEAQGYKNLHEFEEDF
                     DLIIDNCMKYNARDTVFYRAAVRLRDQGGVVLRQARREVDSIGLEEASGMHLPERPAA
                     APRRPFSWEDVDRLLDPANRAHLGLEEQLRELLDMLDLTCAMKSSGSRSKRAKLLKKE
                     IALLRNKLSQQHSQPLPTGPGLEGFEEDGAALGPEAGEEGDKSPPKLEPSDALPLPSN
                     SETNSEPPTLKPVELNPEQSKLFKRVTFDNESHSACTQSALVSGRPPEPTRASSGDVP
                     AAAASAVAEPASDVNRRTSVLFCKSKSVSPPKSAKNTETQPTSPQLGTKTFLSVVLPR
                     LETLLQPRKRSRSTCGDSEVEEESPGKRLDAGLTNGFGGARSEQEPGGGLGRKATPRR
                     RCASESSISSSNSPLCDSSFNAPKCGRGKPALVRRHTLEDRSELISCIENGNYAKAAR
                     IAAEVGQSSMWISTDAAASVLEPLKVVWAKCSGYPSYPALIIDPKMPRVPGHHNGVTI
                     PAPPLDVLKIGEHMQTKSDEKLFLVLFFDNKRSWQWLPKSKMVPLGIDETIDKLKMME
                     GRNSSIRKAVRIAFDRAMNHLSRVHGEPTSDLSDID"
     exon            1759..1915
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2047
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2155
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2468
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2729
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..3227
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3228..3363
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3364..3491
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3492..3601
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3602..3756
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3757..4890
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4872..4877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /note="hexamer: AATAAA"
     polyA_site      4890
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /note="major polyA site"
ORIGIN      
        1 gcattgtttg cttcgctggg gagcgagcga gcgacccggc cctggagtcc gagccagccc
       61 cgcgtcccgc gcccgccgcc cgccgcccgc tcccgcgccc gcgcccgcgc ccgccggccg
      121 ggccccccga gccgggcctc cagctgggcc ccgagcccga gcccgcgccg cgcgagccgc
      181 tgcccgagag tccgcggccg ccgctgccgg gcccggagcc gccgcggccg agaggggccc
      241 gcgcccagga gcggcggcgg ggcccggcct gcgcggccgt tggcggagga gccgcgggcg
      301 ccattagcac cgcctcggcc gcgccggccc ccgcgcccgc ccgcttgccg ggctcccgcg
      361 gccgcggcgc cccgaaggta atcattacca aatgaggagg aaaggacgat gtcatcgagg
      421 ctctgcagcg aggcatcctt cttccccatg cagtgttaaa cactccccta cgcgagaaac
      481 gctgacctac gctcaagctc aaaggatggt agagatagaa attgaagggc gcttgcacag
      541 gatcagtatt tttgatcccc tggagatcat attggaagat gacctcactg ctcaagagat
      601 gagtgagtgc aacagcaaca aggaaaacag cgagcggcct cctgtctgct taagaactaa
      661 gcgtcacaaa aacaacagag tcaaaaagaa aaacgaggcc ctccccagcg cccacggcac
      721 gccggcctcg gccagtgccc tcccggagcc caaggtgcgc atcgtggagt acagccctcc
      781 gtccgccccc aggaggcctc ctgtgtacta caagttcatc gagaagtcgg ccgaggaact
      841 ggacaacgag gtggagtatg acatggacga ggaggactat gcctggctgg agatcgtcaa
      901 tgagaagcgc aagggcgact gcgtccccgc cgtgtcgcag agcatgtttg agttcctgat
      961 ggaccgcttc gagaaggagt cgcactgcga gaaccagaag cagggcgagc agcagtctct
     1021 gatcgacgag gacgccgtgt gctgcatctg catggacggg gagtgtcaga acagcaacgt
     1081 gatcctcttc tgcgacatgt gcaacctggc cgtgcaccag gagtgctacg gggtgcccta
     1141 catccccgag ggccagtggc tctgccgcca ctgcctgcag tcgcgggccc ggcccgccga
     1201 ctgtgtgctg tgccccaaca agggtggtgc cttcaaaaag acagatgacg accgctgggg
     1261 tcacgtggtg tgtgccctgt ggatcccaga ggtcggcttt gccaacacgg tgttcatcga
     1321 gcccatcgat ggggtgagga acatccctcc agcccggtgg aaactgacat gctacctctg
     1381 taagcagaag ggcgtgggtg cctgcatcca gtgccacaaa gcaaactgct acacagcatt
     1441 ccatgtgacg tgtgcccaga aggctggcct gtacatgaaa atggagcccg tgaaggaact
     1501 gactggcggt ggcaccacct tctccgtcag aaagaccgct tactgtgatg tccacacgcc
     1561 tccaggctgc acccggaggc ctctgaatat ttacggggat gtcgaaatga aaaatggcgt
     1621 ctgtcgaaaa gagagctcgg ttaaaacggt caggtccaca tccaaggtca ggaagaaggc
     1681 aaaaaaggct aagaaagctc tggctgagcc ctgcgcggtc ctgccgaccg tgtgcgctcc
     1741 ttatattccc ccgcagaggt taaataggat tgcgaatcag gtggccattc agcggaagaa
     1801 gcagtttgtg gagcgagccc acagctactg gctgctcaag cggctgtcca ggaacggggc
     1861 ccccctgctg cggcggctgc agtccagcct gcagtctcag cgaagctcac agcagagaga
     1921 aaatgatgag gagatgaagg ctgccaaaga gaagctgaag tactggcagc ggctgcggca
     1981 cgacctggag cgcgctcgcc tgctgatcga gctgctgcgc aagcgggaga agctcaagcg
     2041 tgagcaggtg gagcaggtcg ccatggagct gcggctgacc ccgctgacgg tgctgctgcg
     2101 ctcagtgctg gaccagctgc aagacaagga ccccgccagg atatttgcgc agcccgtacc
     2161 agattatttg gatcacatta aacatcccat ggactttgcc acaatgagga aacggttaga
     2221 agctcaaggg tataaaaacc tccatgagtt tgaggaggat tttgatctca ttatagataa
     2281 ctgcatgaag tacaatgcca gggacaccgt gttctataga gccgcggtga ggctgcgcga
     2341 tcagggaggt gttgttctga ggcaggcccg gcgcgaggtg gacagcatcg gcttggaaga
     2401 ggcctcgggg atgcacctgc ctgagcggcc tgctgcggca ccgcggcggc ctttctcctg
     2461 ggaagacgtg gacaggttgc tggaccccgc caacagagcc cacctgggcc tggaggagca
     2521 gctgagagag ctgctggaca tgctcgacct cacctgcgct atgaagtcca gcggctcccg
     2581 gagcaagcgg gcaaagctgc tcaaaaagga aattgccctt ctccgaaaca agctgagcca
     2641 gcagcacagc cagcccctgc ccacggggcc aggcttggaa ggcttcgaag aggacggagc
     2701 tgcgctgggg ccggaggcgg gcgaggaagg agataaatct ccccctaaac ttgaaccatc
     2761 agatgcatta cctcttcctt caaactcgga gactaattca gaaccaccaa ccctcaaacc
     2821 agtagaactc aacccagagc agagtaaact tttcaaaaga gtcacatttg ataatgaatc
     2881 acatagcgct tgcactcaga gcgcactggt aagcggacgc cctccagagc ccacccgcgc
     2941 cagtagtggc gatgtgccgg cggcggcggc ctccgcggtg gcggagccag caagcgatgt
     3001 aaacagacgc acttctgttc tcttctgcaa atcgaaaagt gtaagccccc caaagtctgc
     3061 caagaacact gaaacccagc caacttctcc tcagctaggg accaaaacct ttttgtctgt
     3121 agtccttccg aggttggaga ctcttctgca gccaaggaaa aggtcgcgga gcacatgcgg
     3181 agactccgag gtggaggagg agtccccagg aaagcgcctg gacgcaggtc tcaccaacgg
     3241 ctttgggggt gcgaggagcg agcaggagcc gggcggcggc ctggggagga aggccacacc
     3301 ccgacgacgc tgtgcctccg agtccagcat ctcctccagc aacagcccgc tctgcgactc
     3361 gagctttaat gcgcccaaat gtgggcgggg caaaccggct cttgtgcgac ggcacacgct
     3421 ggaggaccgc agtgagctga tctcctgcat cgagaatggg aactacgcca aggcggccag
     3481 gatcgcagcc gaagtcggcc agagcagcat gtggatctcc actgatgccg ccgcctcggt
     3541 gctggagcct ctgaaggtgg tgtgggccaa gtgcagcggc tacccctcct acccggcact
     3601 gatcatcgac cccaagatgc cccgtgtgcc tggccaccac aacggcgtca ccatcccggc
     3661 cccacccctg gacgtgctga agattgggga gcacatgcag accaagtctg atgagaagct
     3721 gttcctcgtt ctcttttttg ataataagag aagttggcag tggcttccta agtccaaaat
     3781 ggttcccctt ggtattgacg aaactataga caagttaaag atgatggaag ggaggaattc
     3841 cagcatccgg aaggccgtgc ggatcgcttt tgaccgcgcc atgaaccacc tgagccgcgt
     3901 ccacggggag ccgaccagcg acctcagtga cattgactga cggcccggcc gccagcgcgg
     3961 gtcttgtcca tagtgttgat aagctgtaca tgtttgtata ttgttcaaaa cttaacttat
     4021 tctgattttt agttatagct ctttaattct ttttccccgg ggagggggga ggttttattt
     4081 ccaagttttc taggaaccca tctccgtctg ggcgctgtga gtggggtggg cacgtccggg
     4141 cagcccagtg cgtctgtcgc acgtccccag gccgtgctgc tggcgtcact ttctttgata
     4201 tgtagctttt tcttaaagac ttttgaatgt ttaataattt tgtaaatcat gctctttaca
     4261 cagagtacca cttatttaat aagacgggat gtaaatttac aatgacaaat gtgtatttta
     4321 agaaagaaaa tgacattatt ttgaatggta ctttgtggaa agaggggaga ataaagttat
     4381 gctgtgtaca tcacttgcag atcaccaaaa acactccgct gcccgtgacc gccggtgggt
     4441 gtgtccccgc tcccgtcgtc ccgcccacct caaaccccgc aggtgtgcct cccagcggat
     4501 tatttattgt agaaagtgta ttcatttgct ttataatgaa aaatacattt gcaaaggtat
     4561 attgatatgc atttttatac aggcacataa aaattcaact tggcttggga gcagaatgca
     4621 ttgcattgta taaatgactc tggcctgtgt gtactttgat tttataactt gtaatctttt
     4681 gtttacaatg aggggctttc tgtaacttgt tttaatttag aacactttgg tagcaataga
     4741 aactttggat acatttttgt atggtacctg tgatgtatat agaattagta ctttattttt
     4801 atttttaaga ggtaaagcat tatgttgggg aaagtagggt gggtttccaa atttgcattt
     4861 tttatattaa aaataaagtc aagatttgga
//
