LOCUS       NM_001304808            4911 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens bromodomain containing 1 (BRD1), transcript variant 1,
            mRNA.
ACCESSION   NM_001304808
VERSION     NM_001304808.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4911)
  AUTHORS   Paternoster,V., Comert,C., Kirk,L.S., la Cour,S.H., Fryland,T.,
            Fernandez-Guerra,P., Stougaard,M., Nyengaard,J.R., Qvist,P.,
            Bross,P., Borglum,A.D. and Christensen,J.H.
  TITLE     The psychiatric risk gene BRD1 modulates mitochondrial
            bioenergetics by transcriptional regulation
  JOURNAL   Transl Psychiatry 12 (1), 319 (2022)
   PUBMED   35941107
  REMARK    GeneRIF: The psychiatric risk gene BRD1 modulates mitochondrial
            bioenergetics by transcriptional regulation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4911)
  AUTHORS   Xiao,Y., Li,W., Yang,H., Pan,L., Zhang,L., Lu,L., Chen,J., Wei,W.,
            Ye,J., Li,J., Li,G., Zhang,Y., Tan,M., Ding,J. and Wong,J.
  TITLE     HBO1 is a versatile histone acyltransferase critical for promoter
            histone acylations
  JOURNAL   Nucleic Acids Res 49 (14), 8037-8059 (2021)
   PUBMED   34259319
  REMARK    GeneRIF: HBO1 is a versatile histone acyltransferase critical for
            promoter histone acylations.
REFERENCE   3  (bases 1 to 4911)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4911)
  AUTHORS   Zhang,M., Lei,M., Qin,S., Dong,A., Yang,A., Li,Y., Loppnau,P.,
            Hughes,T.R., Min,J. and Liu,Y.
  TITLE     Crystal structure of the BRPF2 PWWP domain in complex with DNA
            reveals a different binding mode than the HDGF family of PWWP
            domains
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (3), 194688 (2021)
   PUBMED   33556623
  REMARK    GeneRIF: Crystal structure of the BRPF2 PWWP domain in complex with
            DNA reveals a different binding mode than the HDGF family of PWWP
            domains.
REFERENCE   5  (bases 1 to 4911)
  AUTHORS   Li,Z., Wang,J., Ji,Y. and Song,F.
  TITLE     Expression Characteristics and Clinical Correlations of BRD1 in
            Colorectal Cancer Samples
  JOURNAL   Technol Cancer Res Treat 20, 15330338211039678 (2021)
   PUBMED   34482774
  REMARK    GeneRIF: Expression Characteristics and Clinical Correlations of
            BRD1 in Colorectal Cancer Samples.
REFERENCE   6  (bases 1 to 4911)
  AUTHORS   Ullah,M., Pelletier,N., Xiao,L., Zhao,S.P., Wang,K., Degerny,C.,
            Tahmasebi,S., Cayrou,C., Doyon,Y., Goh,S.L., Champagne,N., Cote,J.
            and Yang,X.J.
  TITLE     Molecular architecture of quartet MOZ/MORF histone
            acetyltransferase complexes
  JOURNAL   Mol Cell Biol 28 (22), 6828-6843 (2008)
   PUBMED   18794358
  REMARK    Erratum:[Mol Cell Biol. 2009 Feb;29(3):942]
REFERENCE   7  (bases 1 to 4911)
  AUTHORS   Severinsen,J.E., Bjarkam,C.R., Kiaer-Larsen,S., Olsen,I.M.,
            Nielsen,M.M., Blechingberg,J., Nielsen,A.L., Holm,I.E.,
            Foldager,L., Young,B.D., Muir,W.J., Blackwood,D.H., Corydon,T.J.,
            Mors,O. and Borglum,A.D.
  TITLE     Evidence implicating BRD1 with brain development and susceptibility
            to both schizophrenia and bipolar affective disorder
  JOURNAL   Mol Psychiatry 11 (12), 1126-1138 (2006)
   PUBMED   16924267
REFERENCE   8  (bases 1 to 4911)
  AUTHORS   Doyon,Y., Cayrou,C., Ullah,M., Landry,A.J., Cote,V., Selleck,W.,
            Lane,W.S., Tan,S., Yang,X.J. and Cote,J.
  TITLE     ING tumor suppressor proteins are critical regulators of chromatin
            acetylation required for genome expression and perpetuation
  JOURNAL   Mol Cell 21 (1), 51-64 (2006)
   PUBMED   16387653
REFERENCE   9  (bases 1 to 4911)
  AUTHORS   McCullagh,P., Chaplin,T., Meerabux,J., Grenzelias,D.,
            Lillington,D., Poulsom,R., Gregorini,A., Saha,V. and Young,B.D.
  TITLE     The cloning, mapping and expression of a novel gene, BRL, related
            to the AF10 leukaemia gene
  JOURNAL   Oncogene 18 (52), 7442-7452 (1999)
   PUBMED   10602503
REFERENCE   10 (bases 1 to 4911)
  AUTHORS   Haynes,S.R., Dollard,C., Winston,F., Beck,S., Trowsdale,J. and
            Dawid,I.B.
  TITLE     The bromodomain: a conserved sequence found in human, Drosophila
            and yeast proteins
  JOURNAL   Nucleic Acids Res 20 (10), 2603 (1992)
   PUBMED   1350857
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z98885.1 and AK292428.1.
            
            On Jun 3, 2019 this sequence version replaced NM_001304808.2.
            
            Summary: This gene encodes a bromodomain-containing protein that
            localizes to the nucleus and can interact with DNA and histone
            tails. The encoded protein is a component of the MOZ/MORF
            acetyltransferase complex and can stimulate acetylation of histones
            H3 and H4, thereby potentially playing a role in gene activation.
            Variation in this gene is associated with schizophrenia and bipolar
            disorder in some study populations. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Mar 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292428.1, SRR14038197.868835.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000404760.6/ ENSP00000385858.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-325               Z98885.1           68654-68978         c
            326-4189            AK292428.1         1-3864
            4190-4911           Z98885.1           14388-15109         c
FEATURES             Location/Qualifiers
     source          1..4911
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     gene            1..4911
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /note="bromodomain containing 1"
                     /db_xref="GeneID:23774"
                     /db_xref="HGNC:HGNC:1102"
                     /db_xref="MIM:604589"
     exon            1..377
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            378..1758
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             392..3961
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     bromodomain-containing protein 1; BR140-like protein;
                     bromodomain and PHD finger-containing protein 2"
                     /codon_start=1
                     /product="bromodomain-containing protein 1 isoform 1"
                     /protein_id="NP_001291737.1"
                     /db_xref="CCDS:CCDS77686.1"
                     /db_xref="GeneID:23774"
                     /db_xref="HGNC:HGNC:1102"
                     /db_xref="MIM:604589"
                     /translation="MRRKGRCHRGSAARHPSSPCSVKHSPTRETLTYAQAQRMVEIEI
                     EGRLHRISIFDPLEIILEDDLTAQEMSECNSNKENSERPPVCLRTKRHKNNRVKKKNE
                     ALPSAHGTPASASALPEPKVRIVEYSPPSAPRRPPVYYKFIEKSAEELDNEVEYDMDE
                     EDYAWLEIVNEKRKGDCVPAVSQSMFEFLMDRFEKESHCENQKQGEQQSLIDEDAVCC
                     ICMDGECQNSNVILFCDMCNLAVHQECYGVPYIPEGQWLCRHCLQSRARPADCVLCPN
                     KGGAFKKTDDDRWGHVVCALWIPEVGFANTVFIEPIDGVRNIPPARWKLTCYLCKQKG
                     VGACIQCHKANCYTAFHVTCAQKAGLYMKMEPVKELTGGGTTFSVRKTAYCDVHTPPG
                     CTRRPLNIYGDVEMKNGVCRKESSVKTVRSTSKVRKKAKKAKKALAEPCAVLPTVCAP
                     YIPPQRLNRIANQVAIQRKKQFVERAHSYWLLKRLSRNGAPLLRRLQSSLQSQRSSQQ
                     RENDEEMKAAKEKLKYWQRLRHDLERARLLIELLRKREKLKREQVKVEQVAMELRLTP
                     LTVLLRSVLDQLQDKDPARIFAQPVSLKEVPDYLDHIKHPMDFATMRKRLEAQGYKNL
                     HEFEEDFDLIIDNCMKYNARDTVFYRAAVRLRDQGGVVLRQARREVDSIGLEEASGMH
                     LPERPAAAPRRPFSWEDVDRLLDPANRAHLGLEEQLRELLDMLDLTCAMKSSGSRSKR
                     AKLLKKEIALLRNKLSQQHSQPLPTGPGLEGFEEDGAALGPEAGEEGDKSPPKLEPSD
                     ALPLPSNSETNSEPPTLKPVELNPEQSKLFKRVTFDNESHSACTQSALVSGRPPEPTR
                     ASSGDVPAAAASAVAEPASDVNRRTSVLFCKSKSVSPPKSAKNTETQPTSPQLGTKTF
                     LSVVLPRLETLLQPRKRSRSTCGDSEVEEESPGKRLDAGLTNGFGGARSEQEPGGGLG
                     RKATPRRRCASESSISSSNSPLCDSSFNAPKCGRGKPALVRRHTLEDRSELISCIENG
                     NYAKAARIAAEVGQSSMWISTDAAASVLEPLKVVWAKCSGYPSYPALIIDPKMPRVPG
                     HHNGVTIPAPPLDVLKIGEHMQTKSDEKLFLVLFFDNKRSWQWLPKSKMVPLGIDETI
                     DKLKMMEGRNSSIRKAVRIAFDRAMNHLSRVHGEPTSDLSDID"
     exon            1759..1915
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2047
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2176
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2489
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2750
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            2751..3248
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3249..3384
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3385..3512
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3513..3622
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3623..3777
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /inference="alignment:Splign:2.1.0"
     exon            3778..4911
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4893..4898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /note="hexamer: AATAAA"
     polyA_site      4911
                     /gene="BRD1"
                     /gene_synonym="BRL; BRPF1; BRPF2"
                     /note="major polyA site"
ORIGIN      
        1 gcattgtttg cttcgctggg gagcgagcga gcgacccggc cctggagtcc gagccagccc
       61 cgcgtcccgc gcccgccgcc cgccgcccgc tcccgcgccc gcgcccgcgc ccgccggccg
      121 ggccccccga gccgggcctc cagctgggcc ccgagcccga gcccgcgccg cgcgagccgc
      181 tgcccgagag tccgcggccg ccgctgccgg gcccggagcc gccgcggccg agaggggccc
      241 gcgcccagga gcggcggcgg ggcccggcct gcgcggccgt tggcggagga gccgcgggcg
      301 ccattagcac cgcctcggcc gcgccggccc ccgcgcccgc ccgcttgccg ggctcccgcg
      361 gccgcggcgc cccgaaggta atcattacca aatgaggagg aaaggacgat gtcatcgagg
      421 ctctgcagcg aggcatcctt cttccccatg cagtgttaaa cactccccta cgcgagaaac
      481 gctgacctac gctcaagctc aaaggatggt agagatagaa attgaagggc gcttgcacag
      541 gatcagtatt tttgatcccc tggagatcat attggaagat gacctcactg ctcaagagat
      601 gagtgagtgc aacagcaaca aggaaaacag cgagcggcct cctgtctgct taagaactaa
      661 gcgtcacaaa aacaacagag tcaaaaagaa aaacgaggcc ctccccagcg cccacggcac
      721 gccggcctcg gccagtgccc tcccggagcc caaggtgcgc atcgtggagt acagccctcc
      781 gtccgccccc aggaggcctc ctgtgtacta caagttcatc gagaagtcgg ccgaggaact
      841 ggacaacgag gtggagtatg acatggacga ggaggactat gcctggctgg agatcgtcaa
      901 tgagaagcgc aagggcgact gcgtccccgc cgtgtcgcag agcatgtttg agttcctgat
      961 ggaccgcttc gagaaggagt cgcactgcga gaaccagaag cagggcgagc agcagtctct
     1021 gatcgacgag gacgccgtgt gctgcatctg catggacggg gagtgtcaga acagcaacgt
     1081 gatcctcttc tgcgacatgt gcaacctggc cgtgcaccag gagtgctacg gggtgcccta
     1141 catccccgag ggccagtggc tctgccgcca ctgcctgcag tcgcgggccc ggcccgccga
     1201 ctgtgtgctg tgccccaaca agggtggtgc cttcaaaaag acagatgacg accgctgggg
     1261 tcacgtggtg tgtgccctgt ggatcccaga ggtcggcttt gccaacacgg tgttcatcga
     1321 gcccatcgat ggggtgagga acatccctcc agcccggtgg aaactgacat gctacctctg
     1381 taagcagaag ggcgtgggtg cctgcatcca gtgccacaaa gcaaactgct acacagcatt
     1441 ccatgtgacg tgtgcccaga aggctggcct gtacatgaaa atggagcccg tgaaggaact
     1501 gactggcggt ggcaccacct tctccgtcag aaagaccgct tactgtgatg tccacacgcc
     1561 tccaggctgc acccggaggc ctctgaatat ttacggggat gtcgaaatga aaaatggcgt
     1621 ctgtcgaaaa gagagctcgg ttaaaacggt caggtccaca tccaaggtca ggaagaaggc
     1681 aaaaaaggct aagaaagctc tggctgagcc ctgcgcggtc ctgccgaccg tgtgcgctcc
     1741 ttatattccc ccgcagaggt taaataggat tgcgaatcag gtggccattc agcggaagaa
     1801 gcagtttgtg gagcgagccc acagctactg gctgctcaag cggctgtcca ggaacggggc
     1861 ccccctgctg cggcggctgc agtccagcct gcagtctcag cgaagctcac agcagagaga
     1921 aaatgatgag gagatgaagg ctgccaaaga gaagctgaag tactggcagc ggctgcggca
     1981 cgacctggag cgcgctcgcc tgctgatcga gctgctgcgc aagcgggaga agctcaagcg
     2041 tgagcaggtg aaggtggagc aggtcgccat ggagctgcgg ctgaccccgc tgacggtgct
     2101 gctgcgctca gtgctggacc agctgcaaga caaggacccc gccaggatat ttgcgcagcc
     2161 cgtgagtctg aaggaggtac cagattattt ggatcacatt aaacatccca tggactttgc
     2221 cacaatgagg aaacggttag aagctcaagg gtataaaaac ctccatgagt ttgaggagga
     2281 ttttgatctc attatagata actgcatgaa gtacaatgcc agggacaccg tgttctatag
     2341 agccgcggtg aggctgcgcg atcagggagg tgttgttctg aggcaggccc ggcgcgaggt
     2401 ggacagcatc ggcttggaag aggcctcggg gatgcacctg cctgagcggc ctgctgcggc
     2461 accgcggcgg cctttctcct gggaagacgt ggacaggttg ctggaccccg ccaacagagc
     2521 ccacctgggc ctggaggagc agctgagaga gctgctggac atgctcgacc tcacctgcgc
     2581 tatgaagtcc agcggctccc ggagcaagcg ggcaaagctg ctcaaaaagg aaattgccct
     2641 tctccgaaac aagctgagcc agcagcacag ccagcccctg cccacggggc caggcttgga
     2701 aggcttcgaa gaggacggag ctgcgctggg gccggaggcg ggcgaggaag gagataaatc
     2761 tccccctaaa cttgaaccat cagatgcatt acctcttcct tcaaactcgg agactaattc
     2821 agaaccacca accctcaaac cagtagaact caacccagag cagagtaaac ttttcaaaag
     2881 agtcacattt gataatgaat cacatagcgc ttgcactcag agcgcactgg taagcggacg
     2941 ccctccagag cccacccgcg ccagtagtgg cgatgtgccg gcggcggcgg cctccgcggt
     3001 ggcggagcca gcaagcgatg taaacagacg cacttctgtt ctcttctgca aatcgaaaag
     3061 tgtaagcccc ccaaagtctg ccaagaacac tgaaacccag ccaacttctc ctcagctagg
     3121 gaccaaaacc tttttgtctg tagtccttcc gaggttggag actcttctgc agccaaggaa
     3181 aaggtcgcgg agcacatgcg gagactccga ggtggaggag gagtccccag gaaagcgcct
     3241 ggacgcaggt ctcaccaacg gctttggggg tgcgaggagc gagcaggagc cgggcggcgg
     3301 cctggggagg aaggccacac cccgacgacg ctgtgcctcc gagtccagca tctcctccag
     3361 caacagcccg ctctgcgact cgagctttaa tgcgcccaaa tgtgggcggg gcaaaccggc
     3421 tcttgtgcga cggcacacgc tggaggaccg cagtgagctg atctcctgca tcgagaatgg
     3481 gaactacgcc aaggcggcca ggatcgcagc cgaagtcggc cagagcagca tgtggatctc
     3541 cactgatgcc gccgcctcgg tgctggagcc tctgaaggtg gtgtgggcca agtgcagcgg
     3601 ctacccctcc tacccggcac tgatcatcga ccccaagatg ccccgtgtgc ctggccacca
     3661 caacggcgtc accatcccgg ccccacccct ggacgtgctg aagattgggg agcacatgca
     3721 gaccaagtct gatgagaagc tgttcctcgt tctctttttt gataataaga gaagttggca
     3781 gtggcttcct aagtccaaaa tggttcccct tggtattgac gaaactatag acaagttaaa
     3841 gatgatggaa gggaggaatt ccagcatccg gaaggccgtg cggatcgctt ttgaccgcgc
     3901 catgaaccac ctgagccgcg tccacgggga gccgaccagc gacctcagtg acattgactg
     3961 acggcccggc cgccagcgcg ggtcttgtcc atagtgttga taagctgtac atgtttgtat
     4021 attgttcaaa acttaactta ttctgatttt tagttatagc tctttaattc tttttccccg
     4081 gggagggggg aggttttatt tccaagtttt ctaggaaccc atctccgtct gggcgctgtg
     4141 agtggggtgg gcacgtccgg gcagcccagt gcgtctgtcg cacgtcccca ggccgtgctg
     4201 ctggcgtcac tttctttgat atgtagcttt ttcttaaaga cttttgaatg tttaataatt
     4261 ttgtaaatca tgctctttac acagagtacc acttatttaa taagacggga tgtaaattta
     4321 caatgacaaa tgtgtatttt aagaaagaaa atgacattat tttgaatggt actttgtgga
     4381 aagaggggag aataaagtta tgctgtgtac atcacttgca gatcaccaaa aacactccgc
     4441 tgcccgtgac cgccggtggg tgtgtccccg ctcccgtcgt cccgcccacc tcaaaccccg
     4501 caggtgtgcc tcccagcgga ttatttattg tagaaagtgt attcatttgc tttataatga
     4561 aaaatacatt tgcaaaggta tattgatatg catttttata caggcacata aaaattcaac
     4621 ttggcttggg agcagaatgc attgcattgt ataaatgact ctggcctgtg tgtactttga
     4681 ttttataact tgtaatcttt tgtttacaat gaggggcttt ctgtaacttg ttttaattta
     4741 gaacactttg gtagcaatag aaactttgga tacatttttg tatggtacct gtgatgtata
     4801 tagaattagt actttatttt tatttttaag aggtaaagca ttatgttggg gaaagtaggg
     4861 tgggtttcca aatttgcatt ttttatatta aaaataaagt caagatttgg a
//
