LOCUS       NM_000059              11954 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens BRCA2 DNA repair associated (BRCA2), transcript
            variant 1, mRNA.
ACCESSION   NM_000059
VERSION     NM_000059.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11954)
  AUTHORS   Kotsopoulos,J., Lubinski,J., Huzarski,T., Bychkovsky,B.L.,
            Moller,P., Kim,R.H., Tung,N., Eisen,A., Foulkes,W., Singer,C.F.,
            Aeilts,A., Neuhausen,S.L., Bordeleau,L., Karlan,B., Fruscio,R.,
            Eng,C., Olopade,O., Zakalik,D., Couch,F., Y Cajal,T.R., Sun,P.,
            Gronwald,J. and Narod,S.A.
  TITLE     Incidence of endometrial cancer in BRCA mutation carriers
  JOURNAL   Gynecol Oncol 189, 148-155 (2024)
   PUBMED   39173195
  REMARK    GeneRIF: Incidence of endometrial cancer in BRCA mutation carriers.
REFERENCE   2  (bases 1 to 11954)
  AUTHORS   Huang,Y., Li,W., Foo,T., Ji,J.H., Wu,B., Tomimatsu,N., Fang,Q.,
            Gao,B., Long,M., Xu,J., Maqbool,R., Mukherjee,B., Ni,T., Alejo,S.,
            He,Y., Burma,S., Lan,L., Xia,B. and Zhao,W.
  TITLE     DSS1 restrains BRCA2's engagement with dsDNA for homologous
            recombination, replication fork protection, and R-loop homeostasis
  JOURNAL   Nat Commun 15 (1), 7081 (2024)
   PUBMED   39152168
  REMARK    GeneRIF: DSS1 restrains BRCA2's engagement with dsDNA for
            homologous recombination, replication fork protection, and R-loop
            homeostasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11954)
  AUTHORS   Duarte,C.A.B., Dos Santos,C.A., de Oliveira,C.D.D., Spautz,C.C.,
            Sumita,L.M. and Nakatani,S.M.
  TITLE     Hereditary breast cancer next-generation sequencing panel
            evaluation in the south region of Brazil: A novel BRCA2 candidate
            pathogenic variant is reported
  JOURNAL   Mol Genet Genomic Med 12 (8), e2504 (2024)
   PUBMED   39126233
  REMARK    GeneRIF: Hereditary breast cancer next-generation sequencing panel
            evaluation in the south region of Brazil: A novel BRCA2 candidate
            pathogenic variant is reported.
REFERENCE   4  (bases 1 to 11954)
  AUTHORS   Fishchuk,L., Rossokha,Z., Lobanova,O., Cheshuk,V., Vereshchako,R.,
            Vershyhora,V., Medvedieva,N., Dubitskaa,O. and Gorovenko,N.
  TITLE     Hypermethylation of the BRCA2 gene promoter and its
            co-hypermethylation with the BRCA1 gene promoter in patients with
            breast cancer
  JOURNAL   Cancer Biomark 40 (3-4), 275-283 (2024)
   PUBMED   39177589
  REMARK    GeneRIF: Hypermethylation of the BRCA2 gene promoter and its
            co-hypermethylation with the BRCA1 gene promoter in patients with
            breast cancer.
REFERENCE   5  (bases 1 to 11954)
  AUTHORS   Whitney,M., Thayer,M., Reifsteck,C., Olson,S., Smith,L.,
            Jakobs,P.M., Leach,R., Naylor,S., Joenje,H. and Grompe,M.
  TITLE     Microcell mediated chromosome transfer maps the Fanconi anaemia
            group D gene to chromosome 3p
  JOURNAL   Nat Genet 11 (3), 341-343 (1995)
   PUBMED   7581463
REFERENCE   6  (bases 1 to 11954)
  AUTHORS   Schutte,M., da Costa,L.T., Hahn,S.A., Moskaluk,C., Hoque,A.T.,
            Rozenblum,E., Weinstein,C.L., Bittner,M., Meltzer,P.S., Trent,J.M.
            et al.
  TITLE     Identification by representational difference analysis of a
            homozygous deletion in pancreatic carcinoma that lies within the
            BRCA2 region
  JOURNAL   Proc Natl Acad Sci U S A 92 (13), 5950-5954 (1995)
   PUBMED   7597059
REFERENCE   7  (bases 1 to 11954)
  AUTHORS   Mehta,P.A. and Ebens,C.
  TITLE     Fanconi Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301575
REFERENCE   8  (bases 1 to 11954)
  AUTHORS   Turner,J.T., Brzezinski,J. and Dome,J.S.
  TITLE     Wilms Tumor Predisposition
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301471
REFERENCE   9  (bases 1 to 11954)
  AUTHORS   Petrucelli,N., Daly,M.B. and Pal,T.
  TITLE     BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301425
REFERENCE   10 (bases 1 to 11954)
  AUTHORS   Watson,C.G.
  TITLE     The life of a resolution--how ADA policy is made
  JOURNAL   J Conf Workshop, 14-23 (1975)
   PUBMED   1072445
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL445212.9 and AL137247.14.
            
            On Feb 27, 2020 this sequence version replaced NM_000059.3.
            
            Summary: Inherited mutations in BRCA1 and this gene, BRCA2, confer
            increased lifetime risk of developing breast or ovarian cancer.
            Both BRCA1 and BRCA2 are involved in maintenance of genome
            stability, specifically the homologous recombination pathway for
            double-strand DNA repair. The largest exon in both genes is exon
            11, which harbors the most important and frequent mutations in
            breast cancer patients. The BRCA2 gene was found on chromosome
            13q12.3 in human. The BRCA2 protein contains several copies of a 70
            aa motif called the BRC motif, and these motifs mediate binding to
            the RAD51 recombinase which functions in DNA repair. BRCA2 is
            considered a tumor suppressor gene, as tumors with BRCA2 mutations
            generally exhibit loss of heterozygosity (LOH) of the wild-type
            allele. [provided by RefSeq, May 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.3812502.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380152.8/ ENSP00000369497.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AL445212.9         83696-83855
            161-266             AL445212.9         84610-84715
            267-515             AL445212.9         87265-87513
            516-624             AL445212.9         93264-93372
            625-674             AL445212.9         94289-94338
            675-715             AL445212.9         94430-94470
            716-830             AL445212.9         94687-94801
            831-880             AL445212.9         97631-97680
            881-992             AL445212.9         99107-99218
            993-2108            AL445212.9         100460-101575
            2109-7040           AL445212.9         104453-109384
            7041-7136           AL445212.9         112746-112841
            7137-7206           AL445212.9         115015-115084
            7207-7634           AL445212.9         123049-123476
            7635-7816           AL445212.9         124616-124797
            7817-8004           AL445212.9         125930-126117
            8005-8175           AL445212.9         130711-130881
            8176-8530           AL445212.9         131367-131721
            8531-8686           AL445212.9         138590-138745
            8687-8831           AL445212.9         139144-139288
            8832-8953           AL445212.9         144858-144979
            8954-9152           AL445212.9         147505-147703
            9153-9316           AL445212.9         147938-148101
            9317-9455           AL445212.9         148195-148333
            9456-9700           AL445212.9         162877-163121
            9701-9847           AL445212.9         165086-165232
            9848-10155          AL445212.9         166350-166657
            10156-11954         AL137247.14        101-1899
FEATURES             Location/Qualifiers
     source          1..11954
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q13.1"
     gene            1..11954
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /note="BRCA2 DNA repair associated"
                     /db_xref="GeneID:675"
                     /db_xref="HGNC:HGNC:1101"
                     /db_xref="MIM:600185"
     exon            1..160
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /inference="alignment:Splign:2.1.0"
     exon            161..266
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..10456
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     BRCA1/BRCA2-containing complex, subunit 2; breast cancer
                     type 2 susceptibility protein; DNA repair-associated
                     BRCA2; breast cancer 2 tumor suppressor; breast and
                     ovarian cancer susceptibility gene, early onset; Fanconi
                     anemia group D1 protein; breast and ovarian cancer
                     susceptibility protein 2; breast cancer 2, early onset;
                     mutant BRCA2; mutant DNA repair-associated protein 2;
                     BRCA2 DNA repair associated protein"
                     /codon_start=1
                     /product="breast cancer type 2 susceptibility protein
                     isoform 1"
                     /protein_id="NP_000050.3"
                     /db_xref="CCDS:CCDS9344.1"
                     /db_xref="GeneID:675"
                     /db_xref="HGNC:HGNC:1101"
                     /db_xref="MIM:600185"
                     /translation="MPIGSKERPTFFEIFKTRCNKADLGPISLNWFEELSSEAPPYNS
                     EPAEESEHKNNNYEPNLFKTPQRKPSYNQLASTPIIFKEQGLTLPLYQSPVKELDKFK
                     LDLGRNVPNSRHKSLRTVKTKMDQADDVSCPLLNSCLSESPVVLQCTHVTPQRDKSVV
                     CGSLFHTPKFVKGRQTPKHISESLGAEVDPDMSWSSSLATPPTLSSTVLIVRNEEASE
                     TVFPHDTTANVKSYFSNHDESLKKNDRFIASVTDSENTNQREAASHGFGKTSGNSFKV
                     NSCKDHIGKSMPNVLEDEVYETVVDTSEEDSFSLCFSKCRTKNLQKVRTSKTRKKIFH
                     EANADECEKSKNQVKEKYSFVSEVEPNDTDPLDSNVANQKPFESGSDKISKEVVPSLA
                     CEWSQLTLSGLNGAQMEKIPLLHISSCDQNISEKDLLDTENKRKKDFLTSENSLPRIS
                     SLPKSEKPLNEETVVNKRDEEQHLESHTDCILAVKQAISGTSPVASSFQGIKKSIFRI
                     RESPKETFNASFSGHMTDPNFKKETEASESGLEIHTVCSQKEDSLCPNLIDNGSWPAT
                     TTQNSVALKNAGLISTLKKKTNKFIYAIHDETSYKGKKIPKDQKSELINCSAQFEANA
                     FEAPLTFANADSGLLHSSVKRSCSQNDSEEPTLSLTSSFGTILRKCSRNETCSNNTVI
                     SQDLDYKEAKCNKEKLQLFITPEADSLSCLQEGQCENDPKSKKVSDIKEEVLAAACHP
                     VQHSKVEYSDTDFQSQKSLLYDHENASTLILTPTSKDVLSNLVMISRGKESYKMSDKL
                     KGNNYESDVELTKNIPMEKNQDVCALNENYKNVELLPPEKYMRVASPSRKVQFNQNTN
                     LRVIQKNQEETTSISKITVNPDSEELFSDNENNFVFQVANERNNLALGNTKELHETDL
                     TCVNEPIFKNSTMVLYGDTGDKQATQVSIKKDLVYVLAEENKNSVKQHIKMTLGQDLK
                     SDISLNIDKIPEKNNDYMNKWAGLLGPISNHSFGGSFRTASNKEIKLSEHNIKKSKMF
                     FKDIEEQYPTSLACVEIVNTLALDNQKKLSKPQSINTVSAHLQSSVVVSDCKNSHITP
                     QMLFSKQDFNSNHNLTPSQKAEITELSTILEESGSQFEFTQFRKPSYILQKSTFEVPE
                     NQMTILKTTSEECRDADLHVIMNAPSIGQVDSSKQFEGTVEIKRKFAGLLKNDCNKSA
                     SGYLTDENEVGFRGFYSAHGTKLNVSTEALQKAVKLFSDIENISEETSAEVHPISLSS
                     SKCHDSVVSMFKIENHNDKTVSEKNNKCQLILQNNIEMTTGTFVEEITENYKRNTENE
                     DNKYTAASRNSHNLEFDGSDSSKNDTVCIHKDETDLLFTDQHNICLKLSGQFMKEGNT
                     QIKEDLSDLTFLEVAKAQEACHGNTSNKEQLTATKTEQNIKDFETSDTFFQTASGKNI
                     SVAKESFNKIVNFFDQKPEELHNFSLNSELHSDIRKNKMDILSYEETDIVKHKILKES
                     VPVGTGNQLVTFQGQPERDEKIKEPTLLGFHTASGKKVKIAKESLDKVKNLFDEKEQG
                     TSEITSFSHQWAKTLKYREACKDLELACETIEITAAPKCKEMQNSLNNDKNLVSIETV
                     VPPKLLSDNLCRQTENLKTSKSIFLKVKVHENVEKETAKSPATCYTNQSPYSVIENSA
                     LAFYTSCSRKTSVSQTSLLEAKKWLREGIFDGQPERINTADYVGNYLYENNSNSTIAE
                     NDKNHLSEKQDTYLSNSSMSNSYSYHSDEVYNDSGYLSKNKLDSGIEPVLKNVEDQKN
                     TSFSKVISNVKDANAYPQTVNEDICVEELVTSSSPCKNKNAAIKLSISNSNNFEVGPP
                     AFRIASGKIVCVSHETIKKVKDIFTDSFSKVIKENNENKSKICQTKIMAGCYEALDDS
                     EDILHNSLDNDECSTHSHKVFADIQSEEILQHNQNMSGLEKVSKISPCDVSLETSDIC
                     KCSIGKLHKSVSSANTCGIFSTASGKSVQVSDASLQNARQVFSEIEDSTKQVFSKVLF
                     KSNEHSDQLTREENTAIRTPEHLISQKGFSYNVVNSSAFSGFSTASGKQVSILESSLH
                     KVKGVLEEFDLIRTEHSLHYSPTSRQNVSKILPRVDKRNPEHCVNSEMEKTCSKEFKL
                     SNNLNVEGGSSENNHSIKVSPYLSQFQQDKQQLVLGTKVSLVENIHVLGKEQASPKNV
                     KMEIGKTETFSDVPVKTNIEVCSTYSKDSENYFETEAVEIAKAFMEDDELTDSKLPSH
                     ATHSLFTCPENEEMVLSNSRIGKRRGEPLILVGEPSIKRNLLNEFDRIIENQEKSLKA
                     SKSTPDGTIKDRRLFMHHVSLEPITCVPFRTTKERQEIQNPNFTAPGQEFLSKSHLYE
                     HLTLEKSSSNLAVSGHPFYQVSATRNEKMRHLITTGRPTKVFVPPFKTKSHFHRVEQC
                     VRNINLEENRQKQNIDGHGSDDSKNKINDNEIHQFNKNNSNQAVAVTFTKCEEEPLDL
                     ITSLQNARDIQDMRIKKKQRQRVFPQPGSLYLAKTSTLPRISLKAAVGGQVPSACSHK
                     QLYTYGVSKHCIKINSKNAESFQFHTEDYFGKESLWTGKGIQLADGGWLIPSNDGKAG
                     KEEFYRALCDTPGVDPKLISRIWVYNHYRWIIWKLAAMECAFPKEFANRCLSPERVLL
                     QLKYRYDTEIDRSRRSAIKKIMERDDTAAKTLVLCVSDIISLSANISETSSNKTSSAD
                     TQKVAIIELTDGWYAVKAQLDPPLLAVLKNGRLTVGQKIILHGAELVGSPDACTPLEA
                     PESLMLKISANSTRPARWYTKLGFFPDPRPFPLPLSSLFSDGGNVGCVDVIIQRAYPI
                     QWMEKTSSGLYIFRNEREEEKEAAKYVEAQQKRLEALFTKIQEEFEEHEENTTKPYLP
                     SRALTRQQVRALQDGAELYEAVKNAADPAYLEGYFSEEQLRALNNHRQMLNDKKQAQI
                     QLEIRKAMESAEQKEQGLSRDVTTVWKLRIVSYSKKEKDSVILSIWRPSSDLYSLLTE
                     GKRYRIYHLATSKSKSKSERANIQLAATKKTQYQQLPVSDEILFQIYQPREPLHFSKF
                     LDPDFQPSCSEVDLIGFVVSVVKKTGLAPFVYLSDECYNLLAIKFWIDLNEDIIKPHM
                     LIAASNLQWRPESKSGLLTLFAGDFSVFSASPKEGHFQETFNKMKNTVENIDILCNEA
                     ENKLMHILHANDPKWSTPTKDCTSGPYTAQIIPGTGNKLLMSSPNCEIYYQSPLSLCM
                     AKRKSVSTPVSAQMTSKSCKGEKEIDDQKNCKKRRALDFLSRLPLPPPVSPICTFVSP
                     AAQKAFQPPRSCGTKYETPIKKKELNSPQMTPFKKFNEISLLESNSIADEELALINTQ
                     ALLSGSTGEKQFISVSESTRTAPTSSEDYLRLKRRCTTSLIKEQESSQASTEECEKNK
                     QDTITTKKYI"
     exon            267..515
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /inference="alignment:Splign:2.1.0"
     exon            516..624
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /inference="alignment:Splign:2.1.0"
     exon            625..674
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /inference="alignment:Splign:2.1.0"
     exon            675..715
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /inference="alignment:Splign:2.1.0"
     exon            716..830
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /inference="alignment:Splign:2.1.0"
     exon            831..880
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /inference="alignment:Splign:2.1.0"
     exon            881..992
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /inference="alignment:Splign:2.1.0"
     exon            993..2108
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..7040
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /inference="alignment:Splign:2.1.0"
     exon            7041..7136
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /inference="alignment:Splign:2.1.0"
     exon            7137..7206
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /inference="alignment:Splign:2.1.0"
     exon            7207..7634
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /inference="alignment:Splign:2.1.0"
     exon            7635..7816
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /inference="alignment:Splign:2.1.0"
     exon            7817..8004
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /inference="alignment:Splign:2.1.0"
     exon            8005..8175
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /inference="alignment:Splign:2.1.0"
     exon            8176..8530
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /inference="alignment:Splign:2.1.0"
     exon            8531..8686
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /inference="alignment:Splign:2.1.0"
     exon            8687..8831
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /inference="alignment:Splign:2.1.0"
     exon            8832..8953
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /inference="alignment:Splign:2.1.0"
     exon            8954..9152
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /inference="alignment:Splign:2.1.0"
     exon            9153..9316
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /inference="alignment:Splign:2.1.0"
     exon            9317..9455
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /inference="alignment:Splign:2.1.0"
     exon            9456..9700
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /inference="alignment:Splign:2.1.0"
     exon            9701..9847
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /inference="alignment:Splign:2.1.0"
     exon            9848..11954
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11933..11938
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /note="hexamer: AATAAA"
     polyA_site      11954
                     /gene="BRCA2"
                     /gene_synonym="BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD;
                     FANCD1; GLM3; PNCA2; XRCC11"
                     /note="major polyA site"
ORIGIN      
        1 agaggcggag ccgctgtggc actgctgcgc ctctgctgcg cctcgggtgt cttttgcggc
       61 ggtgggtcgc cgccgggaga agcgtgaggg gacagatttg tgaccggcgc ggtttttgtc
      121 agcttactcc ggccaaaaaa gaactgcacc tctggagcgg acttatttac caagcattgg
      181 aggaatatcg taggtaaaaa tgcctattgg atccaaagag aggccaacat tttttgaaat
      241 ttttaagaca cgctgcaaca aagcagattt aggaccaata agtcttaatt ggtttgaaga
      301 actttcttca gaagctccac cctataattc tgaacctgca gaagaatctg aacataaaaa
      361 caacaattac gaaccaaacc tatttaaaac tccacaaagg aaaccatctt ataatcagct
      421 ggcttcaact ccaataatat tcaaagagca agggctgact ctgccgctgt accaatctcc
      481 tgtaaaagaa ttagataaat tcaaattaga cttaggaagg aatgttccca atagtagaca
      541 taaaagtctt cgcacagtga aaactaaaat ggatcaagca gatgatgttt cctgtccact
      601 tctaaattct tgtcttagtg aaagtcctgt tgttctacaa tgtacacatg taacaccaca
      661 aagagataag tcagtggtat gtgggagttt gtttcataca ccaaagtttg tgaagggtcg
      721 tcagacacca aaacatattt ctgaaagtct aggagctgag gtggatcctg atatgtcttg
      781 gtcaagttct ttagctacac cacccaccct tagttctact gtgctcatag tcagaaatga
      841 agaagcatct gaaactgtat ttcctcatga tactactgct aatgtgaaaa gctatttttc
      901 caatcatgat gaaagtctga agaaaaatga tagatttatc gcttctgtga cagacagtga
      961 aaacacaaat caaagagaag ctgcaagtca tggatttgga aaaacatcag ggaattcatt
     1021 taaagtaaat agctgcaaag accacattgg aaagtcaatg ccaaatgtcc tagaagatga
     1081 agtatatgaa acagttgtag atacctctga agaagatagt ttttcattat gtttttctaa
     1141 atgtagaaca aaaaatctac aaaaagtaag aactagcaag actaggaaaa aaattttcca
     1201 tgaagcaaac gctgatgaat gtgaaaaatc taaaaaccaa gtgaaagaaa aatactcatt
     1261 tgtatctgaa gtggaaccaa atgatactga tccattagat tcaaatgtag caaatcagaa
     1321 gccctttgag agtggaagtg acaaaatctc caaggaagtt gtaccgtctt tggcctgtga
     1381 atggtctcaa ctaacccttt caggtctaaa tggagcccag atggagaaaa tacccctatt
     1441 gcatatttct tcatgtgacc aaaatatttc agaaaaagac ctattagaca cagagaacaa
     1501 aagaaagaaa gattttctta cttcagagaa ttctttgcca cgtatttcta gcctaccaaa
     1561 atcagagaag ccattaaatg aggaaacagt ggtaaataag agagatgaag agcagcatct
     1621 tgaatctcat acagactgca ttcttgcagt aaagcaggca atatctggaa cttctccagt
     1681 ggcttcttca tttcagggta tcaaaaagtc tatattcaga ataagagaat cacctaaaga
     1741 gactttcaat gcaagttttt caggtcatat gactgatcca aactttaaaa aagaaactga
     1801 agcctctgaa agtggactgg aaatacatac tgtttgctca cagaaggagg actccttatg
     1861 tccaaattta attgataatg gaagctggcc agccaccacc acacagaatt ctgtagcttt
     1921 gaagaatgca ggtttaatat ccactttgaa aaagaaaaca aataagttta tttatgctat
     1981 acatgatgaa acatcttata aaggaaaaaa aataccgaaa gaccaaaaat cagaactaat
     2041 taactgttca gcccagtttg aagcaaatgc ttttgaagca ccacttacat ttgcaaatgc
     2101 tgattcaggt ttattgcatt cttctgtgaa aagaagctgt tcacagaatg attctgaaga
     2161 accaactttg tccttaacta gctcttttgg gacaattctg aggaaatgtt ctagaaatga
     2221 aacatgttct aataatacag taatctctca ggatcttgat tataaagaag caaaatgtaa
     2281 taaggaaaaa ctacagttat ttattacccc agaagctgat tctctgtcat gcctgcagga
     2341 aggacagtgt gaaaatgatc caaaaagcaa aaaagtttca gatataaaag aagaggtctt
     2401 ggctgcagca tgtcacccag tacaacattc aaaagtggaa tacagtgata ctgactttca
     2461 atcccagaaa agtcttttat atgatcatga aaatgccagc actcttattt taactcctac
     2521 ttccaaggat gttctgtcaa acctagtcat gatttctaga ggcaaagaat catacaaaat
     2581 gtcagacaag ctcaaaggta acaattatga atctgatgtt gaattaacca aaaatattcc
     2641 catggaaaag aatcaagatg tatgtgcttt aaatgaaaat tataaaaacg ttgagctgtt
     2701 gccacctgaa aaatacatga gagtagcatc accttcaaga aaggtacaat tcaaccaaaa
     2761 cacaaatcta agagtaatcc aaaaaaatca agaagaaact acttcaattt caaaaataac
     2821 tgtcaatcca gactctgaag aacttttctc agacaatgag aataattttg tcttccaagt
     2881 agctaatgaa aggaataatc ttgctttagg aaatactaag gaacttcatg aaacagactt
     2941 gacttgtgta aacgaaccca ttttcaagaa ctctaccatg gttttatatg gagacacagg
     3001 tgataaacaa gcaacccaag tgtcaattaa aaaagatttg gtttatgttc ttgcagagga
     3061 gaacaaaaat agtgtaaagc agcatataaa aatgactcta ggtcaagatt taaaatcgga
     3121 catctccttg aatatagata aaataccaga aaaaaataat gattacatga acaaatgggc
     3181 aggactctta ggtccaattt caaatcacag ttttggaggt agcttcagaa cagcttcaaa
     3241 taaggaaatc aagctctctg aacataacat taagaagagc aaaatgttct tcaaagatat
     3301 tgaagaacaa tatcctacta gtttagcttg tgttgaaatt gtaaatacct tggcattaga
     3361 taatcaaaag aaactgagca agcctcagtc aattaatact gtatctgcac atttacagag
     3421 tagtgtagtt gtttctgatt gtaaaaatag tcatataacc cctcagatgt tattttccaa
     3481 gcaggatttt aattcaaacc ataatttaac acctagccaa aaggcagaaa ttacagaact
     3541 ttctactata ttagaagaat caggaagtca gtttgaattt actcagttta gaaaaccaag
     3601 ctacatattg cagaagagta catttgaagt gcctgaaaac cagatgacta tcttaaagac
     3661 cacttctgag gaatgcagag atgctgatct tcatgtcata atgaatgccc catcgattgg
     3721 tcaggtagac agcagcaagc aatttgaagg tacagttgaa attaaacgga agtttgctgg
     3781 cctgttgaaa aatgactgta acaaaagtgc ttctggttat ttaacagatg aaaatgaagt
     3841 ggggtttagg ggcttttatt ctgctcatgg cacaaaactg aatgtttcta ctgaagctct
     3901 gcaaaaagct gtgaaactgt ttagtgatat tgagaatatt agtgaggaaa cttctgcaga
     3961 ggtacatcca ataagtttat cttcaagtaa atgtcatgat tctgttgttt caatgtttaa
     4021 gatagaaaat cataatgata aaactgtaag tgaaaaaaat aataaatgcc aactgatatt
     4081 acaaaataat attgaaatga ctactggcac ttttgttgaa gaaattactg aaaattacaa
     4141 gagaaatact gaaaatgaag ataacaaata tactgctgcc agtagaaatt ctcataactt
     4201 agaatttgat ggcagtgatt caagtaaaaa tgatactgtt tgtattcata aagatgaaac
     4261 ggacttgcta tttactgatc agcacaacat atgtcttaaa ttatctggcc agtttatgaa
     4321 ggagggaaac actcagatta aagaagattt gtcagattta acttttttgg aagttgcgaa
     4381 agctcaagaa gcatgtcatg gtaatacttc aaataaagaa cagttaactg ctactaaaac
     4441 ggagcaaaat ataaaagatt ttgagacttc tgatacattt tttcagactg caagtgggaa
     4501 aaatattagt gtcgccaaag agtcatttaa taaaattgta aatttctttg atcagaaacc
     4561 agaagaattg cataactttt ccttaaattc tgaattacat tctgacataa gaaagaacaa
     4621 aatggacatt ctaagttatg aggaaacaga catagttaaa cacaaaatac tgaaagaaag
     4681 tgtcccagtt ggtactggaa atcaactagt gaccttccag ggacaacccg aacgtgatga
     4741 aaagatcaaa gaacctactc tattgggttt tcatacagct agcgggaaaa aagttaaaat
     4801 tgcaaaggaa tctttggaca aagtgaaaaa cctttttgat gaaaaagagc aaggtactag
     4861 tgaaatcacc agttttagcc atcaatgggc aaagacccta aagtacagag aggcctgtaa
     4921 agaccttgaa ttagcatgtg agaccattga gatcacagct gccccaaagt gtaaagaaat
     4981 gcagaattct ctcaataatg ataaaaacct tgtttctatt gagactgtgg tgccacctaa
     5041 gctcttaagt gataatttat gtagacaaac tgaaaatctc aaaacatcaa aaagtatctt
     5101 tttgaaagtt aaagtacatg aaaatgtaga aaaagaaaca gcaaaaagtc ctgcaacttg
     5161 ttacacaaat cagtcccctt attcagtcat tgaaaattca gccttagctt tttacacaag
     5221 ttgtagtaga aaaacttctg tgagtcagac ttcattactt gaagcaaaaa aatggcttag
     5281 agaaggaata tttgatggtc aaccagaaag aataaatact gcagattatg taggaaatta
     5341 tttgtatgaa aataattcaa acagtactat agctgaaaat gacaaaaatc atctctccga
     5401 aaaacaagat acttatttaa gtaacagtag catgtctaac agctattcct accattctga
     5461 tgaggtatat aatgattcag gatatctctc aaaaaataaa cttgattctg gtattgagcc
     5521 agtattgaag aatgttgaag atcaaaaaaa cactagtttt tccaaagtaa tatccaatgt
     5581 aaaagatgca aatgcatacc cacaaactgt aaatgaagat atttgcgttg aggaacttgt
     5641 gactagctct tcaccctgca aaaataaaaa tgcagccatt aaattgtcca tatctaatag
     5701 taataatttt gaggtagggc cacctgcatt taggatagcc agtggtaaaa tcgtttgtgt
     5761 ttcacatgaa acaattaaaa aagtgaaaga catatttaca gacagtttca gtaaagtaat
     5821 taaggaaaac aacgagaata aatcaaaaat ttgccaaacg aaaattatgg caggttgtta
     5881 cgaggcattg gatgattcag aggatattct tcataactct ctagataatg atgaatgtag
     5941 cacgcattca cataaggttt ttgctgacat tcagagtgaa gaaattttac aacataacca
     6001 aaatatgtct ggattggaga aagtttctaa aatatcacct tgtgatgtta gtttggaaac
     6061 ttcagatata tgtaaatgta gtatagggaa gcttcataag tcagtctcat ctgcaaatac
     6121 ttgtgggatt tttagcacag caagtggaaa atctgtccag gtatcagatg cttcattaca
     6181 aaacgcaaga caagtgtttt ctgaaataga agatagtacc aagcaagtct tttccaaagt
     6241 attgtttaaa agtaacgaac attcagacca gctcacaaga gaagaaaata ctgctatacg
     6301 tactccagaa catttaatat cccaaaaagg cttttcatat aatgtggtaa attcatctgc
     6361 tttctctgga tttagtacag caagtggaaa gcaagtttcc attttagaaa gttccttaca
     6421 caaagttaag ggagtgttag aggaatttga tttaatcaga actgagcata gtcttcacta
     6481 ttcacctacg tctagacaaa atgtatcaaa aatacttcct cgtgttgata agagaaaccc
     6541 agagcactgt gtaaactcag aaatggaaaa aacctgcagt aaagaattta aattatcaaa
     6601 taacttaaat gttgaaggtg gttcttcaga aaataatcac tctattaaag tttctccata
     6661 tctctctcaa tttcaacaag acaaacaaca gttggtatta ggaaccaaag tgtcacttgt
     6721 tgagaacatt catgttttgg gaaaagaaca ggcttcacct aaaaacgtaa aaatggaaat
     6781 tggtaaaact gaaacttttt ctgatgttcc tgtgaaaaca aatatagaag tttgttctac
     6841 ttactccaaa gattcagaaa actactttga aacagaagca gtagaaattg ctaaagcttt
     6901 tatggaagat gatgaactga cagattctaa actgccaagt catgccacac attctctttt
     6961 tacatgtccc gaaaatgagg aaatggtttt gtcaaattca agaattggaa aaagaagagg
     7021 agagcccctt atcttagtgg gagaaccctc aatcaaaaga aacttattaa atgaatttga
     7081 caggataata gaaaatcaag aaaaatcctt aaaggcttca aaaagcactc cagatggcac
     7141 aataaaagat cgaagattgt ttatgcatca tgtttcttta gagccgatta cctgtgtacc
     7201 ctttcgcaca actaaggaac gtcaagagat acagaatcca aattttaccg cacctggtca
     7261 agaatttctg tctaaatctc atttgtatga acatctgact ttggaaaaat cttcaagcaa
     7321 tttagcagtt tcaggacatc cattttatca agtttctgct acaagaaatg aaaaaatgag
     7381 acacttgatt actacaggca gaccaaccaa agtctttgtt ccacctttta aaactaaatc
     7441 acattttcac agagttgaac agtgtgttag gaatattaac ttggaggaaa acagacaaaa
     7501 gcaaaacatt gatggacatg gctctgatga tagtaaaaat aagattaatg acaatgagat
     7561 tcatcagttt aacaaaaaca actccaatca agcagtagct gtaactttca caaagtgtga
     7621 agaagaacct ttagatttaa ttacaagtct tcagaatgcc agagatatac aggatatgcg
     7681 aattaagaag aaacaaaggc aacgcgtctt tccacagcca ggcagtctgt atcttgcaaa
     7741 aacatccact ctgcctcgaa tctctctgaa agcagcagta ggaggccaag ttccctctgc
     7801 gtgttctcat aaacagctgt atacgtatgg cgtttctaaa cattgcataa aaattaacag
     7861 caaaaatgca gagtcttttc agtttcacac tgaagattat tttggtaagg aaagtttatg
     7921 gactggaaaa ggaatacagt tggctgatgg tggatggctc ataccctcca atgatggaaa
     7981 ggctggaaaa gaagaatttt atagggctct gtgtgacact ccaggtgtgg atccaaagct
     8041 tatttctaga atttgggttt ataatcacta tagatggatc atatggaaac tggcagctat
     8101 ggaatgtgcc tttcctaagg aatttgctaa tagatgccta agcccagaaa gggtgcttct
     8161 tcaactaaaa tacagatatg atacggaaat tgatagaagc agaagatcgg ctataaaaaa
     8221 gataatggaa agggatgaca cagctgcaaa aacacttgtt ctctgtgttt ctgacataat
     8281 ttcattgagc gcaaatatat ctgaaacttc tagcaataaa actagtagtg cagataccca
     8341 aaaagtggcc attattgaac ttacagatgg gtggtatgct gttaaggccc agttagatcc
     8401 tcccctctta gctgtcttaa agaatggcag actgacagtt ggtcagaaga ttattcttca
     8461 tggagcagaa ctggtgggct ctcctgatgc ctgtacacct cttgaagccc cagaatctct
     8521 tatgttaaag atttctgcta acagtactcg gcctgctcgc tggtatacca aacttggatt
     8581 ctttcctgac cctagacctt ttcctctgcc cttatcatcg cttttcagtg atggaggaaa
     8641 tgttggttgt gttgatgtaa ttattcaaag agcataccct atacagtgga tggagaagac
     8701 atcatctgga ttatacatat ttcgcaatga aagagaggaa gaaaaggaag cagcaaaata
     8761 tgtggaggcc caacaaaaga gactagaagc cttattcact aaaattcagg aggaatttga
     8821 agaacatgaa gaaaacacaa caaaaccata tttaccatca cgtgcactaa caagacagca
     8881 agttcgtgct ttgcaagatg gtgcagagct ttatgaagca gtgaagaatg cagcagaccc
     8941 agcttacctt gagggttatt tcagtgaaga gcagttaaga gccttgaata atcacaggca
     9001 aatgttgaat gataagaaac aagctcagat ccagttggaa attaggaagg ccatggaatc
     9061 tgctgaacaa aaggaacaag gtttatcaag ggatgtcaca accgtgtgga agttgcgtat
     9121 tgtaagctat tcaaaaaaag aaaaagattc agttatactg agtatttggc gtccatcatc
     9181 agatttatat tctctgttaa cagaaggaaa gagatacaga atttatcatc ttgcaacttc
     9241 aaaatctaaa agtaaatctg aaagagctaa catacagtta gcagcgacaa aaaaaactca
     9301 gtatcaacaa ctaccggttt cagatgaaat tttatttcag atttaccagc cacgggagcc
     9361 ccttcacttc agcaaatttt tagatccaga ctttcagcca tcttgttctg aggtggacct
     9421 aataggattt gtcgtttctg ttgtgaaaaa aacaggactt gcccctttcg tctatttgtc
     9481 agacgaatgt tacaatttac tggcaataaa gttttggata gaccttaatg aggacattat
     9541 taagcctcat atgttaattg ctgcaagcaa cctccagtgg cgaccagaat ccaaatcagg
     9601 ccttcttact ttatttgctg gagatttttc tgtgttttct gctagtccaa aagagggcca
     9661 ctttcaagag acattcaaca aaatgaaaaa tactgttgag aatattgaca tactttgcaa
     9721 tgaagcagaa aacaagctta tgcatatact gcatgcaaat gatcccaagt ggtccacccc
     9781 aactaaagac tgtacttcag ggccgtacac tgctcaaatc attcctggta caggaaacaa
     9841 gcttctgatg tcttctccta attgtgagat atattatcaa agtcctttat cactttgtat
     9901 ggccaaaagg aagtctgttt ccacacctgt ctcagcccag atgacttcaa agtcttgtaa
     9961 aggggagaaa gagattgatg accaaaagaa ctgcaaaaag agaagagcct tggatttctt
    10021 gagtagactg cctttacctc cacctgttag tcccatttgt acatttgttt ctccggctgc
    10081 acagaaggca tttcagccac caaggagttg tggcaccaaa tacgaaacac ccataaagaa
    10141 aaaagaactg aattctcctc agatgactcc atttaaaaaa ttcaatgaaa tttctctttt
    10201 ggaaagtaat tcaatagctg acgaagaact tgcattgata aatacccaag ctcttttgtc
    10261 tggttcaaca ggagaaaaac aatttatatc tgtcagtgaa tccactagga ctgctcccac
    10321 cagttcagaa gattatctca gactgaaacg acgttgtact acatctctga tcaaagaaca
    10381 ggagagttcc caggccagta cggaagaatg tgagaaaaat aagcaggaca caattacaac
    10441 taaaaaatat atctaagcat ttgcaaaggc gacaataaat tattgacgct taacctttcc
    10501 agtttataag actggaatat aatttcaaac cacacattag tacttatgtt gcacaatgag
    10561 aaaagaaatt agtttcaaat ttacctcagc gtttgtgtat cgggcaaaaa tcgttttgcc
    10621 cgattccgta ttggtatact tttgcttcag ttgcatatct taaaactaaa tgtaatttat
    10681 taactaatca agaaaaacat ctttggctga gctcggtggc tcatgcctgt aatcccaaca
    10741 ctttgagaag ctgaggtggg aggagtgctt gaggccagga gttcaagacc agcctgggca
    10801 acatagggag acccccatct ttacaaagaa aaaaaaaagg ggaaaagaaa atcttttaaa
    10861 tctttggatt tgatcactac aagtattatt ttacaagtga aataaacata ccattttctt
    10921 ttagattgtg tcattaaatg gaatgaggtc tcttagtaca gttattttga tgcagataat
    10981 tccttttagt ttagctacta ttttagggga ttttttttag aggtaactca ctatgaaata
    11041 gttctcctta atgcaaatat gttggttctg ctatagttcc atcctgttca aaagtcagga
    11101 tgaatatgaa gagtggtgtt tccttttgag caattcttca tccttaagtc agcatgatta
    11161 taagaaaaat agaaccctca gtgtaactct aattcctttt tactattcca gtgtgatctc
    11221 tgaaattaaa ttacttcaac taaaaattca aatactttaa atcagaagat ttcatagtta
    11281 atttattttt tttttcaaca aaatggtcat ccaaactcaa acttgagaaa atatcttgct
    11341 ttcaaattgg cactgattct gcctgcttta tttttagcgc tatcacagga cccagagcct
    11401 atgccctttt aaacttacca caaaagcaga agattaattc aatttaagat gatactctca
    11461 tttgttacgt cctttttttt tttttttgga gatggagtct tgctttgtcg cccatgctgg
    11521 agtgcagtgg catgatcctg gctcactgca gcctccactt cccgggttca cgtaattctc
    11581 ccacctcaag cctccctagt agctgggatt acagggacgc accaccatgc ccagctaatt
    11641 tttgcatttt tagtagagac tgggttttac catgttggcc aagctggtct caaactcctg
    11701 atgtcaggtg atccatctgc ctcagcctcc caaagtgctg ggattatagg cgtgagccac
    11761 tgtgcccggc caatatttgt tactttctta ggtttaatag agaaaaggga taaaacattt
    11821 ctaactggga gttaattgca tggagaaggt cttaaatcag atgttttaat gccttaaatg
    11881 tctgtataat atcatgtttt caaatctaat tataaatacg tttaaagcca agaataaatc
    11941 ttttaaaaaa ttga
//
