LOCUS       NM_001408490            3754 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens BRCA1 DNA repair associated (BRCA1), transcript
            variant 344, mRNA.
ACCESSION   NM_001408490
VERSION     NM_001408490.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3754)
  AUTHORS   Orban,T.I. and Olah,E.
  TITLE     Emerging roles of BRCA1 alternative splicing
  JOURNAL   Mol Pathol 56 (4), 191-197 (2003)
   PUBMED   12890739
  REMARK    Review article
REFERENCE   2  (bases 1 to 3754)
  AUTHORS   Orban,T.I. and Olah,E.
  TITLE     Expression profiles of BRCA1 splice variants in asynchronous and in
            G1/S synchronized tumor cell lines
  JOURNAL   Biochem Biophys Res Commun 280 (1), 32-38 (2001)
   PUBMED   11162473
REFERENCE   3  (bases 1 to 3754)
  AUTHORS   Paterson,J.W.
  TITLE     BRCA1: a review of structure and putative functions
  JOURNAL   Dis Markers 13 (4), 261-274 (1998)
   PUBMED   9553742
  REMARK    Review article
REFERENCE   4  (bases 1 to 3754)
  AUTHORS   Xu,C.F., Chambers,J.A., Nicolai,H., Brown,M.A., Hujeirat,Y.,
            Mohammed,S., Hodgson,S., Kelsell,D.P., Spurr,N.K., Bishop,D.T. and
            Solomon,E.
  TITLE     Mutations and alternative splicing of the BRCA1 gene in UK
            breast/ovarian cancer families
  JOURNAL   Genes Chromosomes Cancer 18 (2), 102-110 (1997)
   PUBMED   9115959
REFERENCE   5  (bases 1 to 3754)
  AUTHORS   Wilson,C.A., Payton,M.N., Elliott,G.S., Buaas,F.W., Cajulis,E.E.,
            Grosshans,D., Ramos,L., Reese,D.M., Slamon,D.J. and Calzone,F.J.
  TITLE     Differential subcellular localization, expression and biological
            toxicity of BRCA1 and the splice variant BRCA1-delta11b
  JOURNAL   Oncogene 14 (1), 1-16 (1997)
   PUBMED   9010228
REFERENCE   6  (bases 1 to 3754)
  AUTHORS   Thakur,S., Zhang,H.B., Peng,Y., Le,H., Carroll,B., Ward,T., Yao,J.,
            Farid,L.M., Couch,F.J., Wilson,R.B. and Weber,B.L.
  TITLE     Localization of BRCA1 and a splice variant identifies the nuclear
            localization signal
  JOURNAL   Mol Cell Biol 17 (1), 444-452 (1997)
   PUBMED   8972225
REFERENCE   7  (bases 1 to 3754)
  AUTHORS   Lu,M., Conzen,S.D., Cole,C.N. and Arrick,B.A.
  TITLE     Characterization of functional messenger RNA splice variants of
            BRCA1 expressed in nonmalignant and tumor-derived breast cells
  JOURNAL   Cancer Res 56 (20), 4578-4581 (1996)
   PUBMED   8840964
REFERENCE   8  (bases 1 to 3754)
  AUTHORS   Holt,J.T., Thompson,M.E., Szabo,C., Robinson-Benion,C.,
            Arteaga,C.L., King,M.C. and Jensen,R.A.
  TITLE     Growth retardation and tumour inhibition by BRCA1
  JOURNAL   Nat Genet 12 (3), 298-302 (1996)
   PUBMED   8589721
  REMARK    Erratum:[Nat Genet 1998 May;19(1):102]
REFERENCE   9  (bases 1 to 3754)
  AUTHORS   Xu,C.F., Brown,M.A., Chambers,J.A., Griffiths,B., Nicolai,H. and
            Solomon,E.
  TITLE     Distinct transcription start sites generate two forms of BRCA1 mRNA
  JOURNAL   Hum Mol Genet 4 (12), 2259-2264 (1995)
   PUBMED   8634696
REFERENCE   10 (bases 1 to 3754)
  AUTHORS   Miki,Y., Swensen,J., Shattuck-Eidens,D., Futreal,P.A., Harshman,K.,
            Tavtigian,S., Liu,Q., Cochran,C., Bennett,L.M., Ding,W. et al.
  TITLE     A strong candidate for the breast and ovarian cancer susceptibility
            gene BRCA1
  JOURNAL   Science 266 (5182), 66-71 (1994)
   PUBMED   7545954
REFERENCE   11 (bases 1 to 3754)
  AUTHORS   Mehta,P.A. and Ebens,C.
  TITLE     Fanconi Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301575
REFERENCE   12 (bases 1 to 3754)
  AUTHORS   Petrucelli,N., Daly,M.B. and Pal,T.
  TITLE     BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301425
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC135721.4.
            
            Summary: This gene encodes a 190 kD nuclear phosphoprotein that
            plays a role in maintaining genomic stability, and it also acts as
            a tumor suppressor. The BRCA1 gene contains 22 exons spanning about
            110 kb of DNA. The encoded protein combines with other tumor
            suppressors, DNA damage sensors, and signal transducers to form a
            large multi-subunit protein complex known as the BRCA1-associated
            genome surveillance complex (BASC). This gene product associates
            with RNA polymerase II, and through the C-terminal domain, also
            interacts with histone deacetylase complexes. This protein thus
            plays a role in transcription, DNA repair of double-stranded
            breaks, and recombination. Mutations in this gene are responsible
            for approximately 40% of inherited breast cancers and more than 80%
            of inherited breast and ovarian cancers. Alternative splicing plays
            a role in modulating the subcellular localization and physiological
            function of this gene. Many alternatively spliced transcript
            variants, some of which are disease-associated mutations, have been
            described for this gene, but the full-length natures of only some
            of these variants has been described. A related pseudogene, which
            is also located on chromosome 17, has been identified. [provided by
            RefSeq, May 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.4429038.1,
                                           SRR14038197.474727.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AC135721.4         34056-34149
            95-193              AC135721.4         35305-35403
            194-247             AC135721.4         43641-43694
            248-303             AC135721.4         52887-52942
            304-392             AC135721.4         54464-54552
            393-532             AC135721.4         55159-55298
            533-635             AC135721.4         59543-59645
            636-681             AC135721.4         62131-62176
            682-758             AC135721.4         63498-63574
            759-875             AC135721.4         64560-64676
            876-964             AC135721.4         68388-68476
            965-1136            AC135721.4         76845-77016
            1137-1263           AC135721.4         82806-82932
            1264-1454           AC135721.4         84899-85089
            1455-1765           AC135721.4         88182-88492
            1766-1853           AC135721.4         91725-91812
            1854-1931           AC135721.4         95469-95546
            1932-1972           AC135721.4         96047-96087
            1973-2056           AC135721.4         102285-102368
            2057-2111           AC135721.4         108303-108357
            2112-2185           AC135721.4         110226-110299
            2186-2246           AC135721.4         111717-111777
            2247-3754           AC135721.4         113618-115125
FEATURES             Location/Qualifiers
     source          1..3754
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..3754
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /note="BRCA1 DNA repair associated"
                     /db_xref="GeneID:672"
                     /db_xref="HGNC:HGNC:1100"
                     /db_xref="MIM:113705"
     exon            1..94
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            95..193
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            194..247
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            248..303
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     CDS             302..2371
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /EC_number="2.3.2.27"
                     /note="isoform 130 is encoded by transcript variant 344;
                     BRCA1/BRCA2-containing complex, subunit 1; RING finger
                     protein 53; breast cancer type 1 susceptibility protein;
                     breast and ovarian cancer susceptibility protein 1;
                     protein phosphatase 1, regulatory subunit 53; Fanconi
                     anemia, complementation group S; early onset breast cancer
                     1; breast cancer 1, early onset"
                     /codon_start=1
                     /product="breast cancer type 1 susceptibility protein
                     isoform 130"
                     /protein_id="NP_001395419.1"
                     /db_xref="GeneID:672"
                     /db_xref="HGNC:HGNC:1100"
                     /db_xref="MIM:113705"
                     /translation="MSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNFAKKENNS
                     PEHLKDEVSIIQSMGYRNRAKRLLQSEPENPSLETSLSVQLSNLGTVRTLRTKQRIQP
                     QKTSVYIELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACEFSET
                     DVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGEAASGCESETSVSEDCSGLSSQSDIL
                     TTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALEDLRNPEQSTS
                     EKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSKCPSLDDRW
                     YMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEGTPYLES
                     GISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTTDTAG
                     YNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLITE
                     ETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDV
                     VNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSF
                     TLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIP
                     QIPHSHY"
     exon            304..392
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            393..532
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            533..635
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            636..681
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            682..758
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            759..875
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            876..964
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1136
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1263
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1454
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1765
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1853
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1931
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..1972
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2056
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2111
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2185
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2246
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..3754
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3729..3734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /note="hexamer: AATAAA"
     polyA_site      3754
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /note="major polyA site"
ORIGIN      
        1 gctgagactt cctggacggg ggacaggctg tggggtttct cagataactg ggcccctgcg
       61 ctcaggaggc cttcaccctc tgctctgggt aaagttcatt ggaacagaaa gaaatggatt
      121 tatctgctct tcgcgttgaa gaagtacaaa atgtcattaa tgctatgcag aaaatcttag
      181 agtgtcccat ctgtctggag ttgatcaagg aacctgtctc cacaaagtgt gaccacatat
      241 tttgcaaatt ttgcatgctg aaacttctca accagaagaa agggccttca cagtgtcctt
      301 tatgagccta caagaaagta cgagatttag tcaacttgtt gaagagctat tgaaaatcat
      361 ttgtgctttt cagcttgaca caggtttgga gtatgcaaac agctataatt ttgcaaaaaa
      421 ggaaaataac tctcctgaac atctaaaaga tgaagtttct atcatccaaa gtatgggcta
      481 cagaaaccgt gccaaaagac ttctacagag tgaacccgaa aatccttcct tggaaaccag
      541 tctcagtgtc caactctcta accttggaac tgtgagaact ctgaggacaa agcagcggat
      601 acaacctcaa aagacgtctg tctacattga attgggatct gattcttctg aagataccgt
      661 taataaggca acttattgca gtgtgggaga tcaagaattg ttacaaatca cccctcaagg
      721 aaccagggat gaaatcagtt tggattctgc aaaaaaggct gcttgtgaat tttctgagac
      781 ggatgtaaca aatactgaac atcatcaacc cagtaataat gatttgaaca ccactgagaa
      841 gcgtgcagct gagaggcatc cagaaaagta tcagggtgaa gcagcatctg ggtgtgagag
      901 tgaaacaagc gtctctgaag actgctcagg gctatcctct cagagtgaca ttttaaccac
      961 tcagcagagg gataccatgc aacataacct gataaagctc cagcaggaaa tggctgaact
     1021 agaagctgtg ttagaacagc atgggagcca gccttctaac agctaccctt ccatcataag
     1081 tgactcttct gcccttgagg acctgcgaaa tccagaacaa agcacatcag aaaaagcagt
     1141 attaacttca cagaaaagta gtgaataccc tataagccag aatccagaag gcctttctgc
     1201 tgacaagttt gaggtgtctg cagatagttc taccagtaaa aataaagaac caggagtgga
     1261 aaggtcatcc ccttctaaat gcccatcatt agatgatagg tggtacatgc acagttgctc
     1321 tgggagtctt cagaatagaa actacccatc tcaagaggag ctcattaagg ttgttgatgt
     1381 ggaggagcaa cagctggaag agtctgggcc acacgatttg acggaaacat cttacttgcc
     1441 aaggcaagat ctagagggaa ccccttacct ggaatctgga atcagcctct tctctgatga
     1501 ccctgaatct gatccttctg aagacagagc cccagagtca gctcgtgttg gcaacatacc
     1561 atcttcaacc tctgcattga aagttcccca attgaaagtt gcagaatctg cccagagtcc
     1621 agctgctgct catactactg atactgctgg gtataatgca atggaagaaa gtgtgagcag
     1681 ggagaagcca gaattgacag cttcaacaga aagggtcaac aaaagaatgt ccatggtggt
     1741 gtctggcctg accccagaag aatttatgct cgtgtacaag tttgccagaa aacaccacat
     1801 cactttaact aatctaatta ctgaagagac tactcatgtt gttatgaaaa cagatgctga
     1861 gtttgtgtgt gaacggacac tgaaatattt tctaggaatt gcgggaggaa aatgggtagt
     1921 tagctatttc tgggtgaccc agtctattaa agaaagaaaa atgctgaatg agcatgattt
     1981 tgaagtcaga ggagatgtgg tcaatggaag aaaccaccaa ggtccaaagc gagcaagaga
     2041 atcccaggac agaaagatct tcagggggct agaaatctgt tgctatgggc ccttcaccaa
     2101 catgcccaca gatcaactgg aatggatggt acagctgtgt ggtgcttctg tggtgaagga
     2161 gctttcatca ttcacccttg gcacaggtgt ccacccaatt gtggttgtgc agccagatgc
     2221 ctggacagag gacaatggct tccatgcaat tgggcagatg tgtgaggcac ctgtggtgac
     2281 ccgagagtgg gtgttggaca gtgtagcact ctaccagtgc caggagctgg acacctacct
     2341 gataccccag atcccccaca gccactactg actgcagcca gccacaggta cagagccaca
     2401 ggaccccaag aatgagctta caaagtggcc tttccaggcc ctgggagctc ctctcactct
     2461 tcagtccttc tactgtcctg gctactaaat attttatgta catcagcctg aaaaggactt
     2521 ctggctatgc aagggtccct taaagatttt ctgcttgaag tctcccttgg aaatctgcca
     2581 tgagcacaaa attatggtaa tttttcacct gagaagattt taaaaccatt taaacgccac
     2641 caattgagca agatgctgat tcattattta tcagccctat tctttctatt caggctgttg
     2701 ttggcttagg gctggaagca cagagtggct tggcctcaag agaatagctg gtttccctaa
     2761 gtttacttct ctaaaaccct gtgttcacaa aggcagagag tcagaccctt caatggaagg
     2821 agagtgcttg ggatcgatta tgtgacttaa agtcagaata gtccttgggc agttctcaaa
     2881 tgttggagtg gaacattggg gaggaaattc tgaggcaggt attagaaatg aaaaggaaac
     2941 ttgaaacctg ggcatggtgg ctcacgcctg taatcccagc actttgggag gccaaggtgg
     3001 gcagatcact ggaggtcagg agttcgaaac cagcctggcc aacatggtga aaccccatct
     3061 ctactaaaaa tacagaaatt agccggtcat ggtggtggac acctgtaatc ccagctactc
     3121 aggtggctaa ggcaggagaa tcacttcagc ccgggaggtg gaggttgcag tgagccaaga
     3181 tcataccacg gcactccagc ctgggtgaca gtgagactgt ggctcaaaaa aaaaaaaaaa
     3241 aaaaggaaaa tgaaactaga agagatttct aaaagtctga gatatatttg ctagatttct
     3301 aaagaatgtg ttctaaaaca gcagaagatt ttcaagaacc ggtttccaaa gacagtcttc
     3361 taattcctca ttagtaataa gtaaaatgtt tattgttgta gctctggtat ataatccatt
     3421 cctcttaaaa tataagacct ctggcatgaa tatttcatat ctataaaatg acagatccca
     3481 ccaggaagga agctgttgct ttctttgagg tgattttttt cctttgctcc ctgttgctga
     3541 aaccatacag cttcataaat aattttgctt gctgaaggaa gaaaaagtgt ttttcataaa
     3601 cccattatcc aggactgttt atagctgttg gaaggactag gtcttcccta gcccccccag
     3661 tgtgcaaggg cagtgaagac ttgattgtac aaaatacgtt ttgtaaatgt tgtgctgtta
     3721 acactgcaaa taaacttggt agcaaacact tcca
//
