LOCUS       NM_001408455            3889 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens BRCA1 DNA repair associated (BRCA1), transcript
            variant 314, mRNA.
ACCESSION   NM_001408455
VERSION     NM_001408455.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3889)
  AUTHORS   Orban,T.I. and Olah,E.
  TITLE     Emerging roles of BRCA1 alternative splicing
  JOURNAL   Mol Pathol 56 (4), 191-197 (2003)
   PUBMED   12890739
  REMARK    Review article
REFERENCE   2  (bases 1 to 3889)
  AUTHORS   Orban,T.I. and Olah,E.
  TITLE     Expression profiles of BRCA1 splice variants in asynchronous and in
            G1/S synchronized tumor cell lines
  JOURNAL   Biochem Biophys Res Commun 280 (1), 32-38 (2001)
   PUBMED   11162473
REFERENCE   3  (bases 1 to 3889)
  AUTHORS   Paterson,J.W.
  TITLE     BRCA1: a review of structure and putative functions
  JOURNAL   Dis Markers 13 (4), 261-274 (1998)
   PUBMED   9553742
  REMARK    Review article
REFERENCE   4  (bases 1 to 3889)
  AUTHORS   Xu,C.F., Chambers,J.A., Nicolai,H., Brown,M.A., Hujeirat,Y.,
            Mohammed,S., Hodgson,S., Kelsell,D.P., Spurr,N.K., Bishop,D.T. and
            Solomon,E.
  TITLE     Mutations and alternative splicing of the BRCA1 gene in UK
            breast/ovarian cancer families
  JOURNAL   Genes Chromosomes Cancer 18 (2), 102-110 (1997)
   PUBMED   9115959
REFERENCE   5  (bases 1 to 3889)
  AUTHORS   Wilson,C.A., Payton,M.N., Elliott,G.S., Buaas,F.W., Cajulis,E.E.,
            Grosshans,D., Ramos,L., Reese,D.M., Slamon,D.J. and Calzone,F.J.
  TITLE     Differential subcellular localization, expression and biological
            toxicity of BRCA1 and the splice variant BRCA1-delta11b
  JOURNAL   Oncogene 14 (1), 1-16 (1997)
   PUBMED   9010228
REFERENCE   6  (bases 1 to 3889)
  AUTHORS   Thakur,S., Zhang,H.B., Peng,Y., Le,H., Carroll,B., Ward,T., Yao,J.,
            Farid,L.M., Couch,F.J., Wilson,R.B. and Weber,B.L.
  TITLE     Localization of BRCA1 and a splice variant identifies the nuclear
            localization signal
  JOURNAL   Mol Cell Biol 17 (1), 444-452 (1997)
   PUBMED   8972225
REFERENCE   7  (bases 1 to 3889)
  AUTHORS   Lu,M., Conzen,S.D., Cole,C.N. and Arrick,B.A.
  TITLE     Characterization of functional messenger RNA splice variants of
            BRCA1 expressed in nonmalignant and tumor-derived breast cells
  JOURNAL   Cancer Res 56 (20), 4578-4581 (1996)
   PUBMED   8840964
REFERENCE   8  (bases 1 to 3889)
  AUTHORS   Holt,J.T., Thompson,M.E., Szabo,C., Robinson-Benion,C.,
            Arteaga,C.L., King,M.C. and Jensen,R.A.
  TITLE     Growth retardation and tumour inhibition by BRCA1
  JOURNAL   Nat Genet 12 (3), 298-302 (1996)
   PUBMED   8589721
  REMARK    Erratum:[Nat Genet 1998 May;19(1):102]
REFERENCE   9  (bases 1 to 3889)
  AUTHORS   Xu,C.F., Brown,M.A., Chambers,J.A., Griffiths,B., Nicolai,H. and
            Solomon,E.
  TITLE     Distinct transcription start sites generate two forms of BRCA1 mRNA
  JOURNAL   Hum Mol Genet 4 (12), 2259-2264 (1995)
   PUBMED   8634696
REFERENCE   10 (bases 1 to 3889)
  AUTHORS   Miki,Y., Swensen,J., Shattuck-Eidens,D., Futreal,P.A., Harshman,K.,
            Tavtigian,S., Liu,Q., Cochran,C., Bennett,L.M., Ding,W. et al.
  TITLE     A strong candidate for the breast and ovarian cancer susceptibility
            gene BRCA1
  JOURNAL   Science 266 (5182), 66-71 (1994)
   PUBMED   7545954
REFERENCE   11 (bases 1 to 3889)
  AUTHORS   Mehta,P.A. and Ebens,C.
  TITLE     Fanconi Anemia
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301575
REFERENCE   12 (bases 1 to 3889)
  AUTHORS   Petrucelli,N., Daly,M.B. and Pal,T.
  TITLE     BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301425
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC135721.4.
            
            Summary: This gene encodes a 190 kD nuclear phosphoprotein that
            plays a role in maintaining genomic stability, and it also acts as
            a tumor suppressor. The BRCA1 gene contains 22 exons spanning about
            110 kb of DNA. The encoded protein combines with other tumor
            suppressors, DNA damage sensors, and signal transducers to form a
            large multi-subunit protein complex known as the BRCA1-associated
            genome surveillance complex (BASC). This gene product associates
            with RNA polymerase II, and through the C-terminal domain, also
            interacts with histone deacetylase complexes. This protein thus
            plays a role in transcription, DNA repair of double-stranded
            breaks, and recombination. Mutations in this gene are responsible
            for approximately 40% of inherited breast cancers and more than 80%
            of inherited breast and ovarian cancers. Alternative splicing plays
            a role in modulating the subcellular localization and physiological
            function of this gene. Many alternatively spliced transcript
            variants, some of which are disease-associated mutations, have been
            described for this gene, but the full-length natures of only some
            of these variants has been described. A related pseudogene, which
            is also located on chromosome 17, has been identified. [provided by
            RefSeq, May 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2604308.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                AC135721.4         34056-34143
            89-187              AC135721.4         35305-35403
            188-241             AC135721.4         43641-43694
            242-357             AC135721.4         48840-48955
            358-435             AC135721.4         52887-52964
            436-524             AC135721.4         54464-54552
            525-664             AC135721.4         55159-55298
            665-770             AC135721.4         59540-59645
            771-816             AC135721.4         62131-62176
            817-893             AC135721.4         63498-63574
            894-1010            AC135721.4         64560-64676
            1011-1099           AC135721.4         68388-68476
            1100-1271           AC135721.4         76845-77016
            1272-1398           AC135721.4         82806-82932
            1399-1589           AC135721.4         84899-85089
            1590-1900           AC135721.4         88182-88492
            1901-1988           AC135721.4         91725-91812
            1989-2066           AC135721.4         95469-95546
            2067-2107           AC135721.4         96047-96087
            2108-2191           AC135721.4         102285-102368
            2192-2246           AC135721.4         108303-108357
            2247-2320           AC135721.4         110226-110299
            2321-2381           AC135721.4         111717-111777
            2382-3889           AC135721.4         113618-115125
FEATURES             Location/Qualifiers
     source          1..3889
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..3889
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /note="BRCA1 DNA repair associated"
                     /db_xref="GeneID:672"
                     /db_xref="HGNC:HGNC:1100"
                     /db_xref="MIM:113705"
     exon            1..88
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            89..187
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            188..241
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            242..357
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            358..435
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     CDS             365..2506
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /EC_number="2.3.2.27"
                     /note="isoform 115 is encoded by transcript variant 314;
                     BRCA1/BRCA2-containing complex, subunit 1; RING finger
                     protein 53; breast cancer type 1 susceptibility protein;
                     breast and ovarian cancer susceptibility protein 1;
                     protein phosphatase 1, regulatory subunit 53; Fanconi
                     anemia, complementation group S; early onset breast cancer
                     1; breast cancer 1, early onset"
                     /codon_start=1
                     /product="breast cancer type 1 susceptibility protein
                     isoform 115"
                     /protein_id="NP_001395384.1"
                     /db_xref="GeneID:672"
                     /db_xref="HGNC:HGNC:1100"
                     /db_xref="MIM:113705"
                     /translation="MLKLLNQKKGPSQCPLCKNDITKRSLQESTRFSQLVEELLKIIC
                     AFQLDTGLEYANSYNFAKKENNSPEHLKDEVSIIQSMGYRNRAKRLLQSEPENPSLQE
                     TSLSVQLSNLGTVRTLRTKQRIQPQKTSVYIELGSDSSEDTVNKATYCSVGDQELLQI
                     TPQGTRDEISLDSAKKAACEFSETDVTNTEHHQPSNNDLNTTEKRAAERHPEKYQGEA
                     ASGCESETSVSEDCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPS
                     NSYPSIISDSSALEDLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSS
                     TSKNKEPGVERSSPSKCPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEES
                     GPHDLTETSYLPRQDLEGTPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSAL
                     KVPQLKVAESAQSPAAAHTTDTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLT
                     PEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSY
                     FWVTQSIKERKMLNEHDFEVRGDVVNGRNHQGPKRARESQDRKIFRGLEICCYGPFTN
                     MPTDQLEWMVQLCGASVVKELSSFTLGTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPV
                     VTREWVLDSVALYQCQELDTYLIPQIPHSHY"
     exon            436..524
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            525..664
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            665..770
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            771..816
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            817..893
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1010
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1099
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1271
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1398
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1589
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1900
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            1901..1988
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2066
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..2107
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2191
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2246
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2320
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2381
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..3889
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3864..3869
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /note="hexamer: AATAAA"
     polyA_site      3889
                     /gene="BRCA1"
                     /gene_synonym="BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4;
                     PPP1R53; PSCP; RNF53"
                     /note="major polyA site"
ORIGIN      
        1 gctgagactt cctggacggg ggacaggctg tggggtttct cagataactg ggcccctgcg
       61 ctcaggaggc cttcaccctc tgctctggtt cattggaaca gaaagaaatg gatttatctg
      121 ctcttcgcgt tgaagaagta caaaatgtca ttaatgctat gcagaaaatc ttagagtgtc
      181 ccatctgtct ggagttgatc aaggaacctg tctccacaaa gtgtgaccac atattttgca
      241 aggtcttact ctgttgtccc agctggagta cagtggtgcg atcatgaggc ttactgttgc
      301 cttgacctcc taggctcaag cgatcctatc acctcagtct cccaagtagc tgggactatt
      361 ttgcatgctg aaacttctca accagaagaa agggccttca cagtgtcctt tatgtaagaa
      421 tgatataacc aaaaggagcc tacaagaaag tacgagattt agtcaacttg ttgaagagct
      481 attgaaaatc atttgtgctt ttcagcttga cacaggtttg gagtatgcaa acagctataa
      541 ttttgcaaaa aaggaaaata actctcctga acatctaaaa gatgaagttt ctatcatcca
      601 aagtatgggc tacagaaacc gtgccaaaag acttctacag agtgaacccg aaaatccttc
      661 cttgcaggaa accagtctca gtgtccaact ctctaacctt ggaactgtga gaactctgag
      721 gacaaagcag cggatacaac ctcaaaagac gtctgtctac attgaattgg gatctgattc
      781 ttctgaagat accgttaata aggcaactta ttgcagtgtg ggagatcaag aattgttaca
      841 aatcacccct caaggaacca gggatgaaat cagtttggat tctgcaaaaa aggctgcttg
      901 tgaattttct gagacggatg taacaaatac tgaacatcat caacccagta ataatgattt
      961 gaacaccact gagaagcgtg cagctgagag gcatccagaa aagtatcagg gtgaagcagc
     1021 atctgggtgt gagagtgaaa caagcgtctc tgaagactgc tcagggctat cctctcagag
     1081 tgacatttta accactcagc agagggatac catgcaacat aacctgataa agctccagca
     1141 ggaaatggct gaactagaag ctgtgttaga acagcatggg agccagcctt ctaacagcta
     1201 cccttccatc ataagtgact cttctgccct tgaggacctg cgaaatccag aacaaagcac
     1261 atcagaaaaa gcagtattaa cttcacagaa aagtagtgaa taccctataa gccagaatcc
     1321 agaaggcctt tctgctgaca agtttgaggt gtctgcagat agttctacca gtaaaaataa
     1381 agaaccagga gtggaaaggt catccccttc taaatgccca tcattagatg ataggtggta
     1441 catgcacagt tgctctggga gtcttcagaa tagaaactac ccatctcaag aggagctcat
     1501 taaggttgtt gatgtggagg agcaacagct ggaagagtct gggccacacg atttgacgga
     1561 aacatcttac ttgccaaggc aagatctaga gggaacccct tacctggaat ctggaatcag
     1621 cctcttctct gatgaccctg aatctgatcc ttctgaagac agagccccag agtcagctcg
     1681 tgttggcaac ataccatctt caacctctgc attgaaagtt ccccaattga aagttgcaga
     1741 atctgcccag agtccagctg ctgctcatac tactgatact gctgggtata atgcaatgga
     1801 agaaagtgtg agcagggaga agccagaatt gacagcttca acagaaaggg tcaacaaaag
     1861 aatgtccatg gtggtgtctg gcctgacccc agaagaattt atgctcgtgt acaagtttgc
     1921 cagaaaacac cacatcactt taactaatct aattactgaa gagactactc atgttgttat
     1981 gaaaacagat gctgagtttg tgtgtgaacg gacactgaaa tattttctag gaattgcggg
     2041 aggaaaatgg gtagttagct atttctgggt gacccagtct attaaagaaa gaaaaatgct
     2101 gaatgagcat gattttgaag tcagaggaga tgtggtcaat ggaagaaacc accaaggtcc
     2161 aaagcgagca agagaatccc aggacagaaa gatcttcagg gggctagaaa tctgttgcta
     2221 tgggcccttc accaacatgc ccacagatca actggaatgg atggtacagc tgtgtggtgc
     2281 ttctgtggtg aaggagcttt catcattcac ccttggcaca ggtgtccacc caattgtggt
     2341 tgtgcagcca gatgcctgga cagaggacaa tggcttccat gcaattgggc agatgtgtga
     2401 ggcacctgtg gtgacccgag agtgggtgtt ggacagtgta gcactctacc agtgccagga
     2461 gctggacacc tacctgatac cccagatccc ccacagccac tactgactgc agccagccac
     2521 aggtacagag ccacaggacc ccaagaatga gcttacaaag tggcctttcc aggccctggg
     2581 agctcctctc actcttcagt ccttctactg tcctggctac taaatatttt atgtacatca
     2641 gcctgaaaag gacttctggc tatgcaaggg tcccttaaag attttctgct tgaagtctcc
     2701 cttggaaatc tgccatgagc acaaaattat ggtaattttt cacctgagaa gattttaaaa
     2761 ccatttaaac gccaccaatt gagcaagatg ctgattcatt atttatcagc cctattcttt
     2821 ctattcaggc tgttgttggc ttagggctgg aagcacagag tggcttggcc tcaagagaat
     2881 agctggtttc cctaagttta cttctctaaa accctgtgtt cacaaaggca gagagtcaga
     2941 cccttcaatg gaaggagagt gcttgggatc gattatgtga cttaaagtca gaatagtcct
     3001 tgggcagttc tcaaatgttg gagtggaaca ttggggagga aattctgagg caggtattag
     3061 aaatgaaaag gaaacttgaa acctgggcat ggtggctcac gcctgtaatc ccagcacttt
     3121 gggaggccaa ggtgggcaga tcactggagg tcaggagttc gaaaccagcc tggccaacat
     3181 ggtgaaaccc catctctact aaaaatacag aaattagccg gtcatggtgg tggacacctg
     3241 taatcccagc tactcaggtg gctaaggcag gagaatcact tcagcccggg aggtggaggt
     3301 tgcagtgagc caagatcata ccacggcact ccagcctggg tgacagtgag actgtggctc
     3361 aaaaaaaaaa aaaaaaaaag gaaaatgaaa ctagaagaga tttctaaaag tctgagatat
     3421 atttgctaga tttctaaaga atgtgttcta aaacagcaga agattttcaa gaaccggttt
     3481 ccaaagacag tcttctaatt cctcattagt aataagtaaa atgtttattg ttgtagctct
     3541 ggtatataat ccattcctct taaaatataa gacctctggc atgaatattt catatctata
     3601 aaatgacaga tcccaccagg aaggaagctg ttgctttctt tgaggtgatt tttttccttt
     3661 gctccctgtt gctgaaacca tacagcttca taaataattt tgcttgctga aggaagaaaa
     3721 agtgtttttc ataaacccat tatccaggac tgtttatagc tgttggaagg actaggtctt
     3781 ccctagcccc cccagtgtgc aagggcagtg aagacttgat tgtacaaaat acgttttgta
     3841 aatgttgtgc tgttaacact gcaaataaac ttggtagcaa acacttcca
//
