LOCUS       NM_006768               3996 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens BRCA1 associated protein (BRAP), mRNA.
ACCESSION   NM_006768
VERSION     NM_006768.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3996)
  AUTHORS   Barnett,S.E., Kenyani,J., Tripari,M., Butt,Z., Grosman,R.,
            Querques,F., Shaw,L., Silva,L.C., Goate,Z., Marciniak,S.J.,
            Rassl,D.M., Jackson,R., Lian,L.Y., Szlosarek,P.W., Sacco,J.J. and
            Coulson,J.M.
  TITLE     BAP1 Loss Is Associated with Higher ASS1 Expression in Epithelioid
            Mesothelioma: Implications for Therapeutic Stratification
  JOURNAL   Mol Cancer Res 21 (5), 411-427 (2023)
   PUBMED   36669126
  REMARK    GeneRIF: BAP1 Loss Is Associated with Higher ASS1 Expression in
            Epithelioid Mesothelioma: Implications for Therapeutic
            Stratification.
REFERENCE   2  (bases 1 to 3996)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3996)
  AUTHORS   Chen,I.C., Kuo,P.H., Yang,A.C., Tsai,S.J., Liu,T.H., Liu,H.J.,
            Lan,T.H., Chen,H.M., Huang,H.N., Chung,R.H. and Liu,Y.L.
  TITLE     CUX2, BRAP and ALDH2 are associated with metabolic traits in people
            with excessive alcohol consumption
  JOURNAL   Sci Rep 10 (1), 18118 (2020)
   PUBMED   33093602
  REMARK    GeneRIF: CUX2, BRAP and ALDH2 are associated with metabolic traits
            in people with excessive alcohol consumption.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3996)
  AUTHORS   Shimizu,Y., Arima,K., Noguchi,Y., Kawashiri,S.Y., Yamanashi,H.,
            Tamai,M., Nagata,Y. and Maeda,T.
  TITLE     Potential mechanisms underlying the association between single
            nucleotide polymorphism (BRAP and ALDH2) and hypertension among
            elderly Japanese population
  JOURNAL   Sci Rep 10 (1), 14148 (2020)
   PUBMED   32843694
  REMARK    GeneRIF: Potential mechanisms underlying the association between
            single nucleotide polymorphism (BRAP and ALDH2) and hypertension
            among elderly Japanese population.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3996)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3996)
  AUTHORS   Asada,M., Ohmi,K., Delia,D., Enosawa,S., Suzuki,S., Yuo,A.,
            Suzuki,H. and Mizutani,S.
  TITLE     Brap2 functions as a cytoplasmic retention protein for p21 during
            monocyte differentiation
  JOURNAL   Mol Cell Biol 24 (18), 8236-8243 (2004)
   PUBMED   15340083
  REMARK    GeneRIF: Monocytic differentiation of the promyelomonocytic cell
            lines U937 and HL60 is associated with the upregulation of Brap2
            expression concomitantly with the upregulation and cytoplasmic
            relocalization of p21.
REFERENCE   7  (bases 1 to 3996)
  AUTHORS   Matheny,S.A., Chen,C., Kortum,R.L., Razidlo,G.L., Lewis,R.E. and
            White,M.A.
  TITLE     Ras regulates assembly of mitogenic signalling complexes through
            the effector protein IMP
  JOURNAL   Nature 427 (6971), 256-260 (2004)
   PUBMED   14724641
  REMARK    GeneRIF: modulates sensitivity of the MAP kinase cascade to
            stimulus-dependent activation by limiting functional assembly of
            the core enzymatic components through the inactivation of KSR
REFERENCE   8  (bases 1 to 3996)
  AUTHORS   Liu,W., Nichols,A.F., Graham,J.A., Dualan,R., Abbas,A. and Linn,S.
  TITLE     Nuclear transport of human DDB protein induced by ultraviolet light
  JOURNAL   J Biol Chem 275 (28), 21429-21434 (2000)
   PUBMED   10777491
REFERENCE   9  (bases 1 to 3996)
  AUTHORS   Scanlan,M.J., Gordan,J.D., Williamson,B., Stockert,E., Bander,N.H.,
            Jongeneel,V., Gure,A.O., Jager,D., Jager,E., Knuth,A., Chen,Y.T.
            and Old,L.J.
  TITLE     Antigens recognized by autologous antibody in patients with
            renal-cell carcinoma
  JOURNAL   Int J Cancer 83 (4), 456-464 (1999)
   PUBMED   10508479
REFERENCE   10 (bases 1 to 3996)
  AUTHORS   Li,S., Ku,C.Y., Farmer,A.A., Cong,Y.S., Chen,C.F. and Lee,W.H.
  TITLE     Identification of a novel cytoplasmic protein that specifically
            binds to nuclear localization signal motifs
  JOURNAL   J Biol Chem 273 (11), 6183-6189 (1998)
   PUBMED   9497340
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB460078.1, AB208878.1,
            AC137055.12 and BU674276.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006768.4.
            
            Summary: The protein encoded by this gene was identified by its
            ability to bind to the nuclear localization signal of BRCA1 and
            other proteins. It is a cytoplasmic protein which may regulate
            nuclear targeting by retaining proteins with a nuclear localization
            signal in the cytoplasm. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.178604.1,
                                           SRR1803617.174755.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000419234.9/ ENSP00000403524.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 DB460078.1         45-49
            6-2448              AB208878.1         1-2443
            2449-3337           AC137055.12        34916-35804
            3338-3996           BU674276.1         18-676              c
FEATURES             Location/Qualifiers
     source          1..3996
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.12"
     gene            1..3996
                     /gene="BRAP"
                     /gene_synonym="BRAP2; IMP; RNF52"
                     /note="BRCA1 associated protein"
                     /db_xref="GeneID:8315"
                     /db_xref="HGNC:HGNC:1099"
                     /db_xref="MIM:604986"
     exon            1..246
                     /gene="BRAP"
                     /gene_synonym="BRAP2; IMP; RNF52"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1943
                     /gene="BRAP"
                     /gene_synonym="BRAP2; IMP; RNF52"
                     /EC_number="2.3.2.27"
                     /note="galectin-2-binding protein; impedes mitogenic
                     signal propagation; RING finger protein 52; renal
                     carcinoma antigen NY-REN-63; RING-type E3 ubiquitin
                     transferase BRAP2"
                     /codon_start=1
                     /product="BRCA1-associated protein"
                     /protein_id="NP_006759.3"
                     /db_xref="CCDS:CCDS9154.1"
                     /db_xref="GeneID:8315"
                     /db_xref="HGNC:HGNC:1099"
                     /db_xref="MIM:604986"
                     /translation="MSVSLVVIRLELAEHSPVPAGFGFSAAAGEMSDEEIKKTTLASA
                     VACLEGKSPGEKVAIIHQHLGRREMTDVIIETMKSNPDELKTTVEERKSSEASPTAQR
                     SKDHSKECINAAPDSPSKQLPDQISFFSGNPSVEIVHGIMHLYKTNKMTSLKEDVRRS
                     AMLCILTVPAAMTSHDLMKFVAPFNEVIEQMKIIRDSTPNQYMVLIKFRAQADADSFY
                     MTCNGRQFNSIEDDVCQLVYVERAEVLKSEDGASLPVMDLTELPKCTVCLERMDESVN
                     GILTTLCNHSFHSQCLQRWDDTTCPVCRYCQTPEPVEENKCFECGVQENLWICLICGH
                     IGCGRYVSRHAYKHFEETQHTYAMQLTNHRVWDYAGDNYVHRLVASKTDGKIVQYECE
                     GDTCQEEKIDALQLEYSYLLTSQLESQRIYWENKIVRIEKDTAEEINNMKTKFKETIE
                     KCDNLEHKLNDLLKEKQSVERKCTQLNTKVAKLTNELKEEQEMNKCLRANQVLLQNKL
                     KEEERVLKETCDQKDLQITEIQEQLRDVMFYLETQQKINHLPAETRQEIQEGQINIAM
                     ASASSPASSGGSGKLPSRKGRSKRGK"
     exon            247..408
                     /gene="BRAP"
                     /gene_synonym="BRAP2; IMP; RNF52"
                     /inference="alignment:Splign:2.1.0"
     exon            409..607
                     /gene="BRAP"
                     /gene_synonym="BRAP2; IMP; RNF52"
                     /inference="alignment:Splign:2.1.0"
     exon            608..797
                     /gene="BRAP"
                     /gene_synonym="BRAP2; IMP; RNF52"
                     /inference="alignment:Splign:2.1.0"
     exon            798..911
                     /gene="BRAP"
                     /gene_synonym="BRAP2; IMP; RNF52"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1060
                     /gene="BRAP"
                     /gene_synonym="BRAP2; IMP; RNF52"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1136
                     /gene="BRAP"
                     /gene_synonym="BRAP2; IMP; RNF52"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1275
                     /gene="BRAP"
                     /gene_synonym="BRAP2; IMP; RNF52"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1385
                     /gene="BRAP"
                     /gene_synonym="BRAP2; IMP; RNF52"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1475
                     /gene="BRAP"
                     /gene_synonym="BRAP2; IMP; RNF52"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1579
                     /gene="BRAP"
                     /gene_synonym="BRAP2; IMP; RNF52"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..3996
                     /gene="BRAP"
                     /gene_synonym="BRAP2; IMP; RNF52"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2033..2038
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRAP"
                     /gene_synonym="BRAP2; IMP; RNF52"
                     /note="hexamer: AATAAG"
     polyA_site      2054
                     /gene="BRAP"
                     /gene_synonym="BRAP2; IMP; RNF52"
                     /note="major polyA site"
     regulatory      3971..3976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BRAP"
                     /gene_synonym="BRAP2; IMP; RNF52"
                     /note="hexamer: ATTAAA"
     polyA_site      3996
                     /gene="BRAP"
                     /gene_synonym="BRAP2; IMP; RNF52"
                     /note="major polyA site"
ORIGIN      
        1 gttgttgtgg ctccgagggc tgttcgagga gctgctgctg ctgaggcggc ggcaactgca
       61 ttgaggtggt ggcggcgctg ccggccccgg gccgctcggc ctctcggctc gccttccagc
      121 ctcgcctgag cccgccgggg cccgcgccgg ccagcgcctg ccctatgagt gtgtcactgg
      181 ttgttatccg attggagctc gcggaacact cgcctgtccc cgccggcttc ggcttcagcg
      241 ccgcggccgg ggaaatgtct gatgaggaga taaaaaagac gacactagcc tcagctgtag
      301 cctgtttaga aggcaagtca ccaggagaga aagtagcgat tatccatcag catctcggcc
      361 gtcgagaaat gacagatgtg atcattgaga ccatgaagtc caacccagat gaactaaaaa
      421 ctacagtgga agaaaggaag tcttcagaag cctcccccac tgcgcaaaga agtaaagatc
      481 acagtaagga atgcataaac gctgccccag attctccgtc caaacagctt ccagaccaga
      541 tttcattctt cagtggaaat ccatcagttg aaatagttca tggtattatg cacctatata
      601 agacaaataa gatgacctcc ttaaaagaag atgtgcggcg cagtgccatg ctgtgtattc
      661 tcacagtccc tgctgcaatg accagtcatg accttatgaa gtttgttgcc ccatttaacg
      721 aagtaattga acaaatgaaa attatcagag actctactcc caaccaatat atggtgctga
      781 taaagtttcg tgcacaggct gatgcggata gtttttatat gacatgcaat ggccgccagt
      841 tcaactcaat agaagatgac gtttgccagc tagtgtatgt ggaaagagct gaagtgctca
      901 aatctgaaga tggcgccagc ctcccagtga tggacctgac tgaactcccc aagtgcacgg
      961 tgtgtctgga gcgcatggac gagtctgtga atggcatcct cacaacgtta tgtaaccaca
     1021 gcttccacag ccagtgtcta cagcgctggg acgataccac gtgtcctgtt tgccggtact
     1081 gtcaaacgcc cgagccagta gaagaaaata agtgttttga gtgtggtgtt caggaaaatc
     1141 tttggatttg tttaatatgc ggccacatag gatgtggacg gtatgtcagt cgacatgctt
     1201 ataagcactt tgaggaaacg cagcacacgt atgccatgca gcttaccaac catcgagtct
     1261 gggactatgc tggagataac tatgttcatc gactggttgc aagtaaaaca gatggaaaaa
     1321 tagtacagta tgaatgtgag ggggatactt gccaggaaga gaaaatagat gccttacagt
     1381 tagagtattc atatttacta acaagccagc tggaatctca gcgaatctac tgggaaaaca
     1441 agatagttcg gatagagaag gacacagcag aggaaattaa caacatgaag accaagttta
     1501 aagaaacaat tgagaagtgt gataatctag agcacaaact aaatgatctc ctaaaagaaa
     1561 agcagtctgt ggaaagaaag tgcactcagc taaacacaaa agtggccaaa ctcaccaacg
     1621 agctcaaaga ggagcaggaa atgaacaagt gtttgcgagc caaccaagtc ctcctgcaga
     1681 acaagctaaa agaggaggag agggtgctga aggagacctg tgaccaaaaa gatctgcaga
     1741 tcaccgagat ccaggagcag ctgcgtgacg tcatgttcta cctggagaca cagcagaaga
     1801 tcaaccatct gcctgccgag acccggcagg aaatccagga gggacagatc aacatcgcca
     1861 tggcctcggc ctcgagccct gcctcttcgg ggggcagtgg gaagttgccc tccaggaagg
     1921 gccgcagcaa gaggggcaag tgaccttcag agcaacagac atccctgaga ctgttctccc
     1981 tgacactgtg agagtgtgct gggaccttca gctaaatgtg agggtgggcc ctaataagta
     2041 caagtgagga tcaagccaca gttgtttggc tctttcattt gctagtgtgt gatgtagtga
     2101 atgtaaaggg tgctgactgg agagctgata gaaaggcgct gcgttcgaaa aggtcttaag
     2161 agttcactaa cctcacattc taatgaccat tttgccttcc tgcttggtag aagccccaac
     2221 tctgctgtgc atttttccat tgtatttatg gagttggcgt atttgacatt cagttctggg
     2281 gtaggtttaa gatgttaagt tatttcttgt aacctcaaag gtaaggttat ctagcactaa
     2341 agcaccaaac ctctctgagg gcataacagc tgctttaaag agaggtttcc attggctatt
     2401 aaggagttat gaaaactccc tagcaatagt gtcatatcat tatcatctcc cccttcctct
     2461 ggggagtgga agaattgctt gaatgttatc tgaaaagagg cctggtagta aaccaggccc
     2521 tggctcttta ccagcagtca tctcttcttg ctctggggcc agccaggaaa aacaaacaac
     2581 ccggggcaca ttgggtagac tcagtgtagg aaaaatggtg gcagctccac tgtttatttt
     2641 tggtgacttc gtacatcatt atgaaccgca attaaggagg aggcttaatg gctgttccca
     2701 aactcaaatc tcagagtggg tatcctagca tctagcaaga ctgagtgggg agatttctca
     2761 tccgtgtgaa aatgtagagt gaggcctctg actagctaat tgtgtatttt gttgggttta
     2821 gtattttcta aatgtttaca aaatattggg ctgcatgttc aggttgcagc tagagggagc
     2881 ttgggcagat tttcaattac gctttcaaga tataaccaaa agctgtttct aaatcctaaa
     2941 attagaattt caacagagcc ccctttagaa cagtcatata acgcttgtgt gggccaacag
     3001 aggggctgtg tactctctct ggaaccataa atgtcaaata atttataacc tgcagtaatt
     3061 gagcaaactt aaaataagac ctgtgttgga atttagtttc ttgaagaggt agagggatag
     3121 gttagtaaga tgtattgtta aacaacaggt tttagttttt gctttataat tagccacagg
     3181 ttttcaaatg atcacatttc agaataggtt tttagcctgt aattaggcct catccccttt
     3241 gacctaaatg tcttacatgt tacttgttag cacatcaact gtatcactaa tcaccatctg
     3301 tttttgtggg atgtgctgca gcatttccca aaaaacttta cgtgtaatgt tgcaaaatga
     3361 atgtactcag acattcttaa tttttactta gggcagacca actctttgag tctctcttgg
     3421 acttatatat acagatatct taagagtggg aatgtaaagc ataacctaat tctctttcct
     3481 atagagattc tattttattt aaaatctatt tttacactag ttagaatcct gctgttttgg
     3541 ccaagtactt gtcttgcatg tctgaccttg cagaagctgg ggtggatcat agcatactaa
     3601 tgaagagaat tagaagtagt ttacaaagct cgctcactcc tcatttctct gtgatccctt
     3661 ctatccagtg gccccaccac cacctgggaa aacagatttt tcagtacagg tgggataaat
     3721 gctctgaaag gctgtgccca gaggaatgag caaataggca agtgtttcca aactacttgg
     3781 aggtttacaa aaaatatgtc ccagaaaaaa aaaaaatctt accaagatac gtaaagaaaa
     3841 aaaaattttt ttttaaacag tcaaagagtc atgtttgaat ttcacaaaat cacatcagac
     3901 agaagttgtt ttcttcagga gggaaatgaa ccacttaata tacccatact accttgaaca
     3961 atgaaattga attaaaatag ccaaactttg aaatta
//
