LOCUS       NP_006759                592 aa            linear   PRI 28-APR-2025
DEFINITION  BRCA1-associated protein [Homo sapiens].
ACCESSION   NP_006759
VERSION     NP_006759.3
DBSOURCE    REFSEQ: accession NM_006768.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 592)
  AUTHORS   Barnett,S.E., Kenyani,J., Tripari,M., Butt,Z., Grosman,R.,
            Querques,F., Shaw,L., Silva,L.C., Goate,Z., Marciniak,S.J.,
            Rassl,D.M., Jackson,R., Lian,L.Y., Szlosarek,P.W., Sacco,J.J. and
            Coulson,J.M.
  TITLE     BAP1 Loss Is Associated with Higher ASS1 Expression in Epithelioid
            Mesothelioma: Implications for Therapeutic Stratification
  JOURNAL   Mol Cancer Res 21 (5), 411-427 (2023)
   PUBMED   36669126
  REMARK    GeneRIF: BAP1 Loss Is Associated with Higher ASS1 Expression in
            Epithelioid Mesothelioma: Implications for Therapeutic
            Stratification.
REFERENCE   2  (residues 1 to 592)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (residues 1 to 592)
  AUTHORS   Chen,I.C., Kuo,P.H., Yang,A.C., Tsai,S.J., Liu,T.H., Liu,H.J.,
            Lan,T.H., Chen,H.M., Huang,H.N., Chung,R.H. and Liu,Y.L.
  TITLE     CUX2, BRAP and ALDH2 are associated with metabolic traits in people
            with excessive alcohol consumption
  JOURNAL   Sci Rep 10 (1), 18118 (2020)
   PUBMED   33093602
  REMARK    GeneRIF: CUX2, BRAP and ALDH2 are associated with metabolic traits
            in people with excessive alcohol consumption.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 592)
  AUTHORS   Shimizu,Y., Arima,K., Noguchi,Y., Kawashiri,S.Y., Yamanashi,H.,
            Tamai,M., Nagata,Y. and Maeda,T.
  TITLE     Potential mechanisms underlying the association between single
            nucleotide polymorphism (BRAP and ALDH2) and hypertension among
            elderly Japanese population
  JOURNAL   Sci Rep 10 (1), 14148 (2020)
   PUBMED   32843694
  REMARK    GeneRIF: Potential mechanisms underlying the association between
            single nucleotide polymorphism (BRAP and ALDH2) and hypertension
            among elderly Japanese population.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 592)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (residues 1 to 592)
  AUTHORS   Asada,M., Ohmi,K., Delia,D., Enosawa,S., Suzuki,S., Yuo,A.,
            Suzuki,H. and Mizutani,S.
  TITLE     Brap2 functions as a cytoplasmic retention protein for p21 during
            monocyte differentiation
  JOURNAL   Mol Cell Biol 24 (18), 8236-8243 (2004)
   PUBMED   15340083
  REMARK    GeneRIF: Monocytic differentiation of the promyelomonocytic cell
            lines U937 and HL60 is associated with the upregulation of Brap2
            expression concomitantly with the upregulation and cytoplasmic
            relocalization of p21.
REFERENCE   7  (residues 1 to 592)
  AUTHORS   Matheny,S.A., Chen,C., Kortum,R.L., Razidlo,G.L., Lewis,R.E. and
            White,M.A.
  TITLE     Ras regulates assembly of mitogenic signalling complexes through
            the effector protein IMP
  JOURNAL   Nature 427 (6971), 256-260 (2004)
   PUBMED   14724641
  REMARK    GeneRIF: modulates sensitivity of the MAP kinase cascade to
            stimulus-dependent activation by limiting functional assembly of
            the core enzymatic components through the inactivation of KSR
REFERENCE   8  (residues 1 to 592)
  AUTHORS   Liu,W., Nichols,A.F., Graham,J.A., Dualan,R., Abbas,A. and Linn,S.
  TITLE     Nuclear transport of human DDB protein induced by ultraviolet light
  JOURNAL   J Biol Chem 275 (28), 21429-21434 (2000)
   PUBMED   10777491
REFERENCE   9  (residues 1 to 592)
  AUTHORS   Scanlan,M.J., Gordan,J.D., Williamson,B., Stockert,E., Bander,N.H.,
            Jongeneel,V., Gure,A.O., Jager,D., Jager,E., Knuth,A., Chen,Y.T.
            and Old,L.J.
  TITLE     Antigens recognized by autologous antibody in patients with
            renal-cell carcinoma
  JOURNAL   Int J Cancer 83 (4), 456-464 (1999)
   PUBMED   10508479
REFERENCE   10 (residues 1 to 592)
  AUTHORS   Li,S., Ku,C.Y., Farmer,A.A., Cong,Y.S., Chen,C.F. and Lee,W.H.
  TITLE     Identification of a novel cytoplasmic protein that specifically
            binds to nuclear localization signal motifs
  JOURNAL   J Biol Chem 273 (11), 6183-6189 (1998)
   PUBMED   9497340
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB460078.1, AB208878.1,
            AC137055.12 and BU674276.1.
            
            On May 16, 2008 this sequence version replaced NP_006759.2.
            
            Summary: The protein encoded by this gene was identified by its
            ability to bind to the nuclear localization signal of BRCA1 and
            other proteins. It is a cytoplasmic protein which may regulate
            nuclear targeting by retaining proteins with a nuclear localization
            signal in the cytoplasm. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.178604.1,
                                           SRR1803617.174755.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000419234.9/ ENSP00000403524.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..592
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.12"
     Protein         1..592
                     /product="BRCA1-associated protein"
                     /EC_number="2.3.2.27"
                     /note="galectin-2-binding protein; impedes mitogenic
                     signal propagation; RING finger protein 52; renal
                     carcinoma antigen NY-REN-63; RING-type E3 ubiquitin
                     transferase BRAP2"
                     /calculated_mol_wt=67174
     Site            52
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q7Z569.2)"
     Region          78..124
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7Z569.2)"
     Site            97
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q7Z569.2)"
     Site            117
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q7Z569.2)"
     Site            119
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21406692; propagated from
                     UniProtKB/Swiss-Prot (Q7Z569.2)"
     Region          160..243
                     /region_name="RRM_BRAP2"
                     /note="RNA recognition motif (RRM) found in
                     BRCA1-associated protein (BRAP2); cd12718"
                     /db_xref="CDD:410117"
     Region          262..305
                     /region_name="RING-H2_BRAP2"
                     /note="RING finger, H2 subclass, found in BRCA1-associated
                     protein (BRAP2) and similar proteins; cd16457"
                     /db_xref="CDD:438121"
     Region          317..379
                     /region_name="zf-UBP"
                     /note="Zn-finger in ubiquitin-hydrolases and other
                     protein; pfam02148"
                     /db_xref="CDD:460464"
     Region          <397..557
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          565..592
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7Z569.2)"
     CDS             1..592
                     /gene="BRAP"
                     /gene_synonym="BRAP2; IMP; RNF52"
                     /coded_by="NM_006768.5:165..1943"
                     /db_xref="CCDS:CCDS9154.1"
                     /db_xref="GeneID:8315"
                     /db_xref="HGNC:HGNC:1099"
                     /db_xref="MIM:604986"
ORIGIN      
        1 msvslvvirl elaehspvpa gfgfsaaage msdeeikktt lasavacleg kspgekvaii
       61 hqhlgrremt dviietmksn pdelkttvee rksseaspta qrskdhskec inaapdspsk
      121 qlpdqisffs gnpsveivhg imhlyktnkm tslkedvrrs amlciltvpa amtshdlmkf
      181 vapfnevieq mkiirdstpn qymvlikfra qadadsfymt cngrqfnsie ddvcqlvyve
      241 raevlksedg aslpvmdlte lpkctvcler mdesvngilt tlcnhsfhsq clqrwddttc
      301 pvcrycqtpe pveenkcfec gvqenlwicl icghigcgry vsrhaykhfe etqhtyamql
      361 tnhrvwdyag dnyvhrlvas ktdgkivqye cegdtcqeek idalqleysy lltsqlesqr
      421 iywenkivri ekdtaeeinn mktkfketie kcdnlehkln dllkekqsve rkctqlntkv
      481 akltnelkee qemnkclran qvllqnklke eervlketcd qkdlqiteiq eqlrdvmfyl
      541 etqqkinhlp aetrqeiqeg qiniamasas spassggsgk lpsrkgrskr gk
//
