LOCUS       NM_182641              11075 bp    mRNA    linear   PRI 09-JUL-2024
DEFINITION  Homo sapiens bromodomain PHD finger transcription factor (BPTF),
            transcript variant 1, mRNA.
ACCESSION   NM_182641
VERSION     NM_182641.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11075)
  AUTHORS   Noura,M., Tomita,S., Yasuda,T., Tsuzuki,S., Kiyoi,H. and
            Hayakawa,F.
  TITLE     NUP98-BPTF promotes oncogenic transformation through PIM1
            upregulation
  JOURNAL   Cancer Med 13 (13), e7445 (2024)
   PUBMED   38940430
  REMARK    GeneRIF: NUP98-BPTF promotes oncogenic transformation through PIM1
            upregulation.
REFERENCE   2  (bases 1 to 11075)
  AUTHORS   Yogev,Y., Schaffer,M., Shlapobersky,M., Jean,M.M., Wormser,O.,
            Drabkin,M., Halperin,D., Kassem,R., Livoff,A., Tsitrina,A.A.,
            Asna,N. and Birk,O.S.
  TITLE     A role of BPTF in viral oncogenicity delineated through studies of
            heritable Kaposi sarcoma
  JOURNAL   J Med Virol 96 (2), e29436 (2024)
   PUBMED   38380509
  REMARK    GeneRIF: A role of BPTF in viral oncogenicity delineated through
            studies of heritable Kaposi sarcoma.
REFERENCE   3  (bases 1 to 11075)
  AUTHORS   Gao,S., Zhang,W., Ma,J. and Ni,X.
  TITLE     PHF6 recruits BPTF to promote HIF-dependent pathway and progression
            in YAP-high breast cancer
  JOURNAL   J Transl Med 21 (1), 220 (2023)
   PUBMED   36967443
  REMARK    GeneRIF: PHF6 recruits BPTF to promote HIF-dependent pathway and
            progression in YAP-high breast cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11075)
  AUTHORS   Wu,W. and Chen,R.
  TITLE     The effect of growth hormone treatment in children with novel BPTF
            gene variants: A report of two cases and literature review
  JOURNAL   Mol Genet Genomic Med 11 (1), e2066 (2023)
   PUBMED   36153657
  REMARK    GeneRIF: The effect of growth hormone treatment in children with
            novel BPTF gene variants: A report of two cases and literature
            review.
            Review article
REFERENCE   5  (bases 1 to 11075)
  AUTHORS   Dai,M., Hua,C., Wang,M., Gao,L., Jiang,L. and Liu,Y.
  TITLE     Targeting regulation of VEGF by BPTF in non-small cell lung cancer
            and its potential clinical significance
  JOURNAL   Eur J Med Res 27 (1), 299 (2022)
   PUBMED   36529788
  REMARK    GeneRIF: Targeting regulation of VEGF by BPTF in non-small cell
            lung cancer and its potential clinical significance.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11075)
  AUTHORS   Jordan-Sciutto,K.L., Dragich,J.M. and Bowser,R.
  TITLE     DNA binding activity of the fetal Alz-50 clone 1 (FAC1) protein is
            enhanced by phosphorylation
  JOURNAL   Biochem Biophys Res Commun 260 (3), 785-789 (1999)
   PUBMED   10403843
REFERENCE   7  (bases 1 to 11075)
  AUTHORS   Mu,X., Springer,J.E. and Bowser,R.
  TITLE     FAC1 expression and localization in motor neurons of developing,
            adult, and amyotrophic lateral sclerosis spinal cord
  JOURNAL   Exp Neurol 146 (1), 17-24 (1997)
   PUBMED   9225734
REFERENCE   8  (bases 1 to 11075)
  AUTHORS   Bowser,R.
  TITLE     Assignment of the human FAC1 gene to chromosome 17q24 by
            fluorescence in situ hybridization
  JOURNAL   Genomics 38 (3), 455-457 (1996)
   PUBMED   8975731
REFERENCE   9  (bases 1 to 11075)
  AUTHORS   Zhu,P. and Bowser,R.
  TITLE     Identification and analysis of the complete cDNA sequence for the
            human FAC1 gene
  JOURNAL   Biochim Biophys Acta 1309 (1-2), 5-8 (1996)
   PUBMED   8950167
REFERENCE   10 (bases 1 to 11075)
  AUTHORS   Bowser,R., Giambrone,A. and Davies,P.
  TITLE     FAC1, a novel gene identified with the monoclonal antibody Alz50,
            is developmentally regulated in human brain
  JOURNAL   Dev Neurosci 17 (1), 20-37 (1995)
   PUBMED   7621746
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006534.10, BC037422.1,
            AY282495.1, AB032251.1, AK025776.1, AK022570.1, CV809604.1 and
            AC134407.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_182641.3.
            
            Summary: This gene was identified by the reactivity of its encoded
            protein to a monoclonal antibody prepared against brain homogenates
            from patients with Alzheimer's disease. Analysis of the original
            protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an
            810 aa protein containing a DNA-binding domain and a zinc finger
            motif, suggested it might play a role in the regulation of
            transcription. High levels of FAC1 were detected in fetal brain and
            in patients with neurodegenerative diseases. The protein encoded by
            this gene is actually much larger than originally thought, and it
            also contains a C-terminal bromodomain characteristic of proteins
            that regulate transcription during proliferation. The encoded
            protein is highly similar to the largest subunit of the Drosophila
            NURF (nucleosome remodeling factor) complex. In Drosophila, the
            NURF complex, which catalyzes nucleosome sliding on DNA and
            interacts with sequence-specific transcription factors, is
            necessary for the chromatin remodeling required for transcription.
            Two alternative transcripts encoding different isoforms have been
            described completely. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB032251.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306378.11/ ENSP00000307208.6
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-161               AC006534.10        188956-189116
            162-1577            BC037422.1         152-1567
            1578-1896           AY282495.1         939-1257
            1897-2749           AB032251.1         1729-2581
            2750-3929           AY282495.1         2489-3668
            3930-5368           AB032251.1         3762-5200
            5369-5830           AK025776.1         1032-1493
            5831-6169           AK022570.1         148-486
            6170-7020           AB032251.1         6002-6852
            7021-7464           CV809604.1         48-491
            7465-8248           AB032251.1         7297-8080
            8249-8985           AY282495.1         7559-8295
            8986-11075          AC134407.6         113419-115508
FEATURES             Location/Qualifiers
     source          1..11075
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q24.2"
     gene            1..11075
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /note="bromodomain PHD finger transcription factor"
                     /db_xref="GeneID:2186"
                     /db_xref="HGNC:HGNC:3581"
                     /db_xref="MIM:601819"
     exon            1..835
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..8985
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /note="isoform 1 is encoded by transcript variant 1; fetal
                     Alzheimer antigen; fetal Alz-50 reactive clone 1;
                     nucleosome-remodeling factor subunit BPTF; nucleosome
                     remodeling factor, large subunit; bromodomain and PHD
                     domain transcription factor; fetal Alz-50 clone 1 protein;
                     bromodomain and PHD finger-containing transcription
                     factor"
                     /codon_start=1
                     /product="nucleosome-remodeling factor subunit BPTF
                     isoform 1"
                     /protein_id="NP_872579.2"
                     /db_xref="CCDS:CCDS11673.1"
                     /db_xref="GeneID:2186"
                     /db_xref="HGNC:HGNC:3581"
                     /db_xref="MIM:601819"
                     /translation="MRGRRGRPPKQPAAPAAERCAPAPPPPPPPPTSGPIGGLRSRHR
                     GSSRGRWAAAQAEVAPKTRLSSPRGGSSSRRKPPPPPPAPPSTSAPGRGGRGGGGGRT
                     GGGGGGGHLARTTAARRAVNKVVYDDHESEEEEEEEDMVSEEEEEEDGDAEETQDSED
                     DEEDEMEEDDDDSDYPEEMEDDDDDASYCTESSFRSHSTYSSTPGRRKPRVHRPRSPI
                     LEEKDIPPLEFPKSSEDLMVPNEHIMNVIAIYEVLRNFGTVLRLSPFRFEDFCAALVS
                     QEQCTLMAEMHVVLLKAVLREEDTSNTTFGPADLKDSVNSTLYFIDGMTWPEVLRVYC
                     ESDKEYHHVLPYQEAEDYPYGPVENKIKVLQFLVDQFLTTNIAREELMSEGVIQYDDH
                     CRVCHKLGDLLCCETCSAVYHLECVKPPLEEVPEDEWQCEVCVAHKVPGVTDCVAEIQ
                     KNKPYIRHEPIGYDRSRRKYWFLNRRLIIEEDTENENEKKIWYYSTKVQLAELIDCLD
                     KDYWEAELCKILEEMREEIHRHMDITEDLTNKARGSNKSFLAAANEEILESIRAKKGD
                     IDNVKSPEETEKDKNETENDSKDAEKNREEFEDQSLEKDSDDKTPDDDPEQGKSEVGD
                     FKSEKSNGELSESPGAGKGASGSTRIITRLRNPDSKLSQLKSQQVAAAAHEANKLFKE
                     GKEVLVVNSQGEISRLSTKKEVIMKGNINNYFKLGQEGKYRVYHNQYSTNSFALNKHQ
                     HREDHDKRRHLAHKFCLTPAGEFKWNGSVHGSKVLTISTLRLTITQLENNIPSSFLHP
                     NWASHRANWIKAVQMCSKPREFALALAILECAVKPVVMLPIWRESLGHTRLHRMTSIE
                     REEKEKVKKKEKKQEEEETMQQATWVKYTFPVKHQVWKQKGEEYRVTGYGGWSWISKT
                     HVYRFVPKLPGNTNVNYRKSLEGTKNNMDENMDESDKRKCSRSPKKIKIEPDSEKDEV
                     KGSDAAKGADQNEMDISKITEKKDQDVKELLDSDSDKPCKEEPMEVDDDMKTESHVNC
                     QESSQVDVVNVSEGFHLRTSYKKKTKSSKLDGLLERRIKQFTLEEKQRLEKIKLEGGI
                     KGIGKTSTNSSKNLSESPVITKAKEGCQSDSMRQEQSPNANNDQPEDLIQGCSESDSS
                     VLRMSDPSHTTNKLYPKDRVLDDVSIRSPETKCPKQNSIENDIEEKVSDLASRGQEPS
                     KSKTKGNDFFIDDSKLASADDIGTLICKNKKPLIQEESDTIVSSSKSALHSSVPKSTN
                     DRDATPLSRAMDFEGKLGCDSESNSTLENSSDTVSIQDSSEEDMIVQNSNESISEQFR
                     TREQDVEVLEPLKCELVSGESTGNCEDRLPVKGTEANGKKPSQQKKLEERPVNKCSDQ
                     IKLKNTTDKKNNENRESEKKGQRTSTFQINGKDNKPKIYLKGECLKEISESRVVSGNV
                     EPKVNNINKIIPENDIKSLTVKESAIRPFINGDVIMEDFNERNSSETKSHLLSSSDAE
                     GNYRDSLETLPSTKESDSTQTTTPSASCPESNSVNQVEDMEIETSEVKKVTSSPITSE
                     EESNLSNDFIDENGLPINKNENVNGESKRKTVITEVTTMTSTVATESKTVIKVEKGDK
                     QTVVSSTENCAKSTVTTTTTTVTKLSTPSTGGSVDIISVKEQSKTVVTTTVTDSLTTT
                     GGTLVTSMTVSKEYSTRDKVKLMKFSRPKKTRSGTALPSYRKFVTKSSKKSIFVLPND
                     DLKKLARKGGIREVPYFNYNAKPALDIWPYPSPRPTFGITWRYRLQTVKSLAGVSLML
                     RLLWASLRWDDMAAKAPPGGGTTRTETSETEITTTEIIKRRDVGPYGIRSEYCIRKII
                     CPIGVPETPKETPTPQRKGLRSSALRPKRPETPKQTGPVIIETWVAEEELELWEIRAF
                     AERVEKEKAQAVEQQAKKRLEQQKPTVIATSTTSPTSSTTSTISPAQKVMVAPISGSV
                     TTGTKMVLTTKVGSPATVTFQQNKNFHQTFATWVKQGQSNSGVVQVQQKVLGIIPSST
                     GTSQQTFTSFQPRTATVTIRPNTSGSGGTTSNSQVITGPQIRPGMTVIRTPLQQSTLG
                     KAIIRTPVMVQPGAPQQVMTQIIRGQPVSTAVSAPNTVSSTPGQKSLTSATSTSNIQS
                     SASQPPRPQQGQVKLTMAQLTQLTQGHGGNQGLTVVIQGQGQTTGQLQLIPQGVTVLP
                     GPGQQLMQAAMPNGTVQRFLFTPLATTATTASTTTTTVSTTAAGTGEQRQSKLSPQMQ
                     VHQDKTLPPAQSSSVGPAEAQPQTAQPSAQPQPQTQPQSPAQPEVQTQPEVQTQTTVS
                     SHVPSEAQPTHAQSSKPQVAAQSQPQSNVQGQSPVRVQSPSQTRIRPSTPSQLSPGQQ
                     SQVQTTTSQPIPIQPHTSLQIPSQGQPQSQPQVQSSTQTLSSGQTLNQVTVSSPSRPQ
                     LQIQQPQPQVIAVPQLQQQVQVLSQIQSQVVAQIQAQQSGVPQQIKLQLPIQIQQSSA
                     VQTHQIQNVVTVQAASVQEQLQRVQQLRDQQQKKKQQQIEIKREHTLQASNQSEIIQK
                     QVVMKHNAVIEHLKQKKSMTPAEREENQRMIVCNQVMKYILDKIDKEEKQAAKKRKRE
                     ESVEQKRSKQNATKLSALLFKHKEQLRAEILKKRALLDKDLQIEVQEELKRDLKIKKE
                     KDLMQLAQATAVAAPCPPVTPAPPAPPAPPPSPPPPPAVQHTGLLSTPTLPAASQKRK
                     REEEKDSSSKSKKKKMISTTSKETKKDTKLYCICKTPYDESKFYIGCDRCQNWYHGRC
                     VGILQSEAELIDEYVCPQCQSTEDAMTVLTPLTEKDYEGLKRVLRSLQAHKMAWPFLE
                     PVDPNDAPDYYGVIKEPMDLATMEERVQRRYYEKLTEFVADMTKIFDNCRYYNPSDSP
                     FYQCAEVLESFFVQKLKGFKASRSHNNKLQSTAS"
     exon            836..1658
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1882
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2086
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2277
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2633
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2765
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..2895
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..3034
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     exon            3035..3214
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     exon            3215..5525
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     exon            5526..5650
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     exon            5651..5779
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     exon            5780..5930
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     exon            5931..5973
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     exon            5974..6220
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     exon            6221..6372
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     exon            6373..6481
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     exon            6482..6699
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     exon            6700..6922
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     exon            6923..7839
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     exon            7840..7922
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     exon            7923..8148
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     exon            8149..8483
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     exon            8484..8676
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     exon            8677..8761
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     exon            8762..8948
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     exon            8949..11075
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      9395
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
     regulatory      9823..9828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /note="hexamer: AATAAA"
     polyA_site      9850
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /note="major polyA site"
     regulatory      11050..11055
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
                     /note="hexamer: AATAAA"
     polyA_site      11075
                     /gene="BPTF"
                     /gene_synonym="FAC1; FALZ; NEDDFL; NURF301"
ORIGIN      
        1 agtcaccgag cgagagggaa gaaacaagat ggcggctgaa ggcgatccgg agtggggccc
       61 cagcaattcg gattgagcct tctccctcca cccgcttccg tcggccgggc ccctcccgcc
      121 cggccccgcg ggcctcccca cccggccccg gcgctcccca ccgccccccc tgcgcccgcc
      181 cctccccctt cgctttcctt ctccccccgc ctcggctccg acatgagggg ccggcggggc
      241 aggccgccca agcagcccgc ggctcccgct gcggagcgct gcgccccggc cccgccgcca
      301 ccgccgccgc cgcccacgtc cggacccatc ggggggctcc gctcgcggca ccgcggcagc
      361 agccggggca ggtgggccgc cgcccaggct gaggtggcgc ccaagacgcg gctgagctcg
      421 cccagggggg gcagcagtag ccggaggaag ccgccgccgc cgccgccggc cccccccagc
      481 accagcgccc cgggccgggg ggggcgagga ggcgggggcg gcaggacggg gggcgggggc
      541 ggcggcggcc acctggcccg gaccaccgcg gcccggaggg ccgtcaacaa agtggtgtac
      601 gatgaccacg agagcgagga ggaggaggaa gaggaggaca tggtctccga ggaggaggag
      661 gaggaggacg gcgacgccga ggagacccag gattctgagg acgacgagga ggatgagatg
      721 gaagaggacg acgatgactc cgattatccg gaggagatgg aagacgacga cgacgacgcc
      781 agttactgca cggaaagcag cttcaggagc catagtacct acagcagcac tccaggtagg
      841 cgaaaaccaa gagtacatcg gcctcgttct cctatattgg aagaaaaaga catcccgccc
      901 cttgaatttc ccaagtcctc tgaggattta atggtgccta atgagcatat aatgaatgtc
      961 attgccattt acgaggtact gcggaacttt ggcactgttt tgagattatc tccttttcgc
     1021 tttgaggact tttgtgcagc tctggtgagc caagagcagt gcacactcat ggcagagatg
     1081 catgttgtgc ttttgaaagc agttctgcgt gaagaagaca cttccaatac tacctttgga
     1141 cctgctgatc tgaaagatag cgttaattcc acactgtatt tcatagatgg gatgacgtgg
     1201 ccagaggtgc tgcgggtgta ctgtgagagt gataaggagt accatcacgt tcttccttac
     1261 caagaggcag aggactaccc atatggacca gtagagaaca agatcaaagt tctacagttt
     1321 ctagtcgatc agtttcttac aacaaatatt gctcgagagg aattgatgtc tgaaggggtg
     1381 atacagtatg atgaccattg tagggtttgt cacaaacttg gggatttgct ttgctgtgag
     1441 acatgttcag cagtatacca tttggaatgt gtgaagccac ctcttgagga ggtgccagag
     1501 gacgagtggc agtgtgaagt ctgtgtagca cacaaggtgc ctggtgtgac tgactgtgtt
     1561 gctgaaatcc aaaaaaataa accatatatt cgacatgaac ctattggata tgatagaagt
     1621 cggaggaaat actggttctt gaaccgaaga ctcataatag aagaagatac agaaaatgaa
     1681 aatgaaaaga aaatttggta ttacagcaca aaggtccaac ttgcagaatt aattgactgt
     1741 ctagacaaag attattggga agcagaactc tgcaaaattc tagaagaaat gcgtgaagaa
     1801 atccaccgac acatggacat aactgaagac ctgaccaata aggctcgggg cagtaacaaa
     1861 tcctttctgg cggcagctaa tgaagaaatt ttggaatcca taagagccaa aaagggagac
     1921 attgataatg ttaaaagccc agaagaaaca gaaaaagaca agaatgagac tgagaatgac
     1981 tctaaagatg ctgagaaaaa cagagaagaa tttgaagacc agtcccttga aaaagacagt
     2041 gacgacaaaa caccagatga tgaccctgag caaggaaaat ctgaggtagg tgatttcaaa
     2101 tcggagaagt ccaacgggga gctaagtgaa tctcctggag ctggaaaagg agcatctggc
     2161 tcaactcgaa tcatcaccag attgcggaat ccagatagca aacttagtca gctgaagagc
     2221 cagcaggtgg cagccgctgc acatgaagca aataaattat ttaaggaggg caaagaggta
     2281 ctggtagtta actctcaagg agaaatttca cggttgagca ccaaaaagga agtgatcatg
     2341 aaaggaaata tcaacaatta ttttaaattg ggtcaagaag ggaagtatcg cgtctaccac
     2401 aatcaatact ccaccaattc atttgctttg aataagcacc agcacagaga agaccatgat
     2461 aagagaaggc atcttgcaca taagttctgt ctgactccag caggagagtt caaatggaac
     2521 ggttctgtcc atgggtccaa agttcttacc atatctactc tgagactgac tatcacccaa
     2581 ttagaaaaca acatcccttc atcctttctt catcccaact gggcatcaca tagggcaaat
     2641 tggatcaagg cagttcagat gtgtagcaaa cccagagaat ttgcattggc tttagccatt
     2701 ttggagtgtg cagttaaacc agttgtgatg ctaccaatat ggcgagaatc tttaggacat
     2761 accaggttac accggatgac atcaattgaa agagaagaaa aggagaaagt caaaaaaaaa
     2821 gagaagaaac aggaagaaga agaaacgatg cagcaagcga catgggtaaa atacacattt
     2881 ccagttaagc atcaggtttg gaaacaaaaa ggtgaagagt acagagtgac aggatatggt
     2941 ggttggagct ggattagtaa aactcatgtt tataggtttg ttcctaaatt gccaggcaat
     3001 actaatgtga attacagaaa gtcgttagaa ggaaccaaaa ataatatgga tgaaaatatg
     3061 gatgagtcag ataaaagaaa atgttcacga agtccaaaaa aaataaaaat agagcctgat
     3121 tctgaaaaag atgaggtaaa aggttcagat gctgcaaaag gagcagacca aaatgaaatg
     3181 gatatctcaa agattactga gaagaaggac caagatgtga aggagctctt agattctgac
     3241 agtgataaac cctgcaagga agaaccaatg gaagtagacg atgacatgaa aacagagtca
     3301 catgtaaatt gtcaggagag ttctcaagta gatgtggtca atgttagtga gggttttcat
     3361 ctaaggacta gttacaaaaa gaaaacaaaa tcatccaaac tagatggact tcttgaaagg
     3421 agaattaaac agtttacact ggaagaaaaa cagcgactcg aaaaaatcaa gttggagggt
     3481 ggaattaagg gtataggaaa gacttctaca aattcttcaa aaaatctctc tgaatcacca
     3541 gtaataacga aagcaaaaga agggtgtcag agtgactcga tgagacaaga acagagccca
     3601 aatgcaaata atgatcaacc tgaggacttg attcagggat gttcagaaag tgattcctca
     3661 gttcttagaa tgagtgatcc tagtcatacc acaaacaaac tttatccaaa agatcgagtg
     3721 ttagatgatg tctccattcg gagcccagaa acaaaatgtc cgaaacaaaa ttccattgaa
     3781 aatgacatag aagaaaaagt ctctgacctt gccagtagag gccaggaacc cagtaagagt
     3841 aaaacaaaag gaaatgattt tttcatcgat gactctaaac tagccagtgc agatgatatt
     3901 ggtactttga tctgtaagaa caaaaaaccg ctcatacagg aggaaagtga caccattgtt
     3961 tcttcttcca agagtgcttt acattcatca gtgcctaaaa gtaccaatga cagagatgcc
     4021 acacctctgt caagagcaat ggactttgaa ggaaaactgg gatgtgactc tgaatctaat
     4081 agcactttgg aaaatagttc tgataccgtg tctattcagg atagcagtga agaagatatg
     4141 attgttcaga atagcaatga aagcatttct gaacagttca gaactcgaga acaagatgtt
     4201 gaagtcttgg agccgttaaa gtgtgagttg gtttctggtg agtccactgg aaactgtgag
     4261 gacaggctgc cggtcaaggg gactgaagca aatggtaaaa aaccaagtca gcagaagaaa
     4321 ttagaggaga gaccagttaa taaatgtagt gatcaaataa agctaaaaaa taccactgac
     4381 aaaaagaata atgaaaatcg agagtctgaa aagaaaggac agagaacaag tacatttcaa
     4441 ataaatggaa aagataataa acccaaaata tatttgaaag gtgaatgctt gaaagaaatt
     4501 tctgagagta gagtagtaag tggtaatgtt gaaccaaagg ttaataatat aaataaaata
     4561 atccctgaga atgatattaa atcattgact gttaaagaat ctgctataag gccattcatt
     4621 aatggtgatg tcatcatgga agattttaat gaaagaaaca gctccgaaac aaaatcgcat
     4681 ttgctgagtt cttcagatgc tgaaggtaac taccgagata gccttgagac cctgccatca
     4741 accaaagagt ctgacagtac acagacgacc acaccctcag catcttgtcc agaaagcaat
     4801 tcagttaatc aggtagaaga tatggaaata gaaacctcag aagttaagaa agttacttca
     4861 tcacctatta cttctgaaga ggaatctaat ctcagtaatg actttattga tgaaaatggt
     4921 ctgcccatca acaaaaatga aaatgtcaat ggagaatcta aaagaaaaac cgtcatcaca
     4981 gaagtcacca cgatgacctc cacagtggcc acagaatcaa aaactgtgat caaggtagaa
     5041 aaaggcgata agcaaactgt ggtttcttcc acagaaaatt gtgcaaaatc cactgtcaca
     5101 accaccacta caacagtgac caagctttcc acaccctcca caggcggcag tgtggacatc
     5161 atctctgtaa aggagcagag caaaaccgtg gtcaccacga cagtgacaga ctccctgacc
     5221 accacgggag gcacactggt tacatctatg actgtgagca aagagtattc cacacgagac
     5281 aaagtgaaac tgatgaaatt ttcaagacca aagaagactc gttcaggtac agctctgcca
     5341 tcctatagaa aatttgttac caagagcagc aagaagagca tttttgtttt gcctaatgat
     5401 gacttaaaaa agttggcccg aaaaggagga atccgagagg tcccttattt taattacaat
     5461 gcaaaacctg ctttggatat atggccatat ccttctccta gaccgacctt tggcatcact
     5521 tggaggtata gacttcagac agtaaagtcc ttagctggag tgagcctgat gttacggtta
     5581 ctgtgggcaa gtttgagatg ggatgatatg gcggccaagg ctcctccagg aggagggact
     5641 acacggacag aaacatccga aactgaaatc acaacaacag aaataattaa gaggagagat
     5701 gttggtcctt atggcattcg atctgaatat tgtatcagga aaatcatttg tcccattgga
     5761 gttccagaaa caccaaaaga aacgcctaca cctcagagga aaggccttcg atcaagtgca
     5821 ctgcggccaa agagaccaga aacgcccaag caaactggcc ctgttattat tgaaacctgg
     5881 gtagcagaag aagaactgga attgtgggag atcagggcat ttgctgagag agtggagaaa
     5941 gaaaaggcac aagcagttga gcaacaggct aagaaacgac tggagcagca gaagccgaca
     6001 gtgattgcaa cttccactac ttccccaaca agcagtacaa ccagcaccat ctctccagca
     6061 cagaaggtta tggtggcccc cataagtggc tcagttacaa ctggaaccaa aatggtacta
     6121 actactaaag ttggatctcc agctacagta acattccaac aaaacaagaa ctttcatcaa
     6181 acctttgcta catgggttaa gcaaggccag tcaaattcag gcgttgttca agtacagcag
     6241 aaagtcctgg gtatcattcc atcaagtaca ggtaccagtc agcaaacctt tacttcattc
     6301 cagcccagga cagcaacagt cacaattagg cccaatacct caggctctgg aggaaccaca
     6361 agcaattcac aagtaatcac agggcctcag attcgccctg gtatgaccgt gattagaaca
     6421 ccactccaac agtcaacact aggaaaggca attattcgaa cacctgtgat ggtacagcca
     6481 ggtgctcctc agcaagtgat gactcaaatc atcagggggc agcctgtctc cactgcagtc
     6541 tccgccccta acacggtttc ctcaacacct gggcagaaaa gcttaacttc agcaacgtcc
     6601 acttcaaata tacagtcttc agcctcacaa ccccctcgcc cccaacaagg acaagtgaag
     6661 ctcaccatgg ctcaacttac tcagttaaca cagggccacg gtggcaatca aggtttgaca
     6721 gtagtaattc aaggacaagg tcaaactact ggacagttgc agttgatacc tcaaggggtg
     6781 actgtactcc caggcccagg ccagcagcta atgcaagctg caatgccaaa tggtactgtt
     6841 cagcgattcc tctttacccc attggcaaca acagccacca cagccagcac caccaccacc
     6901 actgtttcca cgacagcagc aggtacaggt gaacaaaggc agagtaaact gtcaccccag
     6961 atgcaggtac atcaagacaa aaccctgcca ccagctcagt catcaagtgt gggtccagca
     7021 gaagcccagc cacagactgc tcagccttca gctcagcccc agccccaaac ccagccccag
     7081 tccccagctc agcctgaagt tcagactcag cctgaagttc agacccaaac aactgtttca
     7141 tcccatgtcc cttctgaagc acaacccacc cacgcacagt catccaagcc ccaagttgca
     7201 gcacagtctc agcctcaaag taatgtccaa ggacagtctc ctgttcgtgt ccaaagtcca
     7261 tcacagactc gaatacgtcc atcaactcca tcccaactgt ctcctggaca acaatcccag
     7321 gttcagacta caacctcaca accgattcca attcaaccac atacatctct tcagatacct
     7381 tcccaaggcc agccacagtc acaaccccag gtacagtctt caactcaaac tctttcatca
     7441 ggacaaactt taaatcaagt tactgtttca tccccatccc gtcctcagct acaaatacag
     7501 cagccacagc cccaagtcat tgctgtgcct cagctgcaac aacaagtcca ggttctctct
     7561 cagatccagt cacaggttgt ggctcagata caggctcagc aaagtggtgt gccccagcaa
     7621 atcaaactcc agttacctat ccaaattcag caaagcagtg ctgtgcagac tcaccagatt
     7681 cagaatgtgg ttacagtgca ggcagccagt gtgcaagagc agttgcaaag ggttcagcaa
     7741 ctcagggatc agcagcaaaa gaagaaacag caacagatag aaattaagcg tgaacacacc
     7801 ctccaagctt ctaatcaaag tgaaatcatt cagaaacagg tggtgatgaa gcataatgct
     7861 gtaatagaac atttaaaaca gaaaaagagc atgactccag ctgaaagaga agagaatcaa
     7921 agaatgattg tctgtaacca ggtgatgaag tatattttgg ataagataga taaagaagaa
     7981 aaacaggcag caaaaaaacg gaagcgtgaa gagagtgtgg agcagaaacg tagcaagcag
     8041 aatgccacta agctgtcagc tctgctcttc aagcacaaag agcagctcag agccgagatc
     8101 ctgaagaaga gagcactcct ggacaaggat ctgcaaattg aagtgcagga agagctgaag
     8161 agagacctga aaattaagaa agaaaaagac ctgatgcagt tggctcaggc cacagcagta
     8221 gctgcaccct gccccccagt gacaccagct cctccagccc ctccagcccc tccaccttca
     8281 cctccccctc cacctgctgt gcaacacaca ggccttctgt ccacgcccac cttacctgct
     8341 gcttcccaga agaggaagcg ggaagaggaa aaagactcca gctcaaagtc caagaaaaag
     8401 aaaatgatct ctactacctc aaaggaaact aagaaggaca caaagcttta ctgtatctgt
     8461 aaaacgcctt atgatgaatc taaattttat attggctgtg atcggtgtca gaattggtac
     8521 catgggcgct gcgttggcat cttgcaaagt gaggcagagc tcattgatga gtatgtctgt
     8581 ccacagtgcc agtcaacaga ggatgccatg acagtgctca cgccactaac agagaaggat
     8641 tatgaggggt tgaagagggt gctccgttcc ttacaggccc ataagatggc ctggcctttc
     8701 cttgaaccag tagaccctaa tgatgcacca gattattatg gtgttattaa ggaacctatg
     8761 gaccttgcca ccatggaaga aagagtacaa agacgatatt atgaaaagct gacggaattt
     8821 gtggcagata tgaccaaaat ttttgataac tgtcgttact acaatccaag tgactcccca
     8881 ttttaccagt gtgcagaagt tctcgaatca ttctttgtac agaaattgaa aggcttcaaa
     8941 gctagcaggt ctcataacaa caaactgcag tctacagctt cttaaagttc agcgtgttaa
     9001 cctaacataa aacacagcaa gaatctggtt gtctgaacta ttttaaatta aggagccaga
     9061 tgtttttagt caggctatcc tgacaagact tgacctaaac ttcgttttta ttggtcataa
     9121 cagtccaatt atattcttgg ccaattttgt ccaacggaca agaaaaaagc aaagtcaacg
     9181 acaccattat cttgtcaaga tcagatggtt ttactattgt ggcagaagcg agaaaacttt
     9241 gtttattgaa aaaaaaagaa aaagaaagca agaaaaaaag atactatggg gtcaagtgta
     9301 actccatgga aatgccacgt ctgctcttca gtgaagaagc tggtttagag tctcacagaa
     9361 aacttttgac tgtatttatt tattgttgca aaaaagacgc ttttttattg ctgccctcat
     9421 ttgtcagcta attatttttt cttataaaat ccagccccgg ttacatataa tcatctgtat
     9481 cttatcatga ttcctgtagg taaaagtaca agacgacctc tagatgtctt ttctttctat
     9541 gaaaggagct gctatgtaca catgtgcaca cacacacaac tgggaatcaa caatgagttt
     9601 attgttcatg gtagattaaa attaagcttg cataaaggtt gggctaagtg gtcctggact
     9661 acagactctg ttgccttgaa tataacagta caatttgtca attactctgc accaggctaa
     9721 aatgagtaaa atctatttga aggtatcttg tttgtaaaca tttgtcagat tctaattttt
     9781 ttcttttgta ttaaaattca actatggatg tatatgaaac aaaataaatg gagataattt
     9841 ttctcccaca gacagaggtg tctttgaatg tgcgctaatg attatctgta agcctttgtg
     9901 gggagggagg cctgcaaggt catgaaaggc agaagagtct aattgtgcct ggatttctcc
     9961 aggacagcag tggcccctcg ttttatcatt cccagtccat tgtcatcacg tcagagaaaa
    10021 atcttcaggg gtgctaatcc tgttgcatca gttgatcata ctaacgagaa cggtaatgcg
    10081 acaagataca cattgccttc atctgtacat tctgtgatac caggcaaatt accaattaca
    10141 cacagctact tatattttat gaagggcatt ttttagatga cctcatcctc tgtgttattt
    10201 gttgattggg tttgttttct gtttgttggt ttgtttgttt cttccacgta aggaaaagta
    10261 gtgtaaacag tagcgagaaa atggaaacca cagaggaaga tgtattttgc atgtttttcc
    10321 tttcagtgtt cttacacgtt gtatcactgc attgtggtaa tagcttctat aaaatctgcc
    10381 atagttggat tatgcagctt tgcaaaaatt tttactagat tttgcactaa ctcatattag
    10441 ctttgtccta ccaacttctg gaatttatct aattattgtt tttcaaagtt tctttccttt
    10501 taatgtttcc ctgctatgca aaacctttcc cagacctcag tttcttaaaa gaaagatgtt
    10561 gctacagttc ccgattcttt cttattacag gctcaggtgt acaggttatt ctgggttaat
    10621 tttatctaat gaagcccatt cctttttgta cataaagatg tcacttaaac ttatgcttac
    10681 aaactaaaga ctaatcgctc aatatgaaaa catgaaaaaa tttttgctta aagtattaag
    10741 atggaagtag ttaaatatgg gttattttgt ccttttactt ttttaaaaaa tgttacatat
    10801 tgtatgcact gtgctgatgc aagaattcta cattttaatg agttataaaa ttattctgca
    10861 tctcatcacg tcacagtatt tctgtactat ttattcatat atataaatat atatgggctt
    10921 aatcatttaa aatttgttgc agcaagaact ttcctacctg taggcaatag attgctatgt
    10981 ttttaacaaa ttgtggcaaa ttctaaacag caattctttt gtacgtaata ggacatttca
    11041 tcctagaaaa ataaagtaat gtttttgaca ttgga
//
