LOCUS       NM_017813               7224 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens 3'(2'), 5'-bisphosphate nucleotidase 2 (BPNT2), mRNA.
ACCESSION   NM_017813
VERSION     NM_017813.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7224)
  AUTHORS   Chen,Q.W., Cai,Q.Q., Yang,Y., Dong,S., Liu,Y.Y., Chen,Z.Y.,
            Kang,C.L., Qi,B., Dong,Y.W., Wu,W., Zhuang,L.P., Shen,Y.H.,
            Meng,Z.Q. and Wu,X.Z.
  TITLE     LncRNA BC promotes lung adenocarcinoma progression by modulating
            IMPAD1 alternative splicing
  JOURNAL   Clin Transl Med 13 (1), e1129 (2023)
   PUBMED   36650118
  REMARK    GeneRIF: LncRNA BC promotes lung adenocarcinoma progression by
            modulating IMPAD1 alternative splicing.
REFERENCE   2  (bases 1 to 7224)
  AUTHORS   Yang,Y.F., Wang,Y.Y., Hsiao,M., Lo,S., Chang,Y.C., Jan,Y.H.,
            Lai,T.C., Lee,Y.C., Hsieh,Y.C. and Yuan,S.F.
  TITLE     IMPAD1 functions as mitochondrial electron transport inhibitor that
            prevents ROS production and promotes lung cancer metastasis through
            the AMPK-Notch1-HEY1 pathway
  JOURNAL   Cancer Lett 485, 27-37 (2020)
   PUBMED   32417395
  REMARK    GeneRIF: IMPAD1 functions as mitochondrial electron transport
            inhibitor that prevents ROS production and promotes lung cancer
            metastasis through the AMPK-Notch1-HEY1 pathway.
REFERENCE   3  (bases 1 to 7224)
  AUTHORS   Wu,Z.L., Robey,M.T., Tatge,T., Lin,C., Leymarie,N., Zou,Y. and
            Zaia,J.
  TITLE     Detecting O-GlcNAc using in vitro sulfation
  JOURNAL   Glycobiology 24 (8), 740-747 (2014)
   PUBMED   24799377
REFERENCE   4  (bases 1 to 7224)
  AUTHORS   Nizon,M., Alanay,Y., Tuysuz,B., Kiper,P.O., Genevieve,D.,
            Sillence,D., Huber,C., Munnich,A. and Cormier-Daire,V.
  TITLE     IMPAD1 mutations in two Catel-Manzke like patients
  JOURNAL   Am J Med Genet A 158A (9), 2183-2187 (2012)
   PUBMED   22887726
  REMARK    GeneRIF: concluded that IMPAD1 should be screened for patients with
            Catel-Manzke and additional features
REFERENCE   5  (bases 1 to 7224)
  AUTHORS   Prather,B., Ethen,C.M., Machacek,M. and Wu,Z.L.
  TITLE     Golgi-resident PAP-specific 3'-phosphatase-coupled sulfotransferase
            assays
  JOURNAL   Anal Biochem 423 (1), 86-92 (2012)
   PUBMED   22289690
REFERENCE   6  (bases 1 to 7224)
  AUTHORS   Vissers,L.E., Lausch,E., Unger,S., Campos-Xavier,A.B., Gilissen,C.,
            Rossi,A., Del Rosario,M., Venselaar,H., Knoll,U., Nampoothiri,S.,
            Nair,M., Spranger,J., Brunner,H.G., Bonafe,L., Veltman,J.A.,
            Zabel,B. and Superti-Furga,A.
  TITLE     Chondrodysplasia and abnormal joint development associated with
            mutations in IMPAD1, encoding the Golgi-resident nucleotide
            phosphatase, gPAPP
  JOURNAL   Am J Hum Genet 88 (5), 608-615 (2011)
   PUBMED   21549340
  REMARK    GeneRIF: Affected individuals carried homozygous missense mutations
            in IMPAD1, the gene coding for gPAPP, a Golgi-resident nucleotide
            phosphatase that hydrolyzes phosphoadenosine phosphate (PAP), the
            byproduct of sulfotransferase reactions, to AMP.
REFERENCE   7  (bases 1 to 7224)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 7224)
  AUTHORS   Frederick,J.P., Tafari,A.T., Wu,S.M., Megosh,L.C., Chiou,S.T.,
            Irving,R.P. and York,J.D.
  TITLE     A role for a lithium-inhibited Golgi nucleotidase in skeletal
            development and sulfation
  JOURNAL   Proc Natl Acad Sci U S A 105 (33), 11605-11612 (2008)
   PUBMED   18695242
REFERENCE   9  (bases 1 to 7224)
  AUTHORS   Zhang,H., Li,X.J., Martin,D.B. and Aebersold,R.
  TITLE     Identification and quantification of N-linked glycoproteins using
            hydrazide chemistry, stable isotope labeling and mass spectrometry
  JOURNAL   Nat Biotechnol 21 (6), 660-666 (2003)
   PUBMED   12754519
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI601447.1, BC017797.1,
            AC032027.7 and AI095394.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_017813.4.
            
            Summary: This gene encodes a member of the inositol monophosphatase
            family. The encoded protein is localized to the Golgi apparatus and
            catalyzes the hydrolysis of phosphoadenosine phosphate (PAP) to
            adenosine monophosphate (AMP). Mutations in this gene are a cause
            of GRAPP type chondrodysplasia with joint dislocations, and a
            pseudogene of this gene is located on the long arm of chromosome 1.
            [provided by RefSeq, Dec 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.550838.1,
                                           SRR14038192.3307311.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262644.9/ ENSP00000262644.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                BI601447.1         13-59
            48-1645             BC017797.1         1-1598
            1646-6957           AC032027.7         58642-63953
            6958-7224           AI095394.1         15-281              c
FEATURES             Location/Qualifiers
     source          1..7224
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q12.1"
     gene            1..7224
                     /gene="BPNT2"
                     /gene_synonym="GPAPP; IMP 3; IMP-3; IMPA3; IMPAD1"
                     /note="3'(2'), 5'-bisphosphate nucleotidase 2"
                     /db_xref="GeneID:54928"
                     /db_xref="HGNC:HGNC:26019"
                     /db_xref="MIM:614010"
     exon            1..669
                     /gene="BPNT2"
                     /gene_synonym="GPAPP; IMP 3; IMP-3; IMPA3; IMPAD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             283..1362
                     /gene="BPNT2"
                     /gene_synonym="GPAPP; IMP 3; IMP-3; IMPA3; IMPAD1"
                     /EC_number="3.1.3.7"
                     /note="myo-inositol monophosphatase A3; IMPase 3;
                     inositol-1(or 4)-monophosphatase 3; inositol
                     monophosphatase domain-containing protein 1;
                     golgi-resident PAP phosphatase; Golgi 3-prime
                     phosphoadenosine 5-prime phosphate 3-prime phosphatase;
                     inositol monophosphatase domain containing 1;
                     golgi-resident nucleotide phosphatase; phosphoadenosine
                     phosphate 3'-nucleotidase"
                     /codon_start=1
                     /product="Golgi-resident adenosine 3',5'-bisphosphate
                     3'-phosphatase"
                     /protein_id="NP_060283.3"
                     /db_xref="CCDS:CCDS6169.1"
                     /db_xref="GeneID:54928"
                     /db_xref="HGNC:HGNC:26019"
                     /db_xref="MIM:614010"
                     /translation="MAPMGIRLSPLGVAVFCLLGLGVLYHLYSGFLAGRFSLFGLGGE
                     PGGGAAGPAAAADGGTVDLREMLAVSVLAAVRGGDEVRRVRESNVLHEKSKGKTREGA
                     EDKMTSGDVLSNRKMFYLLKTAFPSVQINTEEHVDAADQEVILWDHKIPEDILKEVTT
                     PKEVPAESVTVWIDPLDATQEYTEDLRKYVTTMVCVAVNGKPMLGVIHKPFSEYTAWA
                     MVDGGSNVKARSSYNEKTPRIVVSRSHSGMVKQVALQTFGNQTTIIPAGGAGYKVLAL
                     LDVPDKSQEKADLYIHVTYIKKWDICAGNAILKALGGHMTTLSGEEISYTGSDGIEGG
                     LLASIRMNHQALVRKLPDLEKTGHK"
     exon            670..832
                     /gene="BPNT2"
                     /gene_synonym="GPAPP; IMP 3; IMP-3; IMPA3; IMPAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            833..928
                     /gene="BPNT2"
                     /gene_synonym="GPAPP; IMP 3; IMP-3; IMPA3; IMPAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1090
                     /gene="BPNT2"
                     /gene_synonym="GPAPP; IMP 3; IMP-3; IMPA3; IMPAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..7224
                     /gene="BPNT2"
                     /gene_synonym="GPAPP; IMP 3; IMP-3; IMPA3; IMPAD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7201..7206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BPNT2"
                     /gene_synonym="GPAPP; IMP 3; IMP-3; IMPA3; IMPAD1"
                     /note="hexamer: AATAAA"
     polyA_site      7224
                     /gene="BPNT2"
                     /gene_synonym="GPAPP; IMP 3; IMP-3; IMPA3; IMPAD1"
                     /note="major polyA site"
ORIGIN      
        1 acctcgcggc cgtaggctaa cgtggaagtc ggaccagccg gccggcggaa gaacctagag
       61 cgcgctgcct ggcgagtcag gcgcgcgggg cggcgttggt ggtcttcgcg gcgcaactcg
      121 gcctttcctg ggagggagtg atggggcgca ccggggccgg ggagcgggcg ccagtgtagc
      181 ccgcgcggcg cctggcccgg agcgcggcgg ctgcggcggc ggcggcggcg ggcgctggag
      241 gcctgtgaga gccgcagccc ggagcgcccg gcttcccacg ccatggcccc catgggcatc
      301 cgcctttccc cactgggggt ggcagtgttt tgcctgctgg ggctcggcgt gctctaccac
      361 ctctactcgg gcttcttggc cggccgcttc agcctcttcg gcctgggcgg cgagcctggc
      421 ggcggcgcgg cggggcccgc ggccgcggcc gatgggggca ccgtggactt gcgcgagatg
      481 ctggctgtgt cagtgctggc cgcagtccgc ggcggcgacg aggtgaggcg cgtccgcgag
      541 agcaacgtcc tccacgagaa gtccaagggg aagacgcgcg agggagccga ggacaagatg
      601 accagcggcg acgtgctgtc caaccgcaag atgttctacc tgctcaagac cgccttcccc
      661 agcgtccaga ttaatactga ggaacacgtg gatgcagctg atcaggaggt tatcttgtgg
      721 gatcataaga ttcctgagga tatcctaaag gaagtaacta ctcctaaaga ggtaccagca
      781 gaaagtgtta ctgtctggat tgacccactt gatgctacac aggaatatac agaggatctt
      841 cgaaagtacg tcactactat ggtgtgtgtg gctgtaaatg gtaaacccat gctaggagtt
      901 atacataagc cattttccga atatacagct tgggcaatgg tagatggtgg ttcaaatgtg
      961 aaagcccgct cttcctacaa tgagaagacc ccaaggatcg ttgtgtctcg ttcccattca
     1021 gggatggtca aacaggtcgc tcttcagact tttggaaacc agactacaat tatcccagct
     1081 ggtggtgctg gttataaagt tttagcactt ttggatgtgc ctgataagag tcaagaaaaa
     1141 gctgatttat acatccatgt gacatacatc aaaaagtggg atatatgtgc tggtaatgcc
     1201 atcttaaaag ccctaggggg gcatatgact accctgagtg gtgaagaaat cagttacact
     1261 ggttcagacg gcattgaagg gggactcctt gctagcatca gaatgaacca ccaggccctg
     1321 gtcagaaaac tcccagatct agaaaagaca ggacataaat gagcataact gattacaggg
     1381 tacagttctt cacagctgaa atggttagcc tgagatgctg gaagcttcaa aggattggtg
     1441 gagactatgc atggttaagg ccatcccgaa ctttttaaag tatttatgaa gcatcagaga
     1501 cttattttcc ctgtaataga atgcaaaatc agggaaaatg ggttgctttg tgtctcaagt
     1561 attgtcttta tttttgagac tattttcata cagttgtcat acacaaggcg catatatata
     1621 tttgtgaatt aaaatctgta gctgagtcta cattgttatg agtcaccatt ttcacacaac
     1681 atcatgaatc ttcactgtta gtactttcat atagaattcg gttgaaggaa agattgattt
     1741 ttgtgtagat gtttaatata actttacaac tatatctcat tgaaaataaa gtcattgggg
     1801 atttttacct ctaatttgga tggaaagcac aagaagccac acattcatta atatgcaaca
     1861 aatgttgtat ttatgttact gaatatttct atggattaaa atagaaaaag tttaattgat
     1921 tttttctttt aaattttaat aacaggttca ccagctggta gaaaatagag acacatgatg
     1981 atttgcattg taataatttc tgtgtgtatg tgtgtgtgtt gttttgtttt tataaagaaa
     2041 agtgtgtttg tacccatgag ttcagcattt ctgccatctt gctattttca ttttccctgt
     2101 ggaagatgca tggttgcatc cttttccttc tgaccaacac ttagtcttta actttgtaag
     2161 gttcggttta aggtttcagg gttagcacta tagttttggt tcattttctc attaacgata
     2221 aaatatgctg taaggcacta taagaatata aatgattcta ttacaattga aagttacttg
     2281 acattacatg aattgaactg cctttcatta tcttcagaca ctttgtttta gtattttttt
     2341 ttaatttgct aggtttgtat atagaagatc ctttcattat caagaatgag tatggttgct
     2401 tttgccatgg ttgcttttac tattaataaa tgtatctagc ctacccaaac tctgtagtaa
     2461 cttttgagat tctcttaatt tcccctcaga ttaaaataga gaaggttgaa ggtacttttt
     2521 gatgaaattt ttttctagtc tggttagaaa aaaaaagttg tgacatattc attgtgttac
     2581 cgtaactaga accttgcttt gtgaactgtc tttcattggg atgtatggtt tctctcaatg
     2641 tgaaatctgg aaacttcatg taaactaccc atgccgttat ttcatgtgac tccagtgccc
     2701 ttgtattcca taacatgctg atgagaggga tttctcacgg tttctttctt tgctaaattt
     2761 tttaaccata aagcagctta ccctttattt tcccatcttg gaagtaaaat tgaccaaaga
     2821 atgtacgttc tagcctggtg gaatgtgcat actttaggtt tgtatgttac attgtccaaa
     2881 gccctttact ttcttattag taaactgaat ctaatatgac acaaatgttt tcacccaatc
     2941 tcttgcaact ggtcaaattc gagaaggtgt tgggccttag cagtaggcct tttcagtgaa
     3001 aattcattca aagttttggt aggtggaaca cttgatattt aaataggact tgaaaatttt
     3061 gaaaagagta tcagagacct catttttttc ctttgcaata agctgaagaa actttctttt
     3121 tcaggagaga tggcaaaggt atatgctgtt gccagagtcc tgtggtataa gcatctgttt
     3181 ttattatagt atgtcaaagt tagggaaatg ggactggcaa gtaaaaaatg gaatttaatt
     3241 tcaatgtttt atgggaactc tgatttaatg ggaagcaaac tagttcatat tagcaggaat
     3301 tattttattt tttcgagaca gagtttcact ctcgttggcc aggctggagt gcaatggcgt
     3361 gatctcggct caccgcaacc tctgcttccc gggttcaagc gattctcctg cctcagcctc
     3421 ccaagtagct gggattacag gcatacacca ccacacccag ctaatttttt tgtatttttg
     3481 ttagagacag ggtttctcca tgttggtcag gctggtctcg aactcccgac ctcaggtgat
     3541 ccgcccacct cggcctccca aagtgatgat tttattttta tttttaattg tattaatctg
     3601 catctagata atgactttgt gaagggtgtg tgttgtgtgc aaaacttaag gtattggttg
     3661 agagttaaat acattatttt tataatatgt tgggtatagt ctagttacta atgatttttt
     3721 ttaagtactt ttataaaaag ttcattttta aaattgtttg tttttaaaag ccaatatacg
     3781 ttgcagaatt aggaacagta tttatattta tttacacaag acattgtgcc atagcatcct
     3841 agtaaaacac cttcatgaat gagtaatgtt atctcccaga attacattaa aattatttct
     3901 aaaaagtagc aaagtcatta ccttttgctt ttaatgaccc acacctcacc agctcctggt
     3961 cttttcttca ctgttgccct tattttgagg caatttttct taaaatatga cttttatgca
     4021 ccacatttag tagaggcagt gacatcagtg atctcagtac ccatcagctg tccccctcct
     4081 ctgcccttct tcatctcttc taccttgtga ccatttccct taccggttca tgttctcctt
     4141 tatctctgct tttctttctt agccaggata cttccctcac aactctcact cccaaattct
     4201 tttagatata catttttctg gatattggct gctgaaatct gaagctctgg taaagttcct
     4261 agtatcagag atcaatcctg gaggaggcct agttcactat tagattacaa agactcctca
     4321 caaagtaaag gaaaatcacc ttcaaaacca caacccttta tgttgtcaag tctaatatga
     4381 gtgtttttac gaagtatttc tttctaccca ttgttcaaga atgtaaatgt aaaaaaaaat
     4441 acaagagagt tgggtagata tgcatgcttg aggaaacttg cttttactgt tttcctactt
     4501 gtatccccag ttcagttgaa tttacaagga cctacaagat ggtcatgttt gtcttggtat
     4561 gtgctacccc aattttagtg tttctttctt tattttaaat cagtaattat tcagttgatt
     4621 gtttatacta tataatgaag taacaaaaac attttggttt gtatgtttta agtaacagtt
     4681 gtgcaaattc ctcttgtttg ttaggtgctc cctttgaata ttttgtgaac tgtgtcagag
     4741 ggagaggggt ggtggctagg aagagggtca gaaagaagct agagggaggt caggagaagg
     4801 gtaacaggga ggatgcaaag cagacatcta ccctggtcac cccaggatca ggatatctgt
     4861 ccttgtttca tgttgaattc aaaaattgga tctcacttag gctttgaagg tgacagccat
     4921 ctctgatagc tgagcataag taaagaaagg tggagtgccg atgcagaaag gaaaatattc
     4981 agctttcctc tcttagatcg cactttgaag atggcctttt ggagacaatc tgacaggtta
     5041 aaacaggaac tgttggaatt attctagctg taactaccta ttggctatgt gttgattgat
     5101 cctagaaaga aaaaataatt tttcatttta gatcttgatt gaatttaaga tgtatttata
     5161 tgcctacaaa aggtctgtct tgtaactgtt gtataaaata aacctaatct atggtttcat
     5221 ttttaatcta aaaaaagttg tgccttaaca atagggcatt gtatgttaat aagggaaaac
     5281 aaccttttta gtagatgggg gaaaatagga actttttgcc attaaaactt aagttctttt
     5341 gatgttttta atattatagt tgggggagat tcattaaaat taaattgaaa taaaattatt
     5401 tttgcataac ctagcattta caactaaagt atgtttttta taagaactgg catcttgatg
     5461 tatataggtc tgaaataata tttcatcttt tgatttttaa ttttaataat attagaccag
     5521 gatagatcac agttttacaa atcttagttt taaataaatt atttcagtgt gctgttagtc
     5581 ctctacagtc attttggttt aaaaagtgac tatttattta tggtagcata tcaataattt
     5641 attaatgtta aaaaatactg tgtatgacat tacaaaccag aacagttcct gggggagagg
     5701 attctaattg attggcagtt ctgagagggc aagaagaatg gaactttata cttcaaaagg
     5761 aggttttggt tttaccaggt actgcttatg taaatcgttt atttttattt catcaaagcc
     5821 tggcaagtat atgcattcca atttaccatt ggcaaagctt tatttatttt taaggttgga
     5881 tgttgaatta attttgtggg aaaatgagat ttgtaagtag ttttctttct agataagata
     5941 acataaacca aactttcaga agttaaggat gatgaataat attgaaatga cttgttatat
     6001 attgtaaggg ttcccttaag tatcataatt aacaatttgt ggaaattgaa aaagcataaa
     6061 ctgtgttatt tgattagtaa tatgttccct taaaattcat tttgaggtgt atgttataca
     6121 cacagtaaat ttttgttcag gaatgacttg ctcattctgt gtttttaaaa ataggaaata
     6181 aggcatagtg agtcatcatt acatcaatta accaaaaaat atttcatccc ctccgtcact
     6241 gaaattatct acttcagcca cctttcttat tctcgtgtta ggagggcacg tttatggact
     6301 ttttaatttc catgtgccat attgtccact accggcagta gccaaagcta gctgtttcag
     6361 tcccacagaa gagacagtgc tctgccatga tgacagggca ctgctagggc tggtttttct
     6421 tgtttttccc ttttggcagt gtggacttca ggaactagat gtatatgcac aagggattga
     6481 gtttacacta aaactaggaa atggagtttt caatctatgt tcttgcctct tcatactttt
     6541 atttattttt tgtcatcctg ccttatactg ggctaacaat gagataaaat aaaaatacct
     6601 ttgaatactc ttttcccttt catgcattta aagccatgga ggaactagac cattagctgt
     6661 tgccgtcaca tgcttagaca ccagtttact tagcgtgtta tgaccttcct cacccatact
     6721 accaaattta aatgggtccc gacttcaccc tctggaagga agtaaactct tctctcccca
     6781 tggtttcaga gcagttttta cctgcaagca ccatctctgt atgtgctctt actagattat
     6841 acagttcttg agagggattg catcttagtg tttttgtatt tccacctcac ccccagcaca
     6901 tagcccagtc tcttgcacaa attaagtact taatgtgtgt tgagctaaat tgaataaagg
     6961 attattagca ttagcatatt ttgtgccttg gttgtataag ctggttgttt gttttgttac
     7021 ctttgcaaat atttatgatt atcacccccc cacatactaa attgttttta aaagttttgc
     7081 ctttccttca gatactaccc caggcaattt gctgtagata atgtgattgc ttccaatgac
     7141 ataattatcc caaactctct gccccggata tactttgcca aacgaaattt gaattctctg
     7201 aataaattgg tcatgtctaa aaga
//
