LOCUS       NM_006085               2400 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens 3'(2'), 5'-bisphosphate nucleotidase 1 (BPNT1),
            transcript variant 1, mRNA.
ACCESSION   NM_006085
VERSION     NM_006085.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2400)
  AUTHORS   Sun,L., Li,F., Bai,S. and Bi,C.
  TITLE     CircRNA HLCS regulates lens epithelial cell apoptosis via
            miR-338-3p/BPNT1 axis
  JOURNAL   Int Ophthalmol 44 (1), 142 (2024)
   PUBMED   38493427
  REMARK    GeneRIF: CircRNA HLCS regulates lens epithelial cell apoptosis via
            miR-338-3p/BPNT1 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2400)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 2400)
  AUTHORS   Johnatty,S.E., Beesley,J., Chen,X., Macgregor,S., Duffy,D.L.,
            Spurdle,A.B., deFazio,A., Gava,N., Webb,P.M., Rossing,M.A.,
            Doherty,J.A., Goodman,M.T., Lurie,G., Thompson,P.J., Wilkens,L.R.,
            Ness,R.B., Moysich,K.B., Chang-Claude,J., Wang-Gohrke,S.,
            Cramer,D.W., Terry,K.L., Hankinson,S.E., Tworoger,S.S.,
            Garcia-Closas,M., Yang,H., Lissowska,J., Chanock,S.J.,
            Pharoah,P.D., Song,H., Whitemore,A.S., Pearce,C.L., Stram,D.O.,
            Wu,A.H., Pike,M.C., Gayther,S.A., Ramus,S.J., Menon,U.,
            Gentry-Maharaj,A., Anton-Culver,H., Ziogas,A., Hogdall,E.,
            Kjaer,S.K., Hogdall,C., Berchuck,A., Schildkraut,J.M.,
            Iversen,E.S., Moorman,P.G., Phelan,C.M., Sellers,T.A.,
            Cunningham,J.M., Vierkant,R.A., Rider,D.N., Goode,E.L., Haviv,I.
            and Chenevix-Trench,G.
  CONSRTM   Ovarian Cancer Association Consortium; Australian Ovarian Cancer
            Study Group; Australian Cancer Study (Ovarian Cancer)
  TITLE     Evaluation of candidate stromal epithelial cross-talk genes
            identifies association between risk of serous ovarian cancer and
            TERT, a cancer susceptibility 'hot-spot'
  JOURNAL   PLoS Genet 6 (7), e1001016 (2010)
   PUBMED   20628624
  REMARK    GeneRIF: Meta-analysis of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2400)
  AUTHORS   Spiegelberg,B.D., Xiong,J.P., Smith,J.J., Gu,R.F. and York,J.D.
  TITLE     Cloning and characterization of a mammalian lithium-sensitive
            bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate
  JOURNAL   J Biol Chem 274 (19), 13619-13628 (1999)
   PUBMED   10224133
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK291943.1 and AC103590.2.
            
            On Nov 22, 2018 this sequence version replaced NM_006085.5.
            
            Summary: BPNT1, also called bisphosphate 3-prime-nucleotidase, or
            BPntase, is a member of a magnesium-dependent phosphomonoesterase
            family. Lithium, a major drug used to treat manic depression, acts
            as an uncompetitive inhibitor of BPntase. The predicted human
            protein is 92% identical to mouse BPntase. BPntase's physiologic
            role in nucleotide metabolism may be regulated by inositol
            signaling pathways. The inhibition of human BPntase may account for
            lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291943.1, SRR1660807.224079.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322067.12/ ENSP00000318852.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1059              AK291943.1         1-1059
            1060-2400           AC103590.2         110446-111786       c
FEATURES             Location/Qualifiers
     source          1..2400
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
     gene            1..2400
                     /gene="BPNT1"
                     /gene_synonym="HEL20; HsPIP; PIP"
                     /note="3'(2'), 5'-bisphosphate nucleotidase 1"
                     /db_xref="GeneID:10380"
                     /db_xref="HGNC:HGNC:1096"
                     /db_xref="MIM:604053"
     exon            1..103
                     /gene="BPNT1"
                     /gene_synonym="HEL20; HsPIP; PIP"
                     /inference="alignment:Splign:2.1.0"
     exon            104..231
                     /gene="BPNT1"
                     /gene_synonym="HEL20; HsPIP; PIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1038
                     /gene="BPNT1"
                     /gene_synonym="HEL20; HsPIP; PIP"
                     /EC_number="3.1.3.57"
                     /EC_number="3.1.3.7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     BPntase; PAP-inositol-1,4-phosphatase; bisphosphate
                     3'-nucleotidase 1; epididymis luminal protein 20;
                     testicular tissue protein Li 29; BPntase 1; PAP
                     phosphatase; inositol-polyphosphate 1-phosphatase;
                     3'-phosphoadenosine 5'-phosphate phosphatase"
                     /codon_start=1
                     /product="3'(2'),5'-bisphosphate nucleotidase 1 isoform 1"
                     /protein_id="NP_006076.4"
                     /db_xref="CCDS:CCDS41469.1"
                     /db_xref="GeneID:10380"
                     /db_xref="HGNC:HGNC:1096"
                     /db_xref="MIM:604053"
                     /translation="MASSNTVLMRLVASAYSIAQKAGMIVRRVIAEGDLGIVEKTCAT
                     DLQTKADRLAQMSICSSLARKFPKLTIIGEEDLPSEEVDQELIEDSQWEEILKQPCPS
                     QYSAIKEEDLVVWVDPLDGTKEYTEGLLDNVTVLIGIAYEGKAIAGVINQPYYNYEAG
                     PDAVLGRTIWGVLGLGAFGFQLKEVPAGKHIITTTRSHSNKLVTDCVAAMNPDAVLRV
                     GGAGNKIIQLIEGKASAYVFASPGCKKWDTCAPEVILHAVGGKLTDIHGNVLQYHKDV
                     KHMNSAGVLATLRNYDYYASRVPESIKNALVP"
     exon            232..336
                     /gene="BPNT1"
                     /gene_synonym="HEL20; HsPIP; PIP"
                     /inference="alignment:Splign:2.1.0"
     exon            337..444
                     /gene="BPNT1"
                     /gene_synonym="HEL20; HsPIP; PIP"
                     /inference="alignment:Splign:2.1.0"
     exon            445..493
                     /gene="BPNT1"
                     /gene_synonym="HEL20; HsPIP; PIP"
                     /inference="alignment:Splign:2.1.0"
     exon            494..585
                     /gene="BPNT1"
                     /gene_synonym="HEL20; HsPIP; PIP"
                     /inference="alignment:Splign:2.1.0"
     exon            586..783
                     /gene="BPNT1"
                     /gene_synonym="HEL20; HsPIP; PIP"
                     /inference="alignment:Splign:2.1.0"
     exon            784..889
                     /gene="BPNT1"
                     /gene_synonym="HEL20; HsPIP; PIP"
                     /inference="alignment:Splign:2.1.0"
     exon            890..2400
                     /gene="BPNT1"
                     /gene_synonym="HEL20; HsPIP; PIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2136..2141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BPNT1"
                     /gene_synonym="HEL20; HsPIP; PIP"
                     /note="hexamer: AATAAA"
     polyA_site      2154
                     /gene="BPNT1"
                     /gene_synonym="HEL20; HsPIP; PIP"
                     /note="major polyA site"
     regulatory      2313..2318
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BPNT1"
                     /gene_synonym="HEL20; HsPIP; PIP"
                     /note="hexamer: ATTAAA"
     polyA_site      2335
                     /gene="BPNT1"
                     /gene_synonym="HEL20; HsPIP; PIP"
     regulatory      2375..2380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BPNT1"
                     /gene_synonym="HEL20; HsPIP; PIP"
                     /note="hexamer: ATTAAA"
     polyA_site      2400
                     /gene="BPNT1"
                     /gene_synonym="HEL20; HsPIP; PIP"
                     /note="major polyA site"
ORIGIN      
        1 attgacagtg ccaaagctcg gtactggaca caacgaggga cctgggtcta cgataacgcg
       61 cttttgctcc tcctgaagtg tctttggtcc aacgttgttc cagagtgtac catggcttcc
      121 agtaacactg tgttgatgcg gttggtagcc tccgcatatt ctattgctca aaaggcagga
      181 atgatagtca gacgtgttat tgctgaagga gacctgggta ttgtggagaa gacctgtgca
      241 acagacctgc agaccaaagc tgaccgattg gcacagatga gcatatgttc ttcattggcc
      301 cggaaattcc ccaaactcac aattataggg gaagaggatc tgccttctga ggaagtggat
      361 caagagctga ttgaagacag tcagtgggaa gaaatactga agcaaccatg cccatcgcag
      421 tacagtgcta ttaaagaaga agatctcgtg gtctgggttg atcctctgga tggaaccaag
      481 gaatataccg aaggtcttct tgacaatgta acagttctta ttggaattgc ttatgaagga
      541 aaagccatag caggagttat taaccagcca tattacaact atgaggcagg accagatgct
      601 gtgttgggga ggacaatctg gggagtttta ggtttaggcg cctttgggtt tcagctgaaa
      661 gaagtccctg ctgggaaaca cattatcaca actactcgat cccatagcaa caagttggtt
      721 actgactgtg ttgctgctat gaaccccgat gctgtgctgc gagtaggagg agcaggaaat
      781 aagattattc agctgattga aggcaaagcc tctgcttatg tatttgcaag tcctggttgt
      841 aagaagtggg atacttgtgc tccagaagtt attttacatg ctgtgggagg caagttaacc
      901 gatatccatg ggaatgttct tcagtaccac aaggatgtga agcatatgaa ctctgcagga
      961 gtcctggcca cactgaggaa ttatgactac tatgcaagcc gagttccaga atctattaaa
     1021 aatgcacttg ttccttaaag gaaagtttca tttggccggg cgcggtggct catgcctgta
     1081 atcccagcac tttgggaggc cgaggcaggt ggatcacttg agctcaggag tttgagacca
     1141 gcctgggcaa tatcgtgaga ccccatctct acaaaaatac aaattaactg ggcatcctgt
     1201 catgcgcctg tcatcccagc tacttgagag gctgaagcag aagaatctct tgagcccgga
     1261 aggcagaggt tgcagtgagc tgagatcgtg ccactgcact ccagcctgag tgacaggagt
     1321 taagccctgt ctcagaaaaa aaaaaaacaa aaacccaaaa agtacttaaa gtttcattta
     1381 cttagctagg agaaagactt ggttctcaaa ataatacatt ttaagattaa ttgggtagaa
     1441 ttagagttcc acctttattc attgttgagc agtgatttat atttagttat tatatttagg
     1501 aatagaaaat agaattaaat aatttaactt gattaatcaa ccagaccaat tttgacgtct
     1561 ggagaactta taaactcaat atgttatatt tgttttcctg tatttaggtg gagaaatgag
     1621 aaaaagcttt agttccaatt gacagttcag gtcaatgttc aatgaacatt cctatcttct
     1681 aaaccagatt tctctttttt tttcctgaga cggagtctcg ctctgtagcc taggctagaa
     1741 tgtagtggcg tgatctcggc tcactgcaag ctccgcctcc cgggttcatg ccattctcct
     1801 gcctcagcct cccgagtagc tgggactgca ggcaccgcca ccacgcctgg ctaatttttt
     1861 gtatttttag tagagaaggt gtttcaccgt gttagccagg atggtcttga tctcctgaca
     1921 tcgtgatctg tctgcctcgg actcccaaag tgctgggatt acaggtgtga gccaccgcac
     1981 ctggcctaaa ccagatttct ttagggcaca attttttctg gaatctcact cttgtttttc
     2041 acagtaattt taaaaacgtt tctactccaa ttaagaatat atatgatgtt attatatatg
     2101 cttatgaaac agatttatga gaaaagtttt ttttaaataa attatttaat cctagctctt
     2161 tgttattcac cagcttttta aaaaagtgtt tgaaaattat acattctcga ctttggggat
     2221 tagtttattc ttgtggcatc attataaggc ttaattgtgg aaagctaagt acttgcttct
     2281 attccttcca atgagagatt ataacataaa ctattaaaat tattctgcta atatacctag
     2341 atttttattt ttaggtctct gtccattgct tttaattaaa attatctgtt ttcaaatcaa
//
