LOCUS       NM_174932               2143 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens BPI fold containing family C (BPIFC), mRNA.
ACCESSION   NM_174932 XM_011530088
VERSION     NM_174932.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2143)
  AUTHORS   Zhang,Y., Zhao,J., Jin,Q. and Zhuang,L.
  TITLE     Transcriptomic Analyses and Experimental Validation Identified
            Immune-Related lncRNA-mRNA Pair MIR210HG-BPIFC Regulating the
            Progression of Hypertrophic Cardiomyopathy
  JOURNAL   Int J Mol Sci 25 (5), 2816 (2024)
   PUBMED   38474063
  REMARK    GeneRIF: Transcriptomic Analyses and Experimental Validation
            Identified Immune-Related lncRNA-mRNA Pair MIR210HG-BPIFC
            Regulating the Progression of Hypertrophic Cardiomyopathy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2143)
  AUTHORS   Fu,X.G., Huang,Z., Zhou,S.J., Yang,J., Peng,Y.J., Cao,L.Y., Guo,H.,
            Wu,G.H., Lin,Y.H. and Huang,B.Y.
  TITLE     Novel heterozygous BPIFC variant in a Chinese pedigree with
            hereditary trichilemmal cysts
  JOURNAL   Mol Genet Genomic Med 7 (6), e697 (2019)
   PUBMED   31033252
  REMARK    GeneRIF: BPIFC c.3G>C mutation segregates with hereditary
            trichilemmal cysts in a large Chinese family.
REFERENCE   3  (bases 1 to 2143)
  AUTHORS   Anttila,V., Winsvold,B.S., Gormley,P., Kurth,T., Bettella,F.,
            McMahon,G., Kallela,M., Malik,R., de Vries,B., Terwindt,G.,
            Medland,S.E., Todt,U., McArdle,W.L., Quaye,L., Koiranen,M.,
            Ikram,M.A., Lehtimaki,T., Stam,A.H., Ligthart,L., Wedenoja,J.,
            Dunham,I., Neale,B.M., Palta,P., Hamalainen,E., Schurks,M.,
            Rose,L.M., Buring,J.E., Ridker,P.M., Steinberg,S., Stefansson,H.,
            Jakobsson,F., Lawlor,D.A., Evans,D.M., Ring,S.M., Farkkila,M.,
            Artto,V., Kaunisto,M.A., Freilinger,T., Schoenen,J., Frants,R.R.,
            Pelzer,N., Weller,C.M., Zielman,R., Heath,A.C., Madden,P.A.F.,
            Montgomery,G.W., Martin,N.G., Borck,G., Gobel,H., Heinze,A.,
            Heinze-Kuhn,K., Williams,F.M.K., Hartikainen,A.L., Pouta,A., van
            den Ende,J., Uitterlinden,A.G., Hofman,A., Amin,N., Hottenga,J.J.,
            Vink,J.M., Heikkila,K., Alexander,M., Muller-Myhsok,B.,
            Schreiber,S., Meitinger,T., Wichmann,H.E., Aromaa,A.,
            Eriksson,J.G., Traynor,B., Trabzuni,D., Rossin,E., Lage,K.,
            Jacobs,S.B.R., Gibbs,J.R., Birney,E., Kaprio,J., Penninx,B.W.,
            Boomsma,D.I., van Duijn,C., Raitakari,O., Jarvelin,M.R.,
            Zwart,J.A., Cherkas,L., Strachan,D.P., Kubisch,C., Ferrari,M.D.,
            van den Maagdenberg,A.M.J.M., Dichgans,M., Wessman,M., Smith,G.D.,
            Stefansson,K., Daly,M.J., Nyholt,D.R., Chasman,D. and Palotie,A.
  CONSRTM   North American Brain Expression Consortium; UK Brain Expression
            Consortium
  TITLE     Genome-wide meta-analysis identifies new susceptibility loci for
            migraine
  JOURNAL   Nat Genet 45 (8), 912-917 (2013)
   PUBMED   23793025
REFERENCE   4  (bases 1 to 2143)
  AUTHORS   Bingle,C.D., Seal,R.L. and Craven,C.J.
  TITLE     Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a
            subfamily of the BPI fold-containing superfamily
  JOURNAL   Biochem Soc Trans 39 (4), 977-983 (2011)
   PUBMED   21787333
REFERENCE   5  (bases 1 to 2143)
  AUTHORS   Toulza,E., Mattiuzzo,N.R., Galliano,M.F., Jonca,N., Dossat,C.,
            Jacob,D., de Daruvar,A., Wincker,P., Serre,G. and Guerrin,M.
  TITLE     Large-scale identification of human genes implicated in epidermal
            barrier function
  JOURNAL   Genome Biol 8 (6), R107 (2007)
   PUBMED   17562024
REFERENCE   6  (bases 1 to 2143)
  AUTHORS   Bingle,C.D., LeClair,E.E., Havard,S., Bingle,L., Gillingham,P. and
            Craven,C.J.
  TITLE     Phylogenetic and evolutionary analysis of the PLUNC gene family
  JOURNAL   Protein Sci 13 (2), 422-430 (2004)
   PUBMED   14739326
REFERENCE   7  (bases 1 to 2143)
  AUTHORS   Mulero,J.J., Boyle,B.J., Bradley,S., Bright,J.M., Nelken,S.T.,
            Ho,T.T., Mize,N.K., Childs,J.D., Ballinger,D.G., Ford,J.E. and
            Rupp,F.
  TITLE     Three new human members of the lipid transfer/lipopolysaccharide
            binding protein family (LT/LBP)
  JOURNAL   Immunogenetics 54 (5), 293-300 (2002)
   PUBMED   12185532
  REMARK    GeneRIF: BPIL2maps to Chr 22q13. AA sequence is reported.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL021937.1, AF465766.1, CU456409.1 and CK823453.1.
            
            On or before Oct 26, 2020 this sequence version replaced
            XM_011530088.2, NM_174932.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372079.1370832.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2142670 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300399.9/ ENSP00000300399.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AL021937.1         152916-152988       c
            74-161              AL021937.1         150116-150203       c
            162-1685            AF465766.1         1-1524
            1686-1878           CU456409.1         573-765
            1879-2141           CK823453.1         1-263               c
            2142-2143           AL021937.1         102387-102388       c
FEATURES             Location/Qualifiers
     source          1..2143
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..2143
                     /gene="BPIFC"
                     /gene_synonym="BPIL2"
                     /note="BPI fold containing family C"
                     /db_xref="GeneID:254240"
                     /db_xref="HGNC:HGNC:16503"
                     /db_xref="MIM:614109"
     exon            1..73
                     /gene="BPIFC"
                     /gene_synonym="BPIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            74..161
                     /gene="BPIFC"
                     /gene_synonym="BPIL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1685
                     /gene="BPIFC"
                     /gene_synonym="BPIL2"
                     /note="bactericidal/permeability-increasing protein-like
                     2; BPI-like 2; BPI fold-containing family C protein"
                     /codon_start=1
                     /product="BPI fold-containing family C protein precursor"
                     /protein_id="NP_777592.1"
                     /db_xref="CCDS:CCDS13906.1"
                     /db_xref="GeneID:254240"
                     /db_xref="HGNC:HGNC:16503"
                     /db_xref="MIM:614109"
                     /translation="MCTKTIPVLWGCFLLWNLYVSSSQTIYPGIKARITQRALDYGVQ
                     AGMKMIEQMLKEKKLPDLSGSESLEFLKVDYVNYNFSNIKISAFSFPNTSLAFVPGVG
                     IKALTNHGTANISTDWGFESPLFQDTGGADLFLSGVYFTGIIILTRNDFGHPTLKLQD
                     CYAQLSHAHVSFSGELSVLYNSFAEPMEKPILKNLNEMLCPIIASEVKALNANLSTLE
                     VLTKIDNYTLLDYSLISSPEITENYLDLNLKGVFYPLENLTDPPFSPVPFVLPERSNS
                     MLYIGIAEYFFKSASFAHFTAGVFNVTLSTEEISNHFVQNSQGLGNVLSRIAEIYILS
                     QPFMVRIMATEPPIINLQPGNFTLDIPASIMMLTQPKNSTVETIVSMDFVASTSVGLV
                     ILGQRLVCSLSLNRFRLALPESNRSNIEVLRFENILSSILHFGVLPLANAKLQQGFPL
                     SNPHKFLFVNSDIEVLEGFLLISTDLKYETSSKQQPSFHVWEGLNLISRQWRGKSAP"
     exon            162..285
                     /gene="BPIFC"
                     /gene_synonym="BPIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            286..406
                     /gene="BPIFC"
                     /gene_synonym="BPIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            407..535
                     /gene="BPIFC"
                     /gene_synonym="BPIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            536..691
                     /gene="BPIFC"
                     /gene_synonym="BPIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            692..755
                     /gene="BPIFC"
                     /gene_synonym="BPIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            756..816
                     /gene="BPIFC"
                     /gene_synonym="BPIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            817..908
                     /gene="BPIFC"
                     /gene_synonym="BPIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1085
                     /gene="BPIFC"
                     /gene_synonym="BPIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1139
                     /gene="BPIFC"
                     /gene_synonym="BPIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1310
                     /gene="BPIFC"
                     /gene_synonym="BPIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1378
                     /gene="BPIFC"
                     /gene_synonym="BPIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1421
                     /gene="BPIFC"
                     /gene_synonym="BPIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1485
                     /gene="BPIFC"
                     /gene_synonym="BPIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1562
                     /gene="BPIFC"
                     /gene_synonym="BPIL2"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..2143
                     /gene="BPIFC"
                     /gene_synonym="BPIL2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2117..2122
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BPIFC"
                     /gene_synonym="BPIL2"
                     /note="hexamer: ATTAAA"
     polyA_site      2143
                     /gene="BPIFC"
                     /gene_synonym="BPIL2"
                     /note="major polyA site"
ORIGIN      
        1 ggagaacaca tcagcttcaa aggcagagag aatcgaaggt gctctccagc tttggacact
       61 tcctctgctt gaggacacct tgactaacct ccaagggcaa ctaaaggatc aagaaaggcc
      121 cagcacagca gaagatcagc tggatctagc tcctgcagga gatgtgtaca aagacaatcc
      181 cagtcctctg gggatgtttc ctcctgtgga atctctatgt ctcatcctct cagaccattt
      241 accctggaat caaggcaagg attactcaga gggcacttga ctatggtgtt caagctggaa
      301 tgaagatgat tgagcaaatg ctaaaagaaa agaaactccc agatttaagc ggttctgagt
      361 ctcttgaatt tctaaaagtt gattatgtaa actacaattt ttcaaatata aaaatcagtg
      421 ccttttcatt tccaaatacc tcattggctt ttgtgcctgg agtgggaatc aaagcgctaa
      481 ccaaccatgg cactgccaac atcagcacag actgggggtt cgagtctcca cttttccaag
      541 acacaggagg ggctgatctg tttctctccg gagtctactt taccggtatc attatcctaa
      601 cccgaaatga ctttggtcat cctaccctga agctccaaga ttgctacgcc caactgagcc
      661 atgcccacgt ctcattttcc ggagaactca gtgttctgta taactccttt gctgagccca
      721 tggagaaacc cattttaaag aacttaaatg aaatgctctg tcccattatt gcaagtgaag
      781 tcaaagcgct aaatgccaac ctcagcacac tggaggtttt aaccaagatt gacaactaca
      841 ctctgctgga ttactcccta atcagttctc cagaaattac tgagaactac cttgacctga
      901 acttgaaggg tgtattctac ccactggaaa acctcaccga cccccccttc tcaccagttc
      961 cttttgtgct cccagaacgc agcaactcca tgctctacat tggaatcgcc gagtatttct
     1021 ttaaatctgc gtcctttgct catttcacag ctggggtttt caatgtcact ctctccaccg
     1081 aagagatttc caaccatttt gttcaaaact ctcaaggcct tggcaacgtg ctctcccgga
     1141 ttgcagagat ctacatcttg tcccagccct tcatggtgag gatcatggcc acagagcctc
     1201 ccataatcaa tctacaacca ggcaatttca ccctggacat ccctgcctcc atcatgatgc
     1261 tcacccaacc caagaactcc acagttgaaa ccatcgtttc catggacttc gttgctagta
     1321 ccagtgttgg cctggttatt ttgggacaaa gactggtctg ctccttgtct ctgaacagat
     1381 tccgccttgc tttgccagag tccaatcgca gcaacattga ggtcttgagg tttgaaaata
     1441 ttctatcgtc cattcttcac tttggagtcc tcccactggc caatgcaaaa ttgcagcaag
     1501 gatttcctct gtccaatcca cacaaattct tattcgtcaa ttcagatatt gaagttcttg
     1561 agggtttcct tttgatttcc accgacctga agtatgaaac atcctcaaag cagcagccaa
     1621 gtttccacgt atgggaaggt ctgaacctga taagcagaca gtggaggggg aagtcagccc
     1681 cttgattgcc ggtttgcaat tcaccccagg aagtaaatgg tccttaatcc tacaactact
     1741 gtaaacccag aagggaaaga cagtacacac tggaattgta aagcccttgt gaattgctta
     1801 ggcagaaagt tttctttctt aagccttcag gaacccagaa taaggcagac tctgttaaag
     1861 ggataaatag aggtgtctga atgtgagtgt atgcatgctg cgtgtgtctg tgtttatgtt
     1921 tgtttgtttg tttggggcaa gaaagattct aggacaagag ctaggcatgt acttctgacc
     1981 aggtgggtaa gcaactctaa gtctgtattt gtattggtca ttctcagtgg aaatccctta
     2041 ggccctctag tggttttccc ctacctgcat attggttttc atgttttata ttcactgtta
     2101 ctatcttctg tgtttaatta aaattgtttt ctatcaactt caa
//
