LOCUS       NM_174897               1362 bp    mRNA    linear   PRI 04-JUN-2024
DEFINITION  Homo sapiens BPI fold containing family B member 6 (BPIFB6), mRNA.
ACCESSION   NM_174897
VERSION     NM_174897.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1362)
  AUTHORS   Morosky,S., Lennemann,N.J. and Coyne,C.B.
  TITLE     BPIFB6 Regulates Secretory Pathway Trafficking and Enterovirus
            Replication
  JOURNAL   J Virol 90 (10), 5098-5107 (2016)
   PUBMED   26962226
  REMARK    GeneRIF: study reports on the cellular function of BPIFB6 in the
            regulation of secretory pathway trafficking and Golgi complex
            morphology; in addition, findings show that BPIFB6 functions as a
            positive regulator of enterovirus replication via its regulation of
            the secretory pathway
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1362)
  AUTHORS   Bingle,C.D., Seal,R.L. and Craven,C.J.
  TITLE     Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a
            subfamily of the BPI fold-containing superfamily
  JOURNAL   Biochem Soc Trans 39 (4), 977-983 (2011)
   PUBMED   21787333
REFERENCE   3  (bases 1 to 1362)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 1362)
  AUTHORS   Bingle,C.D., LeClair,E.E., Havard,S., Bingle,L., Gillingham,P. and
            Craven,C.J.
  TITLE     Phylogenetic and evolutionary analysis of the PLUNC gene family
  JOURNAL   Protein Sci 13 (2), 422-430 (2004)
   PUBMED   14739326
REFERENCE   5  (bases 1 to 1362)
  AUTHORS   Mulero,J.J., Boyle,B.J., Bradley,S., Bright,J.M., Nelken,S.T.,
            Ho,T.T., Mize,N.K., Childs,J.D., Ballinger,D.G., Ford,J.E. and
            Rupp,F.
  TITLE     Three new human members of the lipid transfer/lipopolysaccharide
            binding protein family (LT/LBP)
  JOURNAL   Immunogenetics 54 (5), 293-300 (2002)
   PUBMED   12185532
  REMARK    GeneRIF: BPIL3 maps to Chromosome 20q11; thus, these novel genes
            form a cluster with BPI and two other members of the LT/LBP gene
            family on the long arm of human Chr 20. AA sequence is reported.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF465767.1 and BC113122.1.
            
            On May 19, 2009 this sequence version replaced NM_174897.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF465767.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000349552.1/ ENSP00000344929.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1106              AF465767.1         1-1106
            1107-1356           BC113122.1         1421-1670
            1357-1362           AF465767.1         1357-1362
FEATURES             Location/Qualifiers
     source          1..1362
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21"
     gene            1..1362
                     /gene="BPIFB6"
                     /gene_synonym="BPIL3; LPLUNC6"
                     /note="BPI fold containing family B member 6"
                     /db_xref="GeneID:128859"
                     /db_xref="HGNC:HGNC:16504"
                     /db_xref="MIM:614110"
     CDS             1..1362
                     /gene="BPIFB6"
                     /gene_synonym="BPIL3; LPLUNC6"
                     /note="bactericidal/permeability-increasing protein-like
                     3"
                     /codon_start=1
                     /product="BPI fold-containing family B member 6 precursor"
                     /protein_id="NP_777557.1"
                     /db_xref="CCDS:CCDS13211.1"
                     /db_xref="GeneID:128859"
                     /db_xref="HGNC:HGNC:16504"
                     /db_xref="MIM:614110"
                     /translation="MLRILCLALCSLLTGTRADPGALLRLGMDIMNQVQSAMDESHIL
                     EKMAAEAGKKQPGMKPIKGITNLKVKDVQLPVITLNFVPGVGIFQCVSTGMTVTGKSF
                     MGGNMEIIVALNITATNRLLRDEETGLPVFKSEGCEVILVNVKTNLPSNMLPKMVNKF
                     LDSTLHKVLPGLMCPAIDAVLVYVNRKWTNLSDPMPVGQMGTVKYVLMSAPATTASYI
                     QLDFSPVVQQQKGKTIKLADAGEALTFPEGYAKGSSQLLLPATFLSAELALLQKSFHV
                     NIQDTMIGELPPQTTKTLARFIPEVAVAYPKSKPLTTQIKIKKPPKVTMKTGKSLLHL
                     HSTLEMFAARWRSKAPMSLFLLEVHFNLKVQYSVHENQLQMATSLDRLLSLSRKSSSI
                     GNFNERELTGFITSYLEEAYIPVVNDVLQVGLPLPDFLAMNYNLAELDIVENALMLDL
                     KLG"
     exon            1..97
                     /gene="BPIFB6"
                     /gene_synonym="BPIL3; LPLUNC6"
                     /inference="alignment:Splign:2.1.0"
     exon            98..197
                     /gene="BPIFB6"
                     /gene_synonym="BPIL3; LPLUNC6"
                     /inference="alignment:Splign:2.1.0"
     exon            198..302
                     /gene="BPIFB6"
                     /gene_synonym="BPIL3; LPLUNC6"
                     /inference="alignment:Splign:2.1.0"
     exon            303..452
                     /gene="BPIFB6"
                     /gene_synonym="BPIL3; LPLUNC6"
                     /inference="alignment:Splign:2.1.0"
     exon            453..516
                     /gene="BPIFB6"
                     /gene_synonym="BPIL3; LPLUNC6"
                     /inference="alignment:Splign:2.1.0"
     exon            517..577
                     /gene="BPIFB6"
                     /gene_synonym="BPIL3; LPLUNC6"
                     /inference="alignment:Splign:2.1.0"
     exon            578..669
                     /gene="BPIFB6"
                     /gene_synonym="BPIL3; LPLUNC6"
                     /inference="alignment:Splign:2.1.0"
     exon            670..846
                     /gene="BPIFB6"
                     /gene_synonym="BPIL3; LPLUNC6"
                     /inference="alignment:Splign:2.1.0"
     exon            847..900
                     /gene="BPIFB6"
                     /gene_synonym="BPIL3; LPLUNC6"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1074
                     /gene="BPIFB6"
                     /gene_synonym="BPIL3; LPLUNC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1142
                     /gene="BPIFB6"
                     /gene_synonym="BPIL3; LPLUNC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1188
                     /gene="BPIFB6"
                     /gene_synonym="BPIL3; LPLUNC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1252
                     /gene="BPIFB6"
                     /gene_synonym="BPIL3; LPLUNC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1329
                     /gene="BPIFB6"
                     /gene_synonym="BPIL3; LPLUNC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1362
                     /gene="BPIFB6"
                     /gene_synonym="BPIL3; LPLUNC6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctgcgga tcctgtgcct ggcactctgc agcctgctga ctggcacgcg agctgaccct
       61 ggggcactgc tgcggttggg catggacatc atgaaccagg tccagagcgc catggatgag
      121 agtcatatcc tggagaagat ggcagccgag gcaggcaaga aacagccagg gatgaaacct
      181 atcaagggca tcaccaattt gaaggtgaag gatgtccagc tgcccgtcat cacactgaac
      241 tttgtacctg gagtgggcat cttccaatgt gtgtccacag gcatgaccgt cactggcaag
      301 agcttcatgg gagggaacat ggagatcatc gtggccctga acatcacagc caccaaccgg
      361 cttctgcggg atgaggagac aggcctcccc gtgttcaaga gtgagggctg tgaggtcatc
      421 ctggtcaatg tgaagactaa cctgcctagc aacatgctcc ccaagatggt caacaagttc
      481 ctggacagca ccctgcacaa agtcctccct gggctgatgt gtcccgccat cgatgcagtc
      541 ctggtgtatg tgaacaggaa gtggaccaac ctcagtgacc ccatgcctgt gggccagatg
      601 ggcaccgtca aatatgttct gatgtccgca ccagccacca cagccagcta catccaactg
      661 gacttcagtc ctgtggtgca gcagcaaaag ggcaaaacca tcaagcttgc tgatgccggg
      721 gaggccctca cgttccctga gggttatgcc aaaggctcgt cgcagctgct gctcccagcc
      781 accttcctct ctgcagagct tgcccttctg cagaagtcct ttcatgtgaa tatccaggat
      841 acaatgattg gtgagctgcc cccacaaacc accaagaccc tggctcgctt cattcctgaa
      901 gtggctgtag cttatcccaa gtcaaagccc ttgacgaccc agatcaagat aaagaagcct
      961 cccaaggtca ctatgaagac aggcaagagc ctgctgcacc tccacagcac cctggagatg
     1021 ttcgcagctc ggtggcggag caaggctcca atgtccctct ttctcctaga agtgcacttc
     1081 aatctgaagg tccagtactc agtgcatgag aaccagctgc agatggccac ttctttggac
     1141 agattactga gcttgtcccg gaagtcctca tcgattggca acttcaatga gagggaatta
     1201 actggcttca tcaccagcta tctcgaagaa gcctacatcc cagttgtcaa tgatgtgctt
     1261 caagtggggc tcccactccc ggactttctg gccatgaatt acaacctggc tgagctggac
     1321 atagtagaga atgccctgat gctggacttg aagctgggct ga
//
