LOCUS       NM_182519               2343 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens BPI fold containing family B member 4 (BPIFB4), mRNA.
ACCESSION   NM_182519
VERSION     NM_182519.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2343)
  AUTHORS   Ciaglia,E., Montella,F., Carrizzo,A., Lopardo,V., Esposito,R.M.,
            Basile,C., Damato,A., De Lucia,M., Maciag,A., Spinetti,G.,
            Milella,M.S., Maselli,D., Vecchione,C. and Puca,A.A.
  TITLE     The longevity-associated BPIFB4 gene guarantees vascular
            homeostasis and immune protection through platelets
  JOURNAL   Geroscience 46 (6), 6347-6359 (2024)
   PUBMED   38884925
  REMARK    GeneRIF: The longevity-associated BPIFB4 gene guarantees vascular
            homeostasis and immune protection through platelets.
REFERENCE   2  (bases 1 to 2343)
  AUTHORS   Cattaneo,M., Aleksova,A., Malovini,A., Avolio,E., Thomas,A.,
            Alvino,V.V., Kilcooley,M., Pieronne-Deperrois,M.,
            Ouvrard-Pascaud,A., Maciag,A., Spinetti,G., Kussauer,S., Lemcke,H.,
            Skorska,A., Vasudevan,P., Castiglione,S., Raucci,A., David,R.,
            Richard,V., Beltrami,A.P., Madeddu,P. and Puca,A.A.
  TITLE     BPIFB4 and its longevity-associated haplotype protect from cardiac
            ischemia in humans and mice
  JOURNAL   Cell Death Dis 14 (8), 523 (2023)
   PUBMED   37582912
  REMARK    GeneRIF: BPIFB4 and its longevity-associated haplotype protect from
            cardiac ischemia in humans and mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2343)
  AUTHORS   Puca,A.A., Lopardo,V., Montella,F., Di Pietro,P., Cesselli,D.,
            Rolle,I.G., Bulfoni,M., Di Sarno,V., Iaconetta,G., Campiglia,P.,
            Vecchione,C., Beltrami,A.P. and Ciaglia,E.
  TITLE     The Longevity-Associated Variant of BPIFB4 Reduces Senescence in
            Glioma Cells and in Patients' Lymphocytes Favoring Chemotherapy
            Efficacy
  JOURNAL   Cells 11 (2), 294 (2022)
   PUBMED   35053408
  REMARK    GeneRIF: The Longevity-Associated Variant of BPIFB4 Reduces
            Senescence in Glioma Cells and in Patients' Lymphocytes Favoring
            Chemotherapy Efficacy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2343)
  AUTHORS   Dossena,M., Ferrario,A., Lopardo,V., Ciaglia,E. and Puca,A.A.
  TITLE     New Insights for BPIFB4 in Cardiovascular Therapy
  JOURNAL   Int J Mol Sci 21 (19), 7163 (2020)
   PUBMED   32998388
  REMARK    GeneRIF: New Insights for BPIFB4 in Cardiovascular Therapy.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2343)
  AUTHORS   Ciaglia,E., Montella,F., Lopardo,V., Scala,P., Ferrario,A.,
            Cattaneo,M., Carrizzo,A., Malovini,A., Madeddu,P., Vecchione,C. and
            Puca,A.A.
  TITLE     Circulating BPIFB4 Levels Associate With and Influence the
            Abundance of Reparative Monocytes and Macrophages in Long Living
            Individuals
  JOURNAL   Front Immunol 11, 1034 (2020)
   PUBMED   32547549
  REMARK    GeneRIF: Circulating BPIFB4 Levels Associate With and Influence the
            Abundance of Reparative Monocytes and Macrophages in Long Living
            Individuals.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2343)
  AUTHORS   Bingle,C.D., LeClair,E.E., Havard,S., Bingle,L., Gillingham,P. and
            Craven,C.J.
  TITLE     Phylogenetic and evolutionary analysis of the PLUNC gene family
  JOURNAL   Protein Sci 13 (2), 422-430 (2004)
   PUBMED   14739326
REFERENCE   7  (bases 1 to 2343)
  AUTHORS   Bingle,C.D. and Craven,C.J.
  TITLE     Comparative analysis of the PLUNC (palate, lung and nasal
            epithelium clone) protein families
  JOURNAL   Biochem Soc Trans 31 (Pt 4), 806-809 (2003)
   PUBMED   12887310
  REMARK    Review article
REFERENCE   8  (bases 1 to 2343)
  AUTHORS   Andrault,J.B., Gaillard,I., Giorgi,D. and Rouquier,S.
  TITLE     Expansion of the BPI family by duplication on human chromosome 20:
            characterization of the RY gene cluster in 20q11.21 encoding
            olfactory transporters/antimicrobial-like peptides
  JOURNAL   Genomics 82 (2), 172-184 (2003)
   PUBMED   12837268
REFERENCE   9  (bases 1 to 2343)
  AUTHORS   Bingle,C.D. and Craven,C.J.
  TITLE     PLUNC: a novel family of candidate host defence proteins expressed
            in the upper airways and nasopharynx
  JOURNAL   Hum Mol Genet 11 (8), 937-943 (2002)
   PUBMED   11971875
REFERENCE   10 (bases 1 to 2343)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL121756.14.
            
            On Sep 18, 2020 this sequence version replaced NM_182519.2.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            inferred exon combination        :: based on alignments, homology
            MANE Ensembl match               :: ENST00000375483.4/
                                                ENSP00000364632.3
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AL121756.14        91323-91383
            62-169              AL121756.14        92149-92256
            170-290             AL121756.14        93192-93312
            291-353             AL121756.14        94618-94680
            354-861             AL121756.14        95047-95554
            862-966             AL121756.14        96572-96676
            967-1110            AL121756.14        97701-97844
            1111-1174           AL121756.14        100646-100709
            1175-1235           AL121756.14        101178-101238
            1236-1327           AL121756.14        102388-102479
            1328-1528           AL121756.14        104138-104338
            1529-1582           AL121756.14        106780-106833
            1583-1753           AL121756.14        109297-109467
            1754-1821           AL121756.14        112106-112173
            1822-1864           AL121756.14        114652-114694
            1865-1928           AL121756.14        116490-116553
            1929-2005           AL121756.14        119424-119500
            2006-2343           AL121756.14        123094-123431
FEATURES             Location/Qualifiers
     source          1..2343
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21"
     gene            1..2343
                     /gene="BPIFB4"
                     /gene_synonym="C20orf186; dJ726C3.5; LPLUNC4; RY2G5"
                     /note="BPI fold containing family B member 4"
                     /db_xref="GeneID:149954"
                     /db_xref="HGNC:HGNC:16179"
                     /db_xref="MIM:615718"
     exon            1..61
                     /gene="BPIFB4"
                     /gene_synonym="C20orf186; dJ726C3.5; LPLUNC4; RY2G5"
                     /inference="alignment:Splign:2.1.0"
     exon            62..169
                     /gene="BPIFB4"
                     /gene_synonym="C20orf186; dJ726C3.5; LPLUNC4; RY2G5"
                     /inference="alignment:Splign:2.1.0"
     exon            170..290
                     /gene="BPIFB4"
                     /gene_synonym="C20orf186; dJ726C3.5; LPLUNC4; RY2G5"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..2029
                     /gene="BPIFB4"
                     /gene_synonym="C20orf186; dJ726C3.5; LPLUNC4; RY2G5"
                     /note="likely ortholog of rat probable ligand-binding
                     protein RY2G5; long palate, lung and nasal epithelium
                     carcinoma associated 4; long palate, lung and nasal
                     epithelium carcinoma-associated protein 4"
                     /codon_start=1
                     /product="BPI fold-containing family B member 4 precursor"
                     /protein_id="NP_872325.2"
                     /db_xref="CCDS:CCDS13213.2"
                     /db_xref="GeneID:149954"
                     /db_xref="HGNC:HGNC:16179"
                     /db_xref="MIM:615718"
                     /translation="MWMAWCVAALSVVAVCGTSHETNTVLRVTKDVLSNAISGMLQQS
                     DALHSALREVPLGVGDIPYNDFHVRGPPPVYTNGKKLDGIYQYGHIETNDNTAQLGGK
                     YRYGEILESEGSIRDLRNSGYRSAENAYGGHRGLGRYRAAPVGRLHRRELQPGEIPPG
                     VATGAVGPGGLLGTGGMLAADGILAGQGGLLGGGGLLGDGGLLGGGGVLGVLGEGGIL
                     STVQGITGLRIVELTLPRVSVRLLPGVGVYLSLYTRVAINGKSLIGFLDIAVEVNITA
                     KVRLTMDRTGYPRLVIERCDTLLGGIKVKLLRGLLPNLVDNLVNRVLADVLPDLLCPI
                     VDVVLGLVNDQLGLVDSLIPLGILGSVQYTFSSLPLVTGEFLELDLNTLVGEAGGGLI
                     DYPLGWPAVSPKPMPELPPMGDNTKSQLAMSANFLGSVLTLLQKQHALDLDITNGMFE
                     ELPPLTTATLGALIPKVFQQYPESCPLIIRIQVLNPPSVMLQKDKALVKVLATAEVMV
                     SQPKDLETTICLIDVDTEFLASFSTEGDKLMIDAKLEKTSLNLRTSNVGNFDIGLMEV
                     LVEKIFDLAFMPAMNAVLGSGVPLPKILNIDFSNADIDVLEDLLVLSA"
     exon            291..353
                     /gene="BPIFB4"
                     /gene_synonym="C20orf186; dJ726C3.5; LPLUNC4; RY2G5"
                     /inference="alignment:Splign:2.1.0"
     exon            354..861
                     /gene="BPIFB4"
                     /gene_synonym="C20orf186; dJ726C3.5; LPLUNC4; RY2G5"
                     /inference="alignment:Splign:2.1.0"
     exon            862..966
                     /gene="BPIFB4"
                     /gene_synonym="C20orf186; dJ726C3.5; LPLUNC4; RY2G5"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1110
                     /gene="BPIFB4"
                     /gene_synonym="C20orf186; dJ726C3.5; LPLUNC4; RY2G5"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1174
                     /gene="BPIFB4"
                     /gene_synonym="C20orf186; dJ726C3.5; LPLUNC4; RY2G5"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1235
                     /gene="BPIFB4"
                     /gene_synonym="C20orf186; dJ726C3.5; LPLUNC4; RY2G5"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1327
                     /gene="BPIFB4"
                     /gene_synonym="C20orf186; dJ726C3.5; LPLUNC4; RY2G5"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1528
                     /gene="BPIFB4"
                     /gene_synonym="C20orf186; dJ726C3.5; LPLUNC4; RY2G5"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1582
                     /gene="BPIFB4"
                     /gene_synonym="C20orf186; dJ726C3.5; LPLUNC4; RY2G5"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1753
                     /gene="BPIFB4"
                     /gene_synonym="C20orf186; dJ726C3.5; LPLUNC4; RY2G5"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1821
                     /gene="BPIFB4"
                     /gene_synonym="C20orf186; dJ726C3.5; LPLUNC4; RY2G5"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..1864
                     /gene="BPIFB4"
                     /gene_synonym="C20orf186; dJ726C3.5; LPLUNC4; RY2G5"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1928
                     /gene="BPIFB4"
                     /gene_synonym="C20orf186; dJ726C3.5; LPLUNC4; RY2G5"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2005
                     /gene="BPIFB4"
                     /gene_synonym="C20orf186; dJ726C3.5; LPLUNC4; RY2G5"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2343
                     /gene="BPIFB4"
                     /gene_synonym="C20orf186; dJ726C3.5; LPLUNC4; RY2G5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2319..2324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BPIFB4"
                     /gene_synonym="C20orf186; dJ726C3.5; LPLUNC4; RY2G5"
                     /note="hexamer: AATAAA"
     polyA_site      2343
                     /gene="BPIFB4"
                     /gene_synonym="C20orf186; dJ726C3.5; LPLUNC4; RY2G5"
                     /note="major polyA site"
ORIGIN      
        1 caaaagcaga ggggctgggg aacaggactt ctcaagactc agcggcaggg acctcctagg
       61 ggggtctgaa ataacagtcc caaagtaata acaatagctg ctctttattg agtgtctact
      121 atgtatgaga tacaacttgt ttgtgatttg ggagcagaag ttcaaaaagg gaagcagtgc
      181 cagcatgtgg atggcctggt gtgtggctgc gctgtctgtg gtggctgtgt gtggcaccag
      241 ccacgagaca aacacggtcc tcagggtgac gaaagatgtg ttgagcaatg ccatttcagg
      301 catgctgcag caaagtgatg ctctccactc ggccctgaga gaggtgccct tgggtgttgg
      361 tgatattccc tacaatgact tccatgtccg aggacccccc ccagtatata ccaacggcaa
      421 aaaacttgat ggtatttacc agtatggtca cattgagacc aacgacaaca ctgctcagct
      481 ggggggcaaa taccgatatg gtgagatcct tgagtccgag ggaagcatca gggacctccg
      541 aaacagtggc tatcgcagtg ccgagaatgc atatggaggc cacaggggcc tcgggcgata
      601 cagggcagca cctgtgggca ggcttcaccg gcgagagctg cagcctggag aaatcccacc
      661 tggagttgcc actggggcgg tgggcccagg tggtttgctg ggcactggag gcatgctggc
      721 agctgatggc atcctcgcag gccaaggtgg cctgctcggc ggaggtggtc tccttggtga
      781 tggaggactt cttggaggag ggggtgtcct gggcgtgctc ggcgagggtg gcatcctcag
      841 cactgtgcaa ggcatcacgg ggctgcgtat cgtggagctg accctccctc gggtgtccgt
      901 gcggctcctg cccggcgtgg gtgtctacct gagcttgtac acccgtgtgg ccatcaacgg
      961 gaagagtctt attggcttcc tggacatcgc agtagaagtg aacatcacag ccaaggtccg
     1021 gctgaccatg gaccgcacgg gttatcctcg gctggtcatt gagcgatgtg acaccctcct
     1081 agggggcatc aaagtcaagc tgctgcgagg gcttctcccc aatctcgtgg acaatttagt
     1141 gaaccgagtc ctggccgacg tcctccctga cttgctctgc cccatcgtgg atgtggtgct
     1201 gggtcttgtc aatgaccagc tgggcctcgt ggattctctg attcctctgg ggatattggg
     1261 aagtgtccag tacaccttct ccagcctccc gcttgtgacc ggggaattcc tggagctgga
     1321 cctcaacacg ctggttgggg aggctggagg aggactcatc gactacccat tggggtggcc
     1381 agctgtgtct cccaagccga tgccagagct gcctcccatg ggtgacaaca ccaagtccca
     1441 gctggccatg tctgccaact tcctgggctc agtgctgact ctactgcaga agcagcatgc
     1501 tctagacctg gatatcacca atggcatgtt tgaagagctt cctccactta ccacagccac
     1561 actgggagcc ctgatcccca aggtgttcca gcagtacccc gagtcctgcc cacttatcat
     1621 caggatccag gtgctgaacc caccatctgt gatgctgcag aaggacaaag cgctggtgaa
     1681 ggtgttggcc actgccgagg tcatggtctc ccagcccaaa gacctggaga ctaccatctg
     1741 cctcattgac gtggacacag aattcttggc ctcattttcc acagaaggag ataagctcat
     1801 gattgatgcc aagctggaga agaccagcct caacctcaga acctcaaacg tgggcaactt
     1861 tgatattggc ctcatggagg tgctggtgga gaagattttt gacctggcat tcatgcccgc
     1921 aatgaacgct gtgctgggtt ctggcgtccc tctccccaaa atcctcaaca tcgactttag
     1981 caatgcagac attgacgtgt tggaggacct tttggtgctg agcgcatgag tgacagaggc
     2041 agagatgctg ctgcaactgg aagaagctgg aaccagtccc agagaggctc ggcctggaaa
     2101 cagtcccctg cccagagtcc cctcagcctc catgacaggt ccctccctgg ccccccaacc
     2161 ctcttcctcc cttgccccaa ccctgagaaa gggtccagcc actaccctgt tggcaaacat
     2221 tcccttccat ggtcagcctg ccaggaggag gggagtcacc ttggggctgg aggcctctca
     2281 gaccccatcc tgacagcagg ttgagtattc ccactttcaa taaaagactc cactttcccg
     2341 gca
//
