LOCUS       NM_001376932            1738 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens BPI fold containing family B member 3 (BPIFB3),
            transcript variant 2, mRNA.
ACCESSION   NM_001376932
VERSION     NM_001376932.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1738)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1738)
  AUTHORS   Delorme-Axford,E., Morosky,S., Bomberger,J., Stolz,D.B.,
            Jackson,W.T. and Coyne,C.B.
  TITLE     BPIFB3 regulates autophagy and coxsackievirus B replication through
            a noncanonical pathway independent of the core initiation machinery
  JOURNAL   mBio 5 (6), e02147 (2014)
   PUBMED   25491355
  REMARK    GeneRIF: Overexpression of BPIFB3 inhibits coxsackievirus B
            replication, dramatically alters the morphology of LC3B-positive
            vesicles, and suppresses autophagy in response to rapamycin.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1738)
  AUTHORS   Bingle,C.D., Seal,R.L. and Craven,C.J.
  TITLE     Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a
            subfamily of the BPI fold-containing superfamily
  JOURNAL   Biochem Soc Trans 39 (4), 977-983 (2011)
   PUBMED   21787333
REFERENCE   4  (bases 1 to 1738)
  AUTHORS   Bingle,C.D., LeClair,E.E., Havard,S., Bingle,L., Gillingham,P. and
            Craven,C.J.
  TITLE     Phylogenetic and evolutionary analysis of the PLUNC gene family
  JOURNAL   Protein Sci 13 (2), 422-430 (2004)
   PUBMED   14739326
REFERENCE   5  (bases 1 to 1738)
  AUTHORS   Andrault,J.B., Gaillard,I., Giorgi,D. and Rouquier,S.
  TITLE     Expansion of the BPI family by duplication on human chromosome 20:
            characterization of the RY gene cluster in 20q11.21 encoding
            olfactory transporters/antimicrobial-like peptides
  JOURNAL   Genomics 82 (2), 172-184 (2003)
   PUBMED   12837268
REFERENCE   6  (bases 1 to 1738)
  AUTHORS   Bingle,C.D. and Craven,C.J.
  TITLE     PLUNC: a novel family of candidate host defence proteins expressed
            in the upper airways and nasopharynx
  JOURNAL   Hum Mol Genet 11 (8), 937-943 (2002)
   PUBMED   11971875
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL121756.14.
            
            On Apr 22, 2021 this sequence version replaced NM_001376932.2.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF549189.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1968832,
                                    SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            inferred exon combination        :: based on alignments, homology
            MANE Ensembl match               :: ENST00000375494.4/
                                                ENSP00000364643.4
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AL121756.14        65583-65645
            64-189              AL121756.14        67102-67227
            190-346             AL121756.14        68222-68378
            347-451             AL121756.14        71058-71162
            452-592             AL121756.14        71571-71711
            593-656             AL121756.14        73448-73511
            657-717             AL121756.14        75295-75355
            718-809             AL121756.14        76137-76228
            810-989             AL121756.14        76346-76525
            990-1043            AL121756.14        78504-78557
            1044-1214           AL121756.14        80483-80653
            1215-1282           AL121756.14        81568-81635
            1283-1325           AL121756.14        82933-82975
            1326-1389           AL121756.14        83784-83847
            1390-1466           AL121756.14        84397-84473
            1467-1738           AL121756.14        85256-85527
FEATURES             Location/Qualifiers
     source          1..1738
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21"
     gene            1..1738
                     /gene="BPIFB3"
                     /gene_synonym="C20orf185; LPLUNC3; RYA3"
                     /note="BPI fold containing family B member 3"
                     /db_xref="GeneID:359710"
                     /db_xref="HGNC:HGNC:16178"
                     /db_xref="MIM:615717"
     exon            1..63
                     /gene="BPIFB3"
                     /gene_synonym="C20orf185; LPLUNC3; RYA3"
                     /inference="alignment:Splign:2.1.0"
     exon            64..189
                     /gene="BPIFB3"
                     /gene_synonym="C20orf185; LPLUNC3; RYA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1496
                     /gene="BPIFB3"
                     /gene_synonym="C20orf185; LPLUNC3; RYA3"
                     /note="long palate, lung and nasal epithelium
                     carcinoma-associated protein 3; ligand-binding protein
                     RYA3"
                     /codon_start=1
                     /product="BPI fold-containing family B member 3 precursor"
                     /protein_id="NP_001363861.2"
                     /db_xref="CCDS:CCDS13212.2"
                     /db_xref="GeneID:359710"
                     /db_xref="HGNC:HGNC:16178"
                     /db_xref="MIM:615717"
                     /translation="MLALWSLLLLWGLATPCQELLETVGTLARIDKDELGKAIQNSLV
                     GEPILQNVLGSVTAVNRGLLGSGGLLGGGGLLGHGGVFGVVEELSGLKIEELTLPKVL
                     LKLLPGFGVQLSLHTKVGMHCSGPLGGLLQLAAEVNVTSRVALAVSSRGTPILILKRC
                     STLLGHISLFSGLLPTPLFGVVEQMLFKVLPGLLCPVVDSVLGVVNELLGAVLGLVSL
                     GALGSVEFSLATLPLISNQYIELDINPIVKSVAGDIIDFPKSRAPAKVPPKKDHTSQV
                     MVPLYLFNTTFGLLQTNGALDMDITPELVPSDVPLTTTDLAALLPEALGKLPLHQQLL
                     LFLRVREAPTVTLHNKKALVSLPANIHVLFYVPKGTPESLFELNSVMTVRAQLAPSAT
                     KLHISLSLERLSVKVASSFTHAFDGSRLEEWLSHVVGAVYAPKLNVALDVGIPLPKVL
                     NINFSNSVLEIVENAVVLTVAS"
     exon            190..346
                     /gene="BPIFB3"
                     /gene_synonym="C20orf185; LPLUNC3; RYA3"
                     /inference="alignment:Splign:2.1.0"
     exon            347..451
                     /gene="BPIFB3"
                     /gene_synonym="C20orf185; LPLUNC3; RYA3"
                     /inference="alignment:Splign:2.1.0"
     exon            452..592
                     /gene="BPIFB3"
                     /gene_synonym="C20orf185; LPLUNC3; RYA3"
                     /inference="alignment:Splign:2.1.0"
     exon            593..656
                     /gene="BPIFB3"
                     /gene_synonym="C20orf185; LPLUNC3; RYA3"
                     /inference="alignment:Splign:2.1.0"
     exon            657..717
                     /gene="BPIFB3"
                     /gene_synonym="C20orf185; LPLUNC3; RYA3"
                     /inference="alignment:Splign:2.1.0"
     exon            718..809
                     /gene="BPIFB3"
                     /gene_synonym="C20orf185; LPLUNC3; RYA3"
                     /inference="alignment:Splign:2.1.0"
     exon            810..989
                     /gene="BPIFB3"
                     /gene_synonym="C20orf185; LPLUNC3; RYA3"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1043
                     /gene="BPIFB3"
                     /gene_synonym="C20orf185; LPLUNC3; RYA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1214
                     /gene="BPIFB3"
                     /gene_synonym="C20orf185; LPLUNC3; RYA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1282
                     /gene="BPIFB3"
                     /gene_synonym="C20orf185; LPLUNC3; RYA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1325
                     /gene="BPIFB3"
                     /gene_synonym="C20orf185; LPLUNC3; RYA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1389
                     /gene="BPIFB3"
                     /gene_synonym="C20orf185; LPLUNC3; RYA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1466
                     /gene="BPIFB3"
                     /gene_synonym="C20orf185; LPLUNC3; RYA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1738
                     /gene="BPIFB3"
                     /gene_synonym="C20orf185; LPLUNC3; RYA3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1714..1719
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BPIFB3"
                     /gene_synonym="C20orf185; LPLUNC3; RYA3"
                     /note="hexamer: AATAAA"
     polyA_site      1738
                     /gene="BPIFB3"
                     /gene_synonym="C20orf185; LPLUNC3; RYA3"
                     /note="major polyA site"
ORIGIN      
        1 gtggaggaac cgacaggagg ccgggagccc ccacctaccc cttgtggagc tgcaggagca
       61 agggcatgca gccagtcatg ctggccctgt ggtccctgct tctgctctgg ggcctggcga
      121 ctccatgcca ggagctgcta gagacggtgg gcacgctcgc tcggattgac aaggatgaac
      181 tcggcaaagc catccagaac tcactggttg gggagcccat tctgcagaat gtgctgggat
      241 cggtcacagc tgtgaaccgg ggcctcttgg gctcaggagg gctgcttgga ggaggcggct
      301 tgctgggcca cggaggggtt tttggcgttg tcgaggagct ctctggtctg aagattgagg
      361 agctcacgct gccaaaggtg ttgctgaagc tgctgccggg atttggggtg cagctgagcc
      421 tgcacaccaa agtgggcatg cattgctctg gcccccttgg tggccttctg cagctggctg
      481 cggaggtgaa cgtgacatcg cgggtggcgc tggccgtgag ctcaaggggc acacccatcc
      541 ttatcctcaa gcgctgcagc acgctcctgg gccacatcag cctgttctca gggctgctgc
      601 ccacaccact ctttggggtc gtggaacaga tgctcttcaa ggtgcttccg ggactgctgt
      661 gccccgtggt ggacagtgtg ctgggtgtgg tgaatgagct cctgggggct gtgctgggcc
      721 tggtgtccct tggggctctt gggtccgtgg aattctctct ggccacattg cctctcatct
      781 ccaaccagta catagaactg gacatcaacc ctatcgtgaa gagtgtagct ggtgatatca
      841 ttgacttccc caagtcccgt gccccagcca aggtgccccc caagaaggac cacacatccc
      901 aggtgatggt gccactgtac ctcttcaaca ccacgtttgg actcctgcag accaacggcg
      961 ccctcgacat ggacatcacc cctgagctgg ttcccagcga tgtcccactg acaactacag
     1021 acctggcagc tttgctccct gaggccctgg ggaagctgcc cctgcaccag caactcctac
     1081 tgttcctgcg ggtgagggaa gctcccacgg tcacactcca caacaagaag gccttggtct
     1141 ccctcccagc caacatccat gtgctgttct atgtccctaa ggggacccct gaatccctct
     1201 ttgagctgaa ctccgtcatg actgtgcgtg cccagctggc tccctcggct accaagctgc
     1261 acatctccct gtccctggaa cggctcagtg tcaaggtggc ctcctccttt acccatgcct
     1321 ttgacggatc gcgtttagaa gaatggctca gccatgtggt cggggcagtg tatgcaccaa
     1381 agcttaacgt ggccctggat gttggaattc ccctgcctaa ggttcttaat atcaattttt
     1441 ccaattcagt tctggagatc gtagagaatg ctgttgtgct gaccgtggca tcctgaggct
     1501 gagacatggc caccagcctt ccctgttgac tactagagac cacctgtcta ctctgcctca
     1561 atttccctcc cagtctctag ctgatgttgg tgacagtaaa aatgccctct ggccctgaag
     1621 cactactcca agtttggggt gggaactgcc tggctaatca tagaactgcc tcagagagag
     1681 ctctggggcc tcagtagcaa accctgagct ttcaataaat gactcctgta tctcggta
//
