LOCUS       NM_033197               1641 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens BPI fold containing family B member 1 (BPIFB1), mRNA.
ACCESSION   NM_033197
VERSION     NM_033197.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1641)
  AUTHORS   Donoghue,L.J., Markovetz,M.R., Morrison,C.B., Chen,G.,
            McFadden,K.M., Sadritabrizi,T., Gutay,M.I., Kato,T., Rogers,T.D.,
            Snead,J.Y., Livraghi-Butrico,A., Button,B., Ehre,C., Grubb,B.R.,
            Hill,D.B. and Kelada,S.N.P.
  TITLE     BPIFB1 loss alters airway mucus properties and diminishes
            mucociliary clearance
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 325 (6), L765-L775 (2023)
   PUBMED   37847709
  REMARK    GeneRIF: BPIFB1 loss alters airway mucus properties and diminishes
            mucociliary clearance.
REFERENCE   2  (bases 1 to 1641)
  AUTHORS   Wang,H., Zhou,Y., Oyang,L., Han,Y., Xia,L., Lin,J., Tang,Y., Su,M.,
            Tan,S., Tian,Y., Chen,X., Luo,X., Liang,J., Rao,S., Wang,Y.,
            Xiong,W., Zeng,Z., Wang,H., Li,G. and Liao,Q.
  TITLE     LPLUNC1 stabilises PHB1 by counteracting TRIM21-mediated
            ubiquitination to inhibit NF-kappaB activity in nasopharyngeal
            carcinoma
  JOURNAL   Oncogene 38 (25), 5062-5075 (2019)
   PUBMED   30886235
  REMARK    GeneRIF: A novel mechanism underlying the anticancer effect of
            LPLUNC1 and clarifying that PHB1 may represent a novel, promising
            candidate tumour suppressor gene in Nasopharyngeal carcinoma, with
            potential therapeutic target value.
REFERENCE   3  (bases 1 to 1641)
  AUTHORS   Wei,F., Tang,L., He,Y., Wu,Y., Shi,L., Xiong,F., Gong,Z., Guo,C.,
            Li,X., Liao,Q., Zhang,W., Ni,Q., Luo,J., Li,X., Li,Y., Peng,C.,
            Chen,X., Li,G., Xiong,W. and Zeng,Z.
  TITLE     BPIFB1 (LPLUNC1) inhibits radioresistance in nasopharyngeal
            carcinoma by inhibiting VTN expression
  JOURNAL   Cell Death Dis 9 (4), 432 (2018)
   PUBMED   29568064
  REMARK    GeneRIF: BPIFB1 negatively regulates its interactor VTN, thereby
            inhibiting VTN-induced proliferation, antiapoptotic effects, G2/M
            phase arrest, DSB repair, and the activation of the ATM-Chk2 and
            ATR-Chk1 pathways after irradiation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1641)
  AUTHORS   Wei,F., Wu,Y., Tang,L., He,Y., Shi,L., Xiong,F., Gong,Z., Guo,C.,
            Li,X., Liao,Q., Zhang,W., Zhou,M., Xiang,B., Li,X., Li,Y., Li,G.,
            Xiong,W. and Zeng,Z.
  TITLE     BPIFB1 (LPLUNC1) inhibits migration and invasion of nasopharyngeal
            carcinoma by interacting with VTN and VIM
  JOURNAL   Br J Cancer 118 (2), 233-247 (2018)
   PUBMED   29123267
  REMARK    GeneRIF: Results showed that BPIFB1 expression markedly inhibited
            NPC cell migration, invasion, and lung-metastatic abilities.
            Additionally, identification of two BPIFB1-interacting proteins,
            VTN and VIM, showed that BPIFB1 reduced VTN expression and the
            formation of a VTN-integrin alphaV complex in NPC cells, leading to
            inhibition of the FAK/Src/ERK signalling pathway.
REFERENCE   5  (bases 1 to 1641)
  AUTHORS   De Smet,E.G., Seys,L.J., Verhamme,F.M., Vanaudenaerde,B.M.,
            Brusselle,G.G., Bingle,C.D. and Bracke,K.R.
  TITLE     Association of innate defense proteins BPIFA1 and BPIFB1 with
            disease severity in COPD
  JOURNAL   Int J Chron Obstruct Pulmon Dis 13, 11-27 (2017)
   PUBMED   29296079
  REMARK    GeneRIF: BPIFA1 and BPIFB1 expressions are correlated with goblet
            cell metaplasia and inversely correlated with lung function
            parameters of airway obstruction (FEV1 and FEV1/FVC) in COPD
            patients.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1641)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 1641)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 1641)
  AUTHORS   Zhang,B., Nie,X., Xiao,B., Xiang,J., Shen,S., Gong,J., Zhou,M.,
            Zhu,S., Zhou,J., Qian,J., Lu,H., He,X., Li,X., Hu,G. and Li,G.
  TITLE     Identification of tissue-specific genes in nasopharyngeal
            epithelial tissue and differentially expressed genes in
            nasopharyngeal carcinoma by suppression subtractive hybridization
            and cDNA microarray
  JOURNAL   Genes Chromosomes Cancer 38 (1), 80-90 (2003)
   PUBMED   12874788
  REMARK    GeneRIF: LPLUNC1 is found to be down-expressed in 33 of 48
            nasopharyngeal carcinoma biopsies.
REFERENCE   9  (bases 1 to 1641)
  AUTHORS   Bingle,C.D. and Craven,C.J.
  TITLE     PLUNC: a novel family of candidate host defence proteins expressed
            in the upper airways and nasopharynx
  JOURNAL   Hum Mol Genet 11 (8), 937-943 (2002)
   PUBMED   11971875
REFERENCE   10 (bases 1 to 1641)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CD696225.1 and AF364078.1.
            
            On Nov 23, 2018 this sequence version replaced NM_033197.2.
            
            Summary: The protein encoded by this gene may be involved in the
            innate immune response to bacterial exposure in the mouth, nasal
            cavities, and lungs. The encoded protein is secreted and is a
            member of the BPI/LBP/PLUNC protein superfamily. This gene is found
            with other members of the superfamily in a cluster on chromosome
            20. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008429.1, AF364078.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000253354.2/ ENSP00000253354.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-331               CD696225.1         102-432
            332-1641            AF364078.1         336-1645
FEATURES             Location/Qualifiers
     source          1..1641
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.21"
     gene            1..1641
                     /gene="BPIFB1"
                     /gene_synonym="C20orf114; LPLUNC1"
                     /note="BPI fold containing family B member 1"
                     /db_xref="GeneID:92747"
                     /db_xref="HGNC:HGNC:16108"
     exon            1..41
                     /gene="BPIFB1"
                     /gene_synonym="C20orf114; LPLUNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            42..197
                     /gene="BPIFB1"
                     /gene_synonym="C20orf114; LPLUNC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1537
                     /gene="BPIFB1"
                     /gene_synonym="C20orf114; LPLUNC1"
                     /note="long palate, lung and nasal epithelium carcinoma
                     associated 1; long palate, lung and nasal epithelium
                     carcinoma-associated protein 1; von Ebner minor salivary
                     gland protein; VEMSGP"
                     /codon_start=1
                     /product="BPI fold-containing family B member 1 precursor"
                     /protein_id="NP_149974.2"
                     /db_xref="CCDS:CCDS13218.1"
                     /db_xref="GeneID:92747"
                     /db_xref="HGNC:HGNC:16108"
                     /translation="MAGPWTFTLLCGLLAATLIQATLSPTAVLILGPKVIKEKLTQEL
                     KDHNATSILQQLPLLSAMREKPAGGIPVLGSLVNTVLKHIIWLKVITANILQLQVKPS
                     ANDQELLVKIPLDMVAGFNTPLVKTIVEFHMTTEAQATIRMDTSASGPTRLVLSDCAT
                     SHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKNQLCPVIEASFNGMYADLLQL
                     VKVPISLSIDRLEFDLLYPAIKGDTIQLYLGAKLLDSQGKVTKWFNNSAASLTMPTLD
                     NIPFSLIVSQDVVKAAVAAVLSPEEFMVLLDSVLPESAHRLKSSIGLINEKAADKLGS
                     TQIVKILTQDTPEFFIDQGHAKVAQLIVLEVFPSSEALRPLFTLGIEASSEAQFYTKG
                     DQLILNLNNISSDRIQLMNSGIGWFQPDVLKNIITEIIHSILLPNQNGKLRSGVPVSL
                     VKALGFEAAESSLTKDALVLTPASLWKPSSPVSQ"
     exon            198..339
                     /gene="BPIFB1"
                     /gene_synonym="C20orf114; LPLUNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            340..447
                     /gene="BPIFB1"
                     /gene_synonym="C20orf114; LPLUNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            448..597
                     /gene="BPIFB1"
                     /gene_synonym="C20orf114; LPLUNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            598..679
                     /gene="BPIFB1"
                     /gene_synonym="C20orf114; LPLUNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            680..743
                     /gene="BPIFB1"
                     /gene_synonym="C20orf114; LPLUNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            744..829
                     /gene="BPIFB1"
                     /gene_synonym="C20orf114; LPLUNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            830..1009
                     /gene="BPIFB1"
                     /gene_synonym="C20orf114; LPLUNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1063
                     /gene="BPIFB1"
                     /gene_synonym="C20orf114; LPLUNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1222
                     /gene="BPIFB1"
                     /gene_synonym="C20orf114; LPLUNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1290
                     /gene="BPIFB1"
                     /gene_synonym="C20orf114; LPLUNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1336
                     /gene="BPIFB1"
                     /gene_synonym="C20orf114; LPLUNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1400
                     /gene="BPIFB1"
                     /gene_synonym="C20orf114; LPLUNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1477
                     /gene="BPIFB1"
                     /gene_synonym="C20orf114; LPLUNC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1641
                     /gene="BPIFB1"
                     /gene_synonym="C20orf114; LPLUNC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1623..1628
                     /regulatory_class="polyA_signal_sequence"
                     /gene="BPIFB1"
                     /gene_synonym="C20orf114; LPLUNC1"
                     /note="hexamer: AATAAA"
     polyA_site      1641
                     /gene="BPIFB1"
                     /gene_synonym="C20orf114; LPLUNC1"
                     /note="major polyA site"
ORIGIN      
        1 gggagaggag aggagcgggc cgaggactcc agcgtgccca ggtctggcat cctgcacttg
       61 ctgccctctg acacctggga agatggccgg cccgtggacc ttcacccttc tctgtggttt
      121 gctggcagcc accttgatcc aagccaccct cagtcccact gcagttctca tcctcggccc
      181 aaaagtcatc aaagaaaagc tgacacagga gctgaaggac cacaacgcca ccagcatcct
      241 gcagcagctg ccgctgctca gtgccatgcg ggaaaagcca gccggaggca tccctgtgct
      301 gggcagcctg gtgaacaccg tcctgaagca catcatctgg ctgaaggtca tcacagctaa
      361 catcctccag ctgcaggtga agccctcggc caatgaccag gagctgctag tcaagatccc
      421 cctggacatg gtggctggat tcaacacgcc cctggtcaag accatcgtgg agttccacat
      481 gacgactgag gcccaagcca ccatccgcat ggacaccagt gcaagtggcc ccacccgcct
      541 ggtcctcagt gactgtgcca ccagccatgg gagcctgcgc atccaactgc tgcataagct
      601 ctccttcctg gtgaacgcct tagctaagca ggtcatgaac ctcctagtgc catccctgcc
      661 caatctagtg aaaaaccagc tgtgtcccgt gatcgaggct tccttcaatg gcatgtatgc
      721 agacctcctg cagctggtga aggtgcccat ttccctcagc attgaccgtc tggagtttga
      781 ccttctgtat cctgccatca agggtgacac cattcagctc tacctggggg ccaagttgtt
      841 ggactcacag ggaaaggtga ccaagtggtt caataactct gcagcttccc tgacaatgcc
      901 caccctggac aacatcccgt tcagcctcat cgtgagtcag gacgtggtga aagctgcagt
      961 ggctgctgtg ctctctccag aagaattcat ggtcctgttg gactctgtgc ttcctgagag
     1021 tgcccatcgg ctgaagtcaa gcatcgggct gatcaatgaa aaggctgcag ataagctggg
     1081 atctacccag atcgtgaaga tcctaactca ggacactccc gagtttttta tagaccaagg
     1141 ccatgccaag gtggcccaac tgatcgtgct ggaagtgttt ccctccagtg aagccctccg
     1201 ccctttgttc accctgggca tcgaagccag ctcggaagct cagttttaca ccaaaggtga
     1261 ccaacttata ctcaacttga ataacatcag ctctgatcgg atccagctga tgaactctgg
     1321 gattggctgg ttccaacctg atgttctgaa aaacatcatc actgagatca tccactccat
     1381 cctgctgccg aaccagaatg gcaaattaag atctggggtc ccagtgtcat tggtgaaggc
     1441 cttgggattc gaggcagctg agtcctcact gaccaaggat gcccttgtgc ttactccagc
     1501 ctccttgtgg aaacccagct ctcctgtctc ccagtgaaga cttggatggc agccatcagg
     1561 gaaggctggg tcccagctgg gagtatgggt gtgagctcta tagaccatcc ctctctgcaa
     1621 tcaataaaca cttgcctgtg a
//
